FLUTOLANIL (BioDeep_00000002248)

   

natural product Industrial Pollutants


代谢物信息卡片


Pesticide4_Flutolanil_C17H16F3NO2_Benzamide, N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)-

化学式: C17H16F3NO2 (323.1133)
中文名称: 氟酰胺, 氟唑醇
谱图信息: 最多检出来源 Escherichia coli(natural_products) 82.61%

分子结构信息

SMILES: CC(C)OC1=CC(NC(=O)C2=C(C=CC=C2)C(F)(F)F)=CC=C1
InChI: InChI=1S/C17H16F3NO2/c1-11(2)23-13-7-5-6-12(10-13)21-16(22)14-8-3-4-9-15(14)17(18,19)20/h3-11H,1-2H3,(H,21,22)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4349; ORIGINAL_PRECURSOR_SCAN_NO 4346
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4226; ORIGINAL_PRECURSOR_SCAN_NO 4222
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9058; ORIGINAL_PRECURSOR_SCAN_NO 9056
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9153; ORIGINAL_PRECURSOR_SCAN_NO 9152
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4243; ORIGINAL_PRECURSOR_SCAN_NO 4241
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4249; ORIGINAL_PRECURSOR_SCAN_NO 4247
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9072; ORIGINAL_PRECURSOR_SCAN_NO 9070
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9189; ORIGINAL_PRECURSOR_SCAN_NO 9186
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4277; ORIGINAL_PRECURSOR_SCAN_NO 4275
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9107; ORIGINAL_PRECURSOR_SCAN_NO 9105
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4271; ORIGINAL_PRECURSOR_SCAN_NO 4268
CONFIDENCE standard compound; INTERNAL_ID 1175; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9124; ORIGINAL_PRECURSOR_SCAN_NO 9123

同义名列表

5 个代谢物同义名

FLUTOLANIL; Pesticide4_Flutolanil_C17H16F3NO2_Benzamide, N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)-; FTN; Flutolanil; Flutolanil



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ARHGAP45, CAPN1, CASP3, CRY1, ESR1, GPI, PGR, PPM1G, SREBF1
Peripheral membrane protein 3 ESR1, NDUFA5, SDHB
Endoplasmic reticulum membrane 3 DIO1, SREBF1, TAP1
Nucleus 7 CASP3, CRY1, ESR1, PGR, PPM1G, SREBF1, THRA
cytosol 8 ARHGAP45, CAPN1, CASP3, ESR1, GPI, PGR, SREBF1, THRA
mitochondrial membrane 1 SDHB
nucleoplasm 7 CASP3, ESR1, PGR, PPM1G, SDHB, SREBF1, THRA
RNA polymerase II transcription regulator complex 1 THRA
Cell membrane 3 CAPN1, ESR1, TSHR
Lipid-anchor 1 PPM1G
Cytoplasmic side 1 ESR1
ruffle membrane 1 ARHGAP45
Multi-pass membrane protein 5 SDHC, SDHD, SREBF1, TAP1, TSHR
Golgi apparatus membrane 1 SREBF1
cell surface 1 TSHR
glutamatergic synapse 1 CASP3
Golgi apparatus 1 ESR1
Golgi membrane 1 SREBF1
mitochondrial inner membrane 4 NDUFA5, SDHB, SDHC, SDHD
neuronal cell body 1 CASP3
Lysosome 1 CAPN1
plasma membrane 8 ARHGAP45, CAPN1, DIO1, ESR1, PGR, SDHB, TAP1, TSHR
Membrane 9 ARHGAP45, CAPN1, DIO1, ESR1, GPI, PPM1G, SDHC, TAP1, TSHR
basolateral plasma membrane 1 TSHR
extracellular exosome 2 CAPN1, GPI
endoplasmic reticulum 2 SREBF1, TAP1
extracellular space 1 GPI
mitochondrion 6 CAPN1, CRY1, NDUFA5, SDHB, SDHC, SDHD
protein-containing complex 2 ESR1, SREBF1
postsynaptic density 1 CASP3
Secreted 1 GPI
extracellular region 3 ARHGAP45, CAPN1, GPI
Single-pass membrane protein 1 DIO1
mitochondrial outer membrane 1 PGR
mitochondrial matrix 1 SDHB
transcription regulator complex 1 ESR1
centriolar satellite 1 TAP1
ciliary membrane 1 GPI
Cell projection, ruffle membrane 1 ARHGAP45
Mitochondrion inner membrane 4 NDUFA5, SDHB, SDHC, SDHD
Matrix side 2 NDUFA5, SDHB
focal adhesion 1 CAPN1
lateral plasma membrane 1 TSHR
receptor complex 1 TSHR
chromatin 4 ESR1, PGR, SREBF1, THRA
phagocytic vesicle membrane 1 TAP1
Basolateral cell membrane 1 TSHR
nuclear envelope 1 SREBF1
Endomembrane system 1 DIO1
Cornified envelope 1 CAPN1
Cytoplasmic vesicle membrane 1 SREBF1
euchromatin 1 ESR1
respiratory chain complex I 1 NDUFA5
ficolin-1-rich granule lumen 2 CAPN1, GPI
secretory granule lumen 2 ARHGAP45, GPI
azurophil granule lumen 1 ARHGAP45
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 TAP1
mitochondrial envelope 1 SDHD
respiratory chain complex II (succinate dehydrogenase) 3 SDHB, SDHC, SDHD
ER to Golgi transport vesicle membrane 1 SREBF1
[Isoform 1]: Nucleus 1 ESR1
death-inducing signaling complex 1 CASP3
MHC class I peptide loading complex 1 TAP1
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
calpain complex 1 CAPN1
[Isoform 4]: Mitochondrion outer membrane 1 PGR
[Isoform Alpha-2]: Cytoplasm 1 THRA
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1
TAP complex 1 TAP1


文献列表

  • Yang Yang, Bin He, Xiyan Mu, Suzhen Qi. Exposure to flutolanil at environmentally relevant concentrations can induce image and non-image-forming failure of zebrafish larvae through neuro and visual disruptions. Journal of hazardous materials. 2024 May; 469(?):134108. doi: 10.1016/j.jhazmat.2024.134108. [PMID: 38521039]
  • Yang Yang, Xiyan Xu, Bin He, Jinhe Chang, Yongquan Zheng, Yuanbo Li. The role of miRNA-26a-5p and target gene socs1a in flutolanil induced hepatotoxicity of zebrafish at environmental relevant levels. Environmental pollution (Barking, Essex : 1987). 2023 Aug; 335(?):122322. doi: 10.1016/j.envpol.2023.122322. [PMID: 37544405]
  • Constantin Yanicostas, Nadia Soussi-Yanicostas. SDHI Fungicide Toxicity and Associated Adverse Outcome Pathways: What Can Zebrafish Tell Us?. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212362. [PMID: 34830252]
  • Yang Yang, Fengshou Dong, Xingang Liu, Jun Xu, Xiaohu Wu, Yongquan Zheng. Flutolanil affects circadian rhythm in zebrafish (Danio rerio) by disrupting the positive regulators. Chemosphere. 2019 Aug; 228(?):649-655. doi: 10.1016/j.chemosphere.2019.04.207. [PMID: 31063912]
  • Jung-Ah Shin, Hoonho Cho, Dong-Woo Seo, Hee-Gon Jeong, Sung Chul Kim, Jeung-Hee Lee, Soon-Taek Hong, Ki-Teak Lee. Approach Study for Mass Balance of Pesticide Residues in Distillers' Stillage along with Distillate and Absence Verification of Pesticides in Distilled Spirits from Pilot-Scale of Distillation Column. Molecules (Basel, Switzerland). 2019 Jul; 24(14):. doi: 10.3390/molecules24142572. [PMID: 31311184]
  • Yu Zhang, Jingle Lu, Jianxin Wang, MingGuo Zhou, Changjun Chen. Baseline sensitivity and resistance risk assessmemt of Rhizoctonia cerealis to thifluzamide, a succinate dehydrogenase inhibitor. Pesticide biochemistry and physiology. 2015 Oct; 124(?):97-102. doi: 10.1016/j.pestbp.2015.05.004. [PMID: 26453237]
  • Gabriel Scalliet, Judith Bowler, Torsten Luksch, Lucy Kirchhofer-Allan, Diana Steinhauer, Keith Ward, Michael Niklaus, Andreas Verras, Michael Csukai, Antoine Daina, Raymonde Fonné-Pfister. Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. PloS one. 2012; 7(4):e35429. doi: 10.1371/journal.pone.0035429. [PMID: 22536383]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Tung-Hsen Liu, Mei-Ju Lin, Wen-Hsiung Ko. Development of artificial conidia for ecological studies of Rhizoctonia solani in soil. New biotechnology. 2011 Jan; 28(1):86-91. doi: 10.1016/j.nbt.2010.08.004. [PMID: 20713193]
  • Melvin D Bolton, Lee Panella, Larry Campbell, Mohamed F R Khan. Temperature, moisture, and fungicide effects in managing Rhizoctonia root and crown rot of sugar beet. Phytopathology. 2010 Jul; 100(7):689-97. doi: 10.1094/phyto-100-7-0689. [PMID: 20528187]
  • James W Buck, Leon L Burpee. The effects of fungicides on the phylloplane yeast populations of creeping bentgrass. Canadian journal of microbiology. 2002 Jun; 48(6):522-9. doi: 10.1139/w02-050. [PMID: 12166679]
  • M Kondoh, M Hirai, M Shoda. Integrated biological and chemical control of damping-off caused by Rhizoctonia solani using Bacillus subtilis RB14-C and flutolanil. Journal of bioscience and bioengineering. 2001; 91(2):173-7. doi: 10.1016/s1389-1723(01)80061-x. [PMID: 16232970]
  • D E Wedge, D G Nagle. A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens. Journal of natural products. 2000 Aug; 63(8):1050-4. doi: 10.1021/np990628r. [PMID: 10978195]