Debromohymenialdisine (BioDeep_00000002657)

   

natural product


代谢物信息卡片


(Z)-Debromohymenialdisine

化学式: C11H11N5O2 (245.0913)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 51.38%

分子结构信息

SMILES: C1CNC(=O)C2=C(C1=C3C(=O)NC(=N3)N)C=CN2
InChI: InChI=1S/C11H11N5O2/c12-11-15-8(10(18)16-11)6-2-4-14-9(17)7-5(6)1-3-13-7/h1,3,6,13H,2,4H2,(H,14,17)(H2,12,16,18)

描述信息

同义名列表

4 个代谢物同义名

Debromohymenialdisine; (Z)-Debromohymenialdisine; DBH; DBHA-SKF; SKF 108753; DBH



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 AIMP2, ATM, BRCA1, CDC25A, CDC25B, CDC25C, CDK1, CDK2, CDK4, CHEK2, HDAC9, NUAK1, PDGFRB, PLK1, VEGFA, WEE1
Endoplasmic reticulum membrane 2 CDK1, HMOX1
Nucleus 17 AIMP2, ATM, BRCA1, CDC25A, CDC25B, CDC25C, CDK1, CDK2, CDK4, CHEK2, HDAC9, HMOX1, NUAK1, PDGFRB, PLK1, VEGFA, WEE1
cytosol 11 AIMP2, ATM, CD44, CDC25A, CDC25B, CDC25C, CDK1, CDK2, CDK4, HMOX1, PLK1
dendrite 1 UCN
nuclear body 1 BRCA1
centrosome 5 ATM, CDC25B, CDK1, CDK2, PLK1
nucleoplasm 14 ATM, BRCA1, CDC25A, CDC25B, CDC25C, CDK1, CDK2, CDK4, CHEK2, HDAC9, HMOX1, NUAK1, PLK1, WEE1
Cell membrane 1 CD44
Cytoplasmic side 1 HMOX1
cell surface 3 CD24, CD44, VEGFA
Golgi apparatus 4 CD44, CHEK2, PDGFRB, VEGFA
Cytoplasm, cytosol 1 AIMP2
endosome 1 CDK2
plasma membrane 3 BRCA1, CD44, PDGFRB
Membrane 8 AIMP2, BRCA1, CD24, CD44, CDK1, HMOX1, PDGFRB, VEGFA
apical plasma membrane 2 CD44, PDGFRB
basolateral plasma membrane 1 CD44
extracellular exosome 2 CD44, CDK1
endoplasmic reticulum 2 HMOX1, VEGFA
extracellular space 2 HMOX1, VEGFA
lysosomal lumen 1 PDGFRB
perinuclear region of cytoplasm 2 CDC25C, HMOX1
adherens junction 1 VEGFA
bicellular tight junction 1 CDK4
mitochondrion 1 CDK1
protein-containing complex 1 BRCA1
intracellular membrane-bounded organelle 3 ATM, CD24, PDGFRB
Single-pass type I membrane protein 1 CD44
Secreted 2 CD44, VEGFA
extracellular region 3 CD44, UCN, VEGFA
Single-pass membrane protein 1 CD44
mitochondrial outer membrane 1 HMOX1
mitochondrial matrix 1 CDK1
transcription regulator complex 3 CDK2, CDK4, HDAC9
centriolar satellite 1 PLK1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 5 ATM, CDC25B, CDK1, CDK2, PLK1
Nucleus membrane 1 CDK4
nuclear membrane 1 CDK4
external side of plasma membrane 1 CD24
varicosity 1 UCN
Secreted, extracellular space, extracellular matrix 1 VEGFA
perikaryon 1 UCN
cytoplasmic vesicle 2 ATM, PDGFRB
microtubule cytoskeleton 2 NUAK1, PLK1
nucleolus 3 ATM, CDK4, WEE1
midbody 2 CDK1, PLK1
spindle midzone 1 PLK1
Membrane raft 1 CD24
Cytoplasm, cytoskeleton, spindle 1 PLK1
focal adhesion 2 CD44, PDGFRB
spindle 2 ATM, PLK1
extracellular matrix 1 VEGFA
Peroxisome matrix 1 ATM
peroxisomal matrix 1 ATM
PML body 1 CHEK2
mitochondrial intermembrane space 1 CDC25C
secretory granule 1 VEGFA
receptor complex 1 PDGFRB
chromatin 2 CDK4, PLK1
cell projection 1 CD44
mitotic spindle 1 CDK1
Chromosome 1 BRCA1
centriole 1 PLK1
[Isoform 5]: Cytoplasm 1 BRCA1
spindle pole 2 CDC25B, PLK1
chromosome, telomeric region 2 CDK1, CDK2
site of double-strand break 1 ATM
Cytoplasm, cytoskeleton, spindle pole 1 CDC25B
fibrillar center 1 NUAK1
nuclear envelope 1 CDK2
microvillus 1 CD44
lateral element 1 BRCA1
Cell projection, microvillus 1 CD44
ubiquitin ligase complex 1 BRCA1
secretory granule membrane 1 CD44
histone methyltransferase complex 1 HDAC9
male germ cell nucleus 2 BRCA1, CDK2
platelet alpha granule lumen 1 VEGFA
axon terminus 1 UCN
kinetochore 1 PLK1
histone deacetylase complex 1 HDAC9
mitotic spindle pole 1 PLK1
XY body 1 BRCA1
extrinsic component of synaptic vesicle membrane 1 ATM
Single-pass type IV membrane protein 1 HMOX1
outer kinetochore 1 PLK1
Cajal body 1 CDK2
ribonucleoprotein complex 1 BRCA1
spindle microtubule 1 CDK1
synaptonemal complex 1 PLK1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
intracellular non-membrane-bounded organelle 1 BRCA1
condensed chromosome 1 CDK2
DNA repair complex 2 ATM, BRCA1
Nucleus, Cajal body 1 CDK2
BRCA1-C complex 1 BRCA1
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 3 CDK1, CDK2, CDK4
lamellipodium membrane 1 CD44
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
macrophage migration inhibitory factor receptor complex 1 CD44
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
cyclin D1-CDK4 complex 1 CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 1 BRCA1


文献列表

  • Safia Mahamed, Raeesa Motal, Titus Govender, Nompilo Dlamini, Kwanele Khuboni, Zamahlubi Hadeb, Baji Baba Shaik, Kimeshni Moodley, Sachin Balaso Mohite, Rajshekhar Karpoormath. A concise review on marine bromopyrrole alkaloids as anticancer agents. Bioorganic & medicinal chemistry letters. 2023 01; 80(?):129102. doi: 10.1016/j.bmcl.2022.129102. [PMID: 36496202]
  • Seon Min Lee, Na-Hyun Kim, Sangbum Lee, Yun Na Kim, Jeong-Doo Heo, Jung-Rae Rho, Eun Ju Jeong. (10Z)-Debromohymenialdisine from Marine Sponge Stylissa sp. Regulates Intestinal Inflammatory Responses in Co-Culture Model of Epithelial Caco-2 Cells and THP-1 Macrophage Cells. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183394. [PMID: 31540496]