Granisetron (BioDeep_00000002376)
Secondary id: BioDeep_00000405850
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
1-Methyl-N-(endo-9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide
化学式: C18H24N4O (312.195)
中文名称: 格拉司琼
谱图信息:
最多检出来源 Homo sapiens(blood) 75.36%
分子结构信息
SMILES: CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
InChI: InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)
描述信息
Granisetron is only found in individuals that have used or taken this drug. It is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. [PubChem]Granisetron is a potent, selective antagonist of 5-HT3 receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.
A - Alimentary tract and metabolism > A04 - Antiemetics and antinauseants > A04A - Antiemetics and antinauseants > A04AA - Serotonin (5ht3) antagonists
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
同义名列表
14 个代谢物同义名
1-Methyl-N-(endo-9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide; 1-methyl-N-{9-methyl-9-azabicyclo[3.3.1]nonan-3-yl}-1H-indazole-3-carboxamide; Monohydrochloride, granisetron; Granisetron monohydrochloride; Hydrochloride, granisetron; Granisetron hydrochloride; Granisetron base; granisetron; Sancuso; Kytril; APF530; GRAN; BRL 43694; Granisetron
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:94501
- ChEBI: CHEBI:5537
- KEGG: C07023
- KEGGdrug: D04370
- PubChem: 5284566
- PubChem: 3510
- HMDB: HMDB0015026
- Metlin: METLIN3139
- DrugBank: DB00889
- ChEMBL: CHEMBL1290003
- ChEMBL: CHEMBL399538
- Wikipedia: Granisetron
- MeSH: Granisetron
- chemspider: 3390
- CAS: 124998-65-8
- CAS: 109889-09-0
- PMhub: MS000002463
- ChEBI: CHEBI:184693
- PubChem: 9235
- NIKKAJI: J258.427A
- medchemexpress: HY-B0071
- KNApSAcK: 184693
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Mar; 39(5):387-93. doi:
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Cancer management and research.
2009 Dec; 2(?):1-12. doi:
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British journal of cancer.
2009 Dec; 101(11):1860-8. doi:
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Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2009 Dec; 15(4):223-31. doi:
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European journal of nuclear medicine and molecular imaging.
2009 Dec; 36(12):1968-76. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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Cancer chemotherapy and pharmacology.
2009 Aug; 64(3):509-16. doi:
10.1007/s00280-008-0898-0. [PMID: 19096847] - Mélanie Bergeron, Annik Bergeron, Milton Furtado, Fabio Garofolo. Impact of plasma and whole-blood anticoagulant counter ion choice on drug stability and matrix effects during bioanalysis.
Bioanalysis.
2009 Jun; 1(3):537-48. doi:
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The Lancet. Oncology.
2009 Feb; 10(2):115-24. doi:
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Neuropharmacology.
2009 Jan; 56(1):285-91. doi:
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Cancer chemotherapy and pharmacology.
2008 Dec; 63(1):75-83. doi:
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International journal of pharmaceutics.
2008 Oct; 362(1-2):20-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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Therapeutics and clinical risk management.
2008 Apr; 4(2):501-6. doi:
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Rapid communications in mass spectrometry : RCM.
2008; 22(4):511-8. doi:
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The oncologist.
2007 Sep; 12(9):1151-5. doi:
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Pain.
2007 Aug; 130(3):235-248. doi:
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International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2007 Jul; 17(4):739-63. doi:
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Indian journal of dermatology, venereology and leprology.
2007 Jul; 73(4):231-4. doi:
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Archives of pharmacal research.
2007 Jun; 30(6):778-84. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 May; 850(1-2):101-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Dec; 844(2):268-77. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Oct; 42(4):464-73. doi:
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British journal of cancer.
2006 Sep; 95(6):729-34. doi:
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Biomedical chromatography : BMC.
2006 Sep; 20(9):888-97. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 May; 836(1-2):79-82. doi:
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Cancer journal (Sudbury, Mass.).
2006 Jan; 12(1):69-72. doi:
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Arthritis research & therapy.
2006; 8(4):R99. doi:
10.1186/ar1982. [PMID: 16790074] - Lars Fredriksson, Per Alstergren, Sigvard Kopp. Serotonergic mechanisms influence the response to glucocorticoid treatment in TMJ arthritis.
Mediators of inflammation.
2005 Aug; 2005(4):194-201. doi:
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The Journal of biological chemistry.
2005 May; 280(21):20476-82. doi:
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Current medical research and opinion.
2005 Apr; 21(4):595-601. doi:
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Pain.
2005 Feb; 113(3):265-270. doi:
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British journal of cancer.
2004 Aug; 91(5):844-9. doi:
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British journal of cancer.
2004 Aug; 91(3):476-81. doi:
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British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
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British journal of cancer.
2003 May; 88(10):1516-21. doi:
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Clinical therapeutics.
2003 May; 25(5):1407-19. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2003 Apr; 89(2):311-20. doi:
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British journal of cancer.
2003 Apr; 88(7):1128-34. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2002 Aug; 283(2):G400-7. doi:
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British journal of cancer.
2002 Jul; 87(2):144-50. doi:
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BMC biochemistry.
2002 Jun; 3(?):15. doi:
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BMC biochemistry.
2002 Jun; 3(?):16. doi:
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British journal of cancer.
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