1-Methyladenosine (BioDeep_00000002265)

 

Secondary id: BioDeep_00000229646, BioDeep_00000399907

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-6,9-dihydro-1H-purin-9-yl)oxolane-3,4-diol

化学式: C11H15N5O4 (281.1124)
中文名称: 1-甲基-腺苷, 1-甲基腺苷, 1-甲基腺苷酸
谱图信息: 最多检出来源 Homo sapiens(feces) 23.86%

Reviewed

Last reviewed on 2024-07-16.

Cite this Page

1-Methyladenosine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/1-methyladenosine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002265). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1C=NC2=C(C1=N)N=CN2C3C(C(C(O3)CO)O)O
InChI: InChI=1S/C11H15N5O4/c1-15-3-14-10-6(9(15)12)13-4-16(10)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11-12,17-19H,2H2,1H3

描述信息

1-Methyladenosine, also known as M1A, belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. Precise m6A mapping by m6A-CLIP/IP (briefly m6A-CLIP) revealed that a majority of m6A locates in the last exon of mRNAs in multiple tissues/cultured cells of mouse and human, and the m6A enrichment around stop codons is a coincidence that many stop codons locate round the start of last exons where m6A is truly enriched. The methylation of adenosine is directed by a large m6A methyltransferase complex containing METTL3 as the SAM-binding sub-unit. Insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1-3) are reported as a novel class of m6A readers.
1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.
1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.

同义名列表

7 个代谢物同义名

(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-6,9-dihydro-1H-purin-9-yl)oxolane-3,4-diol; N(1)-Methyladenosine; N1-Methyladenosine; 1-Methyladenosine; M1A; 1-Methyladenosine; 1-Methyladenosine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ADA, ALKBH1, ALKBH3, FTO, MTOR, PIK3CA, PNP, YTHDC2, YTHDF1, YTHDF2, YTHDF3
Peripheral membrane protein 2 ADA, MTOR
Endoplasmic reticulum membrane 1 MTOR
Nucleus 11 ALKBH1, ALKBH3, ALKBH5, CD274, FTO, MTOR, TRMT10C, TRMT6, TRMT61A, YTHDC1, YTHDF2
cytosol 10 ADA, ALKBH3, ALKBH5, FTO, MTOR, PIK3CA, PNP, RRP8, YTHDF2, YTHDF3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 11 ALKBH1, ALKBH3, ALKBH5, CD274, FTO, MTOR, RRP8, TRMT10C, TRMT6, TRMT61A, YTHDC1
Cell membrane 3 ADA, CD27, CD274
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Early endosome membrane 1 CD274
Golgi apparatus membrane 1 MTOR
cell junction 1 ADA
cell surface 1 ADA
Golgi apparatus 1 ALKBH5
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
Cytoplasm, cytosol 2 YTHDF2, YTHDF3
Lysosome 2 ADA, MTOR
plasma membrane 7 ADA, CD27, CD274, FTO, PIK3CA, RRP8, YTHDC1
Membrane 2 ADA, MTOR
extracellular exosome 2 CD274, PNP
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALKBH1, YTHDC2
extracellular space 1 PNP
perinuclear region of cytoplasm 2 PIK3CA, YTHDC2
intercalated disc 1 PIK3CA
mitochondrion 4 ALKBH1, ALKBH3, TRMT10C, TRMT61B
intracellular membrane-bounded organelle 1 FTO
Microsome membrane 1 MTOR
chromatin silencing complex 1 RRP8
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CD27, CD274
Secreted 1 PNP
extracellular region 2 CD27, PNP
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Mitochondrion matrix 1 TRMT61B
mitochondrial matrix 2 TRMT10C, TRMT61B
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
centriolar satellite 1 YTHDF2
external side of plasma membrane 3 ADA, CD27, CD274
actin cytoskeleton 1 CD274
nucleolus 1 RRP8
Cytoplasm, P-body 3 YTHDF1, YTHDF2, YTHDF3
P-body 3 YTHDF1, YTHDF2, YTHDF3
Cytoplasm, perinuclear region 1 YTHDC2
mitochondrial nucleoid 1 TRMT10C
Nucleus, PML body 1 MTOR
PML body 1 MTOR
nuclear speck 3 ALKBH5, FTO, YTHDC1
cytoplasmic ribonucleoprotein granule 1 YTHDF2
Nucleus, nucleolus 1 RRP8
nuclear envelope 1 MTOR
Recycling endosome membrane 1 CD274
Endomembrane system 1 MTOR
Cytoplasm, Stress granule 3 YTHDF1, YTHDF2, YTHDF3
cytoplasmic stress granule 3 YTHDF1, YTHDF2, YTHDF3
Nucleus speckle 3 ALKBH5, FTO, YTHDC1
euchromatin 1 ALKBH1
ficolin-1-rich granule lumen 1 PNP
secretory granule lumen 1 PNP
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
mitochondrial ribonuclease P complex 1 TRMT10C
[Isoform 1]: Cell membrane 1 CD274
eNoSc complex 1 RRP8
rDNA heterochromatin 1 RRP8
[Isoform 4]: Secreted 1 CD274
paraspeckles 1 ALKBH5
Cytoplasmic vesicle, phagosome 1 MTOR
ribonucleoprotein granule 1 YTHDC2
Mitochondrion matrix, mitochondrion nucleoid 1 TRMT10C
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
tRNA methyltransferase complex 1 TRMT10C
tRNA (m1A) methyltransferase complex 3 TRMT6, TRMT61A, TRMT61B
[Isoform 2]: Endomembrane system 1 CD274


文献列表

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