Taurocyamine (BioDeep_00000002598)
Secondary id: BioDeep_00001868591
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C3H9N3O3S (167.0365)
中文名称: 胍基磺酸乙酯
谱图信息:
最多检出来源 Homo sapiens(blood) 32.24%
分子结构信息
SMILES: C(CS(=O)(=O)O)N=C(N)N
InChI: InChI=1S/C3H9N3O3S/c4-3(5)6-1-2-10(7,8)9/h1-2H2,(H4,4,5,6)(H,7,8,9)
描述信息
Taurocyamine is a guanidino-taurine analogue derived from taurine. It is an intermediate of taurine and hypotaurine metabolism. The concentration of taurocyamine present in the human urine and serum could be as low as 8-78 pmol/ml. (PMID: 6520173) Plasma levels of taurocyamine are significantly increased in patients with chronic renal failure with or without hemodialysis. (PMID: 10516995). Taurocyamine is an endogenous alkaline "shifter". It effectively reduces the extent of brain intracellular lactic acidosis brought about by anoxic insult. A pH alkaline shift may protect the brain against the deleterious effects of lactic acidosis. (PMID: 8241459). Taurocyamine is an inhibitor of taurine transport and a glycine receptor antagonist in the brain (PMID: 12411417). [HMDB]
Taurocyamine is a guanidino-taurine analogue derived from taurine. It is an intermediate of taurine and hypotaurine metabolism. The concentration of taurocyamine present in the human urine and serum could be as low as 8-78 pmol/ml. (PMID: 6520173) Plasma levels of taurocyamine are significantly increased in patients with chronic renal failure with or without hemodialysis. (PMID: 10516995). Taurocyamine is an endogenous alkaline "shifter". It effectively reduces the extent of brain intracellular lactic acidosis brought about by anoxic insult. A pH alkaline shift may protect the brain against the deleterious effects of lactic acidosis. (PMID: 8241459). Taurocyamine is an inhibitor of taurine transport and a glycine receptor antagonist in the brain (PMID: 12411417).
同义名列表
19 个代谢物同义名
2-[(diaminomethylidene)amino]ethane-1-sulfonic acid; 2-{[amino(imino)methyl]amino}ethanesulphonic acid; 2-{[amino(imino)methyl]amino}ethanesulfonic acid; 2-[(diaminomethylidene)amino]ethanesulfonic acid; 2-{[amino(imino)methyl]amino}ethanesulphonate; 2-{[amino(imino)methyl]amino}ethanesulfonate; 2-{Carbamimidamido}ethanesulfonic acid; 2-{Carbamimidamido}ethanesulfonate; Guanidinoethane sulphonic acid; Guanidinoethane sulfonic acid; Guanidinoethanesulfonic acid; N-(Aminoiminomethyl) taurine; Guanidinoethane sulphonate; Guanidinoethane sulfonate; Guanodinoethane sulfonate; Guanidinoethyl sulfonate; Guanidinoethanesulfonate; Taurocyamine; Taurocyamine
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:17228
- KEGG: C01959
- PubChem: 68340
- HMDB: HMDB0003584
- Metlin: METLIN6962
- ChEMBL: CHEMBL21832
- foodb: FDB023202
- chemspider: 61635
- CAS: 543-18-0
- PMhub: MS000004065
- PubChem: 5060
- PDB-CCD: 3S5
- 3DMET: B00373
- NIKKAJI: J11.554A
- RefMet: Taurocyamine
- KNApSAcK: 17228
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Meenakshi S Kagda, Andrea L Vu, Audrey M V Ah-Fong, Howard S Judelson. Phosphagen kinase function in flagellated spores of the oomycete Phytophthora infestans integrates transcriptional regulation, metabolic dynamics and protein retargeting.
Molecular microbiology.
2018 10; 110(2):296-308. doi:
10.1111/mmi.14108. [PMID: 30137656] - Luz M Suárez, María-Dolores Muñoz, José C González, Julián Bustamante, Rafael Martín Del Río, José M Solís. The taurine transporter substrate guanidinoethyl sulfonate mimics the action of taurine on long-term synaptic potentiation.
Amino acids.
2016 11; 48(11):2647-2656. doi:
10.1007/s00726-016-2298-9. [PMID: 27422547] - Nicolas Froger, Firas Jammoul, David Gaucher, Lucia Cadetti, Henri Lorach, Julie Degardin, Dorothée Pain, Elisabeth Dubus, Valérie Forster, Ivana Ivkovic, Manuel Simonutti, José-Alain Sahel, Serge Picaud. Taurine is a crucial factor to preserve retinal ganglion cell survival.
Advances in experimental medicine and biology.
2013; 775(?):69-83. doi:
10.1007/978-1-4614-6130-2_6. [PMID: 23392925] - David Gaucher, Emilie Arnault, Zoé Husson, Nicolas Froger, Elisabeth Dubus, Pauline Gondouin, Diane Dherbécourt, Julie Degardin, Manuel Simonutti, Stéphane Fouquet, M A Benahmed, K Elbayed, Izzie-Jacques Namer, Pascale Massin, José-Alain Sahel, Serge Picaud. Taurine deficiency damages retinal neurones: cone photoreceptors and retinal ganglion cells.
Amino acids.
2012 Nov; 43(5):1979-93. doi:
10.1007/s00726-012-1273-3. [PMID: 22476345] - Masanori Tachikawa, Saori Ikeda, Jun Fujinawa, Shirou Hirose, Shin-ichi Akanuma, Ken-ichi Hosoya. γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.
PloS one.
2012; 7(2):e32557. doi:
10.1371/journal.pone.0032557. [PMID: 22384273] - S Cubillos, L Lima. Taurine trophic modulation of goldfish retinal outgrowth and its interaction with the optic tectum.
Amino acids.
2006 Oct; 31(3):325-31. doi:
10.1007/s00726-006-0389-8. [PMID: 16937318] - R O Law. Cerebrocellular swelling in the presence of uraemic guanidino compounds: ameliorative effects of taurine.
Neurochemical research.
2005 Dec; 30(12):1465-70. doi:
10.1007/s11064-005-8823-y. [PMID: 16362765] - Wen Chen, Keiko Matuda, Naomichi Nishimura, Hidehiko Yokogoshi. The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet.
Life sciences.
2004 Feb; 74(15):1889-98. doi:
10.1016/j.lfs.2003.08.041. [PMID: 14761670] - B Ciechanowska. [Taurine as a regulator of fluid-electrolyte balance and arterial pressure].
Annales Academiae Medicae Stetinensis.
1997; 43(?):129-42. doi:
. [PMID: 9471912] - C C Yan, R J Huxtable. Effects of taurine and guanidinoethane sulfonate on toxicity of the pyrrolizidine alkaloid monocrotaline.
Biochemical pharmacology.
1996 Feb; 51(3):321-9. doi:
10.1016/0006-2952(95)02185-x. [PMID: 8573199] - C Shimada, S Tanaka, M Hasegawa, S Kuroda, K Isaka, M Sano, H Araki. Beneficial effect of intravenous taurine infusion on electroretinographic disorder in taurine deficient rats.
Japanese journal of pharmacology.
1992 May; 59(1):43-50. doi:
10.1254/jjp.59.43. [PMID: 1507656] - K Ejiri, S Akahori, K Kudo, K Sekiba, T Ubuka. Effect of guanidinoethyl sulfonate on taurine concentrations and fetal growth in pregnant rats.
Biology of the neonate.
1987; 51(4):234-40. doi:
10.1159/000242658. [PMID: 3580427] - K M Marnela, P Kontro, S S Oja. Effects of prolonged guanidinoethanesulphonate administration on taurine and other amino acids in rat tissues.
Medical biology.
1984; 62(4):239-44. doi:
NULL. [PMID: 6513616] - R J Huxtable. Guanidinoethane sulfonate and the disposition of dietary taurine in the rat.
The Journal of nutrition.
1982 Dec; 112(12):2293-300. doi:
10.1093/jn/112.12.2293. [PMID: 7143111] - J E Shaffer, J J Kocsis. Taurine mobilizing effects of beta alanine and other inhibitors of taurine transport.
Life sciences.
1981 Jun; 28(24):2727-36. doi:
10.1016/0024-3205(81)90173-9. [PMID: 6790889] - N V THOAI, S ZAPPACOSTA, Y ROBIN. [BIOGENESIS OF 2 SULFURATED GUANIDINES: TAUROCYAMINE AND HYPOTAUROCYAMINE].
Comparative biochemistry and physiology.
1963 Nov; 10(?):209-25. doi:
10.1016/0010-406x(63)90035-5. [PMID: 14109748] - NGUYEN-VAN THOAI, J ROCHE, A OLUMUCKI. [The presence of taurocyamine (guanidotaurine) in the urine of the rat and its biochemical significance in nitrogen excretion].
Biochimica et biophysica acta.
1954 Jul; 14(3):448. doi:
10.1016/0006-3002(54)90213-9. [PMID: 13181911]
