Doxazosin (BioDeep_00000002375)

 

Secondary id: BioDeep_00000397848

human metabolite blood metabolite


代谢物信息卡片


1 (4-amino-6,7-Dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)piperazine

化学式: C23H25N5O5 (451.1856)
中文名称: 多沙唑嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 53.98%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
InChI: InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)

描述信息

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It may be used to mild to moderate hypertension and in the management of symptomatic benign prostatic hyperplasia (BPH). α1-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland.
C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

106 个代谢物同义名

1 (4-amino-6,7-Dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)piperazine; 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin; 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin; CT Arzneimittel brand OF doxazosin mesylate; CT-Arzneimittel brand OF doxazosin mesylate; AstraZeneca brand OF doxazosin mesylate; Pharmagenus brand OF doxazosin mesylate; Merck dura brand OF doxazosin mesylate; Ratiopharm brand OF doxazosin mesylate; FindusFit brand OF doxazosin mesylate; Azupharma brand OF doxazosin mesylate; Cantabria brand OF doxazosin mesylate; Betapharm brand OF doxazosin mesylate; Novopharm brand OF doxazosin mesylate; Almirall brand OF doxazosin mesylate; Alpharma brand OF doxazosin mesylate; Genpharm brand OF doxazosin mesylate; Apogepha brand OF doxazosin mesylate; Geminis brand OF doxazosin mesylate; Esparma brand OF doxazosin mesylate; Q Pharm brand OF doxazosin mesylate; combino Brand OF doxazosin mesylate; Heumann brand OF doxazosin mesylate; Q-Pharm brand OF doxazosin mesylate; Linden brand OF doxazosin mesylate; Normon brand OF doxazosin mesylate; Wörwag brand OF doxazosin mesylate; Ciclum brand OF doxazosin mesylate; Solvay brand OF doxazosin mesylate; Apotex brand OF doxazosin mesylate; Pfizer brand OF doxazosin mesylate; Hexal brand OF doxazosin mesylate; Wolff brand OF doxazosin mesylate; Aliud brand OF doxazosin mesylate; Alter brand OF doxazosin mesylate; Cinfa brand OF doxazosin mesylate; Juta brand OF doxazosin mesylate; Kade brand OF doxazosin mesylate; TAD brand OF doxazosin mesylate; MTW Brand OF doxazosin mesylate; Stadapharm brand OF doxazosin; Monohydrochloride, doxazosin; Doxazosin monohydrochloride; Doxazosina combino pharm; Doxazosina pharmagenus; Ratiopharm, doxazosina; Doxazosina ratiopharm; Doxazosin ratiopharm; Doxazosin-ratiopharm; Mesylate, doxazosin; Doxazosin findusfit; Doxazosin mesylate; Doxazosina geminis; Doxazosin mesilate; Doxazosin apogepha; Von CT, doxazosin; Doxazosina normon; Doxazosin heumann; CT, Doxazosin von; Doxazosina cinfa; Doxazosina alter; Doxazosin von CT; Doxazosin klast; ratio Doxazosin; Doxazosin stada; Doxazosin wolff; Doxazosin-wolff; ratio-Doxazosin; novo-Doxazosin; Doxazosin beta; novo Doxazosin; Progandol neo; Gen-doxazosin; apo-Doxazosin; Gen doxazosin; MTW Doxazosin; MTW-Doxazosin; Doxazosin azu; Doxazosina ur; neo, Carduran; apo Doxazosin; Carduran neo; Doxazosin al; Doxazomerck; Doxazosinum; Cardura XL; Doxa puren; Doxa-puren; Doxazosina; Doxazosine; Doxagamma; Doxatensa; doxazosin; Alfamedin; Cardular; Diblocin; Carduran; Doxamax; Cardura; Uriduct; Jutalar; Doxacor; DoxaUro; Zoxan; Doxazosin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ACE, ADRA1A, ALB, APOB, BCL2, CASP3, EGFR, MSMP, NOS3, PIK3CA, TNK1, VEGFA
Peripheral membrane protein 2 LPL, TNK1
Endosome membrane 2 APOB, EGFR
Endoplasmic reticulum membrane 3 APOB, BCL2, EGFR
Nucleus 8 ADRA1A, ALB, BCL2, CASP3, EGFR, KLK3, NOS3, VEGFA
cytosol 7 ADRA1A, ALB, APOB, BCL2, CASP3, NOS3, PIK3CA
centrosome 1 ALB
nucleoplasm 3 ADRA1A, CASP3, NOS3
Cell membrane 6 ACE, ADRA1A, ADRA1D, ADRB3, EGFR, LPL
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 4 ADRA1A, ADRA1D, ADRB3, CACNA1I
cell junction 1 EGFR
cell surface 3 EGFR, LPL, VEGFA
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 3 ALB, NOS3, VEGFA
Golgi membrane 3 EGFR, INS, NOS3
neuronal cell body 2 APOB, CASP3
smooth endoplasmic reticulum 1 APOB
Lysosome 1 ACE
endosome 2 ACE, EGFR
plasma membrane 13 ACE, ADRA1A, ADRA1D, ADRB3, APOB, CACNA1I, EGFR, KLK3, LPL, NOS3, PIK3CA, REN, TNK1
Membrane 7 ACE, BCL2, CACNA1I, EGFR, REN, TNK1, VEGFA
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 2 ADRA1A, NOS3
extracellular exosome 4 ACE, ALB, APOB, KLK3
endoplasmic reticulum 3 ALB, BCL2, VEGFA
extracellular space 11 ACE, ALB, APOB, EGFR, IL6, INS, KLK3, LPL, MSMP, REN, VEGFA
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 3 EGFR, NOS3, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 1 BCL2
protein-containing complex 4 ALB, BCL2, EGFR, KLK3
intracellular membrane-bounded organelle 2 ADRA1A, APOB
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 ACE, EGFR
Secreted 9 ACE, ALB, APOB, IL6, INS, LPL, MSMP, REN, VEGFA
extracellular region 9 ACE, ALB, APOB, IL6, INS, KLK3, LPL, REN, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Extracellular side 1 LPL
anchoring junction 1 ALB
Nucleus membrane 2 ADRA1A, BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 ADRA1A, BCL2, EGFR
external side of plasma membrane 1 ACE
Secreted, extracellular space, extracellular matrix 2 LPL, VEGFA
chylomicron 2 APOB, LPL
low-density lipoprotein particle 1 APOB
very-low-density lipoprotein particle 2 APOB, LPL
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 APOB
apical part of cell 1 REN
Membrane raft 1 EGFR
pore complex 1 BCL2
focal adhesion 1 EGFR
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
secretory granule 2 KLK3, VEGFA
receptor complex 2 ADRB3, EGFR
ciliary basal body 1 ALB
cytoskeleton 1 NOS3
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 1 ALB
sperm midpiece 1 ACE
endosome lumen 2 APOB, INS
Lipid droplet 1 APOB
Membrane, caveola 1 ADRA1A
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
myelin sheath 1 BCL2
basal plasma membrane 2 ACE, EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, APOB, IL6, INS
platelet alpha granule lumen 2 ALB, VEGFA
voltage-gated calcium channel complex 1 CACNA1I
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 2 APOB, EGFR
death-inducing signaling complex 1 CASP3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 APOB
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
mature chylomicron 1 APOB
catalytic complex 1 LPL
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB


文献列表

  • Yi Zheng, Fuding Bai, Nan Zhang, Huifeng Wu. Analysis of Voiding Impairment after Prostate Biopsy and the Effect of Doxazosin Treatment: Outcomes from a Regional Cancer Center. Urologia internationalis. 2022; 106(1):97-102. doi: 10.1159/000517534. [PMID: 34404051]
  • Marta Araujo-Castro, Rogelio Garcia Centeno, María-Carmen López-García, Cristina Lamas, Cristina Álvarez-Escolá, María Calatayud Gutiérrez, Concepción Blanco-Carrera, Paz de Miguel Novoa, Nuria Valdés, Paola Gracia Gimeno, Mariana Tomé Fernández-Ladreda, César Mínguez Ojeda, Juan Carlos Percovich Hualpa, Mireia Mora, Óscar Vidal, Ana Serrano Romero, Felicia Alexandra Hanzu, Victoria Gómez Dos Santos. Risk factors for intraoperative complications in pheochromocytomas. Endocrine-related cancer. 2021 09; 28(11):695-703. doi: 10.1530/erc-21-0230. [PMID: 34379605]
  • Jianming Guo, Rong Tang. Efficacy and tolerability of doxazosin gastro-intestinal therapeutic system versus tamsulosin in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: A systematic review and meta-analysis. Medicine. 2021 Aug; 100(33):e26955. doi: 10.1097/md.0000000000026955. [PMID: 34414962]
  • Hikaru Hori. Doxazosin improved COVID-19 associated nightmare in a patient with major depressive disorder: a case report with a positive rechallenge. International clinical psychopharmacology. 2021 07; 36(4):221-223. doi: 10.1097/yic.0000000000000364. [PMID: 34030164]
  • Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Nicole Fischer, Sakibul Huq, Adham M Khalafallah, Marco Trevisan, Pär Sparen, Juan J Carrero, Akihiko Nishimura, Brian Caffo, Elizabeth A Stuart, Renyuan Bai, Verena Staedtke, David L Thomas, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Shibin Zhou, Chetan Bettegowda, Maximilian F Konig, Brett D Mensh, Joshua T Vogelstein, Susan Athey. Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection. eLife. 2021 06; 10(?):. doi: 10.7554/elife.61700. [PMID: 34114951]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood. Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 02; 77(2):178-189.e1. doi: 10.1053/j.ajkd.2020.07.018. [PMID: 32920153]
  • P Iglesias, E Santacruz, P García-Sancho, A P Marengo, F Guerrero-Pérez, H Pian, C Fajardo, C Villabona, J J Díez. Pheochromocytoma: A three-decade clinical experience in a multicenter study. Revista clinica espanola. 2021 Jan; 221(1):18-25. doi: 10.1016/j.rceng.2019.12.011. [PMID: 33998473]
  • Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults. The Cochrane database of systematic reviews. 2020 11; 11(?):CD013393. doi: 10.1002/14651858.cd013393.pub2. [PMID: 33179245]
  • Mahmoud A Omar, Abobakr A Mohamed, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad. Mending the fluorescence of two α-blockers through a semiquinoid formation: Hyphenated with experimental design optimization. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Oct; 240(?):118624. doi: 10.1016/j.saa.2020.118624. [PMID: 32604051]
  • Samar Rezq, Ahmed M Nasr, Aya Shaheen, Shimaa M Elshazly. Doxazosin down-regulates sodium-glucose cotransporter-2 and exerts a renoprotective effect in rat models of acute renal injury. Basic & clinical pharmacology & toxicology. 2020 May; 126(5):413-423. doi: 10.1111/bcpt.13371. [PMID: 31788938]
  • Daryl I Shorter, Xuefeng Zhang, Coreen B Domingo, Ellen M Nielsen, Thomas R Kosten, David A Nielsen. Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant. The American journal of drug and alcohol abuse. 2020; 46(2):184-193. doi: 10.1080/00952990.2019.1674864. [PMID: 31914324]
  • Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis. Recent advances in understanding and managing resistant/refractory hypertension. F1000Research. 2020; 9(?):. doi: 10.12688/f1000research.21669.1. [PMID: 32201574]
  • N O Mansour. Validated RP-HPLC method for quantification of doxazosin in human plasma: Application in a bioequivalence study. Annales pharmaceutiques francaises. 2020 Jan; 78(1):42-48. doi: 10.1016/j.pharma.2019.10.003. [PMID: 31796268]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Xuefeng Zhang, David A Nielsen, Coreen B Domingo, Daryl I Shorter, Ellen M Nielsen, Thomas R Kosten. Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin. Addiction biology. 2019 05; 24(3):531-538. doi: 10.1111/adb.12611. [PMID: 29498170]
  • Kyle Johnson, Suzanne Oparil, Barry R Davis, Larisa G Tereshchenko. Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. Journal of the American Heart Association. 2019 04; 8(8):e011961. doi: 10.1161/jaha.119.011961. [PMID: 30943832]
  • Mahmoud A Omar, Mohamed A Hammad, Baher I Salman. Micellar enhanced spectrofluorimetric approach for nanogram detection of certain α1 -blocker drugs: Application in pharmaceutical preparations and human plasma. Luminescence : the journal of biological and chemical luminescence. 2018 Nov; 33(7):1226-1234. doi: 10.1002/bio.3539. [PMID: 30094938]
  • Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. The lancet. Diabetes & endocrinology. 2018 06; 6(6):464-475. doi: 10.1016/s2213-8587(18)30071-8. [PMID: 29655877]
  • Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed. An efficient spectrofluorimetric method adopts doxazosin, terazosin and alfuzosin coupling with orthophthalaldehyde: Application in human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Apr; 195(?):215-222. doi: 10.1016/j.saa.2018.01.077. [PMID: 29414581]
  • Daniel Cervantes-Garcia, Adriana Guadalupe Cuellar-Juarez, Gissela Borrego-Soto, Augusto Rojas-Martinez, Liseth Rubi Aldaba-Muruato, Eva Salinas, Javier Ventura-Juarez, Martin Humberto Muñoz-Ortega. Adenoviral‑bone morphogenetic protein‑7 and/or doxazosin therapies promote the reversion of fibrosis/cirrhosis in a cirrhotic hamster model. Molecular medicine reports. 2017 Dec; 16(6):9431-9440. doi: 10.3892/mmr.2017.7785. [PMID: 29039539]
  • Thomas M MacDonald, Bryan Williams, David J Webb, Steve Morant, Mark Caulfield, J Kennedy Cruickshank, Ian Ford, Peter Sever, Isla S Mackenzie, Sandosh Padmanabhan, Gerald P McCann, Jackie Salsbury, Gordon McInnes, Morris J Brown. Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial. Journal of the American Heart Association. 2017 Nov; 6(11):. doi: 10.1161/jaha.117.006986. [PMID: 29151036]
  • Sanket S Dhruva, Chenxi Huang, Erica S Spatz, Andreas C Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Xiao Xu, Curt D Furberg, Barry R Davis, Sara L Pressel, Ronald R Coifman, Harlan M Krumholz. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Hypertension (Dallas, Tex. : 1979). 2017 07; 70(1):94-102. doi: 10.1161/hypertensionaha.117.09221. [PMID: 28559399]
  • Kodai Suzuki, Takahito Miyake, Hideshi Okada, Fuminori Yamaji, Yuichiro Kitagawa, Tetsuya Fukuta, Ryu Yasuda, Yoshihito Tanaka, Haruka Okamoto, Sho Nachi, Tomoaki Doi, Takahiro Yoshida, Keisuke Kumada, Shozo Yoshida, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura. Thyrotoxic and pheochromocytoma multisystem crisis: a case report. Journal of medical case reports. 2017 Jun; 11(1):173. doi: 10.1186/s13256-017-1299-y. [PMID: 28641581]
  • Chun-Sheng Song, Jia-You Zhao, Jun Guo, De-Gui Chang, Lei Chen, Rui Zhang, Fu Wang. [Treatment of Benign Prostatic Hyperplasia by Longbishu Capsule Combined Doxazosin Mesylate Tablet]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2016 Dec; 36(12):1465-1469. doi: ". [PMID: 30650291]
  • V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov. Effect of Doxazosin on Autonomic Nervous Control and Urodynamics of Rat Urinary Bladder during Modeled Infravesical Obstruction. Bulletin of experimental biology and medicine. 2016 Sep; 161(5):657-661. doi: 10.1007/s10517-016-3479-y. [PMID: 27709382]
  • Yung-Chin Lee, Yung-Shun Juan, Chia-Chu Liu, Bo-Ying Bao, Chii-Jye Wang, Wen-Jeng Wu, Chun-Nung Huang, Shu-Pin Huang. The association of endothelial nitric oxide synthase (eNOS) G894T gene polymorphism with responsiveness to a selective α1 -blocker in men with benign prostatic hyperplasia related lower urinary tract symptoms. BJU international. 2016 08; 118(2):313-9. doi: 10.1111/bju.13468. [PMID: 26940040]
  • Qian Du, De-zhi Kong, Pan-pan Zhang, Lei-ming Ren. [Quantification of (-)doxazosin at very low concentration in rat plasma samples by SPE-LC-MS/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 07; 51(7):1125-9. doi: NULL. [PMID: 29897217]
  • Steven A Kaplan, Jeannette Y Lee, Alan G Meehan, John W Kusek. Time Course of Incident Adverse Experiences Associated with Doxazosin, Finasteride and Combination Therapy in Men with Benign Prostatic Hyperplasia: The MTOPS Trial. The Journal of urology. 2016 06; 195(6):1825-9. doi: 10.1016/j.juro.2015.11.065. [PMID: 26678956]
  • Mahmoud A Omar, Mohamed A Hammad, Baher I Salman, Sayed M Derayea. Highly sensitive spectrofluorimetric method for determination of doxazosin through derivatization with fluorescamine; Application to content uniformity testing. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2016 Mar; 157(?):55-60. doi: 10.1016/j.saa.2015.12.012. [PMID: 26716887]
  • Paweł Kroll, Ewa Gajewska, Jacek Zachwieja, Magdalena Sobieska, Przemysław Mańkowski. An Evaluation of the Efficacy of Selective Alpha-Blockers in the Treatment of Children with Neurogenic Bladder Dysfunction--Preliminary Findings. International journal of environmental research and public health. 2016 Mar; 13(3):. doi: 10.3390/ijerph13030321. [PMID: 26999168]
  • José A T Poloni, Lauro da F Beltrão, Elizete Keitel, Tiana Tasca, Liane N Rotta. Trichomonas vaginalis erythrophagocytosis in the urine sediment. International journal of STD & AIDS. 2016 Feb; 27(2):157-8. doi: 10.1177/0956462415610680. [PMID: 26468272]
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