Promazine (BioDeep_00000002688)

 

Secondary id: BioDeep_00001868035

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-Dimethylamino-1-methylethyl thiodiphenylamine

化学式: C17H20N2S (284.1347)
中文名称: 丙嗪
谱图信息: 最多检出来源 Homo sapiens(urine) 20.13%

分子结构信息

SMILES: CN(C)CCCN1C2=CC=CC=C2SC2=CC=CC=C12
InChI: InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3

描述信息

Promazine is only found in individuals that have used or taken this drug. It is a phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. [PubChem]Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Promazines antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Promazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with promazine.
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AA - Phenothiazines with aliphatic side-chain
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics

同义名列表

15 个代谢物同义名

N-Dimethylamino-1-methylethyl thiodiphenylamine; dimethyl[3-(10H-phenothiazin-10-yl)propyl]amine; 10-(3-(Dimethylamino)propyl)phenothiazine; N-(3-Dimethylaminopropyl)phenothiazine; Hydrochloride, promazine; Promazine hydrochloride; Promazinum; Sinophenin; Protactyl; Promazina; promazine; Combelen; Promazin; Sparine; Promazine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, CYP1A1, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, OSCP1
Peripheral membrane protein 3 CYP1A1, CYP2B6, CYP2E1
Endoplasmic reticulum membrane 9 CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Nucleus 3 ALB, DLD, MPO
cytosol 3 ALB, GSR, MB
dendrite 1 DRD2
centrosome 1 ALB
nucleoplasm 1 MPO
Cell membrane 1 DRD2
Multi-pass membrane protein 2 DRD2, SLC45A2
Golgi apparatus membrane 1 DRD2
Synapse 2 CRH, DRD2
glutamatergic synapse 1 DRD2
Golgi apparatus 1 ALB
Golgi membrane 1 DRD2
lysosomal membrane 1 CP
mitochondrial inner membrane 2 CYP1A1, CYP2E1
presynaptic membrane 1 DRD2
Lysosome 2 MPO, SGSH
acrosomal vesicle 2 DLD, DRD2
plasma membrane 5 CP, CYP2C19, CYP2C9, DRD2, OSCP1
synaptic vesicle membrane 1 DRD2
Membrane 4 CYP2A6, CYP2D6, CYP3A4, SLC45A2
axon 1 DRD2
extracellular exosome 6 ALB, CP, GSR, MB, MPO, SGSH
endoplasmic reticulum 2 ALB, CYP2D6
extracellular space 4 ALB, CP, CRH, MPO
lysosomal lumen 1 SGSH
mitochondrion 4 CYP1A1, CYP2D6, DLD, GSR
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 10 CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4, MPO
Microsome membrane 7 CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Secreted 3 ALB, CP, CRH
extracellular region 4 ALB, CP, CRH, MPO
Single-pass membrane protein 1 CYP2D6
Mitochondrion matrix 1 DLD
mitochondrial matrix 2 DLD, GSR
anchoring junction 1 ALB
ciliary membrane 1 DRD2
motile cilium 1 DLD
external side of plasma membrane 1 GSR
varicosity 1 CRH
dendritic spine 1 DRD2
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, DRD2
Melanosome membrane 1 SLC45A2
sarcoplasm 1 MB
postsynaptic membrane 1 DRD2
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
GABA-ergic synapse 1 DRD2
secretory granule 1 MPO
lateral plasma membrane 1 DRD2
ciliary basal body 1 ALB
cilium 1 DRD2
centriole 1 ALB
Cytoplasmic vesicle, secretory vesicle, acrosome 1 DLD
spindle pole 1 ALB
blood microparticle 2 ALB, CP
Cell projection, cilium, flagellum 1 DLD
non-motile cilium 1 DRD2
sperm flagellum 1 DRD2
basal plasma membrane 1 OSCP1
azurophil granule 1 MPO
endoplasmic reticulum lumen 2 ALB, CP
platelet alpha granule lumen 1 ALB
axon terminus 1 DRD2
pyruvate dehydrogenase complex 1 DLD
endocytic vesicle 1 DRD2
azurophil granule lumen 1 MPO
oxoglutarate dehydrogenase complex 1 DLD
phagocytic vesicle lumen 1 MPO
cytoplasmic microtubule 1 CYP2A6
dopaminergic synapse 1 DRD2
Cytoplasm, sarcoplasm 1 MB
acetyltransferase complex 1 DLD
acrosomal matrix 1 DLD
branched-chain alpha-ketoacid dehydrogenase complex 1 DLD
oxoadipate dehydrogenase complex 1 DLD
G protein-coupled receptor complex 1 DRD2
ciliary transition fiber 1 ALB


文献列表

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