Ginkgolide A (BioDeep_00000230810)
Main id: BioDeep_00000230149
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3,2:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1.alpha.,3.beta.,3aS*,4.beta.,6a.alpha.,7a.alpha.,7b.alpha.,8.alpha.,10a.alpha.,11aS*)]-
化学式: C20H24O9 (408.142)
中文名称: 银杏内酯 A, 银杏内酯A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O
InChI: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3
描述信息
9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3,2:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl- is a diterpene lactone.
Ginkgolide A is a natural product found in Ginkgo biloba with data available.
Ginkgolide A is found in fats and oils. Ginkgolide A is a bitter principle from Ginkgo biloba (ginkgo).
Ginkgolide A (BN-52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.
Ginkgolide A (BN-52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.
Ginkgolide A (BN-52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.
同义名列表
15 个代谢物同义名
9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3,2:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1.alpha.,3.beta.,3aS*,4.beta.,6a.alpha.,7a.alpha.,7b.alpha.,8.alpha.,10a.alpha.,11aS*)]-; 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3,2:3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-; 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3,2:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-; (1S,3R,6R,7S,8S,10R,11S,13S,16S,17R)-8-Tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione; 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3,2:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-; 8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0¹,¹¹.0³,⁷.0⁷,¹¹.0¹³,¹⁷]nonadecane-5,15,18-trione; 8-Tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione; Ginkgolide A from Ginkgo biloba leaves; FPUXKXIZEIDQKW-UHFFFAOYSA-N; ginkgolide A; GinkgolideA; Ginkgolide; C20H24O9; BN-52020; Ginkgolide A
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:181554
- PubChem: 23817960
- PubChem: 115221
- HMDB: HMDB0036862
- ChEMBL: CHEMBL1408113
- MeSH: ginkgolide A
- chemspider: 23089476
- chemspider: 9968992
- CAS: 15291-75-5
- RefMet: Ginkgolide A
- medchemexpress: HY-B0355
- KEGG: C07601
- PubChem: 9803
- KNApSAcK: 181554
- LOTUS: LTS0259703
- wikidata: Q104999409
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chun-Yan Yin, Yuan-Pei Lian, Jian-Da Xu, Chan-Ming Liu, Jia-Li Cai, Li Zhu, Di-Jun Wang, Li-Bo Luo, Xiao-Jing Yan. Study on network pharmacology of Ginkgo biloba extract against ischaemic stroke mechanism and establishment of UPLC-MS/MS methods for simultaneous determination of 19 main active components.
Phytochemical analysis : PCA.
2023 Sep; ?(?):. doi:
10.1002/pca.3286. [PMID: 37758241] - Martin Hébert, Gabriel Bellavance, Louis Barriault. Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B.
Journal of the American Chemical Society.
2022 10; 144(39):17792-17796. doi:
10.1021/jacs.2c08351. [PMID: 36150149] - Zhonglin Liu, Yan Yang. Ginkgolide A Participates in LPS-Induced PMVEC Injury by Regulating miR-224 and Inhibiting p21 in a Targeted Manner.
Contrast media & molecular imaging.
2022; 2022(?):6384334. doi:
10.1155/2022/6384334. [PMID: 36134118] - Jianzhong Li, Jian Chen, Yucheng Yang, Rui Ding, Meili Wang, Zhenhua Gu. Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target.
International immunopharmacology.
2021 Jun; 95(?):107514. doi:
10.1016/j.intimp.2021.107514. [PMID: 33677255] - Chandan Sarkar, Cristina Quispe, Sarmin Jamaddar, Rajib Hossain, Pranta Ray, Milon Mondal, Zeinab Abdulwanis Mohamed, Mohammed Sani Jaafaru, Bahare Salehi, Muhammad Torequl Islam, Ahmad Faizal Abdull Razis, Miquel Martorell, Edgar Pastene-Navarrete, Javad Sharifi-Rad. Therapeutic promises of ginkgolide A: A literature-based review.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Dec; 132(?):110908. doi:
10.1016/j.biopha.2020.110908. [PMID: 33254431] - Yu Wang, Yan-Jiao Chen, Cheng Xiang, Guang-Wei Jiang, Yu-Dong Xu, Lei-Miao Yin, Dong-Dong Zhou, Yan-Yan Liu, Yong-Qing Yang. Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulas.
Journal of ethnopharmacology.
2020 Apr; 252(?):112635. doi:
10.1016/j.jep.2020.112635. [PMID: 32004629] - Sundhar Mohandas, Balasubramaniyan Vairappan. Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis.
Chemico-biological interactions.
2020 Jan; 315(?):108891. doi:
10.1016/j.cbi.2019.108891. [PMID: 31697926] - Kazuko Iwamoto, Hirokazu Kawamoto, Fumiaki Takeshita, Shinichi Matsumura, Ikuto Ayaki, Tatsuya Moriyama, Nobuhiro Zaima. Mixing Ginkgo biloba Extract with Sesame Extract and Turmeric Oil Increases Bioavailability of Ginkgolide A in Mice Brain.
Journal of oleo science.
2019 Sep; 68(9):923-930. doi:
10.5650/jos.ess19135. [PMID: 31413248] - Li-Chen Kuo, Yan-Qing Song, Chien-An Yao, Irene H Cheng, Chiang-Ting Chien, Guan-Chiun Lee, Wen-Chin Yang, Yenshou Lin. Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons.
Journal of agricultural and food chemistry.
2019 Jan; 67(1):81-89. doi:
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2018 Jun; 32(6):e4212. doi:
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Chinese journal of natural medicines.
2018 May; 16(5):366-374. doi:
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Chinese journal of natural medicines.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Apr; 88(?):625-634. doi:
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Analytical and bioanalytical chemistry.
2015 Oct; 407(26):7945-56. doi:
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2015 Jul; 40(14):2882-6. doi:
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Fitoterapia.
2015 Apr; 102(?):189-97. doi:
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Journal of ethnopharmacology.
2014 Dec; 158 Pt A(?):132-9. doi:
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Journal of pharmaceutical and biomedical analysis.
2014 Nov; 100(?):138-144. doi:
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Se pu = Chinese journal of chromatography.
2013 Aug; 31(8):795-9. doi:
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Planta medica.
2012 Aug; 78(12):1337-41. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
2012 Aug; 18(8):BR293-298. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 Apr; 36(8):1011-4. doi:
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The Journal of pharmacology and experimental therapeutics.
2010 Dec; 335(3):771-80. doi:
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Phytotherapy research : PTR.
2010 Mar; 24(3):445-50. doi:
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Journal of natural products.
2009 Dec; 72(12):2145-52. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2008 May; 38(5):465-81. doi:
10.1080/00498250701883233. [PMID: 18421621] - Min Liu, Jian-hai Chen, Fu-rong Dong, Yuan Liu. [Optimized preparation of ginkgolides A and B long-circulating solid lipid nanoparticles by central composite design and response surface method].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2008 May; 28(5):700-3. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Mar; 864(1-2):87-94. doi:
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Acta poloniae pharmaceutica.
2007 Jul; 64(4):303-10. doi:
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Cancer letters.
2007 Jun; 251(1):43-52. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Feb; 40(3):763-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2006 Feb; 34(2):234-42. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2005 Dec; 30(24):1915-8. doi:
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Phytochemistry.
2004 Nov; 65(21):2897-902. doi:
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Analytical chemistry.
2004 Aug; 76(15):4332-6. doi:
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Phytotherapy research : PTR.
2004 Jul; 18(7):556-60. doi:
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Analytical and bioanalytical chemistry.
2004 Jun; 379(3):445-8. doi:
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DNA sequence : the journal of DNA sequencing and mapping.
2004 Apr; 15(2):153-8. doi:
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2004 Jan; 27(1):19-20. doi:
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Journal of natural products.
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