Roxithromycin (BioDeep_00000230939)

   

natural product Chemicals and Drugs


代谢物信息卡片


(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-{O-[(2-methoxyethoxy)methyl]oxime} (non-preferred name)

化学式: C41H76N2O15 (836.5245)
中文名称: 罗红霉素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 75.25%

分子结构信息

SMILES: C(OC(O3)CC(OC)(C(O)C(C)3)C)(C1C)C(C(OC(CC)C(C(C(C(C(C)CC(C1OC(C2O)OC(C)CC2N(C)C)(C)O)=NOCOCCOC)C)O)(C)O)=O)C
InChI: InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1

描述信息

Semisynthetic derivative of erythromycin A.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
A minor geometrical isomer of roxithromycin.
Roxithromycin is semisynthetic derivative of erythromycin A. It has a role as an antibacterial drug. It is an erythromycin derivative, a macrolide and a semisynthetic derivative. It is functionally related to an erythromycin A.
Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to [erythromycin], [azithromycin], or [clarithromycin]. It was shown to be more effective against certain Gram-negative bacteria, particularly Legionella pneumophila. Roxithromycin exerts its antibacterial action by binding to the bacterial ribosome and interfering with bacterial protein synthesis. It is marketed in Australia as a treatment for respiratory tract, urinary and soft tissue infections.
Roxithromycin is a semi-synthetic derivative of the macrolide antibiotic erythromycin that includes an N-oxime side chain on the lactone ring, with antibacterial and anti-malarial activities. Roxithromycin binds to the subunit 50S of the bacterial ribosome, which inhibits bacterial protein synthesis and leads to inhibition of bacterial cell growth and replication.
Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
CONFIDENCE standard compound; INTERNAL_ID 409; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8421; ORIGINAL_PRECURSOR_SCAN_NO 8419
CONFIDENCE standard compound; INTERNAL_ID 409; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8435; ORIGINAL_PRECURSOR_SCAN_NO 8434
CONFIDENCE standard compound; INTERNAL_ID 409; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8464; ORIGINAL_PRECURSOR_SCAN_NO 8462
CONFIDENCE standard compound; INTERNAL_ID 409; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8460; ORIGINAL_PRECURSOR_SCAN_NO 8458
CONFIDENCE standard compound; INTERNAL_ID 409; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8482; ORIGINAL_PRECURSOR_SCAN_NO 8478
CONFIDENCE standard compound; INTERNAL_ID 409; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8375; ORIGINAL_PRECURSOR_SCAN_NO 8373
CONFIDENCE standard compound; INTERNAL_ID 2185
CONFIDENCE standard compound; INTERNAL_ID 4097

同义名列表

77 个代谢物同义名

Roxithromycin; Ccris 3461; (Z)-roxithromycin; (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-{O-[(2-methoxyethoxy)methyl]oxime} (non-preferred name); (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)methoxy]imino}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one; (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-10-(((2-methoxyethoxy)methoxy)imino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one; (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one; (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-4-((2,6DIDEOXY-3-C-METHYL-3-O-METHYL-.ALPHA.-L-RIBO-HEXOPYRANOSYL)OXY)-14-ETHYL-7,12,13-TRIHYDROXY-10-((E)((2-METHOXYETHOXY)METHOXY)IMINO)-3,5,7,9,11,13HEXAMETHYL-6-((3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-.BETA.-D-XYLOHEXOPYRANOSYL)OXY)OXACYCLOTETRADECAN-2-ONE; (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-oxacyclotetradecan-2-one; (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-4-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-10-{[(2-methoxyethoxy)methoxy]imino}-6-[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one; (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-4-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-10-{[(2-methoxyethoxy)methoxy]imino}-6-[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one; (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one; (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)m; Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime), (9E)-; 9-[O-[(2-Methoxyethoxy)methyl]oxime]erythromycin, (9E)-; (9E)-erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime); ERYTHROMYCIN 9-(E)-(O-((2-METHOXYETHOXY)METHYL)OXIME); (E)-ERYTHROMYCIN-9-(O-((2-METHOXYETHOXY)METHYL)OXIME); 9-[O-(2-methoxyethoxymethyl)-oxime] of erythromycin; ERYTHROMYCIN A, 9-(O-(2-METHOXYETHOXYMETHYL)-OXIME); Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime); Erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime); Erythromycin 9-[O-[(2-methoxyethoxy)methyl]oxime]; 9-[O-[(2-Methoxyethoxy)methyl]oxime]erythromycin; 9-(O-((2-Methoxyethoxy)methyl)oxime)erythromycin; Roxithromycin [USAN:INN:BAN:JAN]; Roxithromycin (JP17/USAN/INN); ROXITHROMYCIN [EP MONOGRAPH]; ROXITHROMYCIN [EP IMPURITY]; Roxitromicina [Spanish]; Roxithromycinum [Latin]; Roxithromycine [French]; ROXITHROMYCIN [WHO-DD]; ROXITHROMYCIN [MART.]; ROXITHROMYCIN [USAN]; ROXITHROMYCIN [JAN]; Roxi-paed 1A Pharma; ROXITHROMYCIN [INN]; ROXITHROMYCIN [MI]; (E)-roxithromycin; Roxithromycin,(S); MTW-Roxithromycin; Spectrum5_001058; UNII-21KOF230FA; Roxithromycinum; Roxithromycine; Roxi 1A Pharma; Roxitromicina; Roxithro-Lich; Tox21_301835; Tox21_113150; Tox21_110697; Infectoroxit; Rulide (TN); IDI1_000382; Roxi Basics; roxi von ct; Roxi-Wolff; 21KOF230FA; Roxi-Puren; Roxi-saar; Roxigamma; Roxihexal; Rotramin; Roxigrün; Roxibeta; Macrosil; Roxi TAD; roxidura; Claramid; Rotesan; Biaxsig; Rulide; Roxi-Q; Rulid; Roxithromycin (Roxl-150); Roxithromycin



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, CAT, CYP3A4, ELANE, MAPK14, NFKB1, VEGFA
Peripheral membrane protein 1 CAV1
Endoplasmic reticulum membrane 2 CAV1, CYP3A4
Nucleus 4 JUND, MAPK14, NFKB1, VEGFA
cytosol 5 CAT, ELANE, IL1B, MAPK14, NFKB1
phagocytic vesicle 1 ELANE
nucleoplasm 3 JUND, MAPK14, NFKB1
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 3 ABCB1, CAV1, TNF
Early endosome membrane 1 CAV1
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 CAV1
cell cortex 1 CAV1
cell surface 4 ABCB1, ELANE, TNF, VEGFA
glutamatergic synapse 1 MAPK14
Golgi apparatus 2 CAV1, VEGFA
Golgi membrane 1 CAV1
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
endosome 1 CAV1
plasma membrane 5 ABCB1, CAV1, CSF2, IFNLR1, TNF
Membrane 6 ABCB1, CAT, CAV1, CYP3A4, IFNLR1, VEGFA
apical plasma membrane 2 ABCB1, CAV1
basolateral plasma membrane 1 CAV1
caveola 1 CAV1
extracellular exosome 3 ABCB1, CAT, ELANE
endoplasmic reticulum 2 CAV1, VEGFA
extracellular space 12 CCL17, CRP, CSF2, CXCL8, ELANE, IL1B, IL2, IL4, IL5, IL6, TNF, VEGFA
perinuclear region of cytoplasm 1 CAV1
adherens junction 1 VEGFA
mitochondrion 3 CAT, MAPK14, NFKB1
protein-containing complex 2 CAT, CAV1
intracellular membrane-bounded organelle 3 CAT, CSF2, CYP3A4
Microsome membrane 1 CYP3A4
Single-pass type I membrane protein 1 IFNLR1
Secreted 10 CCL17, CRP, CSF2, CXCL8, IL1B, IL2, IL4, IL5, IL6, VEGFA
extracellular region 15 CAT, CCL17, CRP, CSF2, CXCL8, ELANE, IL1B, IL2, IL4, IL5, IL6, MAPK14, NFKB1, TNF, VEGFA
mitochondrial matrix 1 CAT
transcription regulator complex 2 JUND, NFKB1
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
cytoplasmic vesicle 1 CAV1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 2 CAV1, TNF
focal adhesion 2 CAT, CAV1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ELANE
secretory granule 3 ELANE, IL1B, VEGFA
nuclear speck 1 MAPK14
cilium 1 CAV1
chromatin 2 JUND, NFKB1
phagocytic cup 1 TNF
Golgi apparatus, trans-Golgi network 1 CAV1
spindle pole 1 MAPK14
Lipid droplet 1 CAV1
Membrane, caveola 1 CAV1
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, MAPK14, NFKB1
endoplasmic reticulum lumen 1 IL6
transcription repressor complex 2 ELANE, JUND
platelet alpha granule lumen 1 VEGFA
specific granule lumen 2 ELANE, NFKB1
endocytic vesicle membrane 1 CAV1
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 1 ELANE
external side of apical plasma membrane 1 ABCB1
acrosomal membrane 1 CAV1
Cytoplasmic vesicle, phagosome 1 ELANE
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
caveolar macromolecular signaling complex 1 CAV1
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jiahua Guo, Yi Bai, Zhi Chen, Jiezhang Mo, Qi Li, Haotian Sun, Qiang Zhang. Transcriptomic analysis suggests the inhibition of DNA damage repair in green alga Raphidocelis subcapitata exposed to roxithromycin. Ecotoxicology and environmental safety. 2020 Sep; 201(?):110737. doi: 10.1016/j.ecoenv.2020.110737. [PMID: 32505758]
  • Abdelghani Mahmoudi, Mihaela Tertiş, Laura-Mihaela Simon, Ann Van Schepdael, Silvia De Francia, Lia-Monica Junie, Robert Săndulescu. Correlated quantification using microbiological and electrochemical assays for roxithromycin determination in biological and pharmaceutical samples. Talanta. 2020 May; 211(?):120703. doi: 10.1016/j.talanta.2019.120703. [PMID: 32070606]
  • Xiang Liu, Chen Chen, Xiaoying Zhang. Drug-drug interaction of acetaminophen and roxithromycin with the cocktail of cytochrome P450 and hepatotoxicity in rats. International journal of medical sciences. 2020; 17(3):414-421. doi: 10.7150/ijms.38527. [PMID: 32132876]
  • X F Gu, X M Chen, H J Chen, T T Xu, Z W Qiu, D D Sun, X T Ge, S M Ying, Y R Dai. [The role of S100A8/RAGE and Caveolin-1 and the effect of roxithromycin on their expression in a rat model of neutrophilic asthma]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. 2019 Nov; 42(11):845-851. doi: 10.3760/cma.j.issn.1001-0939.2019.11.012. [PMID: 31694095]
  • X F Gu, H J Chen, X M Chen, T T Xu, Z W Qiu, L Q Wu, W Dai, S M Ying, Y R Dai. [Expression of RAGE in asthmatic rats and the intervention of Roxithromycin]. Zhonghua yi xue za zhi. 2019 Aug; 99(32):2542-2546. doi: 10.3760/cma.j.issn.0376-2491.2019.32.015. [PMID: 31484284]
  • Syed Faheem Askari Rizvi, Saleha Tariq, Muhammad Mehdi, Ahmad Junaid Hassan. Synthesis of 99m Tc-roxithromycin: A novel diagnostic agent to discriminate between septic and aseptic inflammation. Chemical biology & drug design. 2019 06; 93(6):1166-1174. doi: 10.1111/cbdd.13412. [PMID: 30370631]
  • Yu Ke, Xiaoye Zhang, Caikun Liu, Meng Xiao, Hong Li, Jiachen Fan, Pengcheng Fu, Shuhao Wang, Fei Zan, Gang Wu. Polypseudorotaxane functionalized magnetic nanoparticles as a dual responsive carrier for roxithromycin delivery. Materials science & engineering. C, Materials for biological applications. 2019 Jun; 99(?):159-170. doi: 10.1016/j.msec.2019.01.078. [PMID: 30889688]
  • Qian Xiong, Li-Xin Hu, You-Sheng Liu, Tuan-Tuan Wang, Guang-Guo Ying. New insight into the toxic effects of chloramphenicol and roxithromycin to algae using FTIR spectroscopy. Aquatic toxicology (Amsterdam, Netherlands). 2019 Feb; 207(?):197-207. doi: 10.1016/j.aquatox.2018.12.017. [PMID: 30584953]
  • C Behr, S Sperber, X Jiang, V Strauss, H Kamp, T Walk, M Herold, K Beekmann, I M C M Rietjens, B van Ravenzwaay. Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics. Toxicology and applied pharmacology. 2018 09; 355(?):198-210. doi: 10.1016/j.taap.2018.06.028. [PMID: 30008377]
  • Giuseppe Maiolino, Giulio Ceolotto, Michele Battistel, Giulio Barbiero, Maurizio Cesari, Laurence Amar, Brasilina Caroccia, Roberto Padrini, Michel Azizi, Gian Paolo Rossi. Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism. Blood pressure. 2018 08; 27(4):200-205. doi: 10.1080/08037051.2018.1436961. [PMID: 29409357]
  • Mengling Xia, Hui Xu, Wei Dai, Cong Zhu, Liqin Wu, Sunshun Yan, Xiangting Ge, Wangfeng Zhou, Cuicui Chen, Yuanrong Dai. The role of HDAC2 in cigarette smoke-induced airway inflammation in a murine model of asthma and the effect of intervention with roxithromycin. The Journal of asthma : official journal of the Association for the Care of Asthma. 2018 04; 55(4):337-344. doi: 10.1080/02770903.2017.1337788. [PMID: 28960099]
  • Zhenhua Yan, Guanghua Lu, Hongwei Sun, Binni Ma. Influence of multi-walled carbon nanotubes on the effects of roxithromycin in crucian carp (Carassius auratus) in the presence of natural organic matter. Chemosphere. 2017 Jul; 178(?):165-172. doi: 10.1016/j.chemosphere.2017.03.043. [PMID: 28324838]
  • Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu, Sung-Ho Kim. Roxithromycin inhibits VEGF-induced human airway smooth muscle cell proliferation: Opportunities for the treatment of asthma. Experimental cell research. 2016 10; 347(2):378-84. doi: 10.1016/j.yexcr.2016.08.024. [PMID: 27587274]
  • Jie Ding, Fengshuang Zhang, Xiaopan Zhang, Long Wang, Changjia Wang, Qi Zhao, Yang Xu, Lan Ding, Nanqi Ren. Determination of roxithromycin from human plasma samples based on magnetic surface molecularly imprinted polymers followed by liquid chromatography-tandem mass spectromer. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 May; 1021(?):221-228. doi: 10.1016/j.jchromb.2015.08.001. [PMID: 26300321]
  • Qing Yan, Guozhong Feng, Xu Gao, Chengxiao Sun, Jin-song Guo, Zhiwei Zhu. Removal of pharmaceutically active compounds (PhACs) and toxicological response of Cyperus alternifolius exposed to PhACs in microcosm constructed wetlands. Journal of hazardous materials. 2016 Jan; 301(?):566-75. doi: 10.1016/j.jhazmat.2015.08.057. [PMID: 26465971]
  • Hanna Wosicka-Frąckowiak, Krzysztof Cal, Justyna Stefanowska, Eliza Główka, Magdalena Nowacka, Wiktoria Struck-Lewicka, Biljana Govedarica, Monika Pasikowska, Renata Dębowska, Teofil Jesionowski, Stane Srčič, Michał Jan Markuszewski. Roxithromycin-loaded lipid nanoparticles for follicular targeting. International journal of pharmaceutics. 2015 Nov; 495(2):807-15. doi: 10.1016/j.ijpharm.2015.09.068. [PMID: 26456292]
  • Inna Galvidis, Gennady Lapa, Maksim Burkin. Group determination of 14-membered macrolide antibiotics and azithromycin using antibodies against common epitopes. Analytical biochemistry. 2015 01; 468(?):75-82. doi: 10.1016/j.ab.2014.09.009. [PMID: 25256165]
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