Pindolol (BioDeep_00000002354)

 

Secondary id: BioDeep_00000408849

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-(1H-indol-4-Yloxy)-3-[(1-methylethyl)amino]propan-2-ol

化学式: C14H20N2O2 (248.1525)
中文名称: 吲哚洛尔, 平多洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 14.04%

Reviewed

Last reviewed on 2024-12-10.

Cite this Page

Pindolol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/pindolol (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002354). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
InChI: InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

描述信息

Pindolol is only found in individuals that have used or taken this drug. It is a moderately lipophilic beta blocker (adrenergic beta-antagonists). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)Pindolol non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, Pindolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
CONFIDENCE standard compound; INTERNAL_ID 4098
CONFIDENCE standard compound; INTERNAL_ID 2663
Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).

同义名列表

28 个代谢物同义名

1-(1H-indol-4-Yloxy)-3-[(1-methylethyl)amino]propan-2-ol; 1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol; 1-(1H-indol-4-Yloxy)-3-(propan-2-ylamino)-propan-2-ol; 1-(1H-indol-4-Yloxy)-3-(isopropylamino)propan-2-ol; 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole; Glauco-visken; Cardilic acid; Blocklin L; Prinodolol; Betapindol; Durapindol; Pindololum; Blocklin-L; Pectobloc; Prindolol; Cardilate; Blockin L; Carvisken; Calvisken; Pynastin; pindolol; Decreten; Pinbetol; Visken; LB-46; LB 46; Pindolol; Pindolol



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ACE, ALB, AXIN2, CA3, POMC
Peripheral membrane protein 1 LPL
Endosome membrane 2 ADRB2, SLC6A4
Nucleus 3 ADRB2, ALB, AXIN2
cytosol 3 ALB, AXIN2, CA3
dendrite 5 HTR1A, HTR1B, HTR2A, HTR2C, HTR7
centrosome 2 ALB, AXIN2
Cell membrane 11 ACE, ADRB2, ADRB3, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR7, LPL, SLC6A4
Cleavage furrow 1 HTR3A
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 10 ADRB2, ADRB3, CACNA1I, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR7, SLC6A4
Synapse 5 HTR1A, HTR2C, HTR3A, HTR7, SLC6A4
cell surface 1 LPL
dendritic shaft 1 HTR2A
glutamatergic synapse 1 HTR2A
Golgi apparatus 2 ADRB2, ALB
Golgi membrane 1 INS
neuronal cell body 1 HTR2A
postsynapse 1 HTR3A
presynaptic membrane 3 HTR1B, HTR2A, SLC6A4
Lysosome 2 ACE, ADRB2
Presynapse 2 HTR2A, SLC6A4
endosome 2 ACE, ADRB2
plasma membrane 15 ACE, ADRB2, ADRB3, AXIN2, CACNA1I, EDNRA, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR7, LPL, REN, SLC6A4
Membrane 7 ACE, ADRB2, CACNA1I, HTR3A, LCAT, REN, SLC6A4
apical plasma membrane 1 ADRB2
axon 1 HTR2A
caveola 1 HTR2A
extracellular exosome 3 ACE, ALB, LCAT
endoplasmic reticulum 2 ALB, HTR1B
extracellular space 7 ACE, ALB, INS, LCAT, LPL, POMC, REN
protein-containing complex 1 ALB
Single-pass type I membrane protein 1 ACE
Secreted 7 ACE, ALB, INS, LCAT, LPL, POMC, REN
extracellular region 7 ACE, ALB, INS, LCAT, LPL, POMC, REN
Extracellular side 1 LPL
anchoring junction 1 ALB
external side of plasma membrane 1 ACE
Secreted, extracellular space, extracellular matrix 1 LPL
chylomicron 1 LPL
high-density lipoprotein particle 1 LCAT
very-low-density lipoprotein particle 1 LPL
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 HTR2A
Early endosome 1 ADRB2
apical part of cell 1 REN
postsynaptic membrane 3 HTR2A, HTR3A, SLC6A4
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
secretory granule 1 POMC
Postsynaptic cell membrane 1 HTR3A
receptor complex 2 ADRB2, ADRB3
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 HTR3A, SLC6A4
ciliary basal body 1 ALB
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 1 ALB
sperm midpiece 1 ACE
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
Membrane, caveola 1 HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 2 HTR1A, HTR2A
basal plasma membrane 1 ACE
trans-Golgi network membrane 1 HTR7
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 ADRB2
neurofilament 1 HTR2A
calyx of Held 1 HTR1B
clathrin-coated endocytic vesicle membrane 1 ADRB2
catalytic complex 1 LPL
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
G protein-coupled serotonin receptor complex 3 HTR1B, HTR2A, HTR2C
serotonergic synapse 2 HTR1B, SLC6A4
ciliary transition fiber 1 ALB


文献列表

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