Diethylstilbestrol (BioDeep_00000002242)

 

Secondary id: BioDeep_00000227695, BioDeep_00000398402

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4-[4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol

化学式: C18H20O2 (268.146322)
中文名称: 己烯雌酚,顺式和反式异构体混合物, 己烯雌酚
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC/C(=C(/CC)\c1ccc(cc1)O)/c1ccc(cc1)O
InChI: InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3

描述信息

Diethylstilbestrol is a synthetic estrogen that was developed to supplement a womans natural estrogen production. In 1971, the Food and Drug Administration (FDA) issued a Drug Bulletin advising physicians to stop prescribing DES to pregnant women because it was linked to a rare vaginal cancer in female offspring. Diethylstilbesterol is found in gram bean.
Diethylstilbestrol is a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed).
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CC - Estrogens, combinations with other drugs
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CB - Synthetic estrogens, plain
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AA - Estrogens
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D009676 - Noxae > D002273 - Carcinogens

同义名列表

14 个代谢物同义名

4-[4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol; Percutatrine oestrogenique iscovesco; trans-Diethylstilboesterol; trans-Diethylstilbesterol; trans-Diethylstilbestrol; Rcra waste number u089; Diethylstilbestrol BP; Diethylstilboesterol; Diethylstilbesterol; Diethylstilbestrol; Dietilestilbestrol; Stilbestrol;DES; Stil; Des



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shrishti Madhan, Rajib Dhar, Arikketh Devi. Plant-derived exosomes: a green approach for cancer drug delivery. Journal of materials chemistry. B. 2024 Feb; 12(9):2236-2252. doi: 10.1039/d3tb02752j. [PMID: 38351750]
  • V Alampanos, A Kabir, K G Furton, V Samanidou. Rapid exposure monitoring of six bisphenols and diethylstilbestrol in human urine using fabric phase sorptive extraction followed by high performance liquid chromatography - photodiode array analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jul; 1177(?):122760. doi: 10.1016/j.jchromb.2021.122760. [PMID: 34052754]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
  • Alessio Ausili, Inés Rodríguez-González, Alejandro Torrecillas, José A Teruel, Juan C Gómez-Fernández. Diethylstilbestrol Modifies the Structure of Model Membranes and Is Localized Close to the First Carbons of the Fatty Acyl Chains. Biomolecules. 2021 02; 11(2):. doi: 10.3390/biom11020220. [PMID: 33557377]
  • Li Zhang, Qiuxia Xu, Yao Li, Hui Zhao, Xingming Shi, Fu Peng, Chenghao Yu. Ameliorative Effects of Component Chinese Medicine From Curcumae Rhizoma and Sparganii Rhizoma, a Traditional Herb Pair, on Uterine Leiomyoma in a Rat Model. Frontiers in public health. 2021; 9(?):674357. doi: 10.3389/fpubh.2021.674357. [PMID: 34123993]
  • Julia A Taylor, Maren Bell Jones, Cynthia L Besch-Williford, Ashley F Berendzen, William A Ricke, Frederick S Vom Saal. Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice. International journal of molecular sciences. 2020 May; 21(11):. doi: 10.3390/ijms21113902. [PMID: 32486162]
  • Xingdong Yang, Yinbiao Wang, Chunmei Song, Xiaofei Hu, Fangyu Wang, Xianyin Zeng. Hapten Synthesis and the Development of an Ultrasensitive Indirect Competitive ELISA for the Determination of Diethylstilbestrol in Food Samples. Scientific reports. 2020 02; 10(1):3270. doi: 10.1038/s41598-020-59112-1. [PMID: 32094434]
  • Nikki Brantley, Charles A Lessman. In vivo assessment of gonad status, secondary sex characteristics and spawning in transparent Casper zebrafish. Mechanisms of development. 2019 12; 160(?):103582. doi: 10.1016/j.mod.2019.103582. [PMID: 31634535]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Dijana Topalović, Dragana Dekanski, Biljana Spremo-Potparević, Andrea Pirković, Sunčica Borozan, Vladan Bajić, Danilo Stojanović, Francesca Giampieri, Massimiliano Gasparrini, Lada Živković. Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro. Mutation research. Genetic toxicology and environmental mutagenesis. 2019 Sep; 845(?):402993. doi: 10.1016/j.mrgentox.2018.12.001. [PMID: 31561897]
  • Sachiyo Oikawa, Sachiyo Kobayashi, Shinichi Miyagawa, Taisen Iguchi, Tomomi Sato. Diethylstilbestrol Alters the Expression of Activins in the Neonatal Mouse Ovary In Vitro. In vivo (Athens, Greece). 2019 Jul; 33(4):1095-1102. doi: 10.21873/invivo.11578. [PMID: 31280197]
  • Weifeng Mao, Yan Song, Haixia Sui, Pei Cao, Zhaoping Liu. Analysis of individual and combined estrogenic effects of bisphenol, nonylphenol and diethylstilbestrol in immature rats with mathematical models. Environmental health and preventive medicine. 2019 May; 24(1):32. doi: 10.1186/s12199-019-0789-5. [PMID: 31084616]
  • Po-Han Lin, Chun-Kuang Shih, Yu-Ting Yen, Wenchang Chiang, Shih-Min Hsia. Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extract and Active Compounds Inhibit Proliferation of Primary Human Leiomyoma Cells and Protect against Sexual Hormone-Induced Mice Smooth Muscle Hyperproliferation. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081556. [PMID: 31010220]
  • Zi-Yi Zhao, Lei Yang, Xiaohong Mu, Lin Xu, Xing Yu, Yong Jiao, Xiaozhe Zhang, Lingling Fu. Cajanine promotes osteogenic differentiation and proliferation of human bone marrow mesenchymal stem cells. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2019 Jan; 28(1):45-50. doi: 10.17219/acem/76638. [PMID: 30141283]
  • Tingting Wu, Tao Yan, Xue Zhang, Yixuan Feng, Dong Wei, Meng Sun, Bin Du, Qin Wei. A competitive photoelectrochemical immunosensor for the detection of diethylstilbestrol based on an Au/UiO-66(NH2)/CdS matrix and a direct Z-scheme Melem/CdTe heterojunction as labels. Biosensors & bioelectronics. 2018 Oct; 117(?):575-582. doi: 10.1016/j.bios.2018.06.050. [PMID: 30005376]
  • Hui Zhao, Yao Li, QiuXia Xu, Fu Peng, JinShuang Zhao, R Clinton Webb, Cheng Peng, ChengHao Yu. Establishment of a rat model for uterine leiomyomas based on Western and traditional Chinese medicine theories. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2018 Jul; 51(9):e7627. doi: 10.1590/1414-431x20187627. [PMID: 29972430]
  • Xue Dong, Guanhui Zhao, Li Liu, Xuan Li, Qin Wei, Wei Cao. Ultrasensitive competitive method-based electrochemiluminescence immunosensor for diethylstilbestrol detection based on Ru(bpy)32+ as luminophor encapsulated in metal-organic frameworks UiO-67. Biosensors & bioelectronics. 2018 Jul; 110(?):201-206. doi: 10.1016/j.bios.2018.03.066. [PMID: 29625327]
  • Zhi-Hao Liu, Qi-Liang Chen, Qiang Chen, Fang Li, Ying-Wen Li. Diethylstilbestrol arrested spermatogenesis and somatic growth in the juveniles of yellow catfish (Pelteobagrus fulvidraco), a fish with sexual dimorphic growth. Fish physiology and biochemistry. 2018 Jun; 44(3):789-803. doi: 10.1007/s10695-018-0469-1. [PMID: 29340879]
  • Yaqin Wang, Yingwen Li, Qiliang Chen, Zhihao Liu. Diethylstilbestrol impaired oogenesis of yellow catfish juveniles through disrupting hypothalamic-pituitary-gonadal axis and germ cell development. Journal of applied toxicology : JAT. 2018 03; 38(3):308-317. doi: 10.1002/jat.3529. [PMID: 28960386]
  • Ovokeroye Akpojevwe Abafe, Pumza M Gatyeni, Tlou Chokwe. Development and validation of a confirmatory method for the determination of stilbene estrogens in ostrich serum. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2018 Mar; 35(3):458-466. doi: 10.1080/19440049.2017.1411617. [PMID: 29210606]
  • Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G Nelson, Wenjun Ju, Matthias Kretzler, Stephen L Atkin, Maria F Gomez, Shang-Zhong Xu. ORAI channels are critical for receptor-mediated endocytosis of albumin. Nature communications. 2017 12; 8(1):1920. doi: 10.1038/s41467-017-02094-y. [PMID: 29203863]
  • M H Blokland, E F van Tricht, L A van Ginkel, S S Sterk. Applicability of an innovative steroid-profiling method to determine synthetic growth promoter abuse in cattle. The Journal of steroid biochemistry and molecular biology. 2017 11; 174(?):265-275. doi: 10.1016/j.jsbmb.2017.10.007. [PMID: 29030156]
  • Giovanna Muscogiuri, Luigi Barrea, Daniela Laudisio, Silvia Savastano, Annamaria Colao. Obesogenic endocrine disruptors and obesity: myths and truths. Archives of toxicology. 2017 Nov; 91(11):3469-3475. doi: 10.1007/s00204-017-2071-1. [PMID: 28975368]
  • Olena Shaliutina, Anna Shaliutina-Kolešová, Ievgen Lebeda, Marek Rodina, Ievgeniia Gazo. The in vitro effect of nonylphenol, propranolol, and diethylstilbestrol on quality parameters and oxidative stress in sterlet (Acipenser ruthenus) spermatozoa. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Sep; 43(?):9-15. doi: 10.1016/j.tiv.2017.05.006. [PMID: 28533019]
  • Yoshitaka Imamichi, Toshio Sekiguchi, Takeshi Kitano, Takashi Kajitani, Reiko Okada, Yoshihiko Inaoka, Kaoru Miyamoto, Junsuke Uwada, Satoru Takahashi, Takahiro Nemoto, Asuka Mano, Md Rafiqul Islam Khan, Md Tariqul Islam, Koh-Ichi Yuhki, Hitoshi Kashiwagi, Fumitaka Ushikubi, Nobuo Suzuki, Takanobu Taniguchi, Takashi Yazawa. Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary. Scientific reports. 2017 08; 7(1):8374. doi: 10.1038/s41598-017-08780-7. [PMID: 28827713]
  • Freddy O Agoreyo, B Rita Ohimai, Magdalene I Omigie. Effect of Solanum Nigrun on Uterus of Non-gravid Rats. Ethiopian journal of health sciences. 2017 May; 27(3):239-244. doi: 10.4314/ejhs.v27i3.5. [PMID: 29217922]
  • Pan Yin, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Liu. Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis. Aquatic toxicology (Amsterdam, Netherlands). 2017 Apr; 185(?):129-137. doi: 10.1016/j.aquatox.2017.02.013. [PMID: 28213303]
  • Dai Zhang, Lifang Zhou, Yajing Lei, Zhan Zhou, Jie Zhou, Shuqing Chen. Investigation of diethylstilbestrol residue level in human urine samples by a specific monoclonal antibody. Environmental science and pollution research international. 2017 Mar; 24(8):7042-7050. doi: 10.1007/s11356-017-8405-y. [PMID: 28092005]
  • Qian-Xing Zou, Zhen Peng, Qing Zhao, Hou-Yang Chen, Yi-Min Cheng, Qing Liu, Yuan-Qiao He, Shi-Qi Weng, Hua-Feng Wang, Tao Wang, Li-Ping Zheng, Tao Luo. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Human reproduction (Oxford, England). 2017 02; 32(2):290-298. doi: 10.1093/humrep/dew332. [PMID: 28031325]
  • V Plesinac-Karapandzic, S Stojanovic Rundic, R Jankovic, M Nadrljanski, Z Milovanovic, A Tomasevic, N Perisie Jeremic. Non-diethylstilbestrol exposed vaginal adenocarcinoma in young patients associated with unilateral renal agenesis: two case reports and literature review. European journal of gynaecological oncology. 2017; 38(1):157-161. doi: . [PMID: 29767889]
  • Liangliang Zhu, Ling Xiao, Wenjuan Li, Yuan Zhang, Wenwen Han, Yu Zhu, Guangbo Ge, Ling Yang. Human UDP-Glucuronosyltransferases 1A1, 1A3, 1A9, 2B4 and 2B7 are Inhibited by Diethylstilbestrol. Basic & clinical pharmacology & toxicology. 2016 Nov; 119(5):505-511. doi: 10.1111/bcpt.12618. [PMID: 27176228]
  • Giorgio Biasiotto, Isabella Zanella, Alice Masserdotti, Roberta Pedrazzani, Matteo Papa, Luigi Caimi, Diego Di Lorenzo. Municipal wastewater affects adipose deposition in male mice and increases 3T3-L1 cell differentiation. Toxicology and applied pharmacology. 2016 Apr; 297(?):32-40. doi: 10.1016/j.taap.2016.02.023. [PMID: 26944108]
  • Benjamin Lemaire, Akira Kubota, Conor M O'Meara, David C Lamb, Robert L Tanguay, Jared V Goldstone, John J Stegeman. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicology and applied pharmacology. 2016 Apr; 296(?):73-84. doi: 10.1016/j.taap.2016.02.001. [PMID: 26853319]
  • C Yang, W Lim, H Bae, G Song. Aquaporin 3 is regulated by estrogen in the chicken oviduct and is involved in progression of epithelial cell-derived ovarian carcinomas. Domestic animal endocrinology. 2016 Apr; 55(?):97-106. doi: 10.1016/j.domaniend.2015.12.003. [PMID: 26808975]
  • Satoko Haeno, Naoyuki Maeda, Kousuke Yamaguchi, Michiko Sato, Aika Uto, Hiroshi Yokota. Adrenal steroidogenesis disruption caused by HDL/cholesterol suppression in diethylstilbestrol-treated adult male rat. Endocrine. 2016 Apr; 52(1):148-56. doi: 10.1007/s12020-015-0732-5. [PMID: 26349937]
  • Onat Kadioglu, Yujie Fu, Benjamin Wiench, Yuangang Zu, Thomas Efferth. Synthetic cajanin stilbene acid derivatives inhibit c-MYC in breast cancer cells. Archives of toxicology. 2016 Mar; 90(3):575-88. doi: 10.1007/s00204-015-1480-2. [PMID: 25716159]
  • Rachel G Felton, Cynthia C Steiner, Barbara S Durrant, Duane H Keisler, Matthew R Milnes, Christopher W Tubbs. Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals. Endocrinology. 2015 Dec; 156(12):4448-57. doi: 10.1210/en.2015-1448. [PMID: 26372180]
  • Mosotho J George, Ljiljana Marjanovic, D Bradley G Williams. Picogram-level quantification of some growth hormones in bovine urine using mixed-solvent bubble-in-drop single drop micro-extraction. Talanta. 2015 Nov; 144(?):445-50. doi: 10.1016/j.talanta.2015.06.070. [PMID: 26452846]
  • Bo-wen Weng, Si-chuan Hou, Hai Zhu, Luo Xu, Xiao Luan, Hai-yan Qi, Wei-min Wang, Wei Liu, Li-jiang Sun. [Expression of nNOS and ultrastructural changes in the penile tissue of rats with prolactinoma-induced erectile dysfunction]. Zhonghua nan ke xue = National journal of andrology. 2015 Oct; 21(10):871-6. doi: . [PMID: 26665672]
  • J Jeong, H Bae, W Lim, F W Bazer, G Song. Diethylstilbestrol regulates expression of avian apolipoprotein D during regression and recrudescence of the oviduct and epithelial-derived ovarian carcinogenesis. Domestic animal endocrinology. 2015 Jul; 52(?):82-9. doi: 10.1016/j.domaniend.2015.03.005. [PMID: 25929245]
  • Pei-Shan Cai, Dan Li, Jing Chen, Chao-Mei Xiong, Jin-Lan Ruan. Comparison of two thin-film microextractions for the analysis of estrogens in aqueous tea extract and environmental water samples by high performance liquid chromatography-ultraviolet detection. Food chemistry. 2015 Apr; 173(?):1158-66. doi: 10.1016/j.foodchem.2014.11.002. [PMID: 25466138]
  • Liangliang Zhu, Ling Xiao, Yangliu Xia, Kun Zhou, Huili Wang, Minyi Huang, Guangbo Ge, Yan Wu, Ganlin Wu, Ling Yang. Diethylstilbestrol can effectively accelerate estradiol-17-O-glucuronidation, while potently inhibiting estradiol-3-O-glucuronidation. Toxicology and applied pharmacology. 2015 Mar; 283(2):109-16. doi: 10.1016/j.taap.2015.01.003. [PMID: 25596428]
  • María M Milesi, Ramiro Alarcón, Jorge G Ramos, Mónica Muñoz-de-Toro, Enrique H Luque, Jorgelina Varayoud. Neonatal exposure to low doses of endosulfan induces implantation failure and disrupts uterine functional differentiation at the pre-implantation period in rats. Molecular and cellular endocrinology. 2015 Feb; 401(?):248-59. doi: 10.1016/j.mce.2014.11.028. [PMID: 25486513]
  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Sona Scsukova, Alzbeta Mlynarcikova, Alexander Kiss, Eva Rollerova. Effect of polymeric nanoparticle poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) on in vitro luteinizing hormone release from anterior pituitary cells of infantile and adult female rats. Neuro endocrinology letters. 2015; 36 Suppl 1(?):88-94. doi: NULL. [PMID: 26757115]
  • Michael L McCaskill, Eleanor Rogan, Ronald D Thomas. Diallyl sulfide inhibits diethylstilbestrol induced DNA damage in human breast epithelial cells (MCF-10A). Steroids. 2014 Dec; 92(?):96-100. doi: 10.1016/j.steroids.2014.09.005. [PMID: 25278253]
  • A N Ivankin, A V Kulikovskiĭ, N L Vostrikova, I M Chernukha. [cis and trans conformational changes of bacterial fatty acids in comparison with analogs of animal and vegetable origin]. Prikladnaia biokhimiia i mikrobiologiia. 2014 Nov; 50(6):604-11. doi: 10.7868/s0555109914060051. [PMID: 25726670]
  • Cécile Héliès-Toussaint, Ludovic Peyre, Claudia Costanzo, Marie-Christine Chagnon, Roger Rahmani. Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study. Toxicology and applied pharmacology. 2014 Oct; 280(2):224-35. doi: 10.1016/j.taap.2014.07.025. [PMID: 25111128]
  • Ran-Fang Xu, Min-Xia Sun, Juan Liu, Hong Wang, Xin Li, Xue-Zhu Zhu, Wan-Ting Ling. [Isolation, identification and characterization of a diethylstilbestrol-degrading bacterial strain Serratia sp]. Huan jing ke xue= Huanjing kexue. 2014 Aug; 35(8):3169-74. doi: ". [PMID: 25338395]
  • Yongzhong Zhang, Longjiang Yu, Wenwen Jin, Mingzhang Ao. Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats. Indian journal of pharmacology. 2014 Jul; 46(4):416-9. doi: 10.4103/0253-7613.135955. [PMID: 25097281]
  • Abdelkader Oumeddour, Emilie Viennois, Françoise Caira, Clélia Decourbey, Salwan Maqdasy, Abdelkrim Tahraoui, Silvère Baron, David H Volle, Jean-Marc A Lobaccaro. Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology. Biochemical and biophysical research communications. 2014 Apr; 446(3):656-62. doi: 10.1016/j.bbrc.2013.12.005. [PMID: 24333430]
  • Tal Grenader, Yevgeni Plotkin, Maya Gips, Nathan Cherny, Alberto Gabizon. Diethylstilbestrol for the treatment of patients with castration-resistant prostate cancer: retrospective analysis of a single institution experience. Oncology reports. 2014 Jan; 31(1):428-34. doi: 10.3892/or.2013.2852. [PMID: 24247716]
  • Hyogo Horiguchi, Etsuko Oguma, Takako Sakamoto, Katsuyuki Murata, Fujio Kayama. Suppression of erythropoietin induction by diethylstilbestrol in rats. Archives of toxicology. 2014 Jan; 88(1):137-44. doi: 10.1007/s00204-013-1095-4. [PMID: 23877121]
  • Said Zulfahmi, Latifah Saiful Yazan, Hairuszah Ithnin, Nurdin Armania. The improvement of in vivo model (Balb/c mice) for cervical carcinogenesis using diethylstilbestrol (DES). Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2013 Nov; 65(7-8):1083-9. doi: 10.1016/j.etp.2013.04.004. [PMID: 23726752]
  • Adel M Hussein, Mohamed H Badawoud, Mustafa H Noaman. The effects of diethylstilbestrol administration on rat kidney. Ultrastructural study. Saudi medical journal. 2013 Nov; 34(11):1114-24. doi: NULL. [PMID: 24252888]
  • Lan Chong, Weikang Chen, Yuehua Luo, Zihua Jiang. Simultaneous determination of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate in rat plasma by UHPLC-ESI-MS/MS after administration of xiyanping injection: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2013 Jul; 27(7):825-30. doi: 10.1002/bmc.2866. [PMID: 23355108]
  • Si En Lin, Jian Ping Huang, Ling Zhi Wu, Tie Wu, Liao Cui. Prevention of osteopenia and dyslipidemia in rats after ovariectomy with combined aspirin and low-dose diethylstilbestrol. Biomedical and environmental sciences : BES. 2013 Apr; 26(4):249-57. doi: 10.3967/0895-3988.2013.04.003. [PMID: 23534465]
  • H Kakuta, A Matsushita, K Arikawa, T Iguchi, T Sato. Cholesterol homeostasis in the ovaries of neonatally diethylstilbestrol-treated mice. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2013 Feb; 121(2):94-101. doi: 10.1055/s-0033-1333780. [PMID: 23426703]
  • Sheikh Shreaz, Rimple Bhatia, Neelofar Khan, Sumathi Muralidhar, Nikhat Manzoor, Luqman Ahmad Khan. Influences of cinnamic aldehydes on H⁺ extrusion activity and ultrastructure of Candida. Journal of medical microbiology. 2013 Feb; 62(Pt 2):232-240. doi: 10.1099/jmm.0.036145-0. [PMID: 22034160]
  • Chul-Hong Lim, Whasun Lim, Wooyoung Jeong, Jin-Young Lee, Seung-Min Bae, Jinyoung Kim, Jae Yong Han, Fuller W Bazer, Gwonhwa Song. Avian WNT4 in the female reproductive tracts: potential role of oviduct development and ovarian carcinogenesis. PloS one. 2013; 8(7):e65935. doi: 10.1371/journal.pone.0065935. [PMID: 23843947]
  • Rod T Mitchell, Richard M Sharpe, Richard A Anderson, Chris McKinnell, Sheila Macpherson, Lee B Smith, W Hamish B Wallace, Christopher J H Kelnar, Sander van den Driesche. Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts. PloS one. 2013; 8(4):e61726. doi: 10.1371/journal.pone.0061726. [PMID: 23620786]
  • Huixiao Hong, William S Branham, Stacey L Dial, Carrie L Moland, Hong Fang, Jie Shen, Roger Perkins, Daniel Sheehan, Weida Tong. Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. Chemical research in toxicology. 2012 Nov; 25(11):2553-66. doi: 10.1021/tx3003406. [PMID: 23013281]
  • Yan Yin, Congxing Lin, G Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma. Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells. Disease models & mechanisms. 2012 Nov; 5(6):870-80. doi: 10.1242/dmm.009076. [PMID: 22679223]
  • Bo Zeng, Gui-Lan Chen, Shang-Zhong Xu. Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca(2+) influx. Biochemical pharmacology. 2012 Oct; 84(8):1024-35. doi: 10.1016/j.bcp.2012.07.013. [PMID: 22842488]
  • Chan-Juan Hao, Xue-Jia Cheng, Hong-Fei Xia, Xu Ma. The endocrine disruptor diethylstilbestrol induces adipocyte differentiation and promotes obesity in mice. Toxicology and applied pharmacology. 2012 Aug; 263(1):102-10. doi: 10.1016/j.taap.2012.06.003. [PMID: 22710028]
  • Yang Yang, Juan Chen, Yan-Ping Shi. Determination of diethylstilbestrol in milk using carbon nanotube-reinforced hollow fiber solid-phase microextraction combined with high-performance liquid chromatography. Talanta. 2012 Aug; 97(?):222-8. doi: 10.1016/j.talanta.2012.04.021. [PMID: 22841071]
  • M Victoria Recouvreux, M Andrea Camilletti, Daniel B Rifkin, Damasia Becu-Villalobos, Graciela Díaz-Torga. Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-β1 (TGF-β1). Endocrinology. 2012 Aug; 153(8):3861-71. doi: 10.1210/en.2012-1007. [PMID: 22700773]
  • Olufemi B Adedeji, Elizabeth J Durhan, Natàlia Garcia-Reyero, Michael D Kahl, Kathleen M Jensen, Carlie A Lalone, Elizabeth A Makynen, Edward J Perkins, Linnea Thomas, Daniel L Villeneuve, Gerald T Ankley. Short-term study investigating the estrogenic potency of diethylstilbesterol in the fathead minnow (Pimephales promelas). Environmental science & technology. 2012 Jul; 46(14):7826-35. doi: 10.1021/es301043b. [PMID: 22708615]
  • Qisheng Zhong, Yufei Hu, Yuling Hu, Gongke Li. Dynamic liquid-liquid-solid microextraction based on molecularly imprinted polymer filaments on-line coupling to high performance liquid chromatography for direct analysis of estrogens in complex samples. Journal of chromatography. A. 2012 Jun; 1241(?):13-20. doi: 10.1016/j.chroma.2012.04.017. [PMID: 22554413]
  • Whasun Lim, Wooyoung Jeong, Jinyoung Kim, Hakhyun Ka, Fuller W Bazer, Jae Yong Han, Gwonhwa Song. Differential expression of secreted phosphoprotein 1 in response to estradiol-17β and in ovarian tumors in chickens. Biochemical and biophysical research communications. 2012 Jun; 422(3):494-500. doi: 10.1016/j.bbrc.2012.05.026. [PMID: 22588173]
  • T Ding, A Luo, S Yang, Z Lai, Y Wang, W Shen, J Jiang, Y Lu, D Ma, S Wang. Effects of basal media and supplements on diethylstilbestrol-treated immature mouse primary granulosa cell growth and regulation of steroidogenesis in vitro. Reproduction in domestic animals = Zuchthygiene. 2012 Jun; 47(3):355-64. doi: 10.1111/j.1439-0531.2011.01879.x. [PMID: 21999365]
  • Meijie Liu, Gary Guishan Xiao, Peijing Rong, Zhiguo Zhang, Jiazi Dong, Hongyan Zhao, Honghong Li, Yan Li, Jinghua Pan, Hong Liu, Wenlai Wang, Qinglin Zha, Dahong Ju. Therapeutic effects of radix dipsaci, pyrola herb, and Cynomorium songaricum on bone metabolism of ovariectomized rats. BMC complementary and alternative medicine. 2012 May; 12(?):67. doi: 10.1186/1472-6882-12-67. [PMID: 22639966]
  • Thorhallur I Halldorsson, Dorte Rytter, Line Småstuen Haug, Bodil Hammer Bech, Inge Danielsen, Georg Becher, Tine Brink Henriksen, Sjurdur F Olsen. Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study. Environmental health perspectives. 2012 May; 120(5):668-73. doi: 10.1289/ehp.1104034. [PMID: 22306490]
  • Mehmet Ali Kobat, Ahmet Celik, Mehmet Balin, Yakup Altas, Adil Baydas, Musa Bulut, Suleyman Aydin, Necati Dagli, Mustafa Ferzeyn Yavuzkir, Selcuk Ilhan. The investigation of serum vaspin level in atherosclerotic coronary artery disease. Journal of clinical medicine research. 2012 Apr; 4(2):110-3. doi: 10.4021/jocmr841w. [PMID: 22505983]
  • Alexander A Terentiev, Nurbubu T Moldogazieva, Olga V Levtsova, Dmitry M Maximenko, Denis A Borozdenko, Konstantin V Shaitan. Modeling of three dimensional structure of human alpha-fetoprotein complexed with diethylstilbestrol: docking and molecular dynamics simulation study. Journal of bioinformatics and computational biology. 2012 Apr; 10(2):1241012. doi: 10.1142/s0219720012410120. [PMID: 22809347]
  • Keiichi Takiue, Hitoshi Sugiyama, Tatsuyuki Inoue, Hiroshi Morinaga, Yoko Kikumoto, Masashi Kitagawa, Shinji Kitamura, Yohei Maeshima, Da-Hong Wang, Noriyoshi Masuoka, Keiki Ogino, Hirofumi Makino. Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis. BMC nephrology. 2012 Mar; 13(?):14. doi: 10.1186/1471-2369-13-14. [PMID: 22443450]
  • Guiyan Chu, Izumi Misawa, Huatao Chen, Nobuhiko Yamauchi, Yasufumi Shigeyoshi, Seiichi Hashimoto, Masa-Aki Hattori. Contribution of FSH and triiodothyronine to the development of circadian clocks during granulosa cell maturation. American journal of physiology. Endocrinology and metabolism. 2012 Mar; 302(6):E645-53. doi: 10.1152/ajpendo.00470.2011. [PMID: 22205630]
  • Shi-Qi Ji, Lin Yao, Xiao-Yu Zhang, Xue-Song Li, Li-Qun Zhou. Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and in vivo. Journal of experimental & clinical cancer research : CR. 2012 Mar; 31(?):22. doi: 10.1186/1756-9966-31-22. [PMID: 22420896]
  • Yiqi Zhou, Jinmiao Zha, Yiping Xu, Bingli Lei, Zijian Wang. Occurrences of six steroid estrogens from different effluents in Beijing, China. Environmental monitoring and assessment. 2012 Mar; 184(3):1719-29. doi: 10.1007/s10661-011-2073-z. [PMID: 21544500]
  • Yan Zou, Yanhua Li, Hua Jin, Huinan Tang, Deqing Zou, Mousheng Liu, Yaling Yang. Determination of estrogens in human urine by high-performance liquid chromatography/diode array detection with ultrasound-assisted cloud-point extraction. Analytical biochemistry. 2012 Feb; 421(2):378-84. doi: 10.1016/j.ab.2011.10.007. [PMID: 22037295]
  • Valentina Di Liberto, Johanna Mäkelä, Laura Korhonen, Melania Olivieri, Timofey Tselykh, Annika Mälkiä, Hai Do Thi, Natale Belluardo, Dan Lindholm, Giuseppa Mudò. Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. Neuropharmacology. 2012 Feb; 62(2):1011-8. doi: 10.1016/j.neuropharm.2011.10.010. [PMID: 22041555]
  • Petri Pehkonen, Lynn Welter-Stahl, Janine Diwo, Jussi Ryynänen, Anke Wienecke-Baldacchino, Sami Heikkinen, Eckardt Treuter, Knut R Steffensen, Carsten Carlberg. Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages. BMC genomics. 2012 Jan; 13(?):50. doi: 10.1186/1471-2164-13-50. [PMID: 22292898]
  • Sayani Banerjee, Pratip Chakraborty, Piyali Saha, Soma Aditya Bandyopadhyay, Sutapa Banerjee, Syed N Kabir. Ovotoxic effects of galactose involve attenuation of follicle-stimulating hormone bioactivity and up-regulation of granulosa cell p53 expression. PloS one. 2012; 7(2):e30709. doi: 10.1371/journal.pone.0030709. [PMID: 22319579]
  • Melissa L Sokolosky, Michael J Wargovich. Homeostatic imbalance and colon cancer: the dynamic epigenetic interplay of inflammation, environmental toxins, and chemopreventive plant compounds. Frontiers in oncology. 2012; 2(?):57. doi: 10.3389/fonc.2012.00057. [PMID: 22675672]
  • María José Soler, Marta Riera, Daniel Batlle. New experimental models of diabetic nephropathy in mice models of type 2 diabetes: efforts to replicate human nephropathy. Experimental diabetes research. 2012; 2012(?):616313. doi: 10.1155/2012/616313. [PMID: 22461787]
  • Maria Greco, Adriana Chiappetta, Leonardo Bruno, Maria Beatrice Bitonti. In Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning. Journal of experimental botany. 2012 Jan; 63(2):695-709. doi: 10.1093/jxb/err313. [PMID: 22058406]
  • Christiaan J Malherbe, Dalene De Beer, Elizabeth Joubert. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. International journal of molecular sciences. 2012; 13(3):3101-3133. doi: 10.3390/ijms13033101. [PMID: 22489144]
  • Stephen J Genuis, Sanjay Beesoon, Detlef Birkholz, Rebecca A Lobo. Human excretion of bisphenol A: blood, urine, and sweat (BUS) study. Journal of environmental and public health. 2012; 2012(?):185731. doi: 10.1155/2012/185731. [PMID: 22253637]
  • Chongming Wu, Juanjuan Feng, Ran Wang, Hong Liu, Huixia Yang, Pedro L Rodriguez, Huanju Qin, Xin Liu, Daowen Wang. HRS1 acts as a negative regulator of abscisic acid signaling to promote timely germination of Arabidopsis seeds. PloS one. 2012; 7(4):e35764. doi: 10.1371/journal.pone.0035764. [PMID: 22545134]
  • Hanako Kakuta, Masami Tanaka, Pierre Chambon, Hajime Watanabe, Taisen Iguchi, Tomomi Sato. Involvement of gonadotropins in the induction of hypertrophy-hyperplasia in the interstitial tissues of ovaries in neonatally diethylstilbestrol-treated mice. Reproductive toxicology (Elmsford, N.Y.). 2012 Jan; 33(1):35-44. doi: 10.1016/j.reprotox.2011.10.013. [PMID: 22100434]
  • Halla Krid, Aude Dorison, Amel Salhi, Lydie Cheval, Gilles Crambert. Expression profile of nuclear receptors along male mouse nephron segments reveals a link between ERRβ and thick ascending limb function. PloS one. 2012; 7(3):e34223. doi: 10.1371/journal.pone.0034223. [PMID: 22457827]
  • C A Frye, E Bo, G Calamandrei, L Calzà, F Dessì-Fulgheri, M Fernández, L Fusani, O Kah, M Kajta, Y Le Page, H B Patisaul, A Venerosi, A K Wojtowicz, G C Panzica. Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems. Journal of neuroendocrinology. 2012 Jan; 24(1):144-59. doi: 10.1111/j.1365-2826.2011.02229.x. [PMID: 21951193]
  • Zuzana Kyselova. Toxicological aspects of the use of phenolic compounds in disease prevention. Interdisciplinary toxicology. 2011 Dec; 4(4):173-83. doi: 10.2478/v10102-011-0027-5. [PMID: 22319251]
  • Judd W Moul, Robert Dreicer. Focusing on testosterone. Urology. 2011 Nov; 78(5 Suppl):S476-7. doi: 10.1016/j.urology.2011.06.004. [PMID: 22054917]
  • Neerja Puri. A study of pathogenesis of acanthosis nigricans and its clinical implications. Indian journal of dermatology. 2011 Nov; 56(6):678-83. doi: 10.4103/0019-5154.91828. [PMID: 22345770]
  • Nicola B Skerman, Annie M Joubert, Marianne J Cronjé. The apoptosis inducing effects of Sutherlandia spp. extracts on an oesophageal cancer cell line. Journal of ethnopharmacology. 2011 Oct; 137(3):1250-60. doi: 10.1016/j.jep.2011.07.054. [PMID: 21824511]
  • Dawu Wang, Minxun Xiao, Yirong Li, Xiaoling Shen, Yuanyuan Lu, Kanglun Liu, Zhenghong Li, Yingjie Hu. [Determination of longistylin A and longistylin C in Cajanus cajan]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Oct; 36(19):2680-3. doi: 10.4268/cjcmm20111916. [PMID: 22242429]
  • S Jisha, S Sreeja, S Manjula. In vitro & in vivo estrogenic activity of glycoside fractions of Solanum nigrum fruit. The Indian journal of medical research. 2011 Sep; 134(?):369-74. doi: ". [PMID: 21985821]