Gemfibrozil (BioDeep_00000002443)

 

Secondary id: BioDeep_00000397811

human metabolite blood metabolite


代谢物信息卡片


2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure

化学式: C15H22O3 (250.1569)
中文名称: 吉非贝齐, 吉非罗齐
谱图信息: 最多检出来源 Homo sapiens(blood) 7.71%

分子结构信息

SMILES: CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
InChI: InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

描述信息

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]
CONFIDENCE standard compound; INTERNAL_ID 448; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5593; ORIGINAL_PRECURSOR_SCAN_NO 5591
CONFIDENCE standard compound; INTERNAL_ID 448; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5614; ORIGINAL_PRECURSOR_SCAN_NO 5613
CONFIDENCE standard compound; INTERNAL_ID 448; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5641; ORIGINAL_PRECURSOR_SCAN_NO 5637
CONFIDENCE standard compound; INTERNAL_ID 448; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5627; ORIGINAL_PRECURSOR_SCAN_NO 5624
CONFIDENCE standard compound; INTERNAL_ID 448; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5626; ORIGINAL_PRECURSOR_SCAN_NO 5624
CONFIDENCE standard compound; INTERNAL_ID 448; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5624; ORIGINAL_PRECURSOR_SCAN_NO 5622
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065687 - Cytochrome P-450 CYP2C8 Inhibitors
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AB - Fibrates
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
CONFIDENCE standard compound; INTERNAL_ID 4077
CONFIDENCE standard compound; INTERNAL_ID 2691
D009676 - Noxae > D000963 - Antimetabolites
Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

同义名列表

83 个代谢物同义名

2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure; 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid; 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure; 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid; Terry white chemists brand OF gemfibrozil; 2,2-Dimethyl-5-(2,5-xylyloxy)valerate; Warner-lambert brand OF gemfibrozil; Warner lambert brand OF gemfibrozil; Pharmascience brand OF gemfibrozil; Healthsense brand OF gemfibrozil; Farmasierra brand OF gemfibrozil; Parke davis brand OF gemfibrozil; Terry white chemists gemfibrozil; United drug brand OF gemfibrozil; Alphapharm brand OF gemfibrozil; Chem mart brand OF gemfibrozil; Cantabria brand OF gemfibrozil; Novopharm brand OF gemfibrozil; Biochemie brand OF gemfibrozil; Nu-pharm brand OF gemfibrozil; Faulding brand OF gemfibrozil; Quimifar brand OF gemfibrozil; Genpharm brand OF gemfibrozil; Nu pharm brand OF gemfibrozil; Menarini brand OF gemfibrozil; Douglas brand OF gemfibrozil; Bayvit brand OF gemfibrozil; Ferrer brand OF gemfibrozil; Apotex brand OF gemfibrozil; Pfizer brand OF gemfibrozil; Hexal brand OF gemfibrozil; Bexal brand OF gemfibrozil; Sigma brand OF gemfibrozil; Ipsen brand OF gemfibrozil; Bull brand OF gemfibrozil; Gemfibrozil, healthsense; TAD brand OF gemfibrozil; 1a Brand OF gemfibrozil; Healthsense gemfibrozil; Chem mart gemfibrozil; Bayvit, gemfibrozilo; Gemfibrozilo bayvit; Gemfibrozil, genrx; Gemfibrozilo bexal; Gemfibrozil, sbpa; GenRX gemfibrozil; Novo-gemfibrozil; Novo gemfibrozil; SBPA gemfibrozil; DBL Gemfibrozil; Apo gemfibrozil; Gen-gemfibrozil; Apo-gemfibrozil; PMS Gemfibrozil; Gemfibrozilo ur; PMS-Gemfibrozil; Gen gemfibrozil; Gemfi 1a pharma; ApoGemfibrozil; GenGemfibrozil; Nu-gemfibrozil; Nu gemfibrozil; Gemfibrozilum; NuGemfibrozil; Gemfibrozilo; Gemfibrosil; gemfibrozil; Lipox gemfi; Gemhexal; Decrelip; Trialmin; Lipazil; Bolutol; Lopid R; Litarek; Pilder; Ausgem; Lipur; Jezil; Lopid; CI-719; Gemfibrozil; Gemfibrozil



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, APOB, APOE, CYP2C19, CYP2C8, CYP2C9, CYP3A4, HPGDS
Peripheral membrane protein 2 CYP1B1, LPL
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 8 APOB, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, HMGCR
Nucleus 3 ALB, APOE, PPARA
cytosol 4 ALB, APOB, GPT, HPGDS
dendrite 1 APOE
centrosome 1 ALB
nucleoplasm 2 HPGDS, PPARA
Cell membrane 2 LPL, SLCO1B1
Multi-pass membrane protein 3 HMGCR, SLC22A8, SLCO1B1
cell surface 1 LPL
glutamatergic synapse 1 APOE
Golgi apparatus 2 ALB, APOE
Golgi membrane 1 INS
neuronal cell body 2 APOB, APOE
smooth endoplasmic reticulum 1 APOB
plasma membrane 9 APOB, APOE, CYP2C19, CYP2C8, CYP2C9, LPL, SERPINE1, SLC22A8, SLCO1B1
Membrane 5 APOE, CYP1B1, CYP3A4, HMGCR, SLCO1B1
apical plasma membrane 1 SLC22A8
basolateral plasma membrane 2 SLC22A8, SLCO1B1
extracellular exosome 8 ALB, APOB, APOC3, APOE, CETP, GPT, SERPINE1, SLC22A8
endoplasmic reticulum 3 ALB, APOE, HMGCR
extracellular space 8 ALB, APOB, APOC3, APOE, CETP, INS, LPL, SERPINE1
lysosomal lumen 1 APOB
mitochondrion 1 CYP1B1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 8 APOB, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, HPGDS
Microsome membrane 4 CYP1A2, CYP1B1, CYP2C9, CYP3A4
Secreted 8 ALB, APOB, APOC3, APOE, CETP, INS, LPL, SERPINE1
extracellular region 8 ALB, APOB, APOC3, APOE, CETP, INS, LPL, SERPINE1
Extracellular side 1 LPL
anchoring junction 1 ALB
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 2 APOE, LPL
chylomicron 4 APOB, APOC3, APOE, LPL
high-density lipoprotein particle 2 APOE, CETP
low-density lipoprotein particle 2 APOB, APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 4 APOB, APOC3, APOE, LPL
Early endosome 3 APOB, APOC3, APOE
vesicle 1 CETP
extracellular matrix 1 APOE
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 3 APOC3, APOE, SERPINE1
lateral plasma membrane 1 SLC22A8
ciliary basal body 1 ALB
chromatin 1 PPARA
centriole 1 ALB
Secreted, extracellular space 1 APOE
spindle pole 1 ALB
blood microparticle 2 ALB, APOE
Basolateral cell membrane 2 SLC22A8, SLCO1B1
endosome lumen 2 APOB, INS
Lipid droplet 1 APOB
Melanosome 1 APOE
Peroxisome membrane 1 HMGCR
basal plasma membrane 1 SLCO1B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, APOB, APOE, INS
platelet alpha granule lumen 2 ALB, SERPINE1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 2 APOB, APOE
synaptic cleft 1 APOE
Basal cell membrane 1 SLCO1B1
serine protease inhibitor complex 1 SERPINE1
discoidal high-density lipoprotein particle 1 APOE
spherical high-density lipoprotein particle 1 APOC3
endocytic vesicle lumen 2 APOB, APOE
peptidase inhibitor complex 1 SERPINE1
chylomicron remnant 2 APOB, APOE
intermediate-density lipoprotein particle 3 APOB, APOC3, APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
mature chylomicron 1 APOB
catalytic complex 1 LPL
ciliary transition fiber 1 ALB


文献列表

  • Kathryn L Linge, Yolanta Gruchlik, Francesco Busetti, Una Ryan, Cynthia A Joll. Use of micropollutant indicator ratios to characterize wastewater treatment plant efficiency and to identify wastewater impact on groundwater. Journal of environmental management. 2024 May; 358(?):120822. doi: 10.1016/j.jenvman.2024.120822. [PMID: 38599088]
  • Anne Kuebart, Katharina Gross, Charlotte Maicher, Max Sonnenschein, Annika Raupach, Jan Schulz, Richard Truse, Stefan Hof, Carsten Marcus, Christian Vollmer, Inge Bauer, Olaf Picker, Borna Relja, Anna Herminghaus. Gemfibrozil Improves Microcirculatory Oxygenation of Colon and Liver without Affecting Mitochondrial Function in a Model of Abdominal Sepsis in Rats. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010262. [PMID: 38203431]
  • Sumita Raha, Debashis Dutta, Ramesh K Paidi, Kalipada Pahan. Lipid-Lowering Drug Gemfibrozil Protects Mice from Tay-Sachs Disease via Peroxisome Proliferator-Activated Receptor α. Cells. 2023 12; 12(24):. doi: 10.3390/cells12242791. [PMID: 38132111]
  • Hugo Alarie, Nadia Côté, Luc Gaudreau, Magali Houde, Pedro A Segura. Are 20-hydroxyecdysone and related genes potential biomarkers of sublethal exposure to lipid-altering contaminants?. Environmental science and pollution research international. 2023 Dec; 30(60):126104-126115. doi: 10.1007/s11356-023-31087-2. [PMID: 38010540]
  • Mehraveh Sadeghi Ivraghi, Mohammad Yasin Zamanian, Reena Gupta, Harun Achmad, Hashem O Alsaab, Ahmed Hjazi, Rosario Mireya Romero-Parra, Enas R Alwaily, Beneen M Hussien, Elham Hakimizadeh. Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms. CNS neuroscience & therapeutics. 2023 Oct; ?(?):. doi: 10.1111/cns.14473. [PMID: 37904726]
  • Nan Wang, Yujing Zhao, Meiyan Wu, Na Li, Chaoying Yan, Hongyan Guo, Qiao Li, Qing Li, Qiang Wang. Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes. Molecular neurobiology. 2023 Sep; ?(?):. doi: 10.1007/s12035-023-03589-0. [PMID: 37697219]
  • Débora Jesabel Pérez, Lucas Rodrigo Lombardero, William Joseph Doucette. Influence of exposure time, physicochemical properties, and plant transpiration on the uptake dynamics and translocation of pharmaceutical and personal care products in the aquatic macrophyte Typha latifolia. The Science of the total environment. 2023 Jun; ?(?):165107. doi: 10.1016/j.scitotenv.2023.165107. [PMID: 37364828]
  • Neha Kamal, Raveendran Sindhu, Preeti Chaturvedi Bhargava. Biodegradation of emerging organic pollutant gemfibrozil: Mechanism, kinetics and pathway modelling. Bioresource technology. 2023 Apr; 374(?):128749. doi: 10.1016/j.biortech.2023.128749. [PMID: 36796732]
  • Laongdao Thongnak, Nattavadee Pengrattanachot, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Krit Jaikumkao, Anusorn Lungkaphin. Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway. Archives of pharmacal research. 2023 Mar; ?(?):. doi: 10.1007/s12272-023-01439-0. [PMID: 36966452]
  • Venkateswarlu Korthikunta, Rohit Singh, Rohit Srivastava, Jyotsana Pandey, Atul Srivastava, Upma Chaturvedi, Akansha Mishra, Arvind K Srivastava, Akhilesh K Tamrakar, Narender Tadigoppula. Design, synthesis, and evaluation of benzofuran-based chromenochalcones for antihyperglycemic and antidyslipidemic activities. RSC medicinal chemistry. 2023 Mar; 14(3):470-481. doi: 10.1039/d2md00341d. [PMID: 36970150]
  • Mohammad Ali Karimi, Mehdi Goudarzi, Mohammad Javad Khodayar, Layasadat Khorsandi, Saeed Mehrzadi, Iman Fatemi. Gemfibrozil palliates adriamycin-induced testicular injury in male rats via modulating oxidative, endocrine and inflammatory changes in rats. Tissue & cell. 2023 Feb; 82(?):102037. doi: 10.1016/j.tice.2023.102037. [PMID: 36863109]
  • Cornel Manuel Bachmann, Daniel Janitschke, Anna Andrea Lauer, Tobias Erhardt, Tobias Hartmann, Marcus Otto Walter Grimm, Heike Sabine Grimm. Gemfibrozil-Induced Intracellular Triglyceride Increase in SH-SY5Y, HEK and Calu-3 Cells. International journal of molecular sciences. 2023 Feb; 24(3):. doi: 10.3390/ijms24032972. [PMID: 36769295]
  • Malabendu Jana, Debashis Dutta, Jit Poddar, Kalipada Pahan. Activation of PPARα exhibits therapeutic efficacy in a mouse model of juvenile neuronal ceroid lipofuscinosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023 Jan; ?(?):. doi: 10.1523/jneurosci.2447-21.2023. [PMID: 36697260]
  • Elham Hakimizadeh, Saeedeh Tadayon, Mohammad Yasin Zamanian, Afsaneh Soltani, Lydia Giménez-Llort, Mahsa Hassanipour, Iman Fatemi. Gemfibrozil, a lipid-lowering drug, improves hepatorenal damages in a mouse model of aging. Fundamental & clinical pharmacology. 2023 Jan; ?(?):. doi: 10.1111/fcp.12865. [PMID: 36600528]
  • Trinita K Barboza, Leonardo Susta, Alex Zur Linden, Sara Gardhouse, Hugues Beaufrère. Association of plasma metabolites and diagnostic imaging findings with hepatic lipidosis in bearded dragons (Pogona vitticeps) and effects of gemfibrozil therapy. PloS one. 2023; 18(2):e0274060. doi: 10.1371/journal.pone.0274060. [PMID: 36735707]
  • Muhammad Hassan Naeem Goraya, Ehsan Ul Haq Abbasi, Muhammad Kashif Amin, Faisal Inayat, Muhammad Junaid Ashraf, Mahrukh Qayyum, Nadeem Hussain, Gul Nawaz, Muhammad Adnan Zaman, Adnan Malik. Acute pancreatitis secondary to tamoxifen-associated hypertriglyceridemia: A clinical update. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2023 Jan; 29(1):218-225. doi: 10.1177/10781552221093969. [PMID: 35410558]
  • Sanjeeb Mohapatra, Daniel Snow, Patrick Shea, Andy Gálvez-Rodríguez, Manish Kumar, Lokesh P Padhye, Suparna Mukherji. Photodegradation of a mixture of five pharmaceuticals commonly found in wastewater: Experimental and computational analysis. Environmental research. 2023 01; 216(Pt 3):114659. doi: 10.1016/j.envres.2022.114659. [PMID: 36328221]
  • Halina Falfushynska, Dmytro Poznanskyi, Nadiia Kasianchuk, Oksana Horyn, Oksana Bodnar. Multimarker Responses of Zebrafish to the Effect of Ibuprofen and Gemfibrozil in Environmentally Relevant Concentrations. Bulletin of environmental contamination and toxicology. 2022 Dec; 109(6):1010-1017. doi: 10.1007/s00128-022-03607-2. [PMID: 36074127]
  • Jielin Xu, Chengsheng Mao, Yuan Hou, Yuan Luo, Jessica L Binder, Yadi Zhou, Lynn M Bekris, Jiyoung Shin, Ming Hu, Fei Wang, Charis Eng, Tudor I Oprea, Margaret E Flanagan, Andrew A Pieper, Jeffrey Cummings, James B Leverenz, Feixiong Cheng. Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease. Cell reports. 2022 11; 41(9):111717. doi: 10.1016/j.celrep.2022.111717. [PMID: 36450252]
  • Manish B Shah. Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges. Biomolecules. 2022 09; 12(9):. doi: 10.3390/biom12091218. [PMID: 36139056]
  • Min Zhao, Junzu Shi, Wei Li, Chunjing Guan, Chen Sun, Ying Peng, Jiang Zheng. Metabolic Activation of Gemfibrozil Mediated by Cytochrome P450 Enzymes and Sulfotransferases. Chemical research in toxicology. 2022 07; 35(7):1257-1266. doi: 10.1021/acs.chemrestox.2c00054. [PMID: 35763595]
  • Elham Hakimizadeh, Mohammad Yassin Zamanian, Vitaliy Viktorovich Borisov, Lydia Giménez-Llort, Vahid Ehsani, Ayat Kaeidi, Jalal Hassanshahi, Fatemeh Khajehasani, Sajjadeh Movahedinia, Iman Fatemi. Gemfibrozil, a lipid-lowering drug, reduces anxiety, enhances memory, and improves brain oxidative stress in d-galactose-induced aging mice. Fundamental & clinical pharmacology. 2022 Jun; 36(3):501-508. doi: 10.1111/fcp.12752. [PMID: 34989025]
  • Stefano Liberi, Sara Linciano, Giulia Moro, Luca De Toni, Laura Cendron, Alessandro Angelini. Structural Analysis of Human Serum Albumin in Complex with the Fibrate Drug Gemfibrozil. International journal of molecular sciences. 2022 Feb; 23(3):. doi: 10.3390/ijms23031769. [PMID: 35163693]
  • Limei Hu, Rui Ding, Xiangping Nie. Comparison of toxic effects of atorvastatin and gemfibrozil on Daphnia magna. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Feb; 252(?):109224. doi: 10.1016/j.cbpc.2021.109224. [PMID: 34756985]
  • Xinli Han, Qianying Lv, Haimei Liu, Rufeng Dai, Jiaojiao Liu, Qian Shen, Li Sun, Jia Rao, Jing Chen, Yihui Zhai, Hong Xu. PPARα agonist exerts protective effects in podocyte injury via inhibition of the ANGPTL3 pathway. Experimental cell research. 2021 10; 407(2):112753. doi: 10.1016/j.yexcr.2021.112753. [PMID: 34499887]
  • Nina Hanke, José David Gómez-Mantilla, Naoki Ishiguro, Peter Stopfer, Valerie Nock. Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions. Pharmaceutical research. 2021 Oct; 38(10):1645-1661. doi: 10.1007/s11095-021-03109-6. [PMID: 34664206]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Carl G Gottschalk, Malabendu Jana, Avik Roy, Dhruv R Patel, Kalipada Pahan. Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021 03; 41(10):2287-2300. doi: 10.1523/jneurosci.3018-19.2021. [PMID: 33514677]
  • Mohsen Zabihi, Fatemeh Askarian, Seyedhossein Hekmatimoghaddam, Mohammad Sajjad Zabihi, Firouzeh Vahidi. Combination of atorvastatin and gemfibrozil plus physical activity: an animal model of statin/fibrate-induced myopathy. Somatosensory & motor research. 2021 03; 38(1):90-94. doi: 10.1080/08990220.2020.1846514. [PMID: 33263458]
  • Nabil N Al-Hashimi, Majed H Shtaiwi, Saja H Hamed, Amjad H El-Sheikh, Rand O Shahin, Linda S Banisakher, Dua'a M Tahboub. Development of Dioctyl Phthalate@Fe3O4 Nanocomposite Reinforced Hollow Fiber Solid/ Liquid Phase Microextraction Followed by HPLC-DAD for the Determination of Atorvastatin and Gemfibrozil in Human Urine. Pharmaceutical nanotechnology. 2021; 9(5):372-382. doi: 10.2174/2211738510666211222113358. [PMID: 34951377]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Azam Hosseinzadeh, Mehdi Goudarzi, Iman Fatemi, Mohammad Javad Khodayar, Saeed Mehrzadi, Hamid Reza Khalili, Mohammad Ali Karimi. Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2020 Oct; 95(7):532-539. doi: 10.1080/10520295.2020.1730967. [PMID: 32242747]
  • Z-J Zhang, Y-H Yuan, M-S Ma, Y-H Hong, Z-X Sun, Y-W Xu, M Wei, Z-Q Qiu. Lipid status and linear relationship between total cholesterol and triglycerides in glycogen storage disease type I. European review for medical and pharmacological sciences. 2020 10; 24(19):10036-10044. doi: 10.26355/eurrev_202010_23218. [PMID: 33090409]
  • Jonathan Q Tran, Peijin Zhang, Atalanta Ghosh, Liangang Liu, Mary Syto, Xiaomin Wang, Maria Palmisano. Single-Dose Pharmacokinetics of Ozanimod and its Major Active Metabolites Alone and in Combination with Gemfibrozil, Itraconazole, or Rifampin in Healthy Subjects: A Randomized, Parallel-Group, Open-Label Study. Advances in therapy. 2020 10; 37(10):4381-4395. doi: 10.1007/s12325-020-01473-0. [PMID: 32857315]
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