Mirtazapine (BioDeep_00000002439)

 

Secondary id: BioDeep_00000399022

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-methyl-2,5,19-triazatetracyclo[13.4.0.0²,⁷.0⁸,¹³]nonadeca-1(15),8,10,12,16,18-hexaene

化学式: C17H19N3 (265.1578894)
中文名称: 米尔塔扎平, 米氮平
谱图信息: 最多检出来源 Viridiplantae(plant) 1.83%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Mirtazapine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/mirtazapine (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000002439). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1CC2C3=CC=CC=C3CC4=CC=CN=C4N2CC1
InChI: InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

描述信息

Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. Mirtazapine has a tetracyclic chemical structure and is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is the only tetracyclic antidepressant that has been approved by the Food and Drug Administration to treat depression. [Wikipedia]
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3622
CONFIDENCE standard compound; INTERNAL_ID 1551
(R)-Mirtazapine ((R)-Org3770) is a R(?)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively[1][2].

同义名列表

25 个代谢物同义名

5-methyl-2,5,19-triazatetracyclo[13.4.0.0²,⁷.0⁸,¹³]nonadeca-1(15),8,10,12,16,18-hexaene; 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine; Mundogen brand OF mirtazapine; Celltech brand OF mirtazapine; Organon brand OF mirtazapine; (N-Methyl-11C)mirtazapine; (S)-Mirtazapine; 6 Azamianserin; 6-Azamianserin; Esmirtazapine; Mirtazapinum; Mirtazepine; mirtazapine; Mepirzepine; Mirtazapina; Remergil; Remeron; Norset; Zispin; Reflex; Rexer; (R)-Org3770; (R)-6-Azamianserin; (R)-Mirtazapine; Org3770



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Katharina Lechner, Sarah Heel, Manfred Uhr, Tatjana Dose, Florian Holsboer, Susanne Lucae, Ludwig Schaaf, Stephany Fulda, Stefan Kloiber, Johannes M Hennings. Weight-gain independent effect of mirtazapine on fasting plasma lipids in healthy men. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Mar; ?(?):. doi: 10.1007/s00210-023-02448-y. [PMID: 36890393]
  • Xiang Wang, Jinxiu Chen, Jing Gong, Ying Wu, Xiang-Hao Liu. JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient. BMC neurology. 2022 Dec; 22(1):462. doi: 10.1186/s12883-022-03004-6. [PMID: 36494784]
  • Sean He, Taylor P Ikner, Brittany V Taylor, Taylor Aguiar, Nina P Thakur, Subhajit Chakravorty. Mirtazapine-associated acute pancreatitis in a patient with insomnia and co-occurring psychiatric disorders. Journal of the National Medical Association. 2022 Dec; 114(6):617-620. doi: 10.1016/j.jnma.2022.08.001. [PMID: 36114064]
  • Syed Gulfishan, Sumita Halder, Rajarshi Kar, Shruti Srivastava, Rachna Gupta. Association of serotonin transporter gene polymorphism with efficacy of the antidepressant drugs sertraline and mirtazapine in newly diagnosed patients with major depressive disorders. Human psychopharmacology. 2022 07; 37(4):e2833. doi: 10.1002/hup.2833. [PMID: 35089613]
  • Takuya Nagashima, Takashi Hayakawa, Hayato Akimoto, Kimino Minagawa, Yasuo Takahashi, Satoshi Asai. Identifying Antidepressants Less Likely to Cause Hyponatremia: Triangulation of Retrospective Cohort, Disproportionality, and Pharmacodynamic Studies. Clinical pharmacology and therapeutics. 2022 06; 111(6):1258-1267. doi: 10.1002/cpt.2573. [PMID: 35258103]
  • Lorenzo Cellini, Domenico De Donatis, Gerald Zernig, Diana De Ronchi, Giancarlo Giupponi, Alessandro Serretti, Hart Xenia, Andreas Conca, Vincenzo Florio. Antidepressant efficacy is correlated with plasma levels: mega-analysis and further evidence. International clinical psychopharmacology. 2022 03; 37(2):29-37. doi: 10.1097/yic.0000000000000386. [PMID: 34908537]
  • Tatiana de Queiroz Oliveira, Adriano José Maia Chaves Filho, Paloma Marinho Jucá, Michelle Verde Ramos Soares, Natássia Lopes Cunha, Charliene Freire Xavier Vieira, Carlos Venício Jataí Gadelha Filho, Glautemberg de Almeida Viana, Gabriela Mariângela Farias De Oliveira, Danielle Silveira Macedo, Silvânia Maria Mendes Vasconcelos. Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. Behavioural brain research. 2022 02; 419(?):113667. doi: 10.1016/j.bbr.2021.113667. [PMID: 34798169]
  • Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian. The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability. Bioengineered. 2022 02; 13(2):3680-3693. doi: 10.1080/21655979.2021.2024962. [PMID: 35081868]
  • Wei Wang, Hui Yang, Yueshan Piao, Meina Quan, Dongmei Guo. Progressive multifocal leukoencephalopathy in a patient with mediastinal teratoma: a case report. BMC neurology. 2022 Jan; 22(1):40. doi: 10.1186/s12883-022-02563-y. [PMID: 35086492]
  • Xin Li, Xiuyu Li, Man Gong, Chaoqun Li, Jing Li, Chao Zhou, Tingting He. Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial. Contrast media & molecular imaging. 2022; 2022(?):8682612. doi: 10.1155/2022/8682612. [PMID: 35833082]
  • Alaa Eldin Elsayed Elsisi, Samia Salem Sokar, Marwa Fouad Shalaby, Sally El-Sayed Abu-Risha. Nephroprotective effects of febuxostat and/or mirtazapine against gentamicin-induced nephrotoxicity through modulation of ERK 1/2, NF-κB and MCP1. Expert review of clinical pharmacology. 2021 Aug; 14(8):1039-1050. doi: 10.1080/17512433.2021.1933435. [PMID: 34030558]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • M S Zastrozhin, VYu Skryabin, VYu Smirnov, A K Zastrozhina, E V Kaverina, D A Klepikov, E A Grishina, K A Ryzhikova, I V Bure, E A Bryun, D A Sychev. Impact of the Omics-Based Biomarkers on the Mirtazapine's Steady-State Concentration, Efficacy and Safety in Patients with Affective Disorders Comorbid with Alcohol Use Disorder. Psychopharmacology bulletin. 2021 03; 51(2):31-42. doi: . [PMID: 34092821]
  • Emily Zhang, Elizabeth Lequesne, Anne Rohs, W Gordon Frankle. Suspected Recurrence of Symptomatic COVID-19: Management During Inpatient Psychiatric Treatment. Journal of psychiatric practice. 2021 Mar; 27(2):137-144. doi: 10.1097/pra.0000000000000534. [PMID: 33656821]
  • Fabrizio Di Maida, Lorenzo Viola, Luca Lambertini, Andrea Mari, Jessica Mencarini, Beatrice Borchi, Marco Carini, Lorenzo Zammarchi, Andrea Minervini. A rare urinary JC virus reactivation after long-term therapy with rituximab. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021 Feb; 103(?):447-449. doi: 10.1016/j.ijid.2020.11.194. [PMID: 33278620]
  • Hye In Woo, Jisook Park, Shinn-Won Lim, Doh Kwan Kim, Soo-Youn Lee. Alteration of transthyretin and thyroxine-binding globulin in major depressive disorder: multiple reaction monitoring-based proteomic analysis. Journal of translational medicine. 2021 01; 19(1):34. doi: 10.1186/s12967-021-02702-y. [PMID: 33451315]
  • Peter M Haddad, Majid Al Abdulla, Javed Latoo, Yousaf Iqbal. Brief psychotic disorder associated with quarantine and mild COVID-19. BMJ case reports. 2020 Dec; 13(12):. doi: 10.1136/bcr-2020-240088. [PMID: 33328211]
  • Lucas J H Lim, Low May Fong, Jayaraman Hariram, Yu Wei Lee, Phern-Chern Tor. COVID-19, a pandemic that affects more than just physical health: Two case reports. Asian journal of psychiatry. 2020 Oct; 53(?):102200. doi: 10.1016/j.ajp.2020.102200. [PMID: 32540751]
  • Randeep Kaur, Nisha Sharma, Kulbhushan Tikoo, V R Sinha. Development of mirtazapine loaded solid lipid nanoparticles for topical delivery: Optimization, characterization and cytotoxicity evaluation. International journal of pharmaceutics. 2020 Aug; 586(?):119439. doi: 10.1016/j.ijpharm.2020.119439. [PMID: 32622808]
  • Zastrozhin, Smirnov, Petukhov, Pankratenko, Zastrozhina, Grishina, Ryzhikova, Bure, Skryabin, Vlasovskih, Bryun, Sychev. The Influence of Concentration of Micro-RNA hsa-miR-370-3p and CYP2D6*4 on Equilibrium Concentration of Mirtazapine in Patients With Major Depressive Disorder. Psychopharmacology bulletin. 2020 07; 50(3):58-75. doi: . [PMID: 32733112]
  • N A Uvais. Psychological Impact of the COVID-19 Pandemic Among the Elderly: A Case Series From India. The primary care companion for CNS disorders. 2020 06; 22(4):. doi: 10.4088/pcc.20com02675. [PMID: 32589829]
  • Mahmoud Gholyaf, Vida Sheikh, Fatemeh Yasrebifar, Younes Mohammadi, Mahtabalsadat Mirjalili, Maryam Mehrpooya. Effect of mirtazapine on pruritus in patients on hemodialysis: a cross-over pilot study. International urology and nephrology. 2020 Jun; 52(6):1155-1165. doi: 10.1007/s11255-020-02473-3. [PMID: 32383050]
  • Hiroki Yamamoto, Tatsunori Takayasu, Yuko Ishida, Mizuho Nosaka, Satoshi Hata, Yumi Kuninaka, Emi Shimada, Yumiko Hashizume, Akiko Ishigami, Mitsunori Ozaki, Mariko Kawaguchi, Akihiko Kimura, Fukumi Furukawa, Toshikazu Kondo. A case of complex suicide due to acute nicotine intoxication caused by cigarette ingestion. International journal of legal medicine. 2020 May; 134(3):997-1002. doi: 10.1007/s00414-019-02228-5. [PMID: 31836934]
  • Jessica M Quimby, Kellyi K Benson, Stacie C Summers, Ashlie Saffire, Andrea K Herndon, Shasha Bai, Daniel L Gustafson. Assessment of compounded transdermal mirtazapine as an appetite stimulant in cats with chronic kidney disease. Journal of feline medicine and surgery. 2020 04; 22(4):376-383. doi: 10.1177/1098612x19851303. [PMID: 31161850]
  • Phillip O Coffin, Glenn-Milo Santos, Jaclyn Hern, Eric Vittinghoff, John E Walker, Tim Matheson, Deirdre Santos, Grant Colfax, Steven L Batki. Effects of Mirtazapine for Methamphetamine Use Disorder Among Cisgender Men and Transgender Women Who Have Sex With Men: A Placebo-Controlled Randomized Clinical Trial. JAMA psychiatry. 2020 03; 77(3):246-255. doi: 10.1001/jamapsychiatry.2019.3655. [PMID: 31825466]
  • Kalpana P Padala, Christopher M Parkes, Prasad R Padala. Neuropsychological and Functional Impact of COVID-19 on Mild Cognitive Impairment. American journal of Alzheimer's disease and other dementias. 2020 Jan; 35(?):1533317520960875. doi: 10.1177/1533317520960875. [PMID: 32969235]
  • Fezile Ozdemir, Emrah Dural, Nilay Sedes Baskak, Yağmur Kır, Bora Baskak, Halt S Suzen. The Association of CYP2D6*4 and POR*28 Polymorphisms on Mirtazapine Plasma Level in Subjects with Major Depressive Disorder and Anxiety Disorders. Combinatorial chemistry & high throughput screening. 2020; 23(10):1032-1040. doi: 10.2174/1386207323666200402081512. [PMID: 32238137]
  • Ryusei Nishigori, Yoko Warabi, Yukiko Shishido-Hara, Kazuo Nakamichi, Yasuhiro Nakata, Takashi Komori, Eiji Isozaki. Inflammatory Cerebellar PML with a CD4/CD8 Ratio of 2.9 Showed a Favorable Prognosis in a Patient with Rheumatoid Arthritis. Internal medicine (Tokyo, Japan). 2019 Nov; 58(22):3323-3329. doi: 10.2169/internalmedicine.3038-19. [PMID: 31366796]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Dorota Żelaszczyk, Magdalena Jakubczyk, Karolina Pytka, Anna Rapacz, Maria Walczak, Paulina Janiszewska, Katarzyna Pańczyk, Paweł Żmudzki, Karolina Słoczyńska, Henryk Marona, Anna M Waszkielewicz. Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system. Bioorganic & medicinal chemistry letters. 2019 11; 29(21):126679. doi: 10.1016/j.bmcl.2019.126679. [PMID: 31537425]
  • Aleida Rodriguez, Leon Fogelfeld, Gary Robertson. Hypernatremic Hydrophobic Transient Adipsia Without Organic or Severe Psychiatric Disorder. The Journal of clinical endocrinology and metabolism. 2019 11; 104(11):5427-5430. doi: 10.1210/jc.2019-01446. [PMID: 31373657]
  • Riley D Bowers, Sara M Valanejad, Ashley A Holombo. Mirtazapine-Induced Pancreatitis-A Case Report. Journal of pharmacy practice. 2019 Oct; 32(5):586-588. doi: 10.1177/0897190018760645. [PMID: 29486665]
  • Hong-Ming Chen, Yao-Hsu Yang, Ko-Jung Chen, Yena Lee, Roger S McIntyre, Mong-Liang Lu, Yi-Chen Lee, Ming-Chia Hsieh, Vincent Chin-Hung Chen. Antidepressants Reduced Risk of Mortality in Patients With Diabetes Mellitus: A Population-Based Cohort Study in Taiwan. The Journal of clinical endocrinology and metabolism. 2019 10; 104(10):4619-4625. doi: 10.1210/jc.2018-02362. [PMID: 31265070]
  • Masataka Shinozaki, Jason Pierce, Yuki Hayashi, Takashi Watanabe, Taro Sasaki, Hazuki Komahashi-Sasaki, Kazufumi Akiyama, Kazuko Kato, Yoshimasa Inoue, Shoko Tsuchimine, Norio Yasui-Furukori, Yuji Ozeki, Kazutaka Shimoda. 8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine. Pharmacopsychiatry. 2019 Sep; 52(5):237-244. doi: 10.1055/a-0918-6408. [PMID: 31158907]
  • Hiroki Nagasawa, Hiroaki Nakanishi, Kazuyuki Saito, Takehisa Matsukawa, Kazuhito Yokoyama, Youichi Yanagawa. Cardiac arrest induced by the intentional ingestion of boric acid and mirtazapine treated by percutaneous cardiopulmonary bypass: a case report. Journal of medical case reports. 2019 May; 13(1):147. doi: 10.1186/s13256-019-2079-7. [PMID: 31092289]
  • Sevgi Gurkan, Fang Liu, Anne Chain, David E Gutstein. A Study to Assess the Proarrhythmic Potential of Mirtazapine Using Concentration-QTc (C-QTc) Analysis. Clinical pharmacology in drug development. 2019 05; 8(4):449-458. doi: 10.1002/cpdd.605. [PMID: 30052325]
  • Erhan Sahin, Ezgi Bektur, Dilek Burukoglu Donmez, Cengiz Baycu, Ozgür Devrim Can, Varol Sahinturk. Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney. Acta histochemica. 2019 Apr; 121(3):289-296. doi: 10.1016/j.acthis.2019.01.007. [PMID: 30711241]
  • Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2. International clinical psychopharmacology. 2019 03; 34(2):93-100. doi: 10.1097/yic.0000000000000250. [PMID: 30557209]
  • Melinda Poole, Jessica M Quimby, Tianhua Hu, Daizie Labelle, William Buhles. A double-blind, placebo-controlled, randomized study to evaluate the weight gain drug, mirtazapine transdermal ointment, in cats with unintended weight loss. Journal of veterinary pharmacology and therapeutics. 2019 Mar; 42(2):179-188. doi: 10.1111/jvp.12738. [PMID: 30506924]
  • Ereny Fekry, A A Rahman, Mona M Awny, Samy Makary. Protective effect of mirtazapine versus ginger against cisplatin-induced testicular damage in adult male albino rats. Ultrastructural pathology. 2019; 43(1):66-79. doi: 10.1080/01913123.2019.1592269. [PMID: 30929557]
  • Jaroslava Červeňová. Combination of mirtazapine and paroxetine: possible clinically demonstrated interaction?. Casopis lekaru ceskych. 2019; 158(7-8):310-313. doi: . [PMID: 31995999]
  • Víctor Navarro, Ilham Boulahfa, Amadeu Obach, Dídac Jerez, Maribel Diaz-Ricart, Cristóbal Gastó, Joana Guarch. Switching to Imipramine Versus Add-on Mirtazapine in Venlafaxine-Resistant Major Depression: A 10-Week Randomized Open Study. Journal of clinical psychopharmacology. 2019 Jan; 39(1):63-66. doi: 10.1097/jcp.0000000000000988. [PMID: 30516574]
  • Randeep Kaur, V R Sinha. Use of thermal and non thermal techniques for assessing compatibility between mirtazapine and solid lipids. Journal of pharmaceutical and biomedical analysis. 2018 Nov; 161(?):144-158. doi: 10.1016/j.jpba.2018.08.041. [PMID: 30149190]
  • Rikki L Fitzpatrick, Jessica M Quimby, Kellyi K Benson, Dominique Ramirez, Liberty G Sieberg, Luke A Wittenburg, Daniel L Gustafson. In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. Journal of veterinary internal medicine. 2018 Nov; 32(6):1951-1957. doi: 10.1111/jvim.15237. [PMID: 30307637]
  • Rahul Lauhan, Alan Hsu, Al Alam, Kristin Beizai. Tianeptine Abuse and Dependence: Case Report and Literature Review. Psychosomatics. 2018 11; 59(6):547-553. doi: 10.1016/j.psym.2018.07.006. [PMID: 30149933]
  • William Buhles, Jessica M Quimby, Daizie Labelle, Valentine S Williams. Single and multiple dose pharmacokinetics of a novel mirtazapine transdermal ointment in cats. Journal of veterinary pharmacology and therapeutics. 2018 Oct; 41(5):644-651. doi: 10.1111/jvp.12691. [PMID: 30004120]
  • Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Bianca Fay, Sandra Unholzer, Gerhard Gründer, Georgios Schoretsanitis. Antidepressant polypharmacy and the potential of pharmacokinetic interactions: Doxepin but not mirtazapine causes clinically relevant changes in venlafaxine metabolism. Journal of affective disorders. 2018 02; 227(?):506-511. doi: 10.1016/j.jad.2017.11.046. [PMID: 29156365]
  • Manish K Jha, Abu Minhajuddin, Bharathi S Gadad, Tracy L Greer, Taryn L Mayes, Madhukar H Trivedi. Interleukin 17 selectively predicts better outcomes with bupropion-SSRI combination: Novel T cell biomarker for antidepressant medication selection. Brain, behavior, and immunity. 2017 Nov; 66(?):103-110. doi: 10.1016/j.bbi.2017.07.005. [PMID: 28698115]
  • Alaa E El-Sisi, Magda E El-Sayad, Nermine M Abdelsalam. Protective effects of mirtazapine and chrysin on experimentally induced testicular damage in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):1059-1066. doi: 10.1016/j.biopha.2017.09.022. [PMID: 28922723]
  • Kellyi K Benson, Lara B Zajic, Paula K Morgan, Sarah R Brown, Ryan J Hansen, Paul J Lunghofer, Luke A Wittenburg, Daniel L Gustafson, Jessica M Quimby. Drug exposure and clinical effect of transdermal mirtazapine in healthy young cats: a pilot study. Journal of feline medicine and surgery. 2017 Oct; 19(10):998-1006. doi: 10.1177/1098612x16667168. [PMID: 27613493]
  • Tatiana de Queiroz Oliveira, Caren Nádia Soares de Sousa, Germana Silva Vasconcelos, Luciene Costa de Sousa, Anneheydi Araújo de Oliveira, Cláudio Felipe Vasconcelos Patrocínio, Ingridy da Silva Medeiros, José Eduardo Ribeiro Honório Júnior, Michael Maes, Danielle Macedo, Silvânia Maria Mendes Vasconcelos. Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. Journal of affective disorders. 2017 09; 219(?):49-57. doi: 10.1016/j.jad.2017.05.022. [PMID: 28521187]
  • Dalia M El-Tanbouly, Walaa Wadie, Rabab H Sayed. Modulation of TGF-β/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice. Toxicology and applied pharmacology. 2017 08; 329(?):224-230. doi: 10.1016/j.taap.2017.06.012. [PMID: 28623179]
  • Johanna Weber, Stefanie Oberfeld, Andrea Bonse, Klaus Telger, Rainer Lingg, Georg Hempel. Validation of a dried blood spot method for therapeutic drug monitoring of citalopram, mirtazapine and risperidone and its active metabolite 9-hydroxyrisperidone using HPLC-MS. Journal of pharmaceutical and biomedical analysis. 2017 Jun; 140(?):347-354. doi: 10.1016/j.jpba.2017.02.061. [PMID: 28395245]
  • Vassiliki A Boumba, Georgios N Rallis, Theodore Vougiouklakis. Poisoning suicide with ingestion of the pyrethroids alpha-cypermethrin and deltamethrin and the antidepressant mirtazapine: A case report. Forensic science international. 2017 May; 274(?):75-78. doi: 10.1016/j.forsciint.2016.11.023. [PMID: 27899216]
  • Mahdi Ghorbani, Mahmoud Chamsaz, Gholam Hossein Rounaghi, Mohsen Aghamohammadhasani, Orkideh Seyedin, Nahid Afshar Lahoori. Development of a novel ultrasonic-assisted magnetic dispersive solid-phase microextraction method coupled with high performance liquid chromatography for determination of mirtazapine and its metabolites in human urine and water samples employing experimental design. Analytical and bioanalytical chemistry. 2016 Nov; 408(27):7719-7729. doi: 10.1007/s00216-016-9869-1. [PMID: 27562753]
  • Eiichi Ohnuki, Shinya Asayama, Tomoko Asayama, Kazuo Nakamichi, Masayuki Saijo, Satoru Kosaka. A case of progressive multifocal leukoencephalopathy with chronic renal failure, whose JC virus in cerebrospinal fluid disappeared after mefloquine-mirtazapine dual therapy. Rinsho shinkeigaku = Clinical neurology. 2016 10; 56(10):705-708. doi: 10.5692/clinicalneurol.cn-000928. [PMID: 27645758]
  • W Zheng, Y F Zhang, H Q Zhong, S M Mai, X H Yang, Y T Xiang. Wuling Capsule for Major Depressive Disorder: A Meta-analysis of Randomised Controlled Trials. East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan. 2016 Sep; 26(3):87-97. doi: ". [PMID: 27703096]
  • M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology. 2016 Aug; 233(15-16):2955-71. doi: 10.1007/s00213-016-4342-6. [PMID: 27259485]
  • Shu-Man Jiang, Lin Jia, Jing Liu, Man-Man Shi, Ming-Zhi Xu. Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss. World journal of gastroenterology. 2016 Jun; 22(22):5260-6. doi: 10.3748/wjg.v22.i22.5260. [PMID: 27298569]
  • S Rzezniczek, M Obuchowicz, W Datka, M Siwek, D Dudek, K Kmiotek, K Oved, N Shomron, D Gurwitz, A Pilc. Decreased sensitivity to paroxetine-induced inhibition of peripheral blood mononuclear cell growth in depressed and antidepressant treatment-resistant patients. Translational psychiatry. 2016 05; 6(5):e827. doi: 10.1038/tp.2016.90. [PMID: 27244236]
  • Katja Biering Leth-Møller, Annette Højmann Hansen, Maia Torstensson, Stig Ejdrup Andersen, Lars Ødum, Gunnar Gislasson, Christian Torp-Pedersen, Ellen Astrid Holm. Antidepressants and the risk of hyponatremia: a Danish register-based population study. BMJ open. 2016 05; 6(5):e011200. doi: 10.1136/bmjopen-2016-011200. [PMID: 27194321]
  • Rachna Gupta, Keshav Gupta, A K Tripathi, M S Bhatia, Lalit K Gupta. Effect of Mirtazapine Treatment on Serum Levels of Brain-Derived Neurotrophic Factor and Tumor Necrosis Factor-α in Patients of Major Depressive Disorder with Severe Depression. Pharmacology. 2016; 97(3-4):184-8. doi: 10.1159/000444220. [PMID: 26854819]
  • Mirte Smit, Koert M Dolman, A Honig. Mirtazapine in pregnancy and lactation - A systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2016 Jan; 26(1):126-135. doi: 10.1016/j.euroneuro.2015.06.014. [PMID: 26631373]
  • Chi-Shun Wu, Show-Hwa Tong, Cheung-Ter Ong, Sheng-Feng Sung. Serotonin Syndrome Induced by Combined Use of Mirtazapine and Olanzapine Complicated with Rhabdomyolysis, Acute Renal Failure, and Acute Pulmonary Edema-A Case Report. Acta neurologica Taiwanica. 2015 Dec; 24(4):117-21. doi: . [PMID: 27333965]
  • M Deuschle, M Gilles, B Scharnholz, K G Kahl. Antidepressant Treatment with Venlafaxine and Mirtazapine: no Effect on Serum Concentration of Vascular Endothelial Growth Factor (VEGF). Pharmacopsychiatry. 2015 Nov; 48(7):292-3. doi: 10.1055/s-0035-1555849. [PMID: 26190286]
  • Y Hayashi, T Watanabe, A Aoki, S Ishiguro, M Ueda, K Akiyama, K Kato, Y Inoue, S Tsuchimine, N Yasui-Furukori, K Shimoda. Factors Affecting Steady-state Plasma Concentrations of Enantiomeric Mirtazapine and its Desmethylated Metabolites in Japanese Psychiatric Patients. Pharmacopsychiatry. 2015 Nov; 48(7):279-85. doi: 10.1055/s-0035-1565069. [PMID: 26595747]
  • Hisatake Matsumoto, Mitsuo Ohnishi, Ryosuke Takegawa, Tomoya Hirose, Yuji Hattori, Takeshi Shimazu. Effect of lipid emulsion during resuscitation of a patient with cardiac arrest after overdose of chlorpromazine and mirtazapine. The American journal of emergency medicine. 2015 Oct; 33(10):1541.e1-2. doi: 10.1016/j.ajem.2015.07.059. [PMID: 26314213]
  • Frank M Schmidt, Claudia Nowak, Juergen Kratzsch, Christian Sander, Ulrich Hegerl, Peter Schönknecht. Dynamics of melanin-concentrating hormone (MCH) serum levels in major depressive disorder during antidepressant treatment. Journal of affective disorders. 2015 Jul; 180(?):207-13. doi: 10.1016/j.jad.2015.03.039. [PMID: 25932975]
  • Yuta Yoshino, Shinichiro Ochi, Kiyohiro Yamazaki, Shunsuke Nakata, Masao Abe, Yoko Mori, Shu-ichi Ueno. Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin. Neuroscience letters. 2015 Jul; 599(?):69-74. doi: 10.1016/j.neulet.2015.05.043. [PMID: 26007704]
  • Maria C Olianas, Simona Dedoni, Pierluigi Onali. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochemical pharmacology. 2015 Jun; 95(4):311-23. doi: 10.1016/j.bcp.2015.04.002. [PMID: 25888927]
  • Michael Paulzen, Gerhard Gründer, Simone C Tauber, Tanja Veselinovic, Christoph Hiemke, Sarah E Groppe. Distribution pattern of mirtazapine and normirtazapine in blood and CSF. Psychopharmacology. 2015 Feb; 232(4):807-13. doi: 10.1007/s00213-014-3717-9. [PMID: 25150039]
  • Maho Okubo, Norie Murayama, Jun Miura, Yasuji Chiba, Hiroshi Yamazaki. Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients. Biochemical pharmacology. 2015 Jan; 93(1):104-9. doi: 10.1016/j.bcp.2014.11.011. [PMID: 25475885]
  • Saliha Ozsoy, Aslı Besirli, Dilek Unal, Ummuhan Abdulrezzak, Okan Orhan. The association between depression, weight loss and leptin/ghrelin levels in male patients with head and neck cancer undergoing radiotherapy. General hospital psychiatry. 2015 Jan; 37(1):31-5. doi: 10.1016/j.genhosppsych.2014.09.002. [PMID: 25440723]
  • Maria Giese, Johannes Beck, Serge Brand, Flavio Muheim, Ulrich Hemmeter, Martin Hatzinger, Edith Holsboer-Trachsler, Anne Eckert. Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation. Journal of psychiatric research. 2014 Dec; 59(?):1-7. doi: 10.1016/j.jpsychires.2014.09.005. [PMID: 25258340]
  • Keith A Hermanstyne, Glenn-Milo Santos, Eric Vittinghoff, Deirdre Santos, Grant Colfax, Phillip Coffin. Event-level relationship between methamphetamine use significantly associated with non-adherence to pharmacologic trial medications in event-level analyses. Drug and alcohol dependence. 2014 Oct; 143(?):277-80. doi: 10.1016/j.drugalcdep.2014.07.031. [PMID: 25156227]
  • Hoo Rim Song, Young Sup Woo, Hee-Ryung Wang, In-Hee Shim, Tae-Youn Jun, Won-Myong Bahk. Does mirtazapine interfere with naturalistic diabetes treatment?. Journal of clinical psychopharmacology. 2014 Oct; 34(5):588-94. doi: 10.1097/jcp.0000000000000183. [PMID: 24987796]
  • W Myung, J-H Jang, H Yoon, S-Y Lee, D K Kim. Therapeutic drug monitoring of mirtazapine in a routine outpatient setting in Asian psychiatric patients. Pharmacopsychiatry. 2014 Sep; 47(6):210-4. doi: 10.1055/s-0034-1383655. [PMID: 25078020]
  • Hun Soo Chang, Hwa-Young Lee, Ji-Hyun Cha, Eun Soo Won, Byung-Joo Ham, Bohye Kim, Min-Soo Lee. Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder. Journal of clinical psychopharmacology. 2014 Aug; 34(4):446-54. doi: 10.1097/jcp.0000000000000143. [PMID: 24911443]
  • N N Darmograĭ, I I Gal'kevich. [The identification and quantitative measurement of mirtazapine isolated from the biological material by high performance liquid chromatography]. Sudebno-meditsinskaia ekspertiza. 2014 Jan; 57(1):37-40. doi: NULL. [PMID: 25275184]
  • Fionn E O'Brien, Gerard Clarke, Timothy G Dinan, John F Cryan, Brendan T Griffin. Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability. The international journal of neuropsychopharmacology. 2013 Nov; 16(10):2259-72. doi: 10.1017/s1461145713000692. [PMID: 23931269]
  • Hirotoshi Sato, Chihiro Ito, Manabu Tashiro, Kotaro Hiraoka, Katsuhiko Shibuya, Yoshihito Funaki, Ren Iwata, Hiroo Matsuoka, Kazuhiko Yanai. Histamine H₁ receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers. Psychopharmacology. 2013 Nov; 230(2):227-34. doi: 10.1007/s00213-013-3146-1. [PMID: 23728612]
  • J M Quimby, K F Lunn. Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial. Veterinary journal (London, England : 1997). 2013 Sep; 197(3):651-5. doi: 10.1016/j.tvjl.2013.05.048. [PMID: 23838205]
  • Zsófia Bognár, Gabriella Vonyik, Gábor Gazdag. [Antidepressant treatment associated hyponatremia -- case report]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. 2013 Sep; 15(3):177-80. doi: NULL. [PMID: 24108183]
  • Marco Iannetta, Anna Bellizzi, Sara Lo Menzo, Elena Anzivino, Alessandra D'Abramo, Alessandra Oliva, Claudia D'Agostino, Gabriella d'Ettorre, Valeria Pietropaolo, Vincenzo Vullo, Maria Rosa Ciardi. HIV-associated progressive multifocal leukoencephalopathy: longitudinal study of JC virus non-coding control region rearrangements and host immunity. Journal of neurovirology. 2013 Jun; 19(3):274-9. doi: 10.1007/s13365-013-0167-9. [PMID: 23715894]
  • M Deuschle, M Gilles, B Scharnholz, F Lederbogen, U E Lang, R Hellweg. Changes of serum concentrations of brain-derived neurotrophic factor (BDNF) during treatment with venlafaxine and mirtazapine: role of medication and response to treatment. Pharmacopsychiatry. 2013 Mar; 46(2):54-8. doi: 10.1055/s-0032-1321908. [PMID: 22961097]
  • Claudia Schilling, Maria Gilles, Werner F Blum, Emmerich Daseking, Michael Colla, Bettina Weber-Hamann, Florian Lederbogen, Bertram Krumm, Isabella Heuser, Stefan A Wudy, Daniel Kopf, Michael Deuschle. Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity?. Journal of clinical psychopharmacology. 2013 Feb; 33(1):99-103. doi: 10.1097/jcp.0b013e31827cb179. [PMID: 23277262]
  • Ney Carter Borges, Rafael Eliseo Barrientos-Astigarraga, Carlos Eduardo Sverdloff, José Luiz Donato, Patricia Moreno, Leila Felix, Paulo Alexandre Rebelo Galvinas, Ronilson Agnaldo Moreno. A fast, sensitive and simple method for mirtazapine quantification in human plasma by HPLC-ESI-MS/MS. Application to a comparative bioavailability study. Biomedical chromatography : BMC. 2012 Nov; 26(11):1399-407. doi: 10.1002/bmc.2711. [PMID: 22345050]
  • Eveline Jaquenoud Sirot, Sabine Harenberg, Pierre Vandel, Carlos A Mendonça Lima, Patrick Perrenoud, Klaus Kemmerling, Daniele F Zullino, Henriette Hilleret, Séverine Crettol, Michèle Jonzier-Perey, Kerry Powell Golay, Muriel Brocard, Chin B Eap, Pierre Baumann. Multicenter study on the clinical effectiveness, pharmacokinetics, and pharmacogenetics of mirtazapine in depression. Journal of clinical psychopharmacology. 2012 Oct; 32(5):622-9. doi: 10.1097/jcp.0b013e3182664d98. [PMID: 22926595]
  • Asuka Katsuki, Reiji Yoshimura, Taro Kishi, Hikaru Hori, Wakako Umene-Nakano, Atsuko Ikenouchi-Sugita, Kenji Hayashi, Kiyokazu Atake, Nakao Iwata, Jun Nakamura. Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD). CNS spectrums. 2012 Sep; 17(3):155-63. doi: 10.1017/s109285291200051x. [PMID: 22883353]
  • Johan Lundberg, Mikael Tiger, Mikael Landén, Christer Halldin, Lars Farde. Serotonin transporter occupancy with TCAs and SSRIs: a PET study in patients with major depressive disorder. The international journal of neuropsychopharmacology. 2012 Sep; 15(8):1167-72. doi: 10.1017/s1461145711001945. [PMID: 22243688]
  • Stefan Unterecker, Philip Müller, Christian Jacob, Peter Riederer, Bruno Pfuhlmann. Therapeutic drug monitoring of antidepressants in haemodialysis patients. Clinical drug investigation. 2012 Aug; 32(8):539-45. doi: 10.1007/bf03261907. [PMID: 22715858]
  • Olivera Lecei, Florian Lederbogen, Wolfgang Gronau, Barbara Scharnholz, Johannes Terhardt, Claudia Schilling, Maria Gilles, Daniel Kopf, Heinz Juergen Roth, Bettina Weber-Hamann, Michael Deuschle. Treatment with mirtazapine and venlafaxine increases noradrenaline excretion in depressed patients. Journal of clinical psychopharmacology. 2012 Aug; 32(4):574-6. doi: 10.1097/jcp.0b013e31825ddf1b. [PMID: 22760352]
  • Frank Martin Schmidt, Carsten Tennert, Daniel Teupser, Hubertus Himmerich. [Optimizing antidepressant pharmacotherapy in a case of inflammatory bowel disease and major depression]. Psychiatrische Praxis. 2012 Jul; 39(5):239-42. doi: 10.1055/s-0032-1305013. [PMID: 22689282]
  • Martin Letmaier, Annamaria Painold, Anna Katharina Holl, Hartmut Vergin, Rolf Engel, Anastasios Konstantinidis, Siegfried Kasper, Renate Grohmann. Hyponatraemia during psychopharmacological treatment: results of a drug surveillance programme. The international journal of neuropsychopharmacology. 2012 Jul; 15(6):739-48. doi: 10.1017/s1461145711001192. [PMID: 21777511]
  • Li Zheng, Qin Yu, Jia Miao, Jin Xiang, Nan Xu. Bioequivalence study of two mirtazapine oral tablet formulations in healthy Chinese male volunteers. International journal of clinical pharmacology and therapeutics. 2012 May; 50(5):368-74. doi: 10.5414/cp201609. [PMID: 22541842]
  • Mario Giorgi, Hyoin Yun. Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: a pilot study. Veterinary journal (London, England : 1997). 2012 May; 192(2):239-41. doi: 10.1016/j.tvjl.2011.05.010. [PMID: 21652240]
  • Helen Pligoropoulou, Ariadni Vonaparti, Irene Panderi. Hydrophilic interaction liquid chromatography/positive ion electrospray mass spectrometry for the quantification of deferasirox, an oral iron chelator, in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 893-894(?):114-20. doi: 10.1016/j.jchromb.2012.02.044. [PMID: 22436822]
  • Maryam Afshar, Clifford M Knapp, Ofra Sarid-Segal, Eric Devine, Laurie Sickles Colaneri, Lisa Tozier, Megan E Waters, Megan A Putnam, Domenic A Ciraulo. The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression. The American journal of drug and alcohol abuse. 2012 Mar; 38(2):181-6. doi: 10.3109/00952990.2011.644002. [PMID: 22221171]
  • Renata Wietecha-Posłuszny, Aneta Garbacik, Michał Woźniakiewicz, Agnieszka Moos, Marcin Wieczorek, Paweł Kościelniak. Application of microextraction by packed sorbent to isolation of psychotropic drugs from human serum. Analytical and bioanalytical chemistry. 2012 Mar; 402(7):2249-57. doi: 10.1007/s00216-011-5442-0. [PMID: 22002590]