Montelukast (BioDeep_00000002541)

 

Secondary id: BioDeep_00000409846

human metabolite blood metabolite


代谢物信息卡片


1-[[[(1R)-1-[3-(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]-methyl]-cyclopropaneacetic acid, monosodium salt

化学式: C35H36ClNO3S (585.2104296000001)
中文名称: 孟鲁司特
谱图信息: 最多检出来源 Homo sapiens(blood) 87.5%

分子结构信息

SMILES: CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O
InChI: InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1

描述信息

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific locus of operation, it does not interact with other allergy medications such as theophylline. Montelukast is marketed in United States and many other countries by Merck & Co. with the brand name Singulair. It is available as oral tablets, chewable tablets, and oral granules. In India and other countries, it is also marketed under the brand name Montair®, produced by Indian company Cipla.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DC - Leukotriene receptor antagonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D020024 - Leukotriene Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
D065693 - Cytochrome P-450 Enzyme Inducers > D065694 - Cytochrome P-450 CYP1A2 Inducers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

19 个代谢物同义名

1-[[[(1R)-1-[3-(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]-methyl]-cyclopropaneacetic acid, monosodium salt; 1-[[[(1 R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulphanyl]methyl]cyclopropaneacetic acid; 1-[[[(1 R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid; 2-[1-({[(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl}methyl)cyclopropyl]acetic acid; 1-[[[(1 R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulphanyl]methyl]cyclopropaneacetate; 1-[[[(1 R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetate; (R-(e))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid; (R-(e))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetate; Sodium 1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate; Merck sharp and dohme brand OF montelukast sodium; Cahill may roberts brand OF montelukast sodium; Merck frosst brand OF montelukast sodium; Merck brand OF montelukast sodium; Montelukast (sodium salt); Montelukast sodium; cis-Montelukast; Montelukast; Singulair; Brondilat



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhi-Hui Fu, Lin Zhou, An-Zheng Nie. [Effect and mechanism of Maxing Shigan Decoction on reducing inflammatory response in rats with cough variant asthma via TLR4/MyD88/NF-κB and p38 MAPK signaling pathways]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):1000-1006. doi: 10.19540/j.cnki.cjcmm.20230921.406. [PMID: 38621907]
  • Surbhi Gupta, Prabhat Singh, Bhupesh Sharma. Montelukast Ameliorates 2K1C-Hypertension Induced Endothelial Dysfunction and Associated Vascular Dementia. Current hypertension reviews. 2024 Jan; ?(?):. doi: 10.2174/0115734021276985231204092425. [PMID: 38192137]
  • Hanan H Hagar, Shaima M Alhazmi, Maha Arafah, Nervana Mustafa Bayoumy. Inhibition of sepsis-induced pancreatic injury by leukotriene receptor antagonism via modulation of oxidative injury, and downregulation of inflammatory markers in experimental rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Nov; ?(?):. doi: 10.1007/s00210-023-02812-y. [PMID: 37962585]
  • Shiyun Pu, Jingyi Zhang, Changyu Ren, Hongjing Zhou, Yan Wang, Yuanli Wu, Shuangyu Yang, Fangyin Cao, Houfeng Zhou. Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation. Life sciences. 2023 Jul; 325(?):121772. doi: 10.1016/j.lfs.2023.121772. [PMID: 37178864]
  • Mohammad Amin Behmanesh, Amin Rasekhian, Forutan Kiani, Mostafa Dehghandoost, Davood Alinezhad Dezfuli, Behnam Ghorbanzadeh. The nitric oxide-cyclic GMP-KATP channels pathway contributes to the effects of montelukast against gastric damage induced by ethanol. Alcohol (Fayetteville, N.Y.). 2023 Jun; ?(?):. doi: 10.1016/j.alcohol.2023.05.008. [PMID: 37295565]
  • Qian Xu, Tingting Lu, Zhongyang Song, Peng Zhu, Yana Wu, Lumei Zhang, Kehu Yang, Zhiming Zhang. Efficacy and safety of montelukast adjuvant therapy in adults with cough variant asthma: A systematic review and meta-analysis. The clinical respiratory journal. 2023 May; ?(?):. doi: 10.1111/crj.13629. [PMID: 37218346]
  • Ahmed M Fleifel, Ayman A Soubh, Dalaal M Abdallah, Kawkab A Ahmed, Hanan S El-Abhar. Preferential effect of Montelukast on Dapagliflozin: Modulation of IRS-1/AKT/GLUT4 and ER stress response elements improves insulin sensitivity in soleus muscle of a type-2 diabetic rat model. Life sciences. 2022 Oct; 307(?):120865. doi: 10.1016/j.lfs.2022.120865. [PMID: 35934057]
  • S Scott Sutton, Joseph Magagnoli, Tammy H Cummings, James W Hardin. Leukotriene receptor antagonism with montelukast as a possible therapeutic for venous thromboembolism prophylaxis: An observational study. Prostaglandins & other lipid mediators. 2022 08; 161(?):106649. doi: 10.1016/j.prostaglandins.2022.106649. [PMID: 35595009]
  • Yun Wu, Chen Cui, Fang-Fang Bi, Cheng-Yu Wu, Jin-Rui Li, Yu-Meng Hou, Ze-Hong Jing, Qing-Ming Pan, Miao Cao, Li-Fang Lv, Xue-Lian Li, Hong-Li Shan, Xin Zhai, Yu-Hong Zhou. Montelukast, cysteinyl leukotriene receptor 1 antagonist, inhibits cardiac fibrosis by activating APJ. European journal of pharmacology. 2022 May; 923(?):174892. doi: 10.1016/j.ejphar.2022.174892. [PMID: 35358494]
  • Giuseppe Fabio Parisi, Sara Manti, Maria Papale, Alessandro Giallongo, Cristiana Indolfi, Michele Miraglia Del Giudice, Carmelo Salpietro, Amelia Licari, Gian Luigi Marseglia, Salvatore Leonardi. Addition of a nutraceutical to montelukast or inhaled steroid in the treatment of wheezing during COVID-19 pandemic: a multicenter, open-label, randomized controlled trial. Acta bio-medica : Atenei Parmensis. 2022 05; 93(2):e2022156. doi: 10.23750/abm.v93i2.11958. [PMID: 35546018]
  • Buğra Kerget, Ferhan Kerget, Murat Aydın, Ömer Karaşahin. Effect of montelukast therapy on clinical course, pulmonary function, and mortality in patients with COVID-19. Journal of medical virology. 2022 05; 94(5):1950-1958. doi: 10.1002/jmv.27552. [PMID: 34958142]
  • Kirsten M Williams, Steven Z Pavletic, Stephanie J Lee, Paul J Martin, Don E Farthing, Frances T Hakim, Jeremy Rose, Beryl L Manning-Geist, Juan C Gea-Banacloche, Leora E Comis, Edward W Cowen, David G Justus, Kristin Baird, Guang-Shing Cheng, Daniele Avila, Seth M Steinberg, Sandra A Mitchell, Ronald E Gress. Prospective Phase II Trial of Montelukast to Treat Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation and Investigation into Bronchiolitis Obliterans Syndrome Pathogenesis. Transplantation and cellular therapy. 2022 05; 28(5):264.e1-264.e9. doi: 10.1016/j.jtct.2022.01.021. [PMID: 35114411]
  • Yongkang Chen, Xiaohuan Wang, Huichun Shi, Peng Zou. Montelukast Inhibits HCoV-OC43 Infection as a Viral Inactivator. Viruses. 2022 04; 14(5):. doi: 10.3390/v14050861. [PMID: 35632604]
  • Ahsan R Khan, Christian Misdary, Nikhil Yegya-Raman, Sinae Kim, Navaneeth Narayanan, Sheraz Siddiqui, Padmini Salgame, Jared Radbel, Frank De Groote, Carl Michel, Janice Mehnert, Caleb Hernandez, Thomas Braciale, Jyoti Malhotra, Michael A Gentile, Salma K Jabbour. Montelukast in hospitalized patients diagnosed with COVID-19. The Journal of asthma : official journal of the Association for the Care of Asthma. 2022 04; 59(4):780-786. doi: 10.1080/02770903.2021.1881967. [PMID: 33577360]
  • Heba M Hafez, Hanaa Hassanein. Montelukast ameliorates doxorubicin-induced cardiotoxicity via modulation of p-glycoprotein and inhibition of ROS-mediated TNF-α/NF-κB pathways. Drug and chemical toxicology. 2022 Mar; 45(2):548-559. doi: 10.1080/01480545.2020.1730885. [PMID: 32106718]
  • Serdar Durdagi, Timucin Avsar, Muge Didem Orhan, Muge Serhatli, Bertan Koray Balcioglu, Hasan Umit Ozturk, Alisan Kayabolen, Yuksel Cetin, Seyma Aydinlik, Tugba Bagci-Onder, Saban Tekin, Hasan Demirci, Mustafa Guzel, Atilla Akdemir, Seyma Calis, Lalehan Oktay, Ilayda Tolu, Yasar Enes Butun, Ece Erdemoglu, Alpsu Olkan, Nurettin Tokay, Şeyma Işık, Aysenur Ozcan, Elif Acar, Sehriban Buyukkilic, Yesim Yumak. The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 02; 30(2):963-974. doi: 10.1016/j.ymthe.2021.10.014. [PMID: 34678509]
  • Bruce Chandler May, Kathleen Holly Gallivan. Levocetirizine and montelukast in the COVID-19 treatment paradigm. International immunopharmacology. 2022 Feb; 103(?):108412. doi: 10.1016/j.intimp.2021.108412. [PMID: 34942461]
  • Francisco Mera-Cordero, Sara Bonet-Monne, Jesús Almeda-Ortega, Ana García-Sangenís, Oriol Cunillera-Puèrtolas, Sara Contreras-Martos, Gemma Alvarez-Muñoz, Ramon Monfà, Marina Balanzo-Joué, Rosa Morros, Betlem Salvador-Gonzalez. Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol. Trials. 2022 Jan; 23(1):19. doi: 10.1186/s13063-021-05951-w. [PMID: 34991703]
  • Zang Ping, Xue Jun, Wang Yan, Zhang Jun. The comparison between the effect of Glycyrrhizae uralensis (Gan-Cao) and Montelukast on the expression of T-bet and GATA-3 genes in children with allergic asthma. Cellular and molecular biology (Noisy-le-Grand, France). 2022 Jan; 67(4):306-312. doi: 10.14715/cmb/2021.67.4.34. [PMID: 35809275]
  • Jiachun Li, Ziliang Huang, Keying Li, Xiaoyun Jian, Binghui Liang. Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma. Computational and mathematical methods in medicine. 2022; 2022(?):9803552. doi: 10.1155/2022/9803552. [PMID: 36132547]
  • Isil Gazioglu, S Evrim Kepekci Tekkeli, Angela Tartaglia, Ceylin Aslan, Marcello Locatelli, Abuzar Kabir. Simultaneous determination of febuxostat and montelukast in human plasma using fabric phase sorptive extraction and high performance liquid chromatography-fluorimetric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jan; 1188(?):123070. doi: 10.1016/j.jchromb.2021.123070. [PMID: 34920289]
  • Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi. Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption. PloS one. 2022; 17(11):e0277307. doi: 10.1371/journal.pone.0277307. [PMID: 36395281]
  • Ashok K Datusalia, Gurpreet Singh, Nikita Yadav, Sachin Gaun, Moumita Manik, Rakesh K Singh. Targeted Delivery of Montelukast for the Treatment of Alzheimer's Disease. CNS & neurological disorders drug targets. 2022; 21(10):913-925. doi: 10.2174/1871527320666210902163756. [PMID: 34477536]
  • Xiuling Zhou, Ye Zhang, Le Liu, Xiaochun Feng, Hongshi Zhang. Therapeutic effect of acupuncture combined montelukast sodium on cough variant asthma in children: A protocol for systematic review and meta-analysis. Medicine. 2021 Dec; 100(51):e28048. doi: 10.1097/md.0000000000028048. [PMID: 34941045]
  • Andrzej Bozek, Janne Winterstein. Montelukast's ability to fight COVID-19 infection. The Journal of asthma : official journal of the Association for the Care of Asthma. 2021 10; 58(10):1348-1349. doi: 10.1080/02770903.2020.1786112. [PMID: 32586154]
  • Niusha Sharifinejad, Samin Sharafian, Sana Salekmoghadam, Marzieh Tavakol, Mostafa Qorbani. Montelukast and Coronavirus Disease 2019: A Scoping Review. Iranian journal of allergy, asthma, and immunology. 2021 Aug; 20(4):384-393. doi: NULL. [PMID: 34418892]
  • Hayder M Al-Kuraishy, Ali I Al-Gareeb, Yaaser Q Almulaiky, Natália Cruz-Martins, Gaber El-Saber Batiha. Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity. European journal of pharmacology. 2021 Aug; 904(?):174196. doi: 10.1016/j.ejphar.2021.174196. [PMID: 34004207]
  • Ahmed M El-Baz, Ahmed Shata, Hanan M Hassan, Mohamed M A El-Sokkary, Ahmed E Khodir. The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress. International immunopharmacology. 2021 Jul; 96(?):107757. doi: 10.1016/j.intimp.2021.107757. [PMID: 33991997]
  • Po-Yu Huang, Yao-Hsu Yang, Ying-Hua Huang, Ho-Chang Kuo, Liang-Jen Wang, Shao-Ju Chien, Ling-Sai Chang. Montelukast does not increase the risk of attention-deficit/hyperactivity disorder in pediatric asthma patients: A nationwide population-based matched cohort study. Journal of the Formosan Medical Association = Taiwan yi zhi. 2021 Jun; 120(6):1369-1376. doi: 10.1016/j.jfma.2020.10.018. [PMID: 33158697]
  • Walaa Yehia Abdelzaher, Remon Roshdy Rofaeil, Sara Mohammed Naguib Abdel-Hafez, Medhat Atta, Mohamed Ahmed Bahaa El-Deen, Dalia Mohamed Ali. Ameliorating effect of leukotriene receptor antagonist in multi-organ toxicity induced in rat offspring, a possible role for epidermal growth factor. Immunopharmacology and immunotoxicology. 2021 Apr; 43(2):183-191. doi: 10.1080/08923973.2021.1878213. [PMID: 33504223]
  • René Lima-Morales, Pablo Méndez-Hernández, Yvonne N Flores, Patricia Osorno-Romero, Christian Ronal Sancho-Hernández, Elizabeth Cuecuecha-Rugerio, Adrián Nava-Zamora, Diego Rolando Hernández-Galdamez, Daniela Karola Romo-Dueñas, Jorge Salmerón. Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021 Apr; 105(?):598-605. doi: 10.1016/j.ijid.2021.02.014. [PMID: 33578014]
  • Johanna Michael, Julia Zirknitzer, Michael Stefan Unger, Rodolphe Poupardin, Tanja Rieß, Nadine Paiement, Horst Zerbe, Birgit Hutter-Paier, Herbert Reitsamer, Ludwig Aigner. The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice. International journal of molecular sciences. 2021 Mar; 22(5):. doi: 10.3390/ijms22052782. [PMID: 33803482]
  • Donald H Arnold, Sara L Van Driest, Theodore F Reiss, Jennifer C King, Wendell S Akers. Pilot Study of Peak Plasma Concentration After High-Dose Oral Montelukast in Children With Acute Asthma Exacerbations. Journal of clinical pharmacology. 2021 03; 61(3):360-367. doi: 10.1002/jcph.1738. [PMID: 32960980]
  • Chunlong Ma, Jun Wang. Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2021 02; 118(8):. doi: 10.1073/pnas.2024420118. [PMID: 33568498]
  • Zhe Li, Yuxi Lin, Yi-You Huang, Runduo Liu, Chang-Guo Zhan, Xin Wang, Hai-Bin Luo. Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2021 02; 118(8):. doi: 10.1073/pnas.2024937118. [PMID: 33568500]
  • Emily Yii Ling Wong, Gabriel Onn Kit Loh, Yvonne Tze Fung Tan, Kok Khiang Peh. Development of LC-MS/MS method and application to bioequivalence study of a light sensitive drug montelukast. Drug development and industrial pharmacy. 2021 Feb; 47(2):197-206. doi: 10.1080/03639045.2020.1862177. [PMID: 33300818]
  • Weihong Li, Yanrong Wang, Yingzi Pei, Yue Xia. Pharmacokinetics and Bioequivalence Evaluation of Two Montelukast Sodium Chewable Tablets in Healthy Chinese Volunteers Under Fasted and Fed Conditions. Drug design, development and therapy. 2021; 15(?):1091-1099. doi: 10.2147/dddt.s298355. [PMID: 33727797]
  • Mangaldeep Dey, Rakesh Kumar Singh. Possible Therapeutic Potential of Cysteinyl Leukotriene Receptor Antagonist Montelukast in Treatment of SARS-CoV-2-Induced COVID-19. Pharmacology. 2021; 106(9-10):469-476. doi: 10.1159/000518359. [PMID: 34350893]
  • Ken Korzekwa. Case Study 5: Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast. Methods in molecular biology (Clifton, N.J.). 2021; 2342(?):685-693. doi: 10.1007/978-1-0716-1554-6_24. [PMID: 34272712]
  • Piñeyro-Garza Everardo, Gómez-Silva Magdalena, Gamino-Peña Maria Elena, Cohen-Muñoz Vanessa, Sánchez-Casado Gabriela. Bioavailability assessment of fexofenadine and montelukast in a fixed-dose combination tablet versus the components administered simultaneously. Allergologia et immunopathologia. 2021; 49(4):15-25. doi: 10.15586/aei.v49i4.89. [PMID: 34224214]
  • Dennis C Copertino, Rodrigo R R Duarte, Timothy R Powell, Miguel de Mulder Rougvie, Douglas F Nixon. Montelukast drug activity and potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Journal of medical virology. 2021 01; 93(1):187-189. doi: 10.1002/jmv.26299. [PMID: 32658304]
  • Nitesh Sanghai, Geoffrey K Tranmer. Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms. Drug discovery today. 2020 12; 25(12):2076-2079. doi: 10.1016/j.drudis.2020.09.013. [PMID: 32949526]
  • Chao-Qing Gao, Jia-Jun Zhou, Ya-Yin Tan, Chang-Jun Tong. Effectiveness of montelukast for uremic pruritus in hemodialysis patients: A protocol for systematic review and meta-analysis. Medicine. 2020 Nov; 99(46):e23229. doi: 10.1097/md.0000000000023229. [PMID: 33181709]
  • Dipankar Bhattacharyya. Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2. Medical hypotheses. 2020 Nov; 144(?):110046. doi: 10.1016/j.mehy.2020.110046. [PMID: 33254480]
  • Nosayba Al-Azzam, Lina Elsalem. Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives. Life sciences. 2020 Nov; 260(?):118452. doi: 10.1016/j.lfs.2020.118452. [PMID: 32956660]
  • Chia Siang Kow, Syed Shahzad Hasan. Montelukast in children with allergic rhinitis amid COVID-19 pandemic. Acta paediatrica (Oslo, Norway : 1992). 2020 10; 109(10):2151. doi: 10.1111/apa.15491. [PMID: 32686128]
  • Francesca Citron, Luigi Perelli, Angela K Deem, Giannicola Genovese, Andrea Viale. Leukotrienes, a potential target for Covid-19. Prostaglandins, leukotrienes, and essential fatty acids. 2020 10; 161(?):102174. doi: 10.1016/j.plefa.2020.102174. [PMID: 32977289]
  • Donald C Moore, Justin R Arnall, Daniel L Thompson, Allison L Martin, Jordan Robinson, Ami Ndiaye, Barry Paul, Shebli Atrash, Manisha Bhutani, Peter M Voorhees, Saad Z Usmani. Evaluation of Montelukast for the Prevention of Infusion-related Reactions With Daratumumab. Clinical lymphoma, myeloma & leukemia. 2020 10; 20(10):e777-e781. doi: 10.1016/j.clml.2020.05.024. [PMID: 32660902]
  • Muhammad Qutayba Almerie, David Daniel Kerrigan. The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast. Medical hypotheses. 2020 Oct; 143(?):109883. doi: 10.1016/j.mehy.2020.109883. [PMID: 32492562]
  • Sushma Bhattachan, Yogesh Neupane, Bibhu Pradhan, Naramaya Thapa. Comparison of Outcomes Between Mometasone Furoate Intranasal Spray and Oral Montelukast in Patients with Allergic Rhinitis. Journal of Nepal Health Research Council. 2020 Sep; 18(2):268-270. doi: 10.33314/jnhrc.v18i2.2509. [PMID: 32969391]
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