Monoethylhexyl phthalic acid (BioDeep_00000002294)

 

Secondary id: BioDeep_00001868295

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


1,2-Benzenedicarboxylic acid, mono(2-ethylhexyl) ester

化学式: C16H22O4 (278.1518012)
中文名称: 邻苯二甲酸单(2-乙基己基)酯
谱图信息: 最多检出来源 Homo sapiens(blood) 0.44%

分子结构信息

SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O
InChI: InChI=1S/C16H22O4/c1-3-5-8-12(4-2)11-20-16(19)14-10-7-6-9-13(14)15(17)18/h6-7,9-10,12H,3-5,8,11H2,1-2H3,(H,17,18)

描述信息

Monoethylhexyl phthalic acid (MEHP) is an active metabolite of Bis(2-ethylhexyl)phthalate (DEHP). DEHP measured from the blood of pregnant women have been significantly associated with the decreased penis width, shorter anogenital distance, and the incomplete descent of testes of their newborn sons, replicating effects identified in animals(Wikipedia). DEHP hydrolyzes to MEHP via the enzyme Bis(2-ethylhexyl)phthalate acylhydrolase(3.1.1.60)and subsequently to phthalate salts. The released alcohol is susceptible to oxidation to the aldehyde and carboxylic acid.
Monoethylhexyl phthalic acid (MEHP) is an active metabolite of Bis(2-ethylhexyl)phthalate (DEHP). DEHP measured from the blood of pregnant women have been significantly associated with the decreased penis width, shorter anogenital distance, and the incomplete descent of testes of their newborn sons, replicating effects identified in animals. DEHP hydrolyzes to MEHP via the enzyme Bis(2-ethylhexyl)phthalate acylhydrolase(3.1.1.60)and subsequently to phthalate salts. The released alcohol is susceptible to oxidation to the aldehyde and carboxylic acid. [HMDB]
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10026; ORIGINAL_PRECURSOR_SCAN_NO 10023
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4968; ORIGINAL_PRECURSOR_SCAN_NO 4967
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4980; ORIGINAL_PRECURSOR_SCAN_NO 4979
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4973; ORIGINAL_PRECURSOR_SCAN_NO 4971
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9948; ORIGINAL_PRECURSOR_SCAN_NO 9944
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9960; ORIGINAL_PRECURSOR_SCAN_NO 9957
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9947; ORIGINAL_PRECURSOR_SCAN_NO 9946
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9930; ORIGINAL_PRECURSOR_SCAN_NO 9925
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4975; ORIGINAL_PRECURSOR_SCAN_NO 4972
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4995; ORIGINAL_PRECURSOR_SCAN_NO 4994
CONFIDENCE standard compound; INTERNAL_ID 1238; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4973; ORIGINAL_PRECURSOR_SCAN_NO 4969
Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1].
Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1].

同义名列表

43 个代谢物同义名

1,2-Benzenedicarboxylic acid, mono(2-ethylhexyl) ester; 1,2-Benzenedicarboxylicacid,mono(2-ethylhexyl)ester; 1,2-Benzenedicarboxylate, mono(2-ethylhexyl) ester; Phthalic acid 1-hydrogen 2-(2-ethylhexyl) ester; Phthalic acid hydrogen 1-(2-ethylhexyl) ester; 2-([(2-Ethylhexyl)oxy]carbonyl)benzoic acid; 2-{[(2-ethylhexyl)oxy]carbonyl}benzoic acid; 2-(((2-Ethylhexyl)oxy)carbonyl)benzoic acid; mono-(2-Ethylhexyl)phthalate, sodium salt; 2-([(2-Ethylhexyl)oxy]carbonyl)benzoate; (2-Ethylhexyl) hydrogen phthalic acid; PHTHALIC ACID mono-2-ethylhexyl ester; 2-Ethylhexyl hydrogen phthalic acid; (2-Ethylhexyl) hydrogen phthalate; Phthalic acid, 2-ethylhexyl ester; phthalicacidmono-2-ETHYLEXYLESTER; mono-(2-Ethylhexyl)phthalic acid; mono(2-Ethylhexyl) phthalic acid; mono-2-Ethylhexyl phthalic acid; Phthalicacidmonoethylhexylester; Monoethylhexyl phthalate (mehp); 2-Ethylhexyl hydrogen phthalate; mono(2-Ethylhexyl)phthalic acid; Phthalicacid,2-ethylhexylester; PHTHALIC ACID monooctyl ester; Phthalate, 2-ethylhexyl ester; Monoethylhexyl phthalic acid; mono-(2-Ethylhexyl)phthalate; mono(2-Ethylhexyl)phthalate; mono-2-Ethylhexyl phthalate; 2-Ethylhexyl phthalic acid; mono(Ethylhexyl) phthalate; PHTHALICACIDMONOETHYLHEXYL; mono-Ethylhexylphthalate; Monoethylhexyl phthalate; Monoethylhexylphthalate; 2-Ethylhexyl phthalate; Monooctyl phthalate; mono-Ethylhexyl; UNII:FU2EWB60RT; MEHP CPD; bar 1; MEHP



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu Hao, Xuan'en Tian, Fengmei Yan, Xiuqin Wang, Jing Huang, Ling Li. Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells. Ecotoxicology and environmental safety. 2024 Jun; 277(?):116394. doi: 10.1016/j.ecoenv.2024.116394. [PMID: 38663197]
  • Xia Wang, Dinggang Li, Xiangqin Zheng, Yifan Hong, Jie Zhao, Wei Deng, Mingxin Wang, Lianju Shen, Chunlan Long, Guanghui Wei, Shengde Wu. Di-(2-ethylhexyl) phthalate induces ferroptosis in prepubertal mouse testes via the lipid metabolism pathway. Environmental toxicology. 2024 Mar; 39(3):1747-1758. doi: 10.1002/tox.24065. [PMID: 38050670]
  • Yiyun Liu, Naima Hamid, Rakia Manzoor, Bao-Fu Zhang, Yan-Ling Liao, Jin-Xia Wang, De-Sheng Pei. PPARβ/δ-ANGPTL4 axis mediates the promotion of mono-2-ethylhexyl phthalic acid on MYCN-amplified neuroblastoma development. The Science of the total environment. 2024 Feb; 912(?):168949. doi: 10.1016/j.scitotenv.2023.168949. [PMID: 38042186]
  • Fulya Dal Yöntem, Sinem Ayaz, Şeyma Bulut, Ebru Hacıosmanoğlu Aldoğan, Müfide Aydoğan Ahbab. Endoplasmic reticulum stress and pro-inflammatory responses induced by phthalate metabolites monoethylhexyl phthalate and monobutyl phthalate in 1.1B4 pancreatic beta cells. Toxicology. 2024 Jan; 501(?):153695. doi: 10.1016/j.tox.2023.153695. [PMID: 38048874]
  • Sean M Harris, Anthony L Su, John F Dou, Rita Loch-Caruso, Elana R Elkin, Sammy Jaber, Kelly M Bakulski. Placental cell conditioned media modifies hematopoietic stem cell transcriptome invitro. Placenta. 2024 Jan; 145(?):117-125. doi: 10.1016/j.placenta.2023.12.016. [PMID: 38128222]
  • Minling Gao, Linsen Bai, Ling Xiao, Hongchang Peng, Qiaoting Chen, Weiwen Qiu, Zhengguo Song. Micro (nano)plastics and phthalate esters drive endophytic bacteria alteration and inhibit wheat root growth. The Science of the total environment. 2023 Oct; ?(?):167734. doi: 10.1016/j.scitotenv.2023.167734. [PMID: 37827310]
  • Qi Xu, Shuang Ding, Wen Qi, Xueting Zhang, Meng Zhang, Jiqiang Xing, Aipeng Ju, Liting Zhou, Lin Ye. JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students. Chemical research in toxicology. 2023 Apr; ?(?):. doi: 10.1021/acs.chemrestox.2c00365. [PMID: 37093692]
  • Yuezhu Zhang, Honghao Qian, Jia Wang, Ying Zhu, Xiaohan Miao, Xu Li, Jianli Yin, Ruxuan Zhang, Jiaming Ye, Chuanyi Huo, Weisen Zhao, Lin Ye. Di-(2-ethylhexyl) phthalate (DEHP) promoted hepatic lipid accumulation by activating Notch signaling pathway. Environmental toxicology. 2023 Mar; ?(?):. doi: 10.1002/tox.23792. [PMID: 36988346]
  • Samuel Thomas, William A Ricke, Lingjun Li. Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases. Chemical research in toxicology. 2023 Feb; 36(2):251-259. doi: 10.1021/acs.chemrestox.2c00328. [PMID: 36749316]
  • Huihua Yang, Yuming Zheng, Xuefeng Lai, Lei Zhao, Linlin Liu, Miao Liu, Wenting Guo, Liangle Yang, Qin Fang, Kejing Zhu, Wencan Dai, Wenhua Mei, Rui Zhu, Xiaomin Zhang. Associations of Urinary Phthalate Metabolites with Thyroid Function and the Mediated Role of Cytokines: A Panel Study of Healthy Children. Environmental science & technology. 2023 Feb; ?(?):. doi: 10.1021/acs.est.2c07656. [PMID: 36760168]
  • Yi Zhao, Hao Zhang, Jia-Gen Cui, Jia-Xin Wang, Ming-Shan Chen, Hao-Ran Wang, Xue-Nan Li, Jin-Long Li. Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor. Redox biology. 2023 02; 59(?):102584. doi: 10.1016/j.redox.2022.102584. [PMID: 36580806]
  • Hyunki Cho, Yohan Seol, Seungyun Baik, Baeckkyoung Sung, Chang Seon Ryu, Young Jun Kim. Mono(2-ethylhexyl) phthalate modulates lipid accumulation and reproductive signaling in Daphnia magna. Environmental science and pollution research international. 2022 Aug; 29(37):55639-55650. doi: 10.1007/s11356-022-19701-1. [PMID: 35320476]
  • Chien-Yu Lin, Ching-Way Chen, Hui-Ling Lee, Charlene Wu, Chikang Wang, Fung-Chang Sung, Ta-Chen Su. Global DNA methylation mediates the association between urine mono-2-ethylhexyl phthalate and serum apoptotic microparticles in a young Taiwanese population. The Science of the total environment. 2022 Feb; 808(?):152054. doi: 10.1016/j.scitotenv.2021.152054. [PMID: 34863772]
  • Miao Xu, Yongning Li, Xiaohong Wang, Qiannan Zhang, Lei Wang, Xin Zhang, Wenming Cui, Xiaomin Han, Ning Ma, Haishan Li, Hongyun Fang, Song Tang, Jingguang Li, Zhaoping Liu, Hui Yang, Xudong Jia. Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice. Environmental health perspectives. 2022 01; 130(1):17005. doi: 10.1289/ehp9373. [PMID: 35019730]
  • Yi-Zhen Yuan, Chong Ye, Jia-Hui Sun, Meng-Yuan Hu, Shao-Jie Huo, Yu-Ting Zhu, Su-Yun Xiang, Shu-Qin Yu. Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique. Toxicology and applied pharmacology. 2022 01; 434(?):115814. doi: 10.1016/j.taap.2021.115814. [PMID: 34843800]
  • Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Frontiers in cell and developmental biology. 2022; 10(?):1014243. doi: 10.3389/fcell.2022.1014243. [PMID: 36438553]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Karilyn E Sant, Hadley M Moreau, Larissa M Williams, Haydee M Jacobs, Anna M Bowsher, Jason D Boisvert, Roxanna M Smolowitz, Jacob Pantazis, Kate Annunziato, Malina Nguyen, Alicia Timme-Laragy. Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of developmental origins of health and disease. 2021 02; 12(1):132-140. doi: 10.1017/s2040174420000057. [PMID: 32063256]
  • Wen Qi, Qi Xu, Yixuan Xu, Zheng Wang, Liwei Yang, Shuangyu Guo, Yanbin Shi, Tianyang Zhao, Liting Zhou, Lin Ye. Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells. Ecotoxicology and environmental safety. 2021 Jan; 208(?):111472. doi: 10.1016/j.ecoenv.2020.111472. [PMID: 33091777]
  • Chun-Yu Lin, Chung-Hao Huang, Wen-Hung Wang, Jyrki Tenhunen, Ling-Chien Hung, Chi-Chou Lin, Yu-Cheng Chen, Yen-Hsu Chen, Wei-Ting Liao. Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses. Frontiers in immunology. 2021; 12(?):599345. doi: 10.3389/fimmu.2021.599345. [PMID: 33659001]
  • Luchen Yang, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong. Exposure to Di-2-ethylhexyl Phthalate and Benign Prostatic Hyperplasia, NHANES 2001-2008. Frontiers in endocrinology. 2021; 12(?):804457. doi: 10.3389/fendo.2021.804457. [PMID: 35095770]
  • Leyla Akın, Mustafa Kendirci, Figen Narin, Selim Kurtoğlu, Nihal Hatipoğlu, Ferhan Elmalı. Endocrine Disruptors and Polycystic Ovary Syndrome: Phthalates. Journal of clinical research in pediatric endocrinology. 2020 11; 12(4):393-400. doi: 10.4274/jcrpe.galenos.2020.2020.0037. [PMID: 32431137]
  • Jhih-Wei Hsu, Chung-Yi Nien, Szu-Ching Yeh, Feng-Yuan Tsai, Hsin-Wei Chen, Tzong-Shyuan Lee, Shen-Liang Chen, Yung-Hsi Kao, Tsui-Chun Tsou. Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Aug; 142(?):111487. doi: 10.1016/j.fct.2020.111487. [PMID: 32522588]
  • Sorour Ashari, Mohammad Karami, Mohammad Shokrzadeh, Morteza Ghandadi, Nasrin Ghassemi-Barghi, Ayat Dashti, Mohammad Ranaee, Hamidreza Mohammadi. The implication of mitochondrial dysfunction and mitochondrial oxidative damage in di (2-ethylhexyl) phthalate induced nephrotoxicity in both in vivo and in vitro models. Toxicology mechanisms and methods. 2020 Jul; 30(6):427-437. doi: 10.1080/15376516.2020.1758980. [PMID: 32312132]
  • Christina M Bailey-Hytholt, Tanaya Puranik, Anubhav Tripathi, Anita Shukla. Investigating interactions of phthalate environmental toxicants with lipid structures. Colloids and surfaces. B, Biointerfaces. 2020 Jun; 190(?):110923. doi: 10.1016/j.colsurfb.2020.110923. [PMID: 32199260]
  • Chang Gyun Park, Baeckkyoung Sung, Chang Seon Ryu, Young Jun Kim. Mono-(2-ethylhexyl) phthalate induces oxidative stress and lipid accumulation in zebrafish liver cells. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2020 Apr; 230(?):108704. doi: 10.1016/j.cbpc.2020.108704. [PMID: 31927120]
  • Qingqing Zhu, Jian Hou, Wenjun Yin, Fang Ye, Tian Xu, Juan Cheng, Zhiqiang Yu, Lin Wang, Jing Yuan. Associations of a mixture of urinary phthalate metabolites with blood lipid traits: A repeated-measures pilot study. Environmental pollution (Barking, Essex : 1987). 2020 Feb; 257(?):113509. doi: 10.1016/j.envpol.2019.113509. [PMID: 31767236]
  • Anna Mentor, Björn Brunström, Anna Mattsson, Maria Jönsson. Developmental exposure to a human relevant mixture of endocrine disruptors alters metabolism and adipogenesis in zebrafish (Danio rerio). Chemosphere. 2020 Jan; 238(?):124584. doi: 10.1016/j.chemosphere.2019.124584. [PMID: 31470313]
  • Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B Alarcon. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reproductive toxicology (Elmsford, N.Y.). 2020 01; 91(?):74-91. doi: 10.1016/j.reprotox.2019.10.004. [PMID: 31711903]
  • Sinem Akgül, Ünzile Sur, Yasemin Düzçeker, Aylin Balcı, Melis Pehlivantürk Kızılkan, Nuray Kanbur, Gürkan Bozdağ, Pınar Erkekoğlu, Ersin Gümüş, Belma Kocer-Gumusel, Orhan Derman. Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2019 Dec; 35(12):1084-1087. doi: 10.1080/09513590.2019.1630608. [PMID: 31219355]
  • Yuezhu Zhang, Shuyue Wang, Tianyang Zhao, Liwei Yang, Shuangyu Guo, Yanbin Shi, Xueting Zhang, Liting Zhou, Lin Ye. Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicology and environmental safety. 2019 Nov; 184(?):109611. doi: 10.1016/j.ecoenv.2019.109611. [PMID: 31491605]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Vladimíra Puklová, Tomáš Janoš, Lenka Sochorová, Adam Vavrouš, Karel Vrbík, Alena Fialová, Lenka Hanzlíková, Milena Černá. Exposure to Mixed Phthalates in Czech Preschool and School Children. Archives of environmental contamination and toxicology. 2019 Nov; 77(4):471-479. doi: 10.1007/s00244-019-00645-6. [PMID: 31214748]
  • Jhih-Wei Hsu, Szu-Ching Yeh, Feng-Yuan Tsai, Hsin-Wei Chen, Tsui-Chun Tsou. Fibroblast growth factor 21 secretion enhances glucose uptake in mono(2-ethylhexyl)phthalate-treated adipocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2019 Sep; 59(?):246-254. doi: 10.1016/j.tiv.2019.04.021. [PMID: 31009676]
  • Fei Wang, Chong Chang, Ruobi Li, Zhen Zhang, Hongmei Jiang, Ni Zeng, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Qing Wang. Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Toxicology. 2019 08; 424(?):152236. doi: 10.1016/j.tox.2019.06.007. [PMID: 31228551]
  • Jianying Bai, Zhen He, Yaofu Li, Xuexia Jiang, Hongmei Yu, Qing Tan. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environmental toxicology and pharmacology. 2019 Jul; 69(?):104-111. doi: 10.1016/j.etap.2019.04.004. [PMID: 31004931]
  • Isabel Kratochvil, Tommy Hofmann, Sandra Rother, Rita Schlichting, Rocco Moretti, Dieter Scharnweber, Vera Hintze, Beate I Escher, Jens Meiler, Stefan Kalkhof, Martin von Bergen. Mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) but not di(2-ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator-activated receptor γ. Rapid communications in mass spectrometry : RCM. 2019 May; 33 Suppl 1(?):75-85. doi: 10.1002/rcm.8258. [PMID: 30085373]
  • Li Zhu, Peng Duan, Xiuxue Hu, Yu Wang, Chunling Chen, Jiang Wan, Mengyi Dai, Xiaoling Liang, Junyi Li, Yan Tan. Exposure to cadmium and mono-(2-ethylhexyl) phthalate induce biochemical changes in rat liver, spleen, lung and kidney as determined by attenuated total reflection-Fourier transform infrared spectroscopy. Journal of applied toxicology : JAT. 2019 05; 39(5):783-797. doi: 10.1002/jat.3767. [PMID: 30680743]
  • Anastasia Repouskou, Emily Panagiotidou, Lydia Panagopoulou, Pernilla Larsdotter Bisting, Astrud R Tuck, Marcus O D Sjödin, Johan Lindberg, Evangelos Bozas, Joëlle Rüegg, Chris Gennings, Carl-Gustaf Bornehag, Pauliina Damdimopoulou, Antonios Stamatakis, Efthymia Kitraki. Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes. Scientific reports. 2019 04; 9(1):6424. doi: 10.1038/s41598-019-42377-6. [PMID: 31015488]
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