Theophylline (BioDeep_00000229644)

Main id: BioDeep_00000000451

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


Theophylline

化学式: C7H8N4O2 (180.0647)
中文名称: 茶碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2
InChI: InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

同义名列表

5 个代谢物同义名

Theophylline; 1,3-Dimethylxanthine; Theo-24; Theophylline; Theophylline



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALB, CA1, CYP2E1, CYP3A4, HDAC2, PRKX, SPTAN1
Peripheral membrane protein 1 CYP2E1
Endoplasmic reticulum membrane 3 CYP1A2, CYP2E1, CYP3A4
Nucleus 3 ALB, HDAC2, PRKX
cytosol 4 ALB, ATP12A, CA1, SPTAN1
dendrite 1 ADORA2A
centrosome 1 ALB
nucleoplasm 2 HDAC2, PRKX
Cell membrane 5 ABCB1, ADORA2A, ADRB3, CD8A, TNF
Multi-pass membrane protein 5 ABCB1, ADORA2A, ADRB3, ATP12A, CACNA1I
cell cortex 1 SPTAN1
cell junction 1 SPTAN1
cell surface 2 ABCB1, TNF
glutamatergic synapse 1 ADORA2A
Golgi apparatus 1 ALB
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 2 ADORA2A, TNF
presynaptic membrane 1 ADORA2A
plasma membrane 11 ABCB1, ADORA2A, ADRB3, ATP12A, CACNA1I, CD8A, GCG, IFNLR1, IGHE, SPTAN1, TNF
presynaptic active zone 1 ADORA2A
Membrane 7 ABCB1, ADORA2A, CACNA1I, CYP3A4, HDAC2, IFNLR1, SPTAN1
apical plasma membrane 2 ABCB1, ATP12A
basolateral plasma membrane 1 ATP12A
extracellular exosome 4 ABCB1, ALB, CA1, SPTAN1
endoplasmic reticulum 1 ALB
extracellular space 6 ALB, GCG, IGHE, IL5, INS, TNF
protein-containing complex 2 ALB, HDAC2
intracellular membrane-bounded organelle 4 CYP1A2, CYP2E1, CYP3A4, SPTAN1
Microsome membrane 3 CYP1A2, CYP2E1, CYP3A4
ESC/E(Z) complex 1 HDAC2
Single-pass type I membrane protein 3 CD8A, IFNLR1, IGHE
Secreted 4 ALB, GCG, IL5, INS
extracellular region 8 ALB, CD8A, GCG, IGHE, IL5, INS, SPTAN1, TNF
[Isoform 2]: Secreted 1 CD8A
anchoring junction 1 ALB
external side of plasma membrane 2 CD8A, TNF
Extracellular vesicle 1 SPTAN1
actin cytoskeleton 2 ATP12A, SPTAN1
microtubule cytoskeleton 1 SPTAN1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 ADORA2A
Apical cell membrane 2 ABCB1, ATP12A
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 SPTAN1
axolemma 1 ADORA2A
intermediate filament 1 ADORA2A
receptor complex 2 ADRB3, CD8A
ciliary basal body 1 ALB
chromatin 1 HDAC2
IgE immunoglobulin complex 1 IGHE
cell projection 1 SPTAN1
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
chromosome, telomeric region 1 HDAC2
Cytoplasm, cell cortex 1 SPTAN1
blood microparticle 1 ALB
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
plasma membrane raft 1 CD8A
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, GCG, INS
cortical actin cytoskeleton 1 SPTAN1
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 1 SPTAN1
tertiary granule lumen 1 SPTAN1
histone deacetylase complex 1 HDAC2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
NuRD complex 1 HDAC2
spectrin 1 SPTAN1
Sin3-type complex 1 HDAC2
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 CD8A
[Isoform 3]: Cell membrane 1 IGHE
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD8A
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
asymmetric synapse 1 ADORA2A
potassium:proton exchanging ATPase complex 1 ATP12A
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
organelle 1 SPTAN1


文献列表

  • Georgios Paraskevopoulos, Ferdinand Fandrei, Ajit Kumar Pratihast, Anna Paraskevopoulou, Eleni Panoutsopoulou, Lukáš Opálka, Venus Singh Mithu, Daniel Huster, Kateřina Vávrová. Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery. Journal of colloid and interface science. 2024 Apr; 659(?):449-462. doi: 10.1016/j.jcis.2023.12.139. [PMID: 38183811]
  • Ashutosh Pareek, Rupal Kothari, Aaushi Pareek, Yashumati Ratan, Pushpa Kashania, Vivek Jain, Philippe Jeandet, Parveen Kumar, Azmat Ali Khan, Amer M Alanazi, Madan Mohan Gupta. Development of a new inhaled swellable microsphere system for the dual delivery of naringenin-loaded solid lipid nanoparticles and doxofylline for the treatment of asthma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Feb; 193(?):106642. doi: 10.1016/j.ejps.2023.106642. [PMID: 37977235]
  • Waqar Ahmed Siddiqui, Muniza Qayyum, Aamina Quddus Qureshi, Momina Khalid, Sehrish Zaffar, Rabiea Bilal. The Bronchodilator Potential of Astragalus sarcocolla: An in vitro Experiment. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2024 Jan; 34(1):58-62. doi: 10.29271/jcpsp.2024.01.58. [PMID: 38185962]
  • Liguo Liu, Dongmei Xu, Fengxin Chen, Shengnan Cai, Jin Wei, Jiaheng Deng, Jianhua Zheng, Qi Jin, Wenhui Lun. Identification of potential biomarkers for diagnosis of syphilis from the cerebrospinal fluid based on untargeted metabolomic analysis. Molecular omics. 2023 Apr; ?(?):. doi: 10.1039/d3mo00026e. [PMID: 37185577]
  • Magdalena Kotańska, Anna Dziubina, Małgorzata Szafarz, Kamil Mika, Marek Bednarski, Noemi Nicosia, Ahmed Temirak, Christa E Müller, Katarzyna Kieć-Kononowicz. Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice. International journal of molecular sciences. 2022 Nov; 23(21):. doi: 10.3390/ijms232113439. [PMID: 36362227]
  • Kenchi Miyasaka, Yoshiaki Manse, Akari Yoneda, Shogo Takeda, Norihito Shimizu, Wakana Yamada, Toshio Morikawa, Hiroshi Shimoda. Anti-melanogenic effects of glucosylceramides and elasticamide derived from rice oil by-products in melanoma cells, melanocytes, and human skin. Journal of food biochemistry. 2022 10; 46(10):e14353. doi: 10.1111/jfbc.14353. [PMID: 35986572]
  • Shuoyuan Huang, Huan Chen, Jianwen Teng, Zhengmei Wu, Li Huang, Baoyao Wei, Ning Xia. Antihyperlipidemic effect and increased antioxidant enzyme levels of aqueous extracts from Liupao tea and green tea in vivo. Journal of food science. 2022 Sep; 87(9):4203-4220. doi: 10.1111/1750-3841.16274. [PMID: 35982642]
  • Ken Wada, Akiko Kurata, Takashi Iwamoto, Junji Gon, Hiroma Shimizu. Oral theophylline augmentation for patients with missed or inadequate seizures with electroconvulsive therapy. Asian journal of psychiatry. 2022 Jul; 73(?):103148. doi: 10.1016/j.ajp.2022.103148. [PMID: 35597185]
  • Gaëlle Magliocco, Jules Desmeules, Caroline Flora Samer, Aurélien Thomas, Youssef Daali. Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots. Clinical and translational science. 2022 06; 15(6):1482-1491. doi: 10.1111/cts.13263. [PMID: 35338582]
  • Miyoko Matsushima, Souma Tanihata, Junpei Kusakabe, Momoha Okahira, Hiroshi Ito, Atsushi Yamamoto, Masanori Yamamoto, Ryohei Yamamoto, Tsutomu Kawabe. Correlation of theophylline levels in rat exhaled breath and lung tissue after its intravenous injection. Journal of breath research. 2022 05; 16(3):. doi: 10.1088/1752-7163/ac6b4b. [PMID: 35483336]
  • Luis M Montaño, Bettina Sommer, Juan C Gomez-Verjan, Genaro S Morales-Paoli, Gema Lizbeth Ramírez-Salinas, Héctor Solís-Chagoyán, Zuly A Sanchez-Florentino, Eduardo Calixto, Gloria E Pérez-Figueroa, Rohan Carter, Ruth Jaimez-Melgoza, Bianca S Romero-Martínez, Edgar Flores-Soto. Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084167. [PMID: 35456985]
  • Jake J Lee, Andrew M Peterson, Dorina Kallogjeri, Pawina Jiramongkolchai, Sara Kukuljan, John S Schneider, Cristine N Klatt-Cromwell, Andrew J Drescher, Joseph D Brunworth, Jay F Piccirillo. Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction. American journal of otolaryngology. 2022 Mar; 43(2):103299. doi: 10.1016/j.amjoto.2021.103299. [PMID: 34894449]
  • Ralf Jäger, Martin Purpura, Shawn D Wells, Kylin Liao, Ashok Godavarthi. Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice. Nutrients. 2022 Feb; 14(4):. doi: 10.3390/nu14040893. [PMID: 35215543]
  • Daniel Janitschke, Anna Andrea Lauer, Cornel Manuel Bachmann, Jakob Winkler, Lea Victoria Griebsch, Sabrina Melanie Pilz, Elena Leoni Theiss, Heike Sabine Grimm, Tobias Hartmann, Marcus Otto Walter Grimm. Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042295. [PMID: 35216410]
  • Kristen J Polinski, Alexandra Purdue-Smithe, Sonia L Robinson, Sifang Kathy Zhao, Karen C Schliep, Robert M Silver, Weihua Guan, Enrique F Schisterman, Sunni L Mumford, Edwina H Yeung. Maternal caffeine intake and DNA methylation in newborn cord blood. The American journal of clinical nutrition. 2022 02; 115(2):482-491. doi: 10.1093/ajcn/nqab348. [PMID: 34669932]
  • Jennifer M Reinhart, Gabriela A R de Oliveira, Lauren Forsythe, Zhong Li. Pharmacokinetics of a 503B outsourcing facility-produced theophylline in dogs. PloS one. 2022; 17(1):e0262336. doi: 10.1371/journal.pone.0262336. [PMID: 34990472]
  • Weiyi Qu, Ze Chen, Xing Hu, Toujun Zou, Yongping Huang, Yanyan Zhang, Yufeng Hu, Song Tian, Juan Wan, Rufang Liao, Lan Bai, Jinhua Xue, Yi Ding, Manli Hu, Xiao-Jing Zhang, Xin Zhang, Jingjing Zhao, Xu Cheng, Zhi-Gang She, Hongliang Li. Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model. Frontiers in endocrinology. 2022; 13(?):849060. doi: 10.3389/fendo.2022.849060. [PMID: 35620391]
  • Archit Dahiya, Rajeev Sharma, Abhimanyu Singh, Piyush Joshi, Harsh Wardhan. Role of Etophylline and Theophylline Prolonged Release Tablet in COVID-19 Associated Sinus Node Dysfunction. The Journal of the Association of Physicians of India. 2022 Jan; 70(1):11-12. doi: . [PMID: 35062804]
  • Martin Kertys, Nela Žideková, Kristián Pršo, Katarína Maráková, Katarína Kmeťová, Juraj Mokrý. Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS. Journal of separation science. 2021 Dec; 44(23):4274-4283. doi: 10.1002/jssc.202100604. [PMID: 34626085]
  • Dusan Petrovic, Menno Pruijm, Belén Ponte, Nasser A Dhayat, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Bruno Vogt, Pierre-Yves Martin, Silvia Stringhini, Sandrine Estoppey-Younès, Lutgarde Thijs, Zhenyu Zhang, Jesus D Melgarejo, Chin B Eap, Jan A Staessen, Murielle Bochud, Idris Guessous. Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies. Mayo Clinic proceedings. 2021 12; 96(12):3071-3085. doi: 10.1016/j.mayocp.2021.05.030. [PMID: 34579945]
  • Ching Thai, Bola Tayo, David Critchley. A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects. Clinical pharmacology in drug development. 2021 11; 10(11):1279-1289. doi: 10.1002/cpdd.950. [PMID: 33951339]
  • Mostafa Boskabady, Azam Alavinezhad, Mohammad Hossein Boskabady. Zataria multiflora induced bronchodilatoion comparable to theophylline syrup in asthmatic patients. Explore (New York, N.Y.). 2021 Nov; 17(6):578-583. doi: 10.1016/j.explore.2020.07.002. [PMID: 32709586]
  • Bassam Lajin, Natascha Schweighofer, Walter Goessler, Barbara Obermayer-Pietsch. The determination of the Paraxanthine/Caffeine ratio as a metabolic biomarker for CYP1A2 activity in various human matrices by UHPLC-ESIMS/MS. Talanta. 2021 Nov; 234(?):122658. doi: 10.1016/j.talanta.2021.122658. [PMID: 34364467]
  • Michelle C Starr, Jennifer R Charlton, Ronnie Guillet, Kimberly Reidy, Trent E Tipple, Jennifer G Jetton, Alison L Kent, Carolyn L Abitbol, Namasivayam Ambalavanan, Maroun J Mhanna, David J Askenazi, David T Selewski, Matthew W Harer. Advances in Neonatal Acute Kidney Injury. Pediatrics. 2021 11; 148(5):. doi: 10.1542/peds.2021-051220. [PMID: 34599008]
  • Kana N Miyata, Chao-Sheng Lo, Shuiling Zhao, Xin-Ping Zhao, Isabelle Chenier, Michifumi Yamashita, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Chan. Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes. Diabetologia. 2021 11; 64(11):2589-2601. doi: 10.1007/s00125-021-05538-9. [PMID: 34370045]
  • Jennifer M Reinhart, Claudia Perkowski, Courtney Lester, Valeria Campos, Saki Kadotani, Zhong Li, Brendan C McKiernan, Ryan Fries. Multidose pharmacokinetics and safety of a modified, compounded theophylline product in dogs. Journal of veterinary pharmacology and therapeutics. 2021 Nov; 44(6):902-909. doi: 10.1111/jvp.12997. [PMID: 34173985]
  • Julia Brunmair, Mathias Gotsmy, Laura Niederstaetter, Benjamin Neuditschko, Andrea Bileck, Astrid Slany, Max Lennart Feuerstein, Clemens Langbauer, Lukas Janker, Jürgen Zanghellini, Samuel M Meier-Menches, Christopher Gerner. Finger sweat analysis enables short interval metabolic biomonitoring in humans. Nature communications. 2021 10; 12(1):5993. doi: 10.1038/s41467-021-26245-4. [PMID: 34645808]
  • Meghan Matheny, Noble Maleque, Natalie Channell, A Robin Eisch, Sara C Auld, Aleena Banerji, Kirk M Druey. Severe Exacerbations of Systemic Capillary Leak Syndrome After COVID-19 Vaccination: A Case Series. Annals of internal medicine. 2021 10; 174(10):1476-1478. doi: 10.7326/l21-0250. [PMID: 34125573]
  • Jader B Ruchel, Viviane M Bernardes, Josiane B S Braun, Alessandra G Manzoni, Daniela F Passos, Lívia G Castilhos, Fátima H Abdalla, Juliana S de Oliveira, Cinthia M de Andrade, Emerson A Casali, Ivana B M da Cruz, Daniela B R Leal. Lipotoxicity-associated inflammation is prevented by guarana (Paullinia cupana) in a model of hyperlipidemia. Drug and chemical toxicology. 2021 Sep; 44(5):524-532. doi: 10.1080/01480545.2019.1624767. [PMID: 31195840]
  • Ioannis Bellos, Aakash Pandita, Monika Yachha. Effectiveness of theophylline administration in neonates with perinatal asphyxia: a meta-analysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2021 Sep; 34(18):3080-3088. doi: 10.1080/14767058.2019.1673722. [PMID: 31558088]
  • Kamilla Nunes Machado, Antony de Paula Barbosa, Aline Alves de Freitas, Luana Farah Alvarenga, Rodrigo Maia de Pádua, André Augusto Gomes Faraco, Fernão Castro Braga, Cristina Duarte Vianna-Soares, Rachel Oliveira Castilho. TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder. Food chemistry. 2021 Sep; 355(?):129563. doi: 10.1016/j.foodchem.2021.129563. [PMID: 33799249]
  • Xianrong Du, Hongju Bao, Daguo Zhao. Efficacy and safety of combined doxofylline and salbutamol in treatment of acute exacerbation of chronic obstructive pulmonary disease. Revista da Associacao Medica Brasileira (1992). 2021 Sep; 67(9):1256-1260. doi: 10.1590/1806-9282.20210429. [PMID: 34816917]
  • Yoshimitsu Ouchi, Miko Yamato, Vishwajit S Chowdhury, Takashi Bungo. Adenosine 5'-monophosphate induces hypothermia and alters gene expressions in the brain and liver of chicks. Brain research bulletin. 2021 07; 172(?):14-21. doi: 10.1016/j.brainresbull.2021.04.008. [PMID: 33862124]
  • Soo Hee Lee, Ju-Tae Sohn. Potential mechanisms underlying the effects of lipid emulsion against theophylline-induced toxicity. The American journal of emergency medicine. 2021 07; 45(?):629-630. doi: 10.1016/j.ajem.2020.11.042. [PMID: 33261948]
  • Geoffrey C Wall, Hayden L Smith, Matthew W Trump, Jason D Mohr, Samuel P DuMontier, Becca L Sabates, Iaswarya Ganapathiraju, Tim J Kable. Pentoxifylline or theophylline use in hospitalized COVID-19 patients requiring oxygen support. The clinical respiratory journal. 2021 Jul; 15(7):843-846. doi: 10.1111/crj.13363. [PMID: 33735520]
  • V P Chandrasekaran, Anand Parthasarathy, Balaji Muruga, Senthamil, Tharanesh. Lipid emulsion in theophylline and salbutamol overdose: Lipid sink theory (MS 25092). The American journal of emergency medicine. 2021 07; 45(?):632. doi: 10.1016/j.ajem.2020.11.040. [PMID: 33323277]
  • Xiaomei I Liu, John N van den Anker, Gilbert J Burckart, André Dallmann. Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups. Journal of clinical pharmacology. 2021 06; 61 Suppl 1(?):S94-S107. doi: 10.1002/jcph.1845. [PMID: 34185902]
  • Ramya R, Thivya P, Nathiya D, Wilson J. Polypyrrole and enzyme free cholesterol flakes based composite: Selective determination of theophylline. Journal of pharmaceutical and biomedical analysis. 2021 May; 199(?):114065. doi: 10.1016/j.jpba.2021.114065. [PMID: 33848914]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Trishul Siddharthan, Suzanne L Pollard, Peter Jackson, Nicole M Robertson, Adaeze C Wosu, Nihaal Rahman, Roma Padalkar, Isaac Sekitoleko, Esther Namazzi, Patricia Alupo, John R Hurst, Robert Kalyesubula, David Dowdy, Robert Wise, Peter J Barnes, William Checkley, Bruce Kirenga. Effectiveness of low-dose theophylline for the management of biomass-associated COPD (LODOT-BCOPD): study protocol for a randomized controlled trial. Trials. 2021 Mar; 22(1):213. doi: 10.1186/s13063-021-05163-2. [PMID: 33726828]
  • Deepa Thomas, Neethu Mathew, Megha S Nath. Starch modified alginate nanoparticles for drug delivery application. International journal of biological macromolecules. 2021 Mar; 173(?):277-284. doi: 10.1016/j.ijbiomac.2020.12.227. [PMID: 33453259]
  • Sharmin Siddiqui, Faisal Ameen, Tasneem Kausar, Shahid M Nayeem, Sayeed Ur Rehman, Mohammad Tabish. Biophysical insight into the binding mechanism of doxofylline to bovine serum albumin: An in vitro and in silico approach. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Mar; 249(?):119296. doi: 10.1016/j.saa.2020.119296. [PMID: 33338935]
  • Zhipeng Zhang, Jie Guo, Maojun Cheng, Weixin Zhou, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Jing Liu, Sai-Sai Xie. Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2021 Mar; 213(?):113154. doi: 10.1016/j.ejmech.2021.113154. [PMID: 33476932]
  • Mengsuo Cui, Hao Pan, Dongyang Fang, Haowei Sun, Sen Qiao, Weisan Pan. Exploration and evaluation of dynamic dose-control platform for pediatric medicine based on Drop-on-Powder 3D printing technology. International journal of pharmaceutics. 2021 Mar; 596(?):120201. doi: 10.1016/j.ijpharm.2021.120201. [PMID: 33539997]
  • Jessica L Gleason, Fasil Tekola-Ayele, Rajeshwari Sundaram, Stefanie N Hinkle, Yassaman Vafai, Germaine M Buck Louis, Nicole Gerlanc, Melissa Amyx, Alaina M Bever, Melissa M Smarr, Morgan Robinson, Kurunthachalam Kannan, Katherine L Grantz. Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons. JAMA network open. 2021 03; 4(3):e213238. doi: 10.1001/jamanetworkopen.2021.3238. [PMID: 33764424]
  • Valerie Y Chock, Seo-Ho Cho, Adam Frymoyer. Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia. Pediatric research. 2021 03; 89(4):974-980. doi: 10.1038/s41390-020-0999-y. [PMID: 32503030]
  • Daniel Janitschke, Anna A Lauer, Cornel M Bachmann, Heike S Grimm, Tobias Hartmann, Marcus O W Grimm. Methylxanthines and Neurodegenerative Diseases: An Update. Nutrients. 2021 Feb; 13(3):. doi: 10.3390/nu13030803. [PMID: 33671099]
  • Li Qian, Yajuan Fan, Fengjie Gao, Binbin Zhao, Bin Yan, Wei Wang, Jian Yang, Xiancang Ma. Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study. The international journal of neuropsychopharmacology. 2021 01; 24(1):32-39. doi: 10.1093/ijnp/pyaa062. [PMID: 32808022]
  • Tomonori Miura, Shotaro Uehara, Makiko Shimizu, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki. Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice. The Journal of toxicological sciences. 2021; 46(11):525-530. doi: 10.2131/jts.46.525. [PMID: 34719555]
  • Grace F Crotty, Romeo Maciuca, Eric A Macklin, Junhua Wang, Manuel Montalban, Sonnet S Davis, Jamal I Alkabsh, Rachit Bakshi, Xiqun Chen, Alberto Ascherio, Giuseppe Astarita, Sarah Huntwork-Rodriguez, Michael A Schwarzschild. Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers: A metabolomic study. Neurology. 2020 12; 95(24):e3428-e3437. doi: 10.1212/wnl.0000000000010863. [PMID: 32999056]
  • Xiaoyun Jiang, Yongling Lu, Lishuang Lv. Trapping Acrolein by Theophylline/Caffeine and Their Metabolites from Green Tea and Coffee in Mice and Humans. Journal of agricultural and food chemistry. 2020 Dec; 68(49):14471-14479. doi: 10.1021/acs.jafc.0c05483. [PMID: 33253558]
  • Peng Jiao, Weiming Li, Lin Shen, Yan Li, Lili Yu, Zhaohui Liu. The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells. Artificial cells, nanomedicine, and biotechnology. 2020 Dec; 48(1):687-694. doi: 10.1080/21691401.2020.1730391. [PMID: 32098511]
  • Adam Frymoyer, Krisa P Van Meurs, David R Drover, Jelena Klawitter, Uwe Christians, Valerie Y Chock. Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatric research. 2020 12; 88(6):871-877. doi: 10.1038/s41390-020-01140-8. [PMID: 32919393]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Daniel Janitschke, Anna A Lauer, Cornel M Bachmann, Martin Seyfried, Heike S Grimm, Tobias Hartmann, Marcus O W Grimm. Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells. International journal of molecular sciences. 2020 Nov; 21(23):. doi: 10.3390/ijms21239015. [PMID: 33260941]
  • Marta Kuczeriszka, Joanna Dorota Sitek, Agnieszka Walkowska, Janusz Sadowski, Leszek Dobrowolski. Interplay of the adenosine system and NO in control of renal haemodynamics and excretion: Comparison of normoglycaemic and streptozotocin diabetic rats. Nitric oxide : biology and chemistry. 2020 11; 104-105(?):20-28. doi: 10.1016/j.niox.2020.08.003. [PMID: 32828841]
  • V P Chandrasekaran, Anand Parthasarathy, Balaji Muruga, Senthamil, Tharanesh. Theophylline toxicity: Successful management of a patient with distributive shock secondary to drug overdose. The American journal of emergency medicine. 2020 11; 38(11):2491.e1-2491.e2. doi: 10.1016/j.ajem.2020.05.112. [PMID: 32826106]
  • Atsushi Ogawa, Yu Itoh. In Vitro Selection of RNA Aptamers Binding to Nanosized DNA for Constructing Artificial Riboswitches. ACS synthetic biology. 2020 10; 9(10):2648-2655. doi: 10.1021/acssynbio.0c00384. [PMID: 33017145]
  • Yuguang Zhao, Jingshan Ren, James Hillier, Weixian Lu, Edith Yvonne Jones. Caffeine inhibits Notum activity by binding at the catalytic pocket. Communications biology. 2020 10; 3(1):555. doi: 10.1038/s42003-020-01286-5. [PMID: 33033363]
  • Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease. European journal of medicinal chemistry. 2020 Sep; 202(?):112475. doi: 10.1016/j.ejmech.2020.112475. [PMID: 32652406]
  • Shou En Wu, Wei-Liang Chen. Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study. Nutrients. 2020 Sep; 12(9):. doi: 10.3390/nu12092803. [PMID: 32933151]
  • Xiaoyun Jiang, Dingmin Zhang, Yongling Lu, Lishuang Lv. Acrolein-Trapping Mechanism of Theophylline in Green Tea, Coffee, and Cocoa: Speedy and Successful. Journal of agricultural and food chemistry. 2020 Sep; 68(36):9718-9724. doi: 10.1021/acs.jafc.0c03895. [PMID: 32786830]
  • Xiaolin Cui, Menghua Song, Yan Liu, Yifan Yuan, Qiang Huang, Yongbing Cao, Feng Lu. Identifying conformational changes of aptamer binding to theophylline: A combined biolayer interferometry, surface-enhanced Raman spectroscopy, and molecular dynamics study. Talanta. 2020 Sep; 217(?):121073. doi: 10.1016/j.talanta.2020.121073. [PMID: 32498900]
  • Ahmed Salaheldin Sayed Zeid, Safinaz Salaheldin Sayed. A Comparative Study of the Use of Dexamethasone, N-acetyl Cysteine, and Theophylline to Ameliorate Renal Ischemia-Reperfusion Injury in Experimental Rat Models: A Biochemical and Immuno-histochemical Approach. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2020 Sep; 31(5):982-997. doi: 10.4103/1319-2442.301203. [PMID: 33229761]
  • Zara Khizer, Jorabar Singh Nirwan, Barbara R Conway, Muhammad Usman Ghori. Okra (Hibiscus esculentus) gum based hydrophilic matrices for controlled drug delivery applications: Estimation of percolation threshold. International journal of biological macromolecules. 2020 Jul; 155(?):835-845. doi: 10.1016/j.ijbiomac.2020.03.227. [PMID: 32240737]
  • Muhammad Fawad Rasool, Ramsha Khalid, Imran Imran, Abdul Majeed, Hamid Saeed, Fawaz Alasmari, Mohammed Mufadhe Alanazi, Faleh Alqahtani. Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach. Drug metabolism and disposition: the biological fate of chemicals. 2020 07; 48(7):570-579. doi: 10.1124/dmd.120.090969. [PMID: 32393652]
  • Haozhen Han, Chunpu Li, Man Li, Lisheng Yang, Sen Zhao, Zhifei Wang, Hong Liu, Dongxiang Liu. Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5. Molecules (Basel, Switzerland). 2020 Jun; 25(12):. doi: 10.3390/molecules25122755. [PMID: 32549218]
  • Xiaohua Zhao, Hong Ma, Qiusha Pan, Haiyi Wang, Xingkai Qian, Peifang Song, Liwei Zou, Mingqing Mao, Shuyue Xia, Guangbo Ge, Ling Yang. Theophylline Acetaldehyde as the Initial Product in Doxophylline Metabolism in Human Liver. Drug metabolism and disposition: the biological fate of chemicals. 2020 05; 48(5):345-352. doi: 10.1124/dmd.119.089565. [PMID: 32086296]
  • Mario Cazzola, Maria Gabriella Matera. The effect of doxofylline in asthma and COPD. Respiratory medicine. 2020 04; 164(?):105904. doi: 10.1016/j.rmed.2020.105904. [PMID: 32094104]
  • Binxing Zhou, Cunqiang Ma, Tao Xia, Xiaohong Li, Chengqin Zheng, Tingting Wu, Xiaohui Liu. Isolation, characterization and application of theophylline-degrading Aspergillus fungi. Microbial cell factories. 2020 Mar; 19(1):72. doi: 10.1186/s12934-020-01333-0. [PMID: 32192512]
  • Ana Clara da Costa Pinaffi, Geni Rodrigues Sampaio, Maiara Jurema Soares, Fereidoon Shahidi, Adriano Costa de Camargo, Elizabeth A F S Torres. Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile. Molecules (Basel, Switzerland). 2020 Feb; 25(3):. doi: 10.3390/molecules25030679. [PMID: 32033416]
  • Paul Billoir, Thomas Clavier, Arnaud Guilbert, Virginie Barbay, Marie Hélène Chrétien, Marielle Fresel, Caroline Abriou, Christophe Girault, Véronique Le Cam Duchez. [Theophylline adenosine dipyridamole (CTAD) and citrate evaluation to survey unfractionated heparin treatment: a delayed centrifugation validation for anti-Xa measurement?]. Annales de biologie clinique. 2020 02; 78(1):27-34. doi: 10.1684/abc.2020.1525. [PMID: 32108577]
  • H D Ponce-Rodríguez, A A García-Robles, P Sáenz-González, J Verdú-Andrés, P Campíns-Falcó. On-line in-tube solid phase microextraction coupled to capillary liquid chromatography-diode array detection for the analysis of caffeine and its metabolites in small amounts of biological samples. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 178(?):112914. doi: 10.1016/j.jpba.2019.112914. [PMID: 31610396]
  • Aliaa Abdelrahman, Swapnil G Yerande, Vigneshwaran Namasivayam, Tim A Klapschinski, Mohamad Wessam Alnouri, Ali El-Tayeb, Christa E Müller. Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists. European journal of medicinal chemistry. 2020 Jan; 186(?):111879. doi: 10.1016/j.ejmech.2019.111879. [PMID: 31780082]
  • Laura Breidenbach, Katja Hempel, Scott W Mittelstadt, James J Lynch. Refinement of the rodent pentylenetetrazole proconvulsion assay, which is a good predictor of convulsions in repeat-dose toxicology studies. Journal of pharmacological and toxicological methods. 2020 Jan; 101(?):106653. doi: 10.1016/j.vascn.2019.106653. [PMID: 31730935]
  • Nana Shanidze, Felina Lenkeit, Jörg S Hartig, Dietmar Funck. A Theophylline-Responsive Riboswitch Regulates Expression of Nuclear-Encoded Genes. Plant physiology. 2020 01; 182(1):123-135. doi: 10.1104/pp.19.00625. [PMID: 31704721]
  • Başak Gökçe, Nurhan Sarıoğlu, Nahit Gençer, Oktay Arslan. Association of human serum paraoxonase-1 with some respiratory drugs. Journal of biochemical and molecular toxicology. 2019 Dec; 33(12):e22407. doi: 10.1002/jbt.22407. [PMID: 31581362]
  • Jing Li, Ming-Rui Li, Bao Sun, Cheng-Ming Liu, Jing Ren, Wen-Qian Zhi, Pei-Yu Zhang, Hai-Ling Qiao, Na Gao. Inhibition of Rat CYP1A2 and CYP2C11 by Honokiol, a Component of Traditional Chinese Medicine. European journal of drug metabolism and pharmacokinetics. 2019 Dec; 44(6):787-796. doi: 10.1007/s13318-019-00565-9. [PMID: 31175627]
  • Priyanka Lohar, Manish Kumar Sharma, Amit Kumar Sahu, Rajeswari Rathod, Pinaki Sengupta. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomedical chromatography : BMC. 2019 Dec; 33(12):e4672. doi: 10.1002/bmc.4672. [PMID: 31386207]
  • Baofang Zhang, Zilin Chen. Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor. Journal of pharmaceutical and biomedical analysis. 2019 Nov; 176(?):112811. doi: 10.1016/j.jpba.2019.112811. [PMID: 31437748]
  • Binxing Zhou, Cunqiang Ma, Xiaoying Ren, Tao Xia, Xiaohong Li, Yang Wu. Production of theophylline via aerobic fermentation of pu-erh tea using tea-derived fungi. BMC microbiology. 2019 11; 19(1):261. doi: 10.1186/s12866-019-1640-2. [PMID: 31771506]
  • Joseph A Rothwell, Pekka Keski-Rahkonen, Nivonirina Robinot, Nada Assi, Corinne Casagrande, Mazda Jenab, Pietro Ferrari, Marie-Christine Boutron-Ruault, Yahya Mahamat-Saleh, Francesca Romana Mancini, Heiner Boeing, Verena Katzke, Tilman Kühn, Katerina Niforou, Antonia Trichopoulou, Elisavet Valanou, Vittorio Krogh, Amalia Mattiello, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, Augustin Scalbert. A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries. Molecular nutrition & food research. 2019 11; 63(22):e1900659. doi: 10.1002/mnfr.201900659. [PMID: 31483556]
  • Carrie L Cavett, Zhong Li, Brendan C McKiernan, Jennifer M Reinhart. Pharmacokinetics of a modified, compounded theophylline product in dogs. Journal of veterinary pharmacology and therapeutics. 2019 Nov; 42(6):593-601. doi: 10.1111/jvp.12813. [PMID: 31529628]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Radhakrishnam Raju Ruddarraju, Gangarapu Kiran, Adharvana Chari Murugulla, Ravichandar Maroju, Devarakonda Krishna Prasad, Boyina Hemanth Kumar, Vasudha Bakshi, Nukala Shravya Reddy. Design, synthesis and biological evaluation of theophylline containing variant acetylene derivatives as α-amylase inhibitors. Bioorganic chemistry. 2019 11; 92(?):103120. doi: 10.1016/j.bioorg.2019.103120. [PMID: 31525527]
  • Nan Zhao, Hao-Ran Tan, Qi-Li Chen, Qi Sun, Lin Wang, Yang Song, Kamara Mohamed Olounfeh, Fan-Hao Meng. Development and Validation of a Sensitive UHPLC-MS/MS Method for the Measurement of Gardneramine in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Study. Molecules (Basel, Switzerland). 2019 Oct; 24(21):. doi: 10.3390/molecules24213953. [PMID: 31683708]
  • Hsien-Tsung Yao, Jia-Hsuan Lin, Yun-Ta Liu, Mei-Ling Li, Wenchang Chiang. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients. 2019 Oct; 11(10):. doi: 10.3390/nu11102473. [PMID: 31618937]
  • Zhipei Sang, Keren Wang, Pengfei Zhang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2019 Oct; 180(?):238-252. doi: 10.1016/j.ejmech.2019.07.021. [PMID: 31310916]
  • Monika Kopečná, Miloslav Macháček, Anna Nováčková, Georgios Paraskevopoulos, Jaroslav Roh, Kateřina Vávrová. Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers. Scientific reports. 2019 10; 9(1):14617. doi: 10.1038/s41598-019-51226-5. [PMID: 31601936]
  • Zhipei Sang, Keren Wang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2019 Sep; 178(?):726-739. doi: 10.1016/j.ejmech.2019.06.026. [PMID: 31229875]
  • Li-Na Fang, Ming-Qing Mao, Xiao-Hua Zhao, Ling Yang, Hui Jia, Shu-Yue Xia. Development and validation of a UPLC-MS/MS method for quantification of doxofylline and its metabolites in human plasma. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):220-225. doi: 10.1016/j.jpba.2019.05.039. [PMID: 31181483]
  • Marluci P Silva, Marcelo Thomazini, Augusto T Holkem, Lorena S Pinho, Maria I Genovese, Carmen S Fávaro-Trindade. Production and characterization of solid lipid microparticles loaded with guaraná (Paullinia cupana) seed extract. Food research international (Ottawa, Ont.). 2019 09; 123(?):144-152. doi: 10.1016/j.foodres.2019.04.055. [PMID: 31284962]
  • So Young Jeung, Sang June Sohn, Ju Hyun An, Hyung Kyu Chae, Qiang Li, Mincheol Choi, Junghee Yoon, Woo Jin Song, Hwa Young Youn. A retrospective study of theophylline-based therapy with tracheal collapse in small-breed dogs: 47 cases (2013-2017). Journal of veterinary science. 2019 Sep; 20(5):e57. doi: 10.4142/jvs.2019.20.e57. [PMID: 31565900]
  • Bhuvanenthiran Mutharani, Palraj Ranganathan, Shen-Ming Chen, Chelladurai Karuppiah. Simultaneous voltammetric determination of acetaminophen, naproxen, and theophylline using an in-situ polymerized poly(acrylic acid) nanogel covalently grafted onto a carbon black/La2O3 composite. Mikrochimica acta. 2019 08; 186(9):651. doi: 10.1007/s00604-019-3752-7. [PMID: 31463587]
  • Michele Brignole, Matteo Iori, Diana Solari, Nicola Bottoni, Giulia Rivasi, Andrea Ungar, Jean Claude Deharo, Regis Guieu. Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG. International journal of cardiology. 2019 08; 289(?):70-73. doi: 10.1016/j.ijcard.2019.03.043. [PMID: 30928258]
  • Vera M Mendes, Margarida Coelho, Angelo R Tomé, Rodrigo A Cunha, Bruno Manadas. Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve. Molecules (Basel, Switzerland). 2019 Aug; 24(16):. doi: 10.3390/molecules24162863. [PMID: 31394755]
  • Paul Billoir, Thomas Clavier, Arnaud Guilbert, Virginie Barbay, Marie Hélène Chrétien, Marielle Fresel, Caroline Abriou, Christophe Girault, Véronique Le Cam Duchez. Is citrate theophylline adenosine dipyridamole (CTAD) better than citrate to survey unfractionated heparin treatment? Has delayed centrifugation a real impact on this survey?. Journal of thrombosis and thrombolysis. 2019 Aug; 48(2):277-283. doi: 10.1007/s11239-019-01882-1. [PMID: 31098816]
  • Ziru Dai, Guibo Sun, Jiada Yang, Jie Hou, Ping Zhou, Weijie Xie, Guangbo Ge, Xiaobo Sun, Ling Yang. Interspecies Variation in NCMN-O-Demethylation in Liver Microsomes from Various Species. Molecules (Basel, Switzerland). 2019 Jul; 24(15):. doi: 10.3390/molecules24152765. [PMID: 31366067]
  • Graham Devereux, Seonaidh Cotton, Shona Fielding, Nicola McMeekin, Peter J Barnes, Andy Briggs, Graham Burns, Rekha Chaudhuri, Henry Chrystyn, Lisa Davies, Anthony De Soyza, Simon Gompertz, John Haughney, Karen Innes, Joanna Kaniewska, Amanda Lee, Alyn Morice, John Norrie, Anita Sullivan, Andrew Wilson, David Price. Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT. Health technology assessment (Winchester, England). 2019 07; 23(37):1-146. doi: 10.3310/hta23370. [PMID: 31343402]