Cefoperazone (BioDeep_00000002202)

 

Secondary id: BioDeep_00000397465

human metabolite blood metabolite Chemicals and Drugs Antibiotics


代谢物信息卡片


(6R,7R)-7-[(2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)(hydroxy)methylidene]amino}-1-hydroxy-2-(4-hydroxyphenyl)ethylidene)amino]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C25H27N9O8S2 (645.1423942000001)
中文名称: 头孢哌酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O
InChI: InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1

描述信息

Cefoperazone is only found in individuals that have used or taken this drug. It is a semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.Like all beta-lactam antibiotics, cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DD - Third-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

17 个代谢物同义名

(6R,7R)-7-[(2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)(hydroxy)methylidene]amino}-1-hydroxy-2-(4-hydroxyphenyl)ethylidene)amino]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[(2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)(hydroxy)methylidene]amino}-1-hydroxy-2-(4-hydroxyphenyl)ethylidene)amino]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; (6R,7R)-7-[(2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)(hydroxy)methylidene]amino}-1-hydroxy-2-(4-hydroxyphenyl)ethylidene)amino]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; (6R,7R)-7-{2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetamido}-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Farmasierra brand OF cefoperazone sodium; Pfizer brand OF cefoperazone sodium; Salt, cefoperazone sodium; Sodium salt, cefoperazone; Cefoperazone sodium salt; Sodium, cefoperazone; Cefoperazone sodium; cefoperazonum; Cefoperazone; Cefoperazon; Céfobis; Cefoperazone Impurity F



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dongying Li, Yueyi Li, Jingyi Wang, Weifeng Yang, Kaiyu Cui, Renjing Su, Lu Li, Xing Ren, Xianyu Li, Yi Wang. In-depth analysis of the treatment effect and synergistic mechanism of TanReQing injection on clinical multi-drug resistant Pseudomonas aeruginosa. Microbiology spectrum. 2024 Apr; 12(4):e0272623. doi: 10.1128/spectrum.02726-23. [PMID: 38415603]
  • Xupeng Shao, Yuanyuan Ren, Na Xie, Kailiang Fan, Haiyan Sun, Jiamin Lu, Jiuxiang Wei, Xincheng Tian. Effect of Cefoperazone/Sulbactam on Blood Coagulation Function in Infected Emergency Department Patients and the Necessity of Vitamin K1 (VK1) Preventive Intervention: A Single-Center, Retrospective Analysis. Medical science monitor : international medical journal of experimental and clinical research. 2023 Jun; 29(?):e939203. doi: 10.12659/msm.939203. [PMID: 37271979]
  • Licai Mo, Jiajia Wang, Jiao Qian, Minfei Peng. Antibiotic Sensitivity of Proteus mirabilis Urinary Tract Infection in Patients with Urinary Calculi. International journal of clinical practice. 2022; 2022(?):7273627. doi: 10.1155/2022/7273627. [PMID: 36628152]
  • Nicholas A Lesniak, Alyxandria M Schubert, Hamide Sinani, Patrick D Schloss. Clearance of Clostridioides difficile Colonization Is Associated with Antibiotic-Specific Bacterial Changes. mSphere. 2021 05; 6(3):. doi: 10.1128/msphere.01238-20. [PMID: 33952668]
  • Christian Diener, Anna C H Hoge, Sean M Kearney, Ulrike Kusebauch, Sushmita Patwardhan, Robert L Moritz, Susan E Erdman, Sean M Gibbons. Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut. Communications biology. 2021 03; 4(1):316. doi: 10.1038/s42003-021-01841-8. [PMID: 33750910]
  • Yee-Huang Ku, Wen-Liang Yu. Cefoperazone/sulbactam: New composites against multiresistant gram negative bacteria?. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2021 03; 88(?):104707. doi: 10.1016/j.meegid.2021.104707. [PMID: 33418147]
  • Bo Zhao, Ji-Yu Chen, Ya-Bin Liao, Yan-Fang Li, Xue-Mei Jiang, Xin Bi, Mi-Feng Yang, Li Li, Jing-Jing Cui. Steroid-resistant nephrotic syndrome in infants caused by a novel compound heterozygous mutation of the NUP93: A CARE case report. Medicine. 2021 Feb; 100(6):e24627. doi: 10.1097/md.0000000000024627. [PMID: 33578576]
  • Kaihang Yu, Weiliang Zeng, Ye Xu, Wenli Liao, Wenya Xu, Tieli Zhou, Jianming Cao, Lijiang Chen. Bloodstream infections caused by ST2 Acinetobacter baumannii: risk factors, antibiotic regimens, and virulence over 6 years period in China. Antimicrobial resistance and infection control. 2021 01; 10(1):16. doi: 10.1186/s13756-020-00876-6. [PMID: 33461617]
  • Jun Miyoshi, Sonny T M Lee, Megan Kennedy, Mora Puertolas, Mary Frith, Jason C Koval, Sawako Miyoshi, Dionysios A Antonopoulos, Vanessa Leone, Eugene B Chang. Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model. Cellular and molecular gastroenterology and hepatology. 2021; 11(2):491-502. doi: 10.1016/j.jcmgh.2020.08.008. [PMID: 32835897]
  • Zhi Rao, Zi-Long Dang, Bin Li, Lei Zhu, Hong-Yan Qin, Xin-An Wu, Yu-Hui Wei. Determination of Total and Unbound Meropenem, Imipenem/Cilastatin, and Cefoperazone/Sulbactam in Human Plasma: Application for Therapeutic Drug Monitoring in Critically Ill Patients. Therapeutic drug monitoring. 2020 08; 42(4):578-587. doi: 10.1097/ftd.0000000000000736. [PMID: 32049891]
  • Min Kan, Yue-E Wu, Xue Li, Yi-Ning Dong, Bin Du, Zi-Xuan Guo, Hai-Yan Shi, Xin Huang, Le-Qun Su, Wen-Qi Wang, Yi Zheng, Wei Zhao. An adapted LC-MS/MS method for the determination of free plasma concentration of cefoperazone in children: Age-dependent protein binding. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 May; 1144(?):122081. doi: 10.1016/j.jchromb.2020.122081. [PMID: 32247185]
  • Matthew K Schnizlein, Kimberly C Vendrov, Summer J Edwards, Eric C Martens, Vincent B Young. Dietary Xanthan Gum Alters Antibiotic Efficacy against the Murine Gut Microbiota and Attenuates Clostridioides difficile Colonization. mSphere. 2020 01; 5(1):. doi: 10.1128/msphere.00708-19. [PMID: 31915217]
  • Liang Meng, Lingti Kong, Chenchen Wu, Benquan Qi, Xiaofei Wu. Pharmacokinetics of cefoperazone/sulbactam in plasma and cerebrospinal fluid in patients with intraventricular hemorrhage after external ventricular drains. European journal of clinical pharmacology. 2020 Jan; 76(1):127-129. doi: 10.1007/s00228-019-02773-3. [PMID: 31642959]
  • Fikret Türkan, Zübeyir Huyut, Yıldıray Basbugan, İlhami Gülçin. Influence of some β-lactam drugs on selected antioxidant enzyme and lipid peroxidation levels in different rat tissues. Drug and chemical toxicology. 2020 Jan; 43(1):27-36. doi: 10.1080/01480545.2019.1608230. [PMID: 31060396]
  • Yan Tan, Qianhui Song, Wenfang Liu, Ming Li, Jian Xiao, Chuanpin Chen. Dual-channel Microchip Electrophoresis with Amperometric Detection System for Rapid Analysis of Cefoperazone and Sulbactam. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2019 Oct; 35(10):1103-1109. doi: 10.2116/analsci.19p088. [PMID: 31231088]
  • Yuzhu Dong, Ying Li, Ying Zhang, Tao Zhang, Li Zhu, Yaling Dong, Taotao Wang. Cefoperazone/sulbactam therapeutic drug monitoring in patients with liver cirrhosis: Potential factors affecting the pharmacokinetic/pharmacodynamic target attainment. Basic & clinical pharmacology & toxicology. 2019 Oct; 125(4):353-359. doi: 10.1111/bcpt.13245. [PMID: 31056857]
  • Jack Guinan, Shaohua Wang, Tony R Hazbun, Hariom Yadav, Shankar Thangamani. Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans. Scientific reports. 2019 06; 9(1):8872. doi: 10.1038/s41598-019-45467-7. [PMID: 31222159]
  • Ashley D Smith, Elissa D Foss, Irma Zhang, Jessica L Hastie, Nicole P Giordano, Lusine Gasparyan, Lam Phuc VinhNguyen, Alyxandria M Schubert, Deepika Prasad, Hannah L McMichael, Jinchun Sun, Richard D Beger, Vahan Simonyan, Siobhán C Cowley, Paul E Carlson. Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection. PloS one. 2019; 14(9):e0223025. doi: 10.1371/journal.pone.0223025. [PMID: 31560732]
  • Mohamed Aboubakr, Ahmed Soliman, Kamil Uney, Muammer Elmas. Plasma disposition of cefoperazone after single intravenous and intramuscular administrations in camels (Camelus dromedarius). Acta veterinaria Hungarica. 2018 Sep; 66(3):444-450. doi: 10.1556/004.2018.039. [PMID: 30264621]
  • Jack Guinan, Shankar Thangamani. Antibiotic-induced alterations in taurocholic acid levels promote gastrointestinal colonization of Candida albicans. FEMS microbiology letters. 2018 09; 365(18):. doi: 10.1093/femsle/fny196. [PMID: 30137306]
  • Yun Cai, Deqing Yang, Jin Wang, Rui Wang. Amikacin and cefoperazone/sulbactam alone or in combination against carbapenem-resistant Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease. 2018 Jun; 91(2):186-190. doi: 10.1016/j.diagmicrobio.2018.01.023. [PMID: 29486972]
  • Hongbin Chen, Qi Wang, Yuyao Yin, Shuguang Li, Deng-Ke Niu, Hui Wang. Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. International journal of antimicrobial agents. 2018 Apr; 51(4):655-658. doi: 10.1016/j.ijantimicag.2017.12.006. [PMID: 29247687]
  • Xiu-Jun Wu, Xin Huang, Hai-Yan Shi, Xing-Kai Chen, Qian Dong, Guo-Xiang Hao, Yan Li, Yi Zheng, Wei Zhao. Determination of cefoperazone and sulbactam in serum by HPLC-MS/MS: An adapted method for therapeutic drug monitoring in children. Biomedical chromatography : BMC. 2018 Apr; 32(4):. doi: 10.1002/bmc.4143. [PMID: 29148595]
  • Fikret Türkan, Zübeyir Huyut, Parham Taslimi, İlhami Gülçin. The in vivo effects of cefazolin, cefuroxime, and cefoperazon on the carbonic anhydrase in different rat tissues. Journal of biochemical and molecular toxicology. 2018 Mar; 32(3):e22041. doi: 10.1002/jbt.22041. [PMID: 29457666]
  • Bülent Şengül, Şükrü Beydemir. The interactions of cephalosporins on polyol pathway enzymes from sheep kidney. Archives of physiology and biochemistry. 2018 Feb; 124(1):35-44. doi: 10.1080/13813455.2017.1358749. [PMID: 28758816]
  • Linsheng Liu, Chenrong Huang, Yicong Bian, Liyan Miao. GC-MS based metabolomics of CSF and blood serum: Metabolic phenotype for a rat model of cefoperazone-induced disulfiram-like reaction. Biochemical and biophysical research communications. 2017 08; 490(3):1066-1073. doi: 10.1016/j.bbrc.2017.06.167. [PMID: 28668395]
  • Imran Ali, Muhammad Shabbir. Antibiotics susceptibility patterns of uropathogenic E. coli with special reference to fluoroquinolones in different age and gender groups. JPMA. The Journal of the Pakistan Medical Association. 2017 Aug; 67(8):1161-1165. doi: NULL. [PMID: 28839298]
  • Lei Yan, Chun-Rong Wu, Chen Wang, Chun-Hui Yang, Guang-Zhi Tong, Jian-Guo Tang. Effect of Candida albicans on Intestinal Ischemia-reperfusion Injury in Rats. Chinese medical journal. 2016 Jul; 129(14):1711-8. doi: 10.4103/0366-6999.185862. [PMID: 27411459]
  • Dong Hao, Zhencai Hu, Xiaoli Liu, Ting Sun, Tao Wang, Huanhuan Tian, Xiaozhi Wang. [Analysis of the distribution characteristics and drug resistance of non-fermenting bacterial infection in intensive care unit from 2009 to 2015]. Zhonghua wei zhong bing ji jiu yi xue. 2016 May; 28(5):439-44. doi: NULL. [PMID: 29920041]
  • Palak Gupta, Jharna Mandal, Sriram Krishnamurthy, Deepak Barathi, Nandini Pandit. Profile of urinary tract infections in paediatric patients. The Indian journal of medical research. 2015 Apr; 141(4):473-7. doi: 10.4103/0971-5916.159299. [PMID: 26112850]
  • Qiang Wang, Yuanxing Wu, Biyao Chen, Jianxin Zhou. Drug concentrations in the serum and cerebrospinal fluid of patients treated with cefoperazone/sulbactam after craniotomy. BMC anesthesiology. 2015; 15(?):33. doi: 10.1186/s12871-015-0012-1. [PMID: 25798070]
  • Sema Aşkin Keçeli, Ayse Willke, Gulden Sonmez Tamer, Ozden Buyukbaba Boral, Nese Sonmez, Penbe Cağatay. Interaction between caspofungin or voriconazole and cefoperazone-sulbactam or piperacillin-tazobactam by in vitro and in vivo methods. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2014 May; 122(5):412-7. doi: 10.1111/apm.12159. [PMID: 24033828]
  • Yun-Gi Kim, Kankanam Gamage Sanath Udayanga, Naoya Totsuka, Jason B Weinberg, Gabriel Núñez, Akira Shibuya. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. Cell host & microbe. 2014 Jan; 15(1):95-102. doi: 10.1016/j.chom.2013.12.010. [PMID: 24439901]
  • Aaron T Wolman, Michael R Gionfriddo, Gregory A Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy, Adam L Vanwert. Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. Drug metabolism and disposition: the biological fate of chemicals. 2013 Apr; 41(4):791-800. doi: 10.1124/dmd.112.049569. [PMID: 23344796]
  • Ken Grime, Stuart W Paine. Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. Drug metabolism and disposition: the biological fate of chemicals. 2013 Feb; 41(2):372-8. doi: 10.1124/dmd.112.049312. [PMID: 23139379]
  • Bai-Yu Zhang, Si-Man Li, Zheng-Hua Gao, Ji-Hong Shen. [Protective effects of snake venom antimicrobial peptide OH-CATH on E. coli induced rabbit urinary tract infection models]. Dong wu xue yan jiu = Zoological research. 2013 Feb; 34(1):27-32. doi: 10.3724/sp.j.1141.2013.01027. [PMID: 23389975]
  • Manjusha Patankar, Sangita Sukumaran, Anita Chhibba, Usha Nayak, Loraine Sequeira. Comparative in-vitro activity of cefoperazone-tazobactam and cefoperazone-sulbactam combinations against ESBL pathogens in respiratory and urinary infections. The Journal of the Association of Physicians of India. 2012 Nov; 60(?):22-4. doi: . [PMID: 23767198]
  • Tuba Kayman, Seçil Abay, Harun Hizlisoy, H İbrahim Atabay, K Serdar Diker, Fuat Aydin. Emerging pathogen Arcobacter spp. in acute gastroenteritis: molecular identification, antibiotic susceptibilities and genotyping of the isolated arcobacters. Journal of medical microbiology. 2012 Oct; 61(Pt 10):1439-1444. doi: 10.1099/jmm.0.044594-0. [PMID: 22700547]
  • M Ugarte-Ruiz, S Gómez-Barrero, M C Porrero, J Alvarez, M García, M C Comerón, T M Wassenaar, L Domínguez. Evaluation of four protocols for the detection and isolation of thermophilic Campylobacter from different matrices. Journal of applied microbiology. 2012 Jul; 113(1):200-8. doi: 10.1111/j.1365-2672.2012.05323.x. [PMID: 22533742]
  • Aurijit Sarkar, Kelcey C Anderson, Glen E Kellogg. Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. European journal of medicinal chemistry. 2012 Jun; 52(?):98-110. doi: 10.1016/j.ejmech.2012.03.008. [PMID: 22483632]
  • Faisal Iqbal Afridi, Badar Jahan Farooqi. Activity of beta-lactam beta-lactamase inhibitor combinations against extended spectrum Beta-lactamase producing Enterobacteriaceae in urinary isolates. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2012 Jun; 22(6):358-62. doi: 06.2012/jcpsp.358362. [PMID: 22630093]
  • Y F Chen, R S Liang, X L Zhuo, X T Wu, J X Zou. Isolation and characterization of Aeromonas schubertii from diseased snakehead, Channa maculata (Lacepède). Journal of fish diseases. 2012 Jun; 35(6):421-30. doi: 10.1111/j.1365-2761.2012.01362.x. [PMID: 22524539]
  • Iram Shaifali, Uma Gupta, Syed Esam Mahmood, Jawed Ahmed. Antibiotic susceptibility patterns of urinary pathogens in female outpatients. North American journal of medical sciences. 2012 Apr; 4(4):163-9. doi: 10.4103/1947-2714.94940. [PMID: 22536558]
  • Ozlem Kurşun, Nesrin Unal, Salih Cesur, Nilgün Altın, Başol Canbakan, Cem Argun, Kamer Koldaş, Irfan Sencan. [A case of ventilator-associated pneumonia due to Pantoea agglomerans]. Mikrobiyoloji bulteni. 2012 Apr; 46(2):295-8. doi: NULL. [PMID: 22639319]
  • N Poudyal, N Gyawali, R Gurung, N R Bhattarai, R Baral, B Khanal, S Shrestha, R Amatya, S K Bhattacharya. In vitro activity of cefoperazone-sulbactam combination against gram negative bacilli. Nepal Medical College journal : NMCJ. 2012 Mar; 14(1):5-8. doi: . [PMID: 23441486]
  • Hye Won Hwang, Jee Hyun Kong, Dong Wook Yu, Woo Taek Kim, Hyun Soo Kim, Chong In Lee. A patient with acquired hemophilia A induced by clopidogrel. The Korean journal of hematology. 2012 Mar; 47(1):80-2. doi: 10.5045/kjh.2012.47.1.80. [PMID: 22479283]
  • Dirk R de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C Paulusma, Ronald P J Oude Elferink. Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):515-21. doi: 10.1124/dmd.111.041731. [PMID: 22166395]
  • Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda, Yuichi Sugiyama. In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):602-9. doi: 10.1124/dmd.111.042101. [PMID: 22190695]
  • A Duarte, S Ferreira, F Silva, F C Domingues. Synergistic activity of coriander oil and conventional antibiotics against Acinetobacter baumannii. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Feb; 19(3-4):236-8. doi: 10.1016/j.phymed.2011.11.010. [PMID: 22240078]
  • Brian B Oakley, Cesar A Morales, J Eric Line, Bruce S Seal, Kelli L Hiett. Application of high-throughput sequencing to measure the performance of commonly used selective cultivation methods for the foodborne pathogen Campylobacter. FEMS microbiology ecology. 2012 Feb; 79(2):327-36. doi: 10.1111/j.1574-6941.2011.01219.x. [PMID: 22092388]
  • Yi-Tsung Lin, L Kristopher Siu, Jung-Chung Lin, Te-Li Chen, Chih-Peng Tseng, Kuo-Ming Yeh, Feng-Yee Chang, Chang-Phone Fung. Seroepidemiology of Klebsiella pneumoniae colonizing the intestinal tract of healthy Chinese and overseas Chinese adults in Asian countries. BMC microbiology. 2012 Jan; 12(?):13. doi: 10.1186/1471-2180-12-13. [PMID: 22260182]
  • Praveen Kumar Kolla, Desai Madhav, Satish Reddy, Suneetha Pentyala, Panil Kumar, Rama Mohan Pathapati. Clinical profile and outcome of conservatively managed emphysematous pyelonephritis. ISRN urology. 2012; 2012(?):931982. doi: 10.5402/2012/931982. [PMID: 22567427]
  • V C C Cheng, W C Yam, O T C Lam, J L Y Tsang, E Y F Tse, G K H Siu, J F W Chan, H Tse, K K W To, J W M Tai, P L Ho, K Y Yuen. Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2011 Nov; 30(11):1371-81. doi: 10.1007/s10096-011-1231-0. [PMID: 21468685]
  • Meher Rizvi, Fatima Khan, Indu Shukla, Abida Malik, Shaheen. Rising prevalence of antimicrobial resistance in urinary tract infections during pregnancy: necessity for exploring newer treatment options. Journal of laboratory physicians. 2011 Jul; 3(2):98-103. doi: 10.4103/0974-2727.86842. [PMID: 22219563]
  • M Ishak Yıldırım, H Murat Tuğrul. [Assessment of efficacies of imipenem, cefoperazone-sulbactam and cefepime in rats with experimental thigh abscess model with multidrug resistant and susceptible Acinetobacter baumannii strains]. Mikrobiyoloji bulteni. 2011 Jul; 45(3):422-9. doi: . [PMID: 21935775]
  • Sarah De Smet, Peter Vandamme, Lieven De Zutter, Stephen L W On, Laid Douidah, Kurt Houf. Arcobacter trophiarum sp. nov., isolated from fattening pigs. International journal of systematic and evolutionary microbiology. 2011 Feb; 61(Pt 2):356-361. doi: 10.1099/ijs.0.022665-0. [PMID: 20305065]
  • Lucie Seyler, Frédéric Cotton, Fabio Silvio Taccone, Daniel De Backer, Pascale Macours, Jean-Louis Vincent, Frédérique Jacobs. Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Critical care (London, England). 2011; 15(3):R137. doi: 10.1186/cc10257. [PMID: 21649882]
  • Gian Maria Pacifici. Pharmacokinetics of cephalosporins in the neonate: a review. Clinics (Sao Paulo, Brazil). 2011; 66(7):1267-74. doi: 10.1590/s1807-59322011000700024. [PMID: 21876985]
  • Yasser M Sanad, Issmat I Kassem, Melanie Abley, Wondwossen Gebreyes, Jeffrey T LeJeune, Gireesh Rajashekara. Genotypic and phenotypic properties of cattle-associated Campylobacter and their implications to public health in the USA. PloS one. 2011; 6(10):e25778. doi: 10.1371/journal.pone.0025778. [PMID: 22046247]
  • Patrick D Vigil, Ann E Stapleton, James R Johnson, Thomas M Hooton, Andrew P Hodges, Yongqun He, Harry L T Mobley. Presence of putative repeat-in-toxin gene tosA in Escherichia coli predicts successful colonization of the urinary tract. mBio. 2011; 2(3):e00066-11. doi: 10.1128/mbio.00066-11. [PMID: 21540363]
  • Y O Adesiji, A O Coker, J K Oloke. Detection of Arcobacter in feces of healthy chickens in Osogbo, Nigeria. Journal of food protection. 2011 Jan; 74(1):119-21. doi: 10.4315/0362-028x.jfp-10-231. [PMID: 21219772]
  • Iman K Behiry, Emad A Abada, Entsar A Ahmed, Rania S Labeeb. Enteropathogenic Escherichia coli associated with diarrhea in children in Cairo, Egypt. TheScientificWorldJournal. 2011; 11(?):2613-9. doi: 10.1100/2011/485381. [PMID: 22262949]
  • Susanne Schjørring, Karen A Krogfelt. Assessment of bacterial antibiotic resistance transfer in the gut. International journal of microbiology. 2011; 2011(?):312956. doi: 10.1155/2011/312956. [PMID: 21318188]
  • Zhuming Wang, Zhenghua Song, Donghua Chen. Study on the binding behavior of bovine serum albumin with cephalosporin analogues by chemiluminescence method. Talanta. 2010 Dec; 83(2):312-9. doi: 10.1016/j.talanta.2010.09.029. [PMID: 21111139]
  • Yingjie Zhou, Jing Zhang, Beining Guo, Jicheng Yu, Yaoguo Shi, Minggui Wang, Yingyuan Zhang. Liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of cefoperazone and sulbactam in plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Nov; 878(30):3119-24. doi: 10.1016/j.jchromb.2010.09.021. [PMID: 20971044]
  • P Cagnardi, R Villa, M Gallo, C Locatelli, S Carli, P Moroni, A Zonca. Cefoperazone sodium preparation behavior after intramammary administration in healthy and infected cows. Journal of dairy science. 2010 Sep; 93(9):4105-10. doi: 10.3168/jds.2010-3379. [PMID: 20723685]
  • Yun Cai, Ran Li, Beibei Liang, Nan Bai, Youning Liu, Rui Wang. In vitro antimicrobial activity and mutant prevention concentration of colistin against Acinetobacter baumannii. Antimicrobial agents and chemotherapy. 2010 Sep; 54(9):3998-9. doi: 10.1128/aac.00264-10. [PMID: 20585134]
  • Roberto Rivera-Sanchez, Dolores Delgado-Ochoa, Rocio R Flores-Paz, Elvia E García-Jiménez, Ramon Espinosa-Hernández, Andres A Bazan-Borges, Myriam Arriaga-Alba. Prospective study of urinary tract infection surveillance after kidney transplantation. BMC infectious diseases. 2010 Aug; 10(?):245. doi: 10.1186/1471-2334-10-245. [PMID: 20723254]
  • Jharna Mandal, Nivedita Mondal, S Mahadevan, Subhash Chandra Parija. Emergence of resistance to third-generation cephalosporin in Shigella--a case report. Journal of tropical pediatrics. 2010 Aug; 56(4):278-9. doi: 10.1093/tropej/fmp118. [PMID: 19955258]
  • Yong Yan, Guo-lin Yue. [Effect of auxiliary Chinese medicine drug therapy via percutaneous medication in treating 78 patients with infantile pneumonia]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2010 Jul; 30(7):772-3. doi: ". [PMID: 20929144]
  • Manmeet Jhawar, Pratish George, Basant Pawar. Salmonella typhi sepsis and rhabdomyolysis with acute renal failure: a rare presentation of a common disease. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2010 Jul; 21(4):732-4. doi: NULL. [PMID: 20587882]
  • Ji-Young Rhee, Young Kyoung Park, Joo Yeon Shin, Ji Young Choi, Mi Young Lee, Kyong Ran Peck, Jae-Hoon Song, Kwan Soo Ko. KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. Antimicrobial agents and chemotherapy. 2010 May; 54(5):2278-9. doi: 10.1128/aac.00011-10. [PMID: 20211897]
  • Biljana Miljković-Selimović, Dragana Lavrnić, Olga Morić, Lai-King Ng, Lawrence Price, Ljubica Suturkova, Branislava Kocic, Tatjana Babić, Ljiljana Ristić, Slobodan Apostolski. Enteritis caused by Campylobacter jejuni followed by acute motor axonal neuropathy: a case report. Journal of medical case reports. 2010 Mar; 4(?):101. doi: 10.1186/1752-1947-4-101. [PMID: 20356396]
  • Melissa A Miller, Barbara A Byrne, Spencer S Jang, Erin M Dodd, Elene Dorfmeier, Michael D Harris, Jack Ames, David Paradies, Karen Worcester, David A Jessup, Woutrina A Miller. Enteric bacterial pathogen detection in southern sea otters (Enhydra lutris nereis) is associated with coastal urbanization and freshwater runoff. Veterinary research. 2010 Jan; 41(1):1. doi: 10.1051/vetres/2009049. [PMID: 19720009]
  • Mitesh H Patel, Grishma R Trivedi, Sachin M Patel, Mahendra M Vegad. Antibiotic susceptibility pattern in urinary isolates of gram negative bacilli with special reference to AmpC β-lactamase in a tertiary care hospital. Urology annals. 2010 Jan; 2(1):7-11. doi: 10.4103/0974-7796.62915. [PMID: 20842250]
  • Mu Li, Lin-Chuan Liao, You-Yi Yan, Lin Yang, Xiao-Min Liu, Jin Dai, Xiao-Na Ma, Xin Sheng, Hong Huang, Gui Su. [Analysis of multiple cephalosporins in blood and urine by HPLC]. Fa yi xue za zhi. 2009 Dec; 25(6):437-9. doi: NULL. [PMID: 20225621]
  • Emirhan Nemutlu, Sedef Kir, Doruk Katlan, M Sinan Beksaç. Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and quantification of cefepime, cefixime and cefoperazone. Talanta. 2009 Nov; 80(1):117-26. doi: 10.1016/j.talanta.2009.06.034. [PMID: 19782200]
  • Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry. 2009 Nov; 44(11):4455-60. doi: 10.1016/j.ejmech.2009.06.004. [PMID: 19586686]
  • Lichuan Niu, Zhenghua Song, Xili He. A study of the chemiluminescence behavior of cephalosporins with luminol and its analytical application. Drug metabolism letters. 2009 Aug; 3(3):144-51. doi: 10.2174/187231209789352157. [PMID: 19702549]
  • J Janifer, S Geethalakshmi, K Satyavani, V Viswanathan. Prevalence of lower urinary tract infection in South Indian type 2 diabetic subjects. Indian journal of nephrology. 2009 Jul; 19(3):107-11. doi: 10.4103/0971-4065.57107. [PMID: 20436730]
  • Guillermo Figueroa, Miriam Troncoso, Cristián López, Patricia Rivas, Magaly Toro. Occurrence and enumeration of Campylobacter spp. during the processing of Chilean broilers. BMC microbiology. 2009 May; 9(?):94. doi: 10.1186/1471-2180-9-94. [PMID: 19445680]
  • Wen-Kui Wang, Li-Zhong Han, Li Yang, Yu-Xing Ni. [Analysis of the molecular epidemiology and distribution of pathogenic bacteria in burn wards of Ruijin Hospital from 2004 to 2006]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2009 Apr; 25(2):94-7. doi: NULL. [PMID: 19799031]
  • Kamil Cam, Ali Kayikci, Ali Erol. Prospective evaluation of the efficacy of antibiotic prophylaxis before cystoscopy. Indian journal of urology : IJU : journal of the Urological Society of India. 2009 Apr; 25(2):203-6. doi: 10.4103/0970-1591.52914. [PMID: 19672347]
  • Janina Drozd, Elzbieta Anuszewska. Effects of bilberry fruit aqueous extract and selected antibiotics on immune response in mice. Acta poloniae pharmaceutica. 2009 Mar; 66(2):181-5. doi: NULL. [PMID: 19719053]
  • Nehaya Al-Karablieh, Helge Weingart, Matthias S Ullrich. Genetic exchange of multidrug efflux pumps among two enterobacterial species with distinctive ecological Niches. International journal of molecular sciences. 2009 Feb; 10(2):629-645. doi: 10.3390/ijms10020629. [PMID: 19333425]
  • Ritu Aggarwal, Uma Chaudhary, Rama Sikka. Detection of Extended Spectrum β-lactamase Production Among Uropathogens. Journal of laboratory physicians. 2009 Jan; 1(1):7-10. doi: 10.4103/0974-2727.44423. [PMID: 21938241]
  • Sayam Kaewvichit, Songwut Yotsawimonwat, Wandee Taesotikul, Wirat Niwatananun, Chadarat Duangrat, Chokchai Wongsinsup, Satawat Thongsawat, Parichat Salee. Bioequivalence study of the two 1.5 g cefoperazone and sulbactam IM injections in Thai healthy male volunteers. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2008 Nov; 91(11):1760-4. doi: NULL. [PMID: 19127801]
  • Ji-Rong Yang, Ho-Sheng Wu, Chuen-Sheue Chiang, Jung-Jung Mu. Pediatric campylobacteriosis in northern Taiwan from 2003 to 2005. BMC infectious diseases. 2008 Oct; 8(?):151. doi: 10.1186/1471-2334-8-151. [PMID: 18973701]
  • Ch Kua, Yf Abdul Aziz. Air in the kidney: between emphysematous pyelitis and pyelonephritis. Biomedical imaging and intervention journal. 2008 Oct; 4(4):e24. doi: 10.2349/biij.4.4.e24. [PMID: 21611013]
  • Viren A Javiya, Somsuvra B Ghatak, Kamlesh R Patel, Jagruti A Patel. Antibiotic susceptibility patterns of Pseudomonas aeruginosa at a tertiary care hospital in Gujarat, India. Indian journal of pharmacology. 2008 Oct; 40(5):230-4. doi: 10.4103/0253-7613.44156. [PMID: 20040963]
  • Zi-qing Hei, Xiao-liang Gan, Pin-jie Huang, Jing Wei, Ning Shen, Wan-ling Gao. Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats. BMC gastroenterology. 2008 Sep; 8(?):42. doi: 10.1186/1471-230x-8-42. [PMID: 18808687]
  • Hajime Fukuda, Rikiya Ohashi, Minoru Tsuda-Tsukimoto, Ikumi Tamai. Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1275-82. doi: 10.1124/dmd.107.019026. [PMID: 18388177]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Yukio Kato, Seiko Takahara, Sayaka Kato, Yoshiyuki Kubo, Yoshimichi Sai, Ikumi Tamai, Hikaru Yabuuchi, Akira Tsuji. Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jun; 36(6):1088-96. doi: 10.1124/dmd.107.019125. [PMID: 18339814]
  • Yu He, He-Fang Wang, Xiu-Ping Yan. Exploring Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of enoxacin in biological fluids. Analytical chemistry. 2008 May; 80(10):3832-7. doi: 10.1021/ac800100y. [PMID: 18407673]
  • Melek Demir, Nural Cevahir, Ilknur Kaleli, Umut Yildirim, Rasim Sahin, Ebru Cevik Tepeli. [Investigation of siderophore, total matrix protease and elastase activity in Pseudomonas aeruginosa isolates from lower respiratory tract and extra-respiratory tract samples]. Mikrobiyoloji bulteni. 2008 Apr; 42(2):197-208. doi: . [PMID: 18697417]
  • Shun-Bin Wang, Xiao-Dong Chen, Bo-Yu Wu, Qiong Jiang, Ji-Hui Yang. [Changes in the plasma levels of endotoxin in severe burn patients under the treatment of antibiotics]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2008 Apr; 24(2):87-9. doi: NULL. [PMID: 18785403]
  • Sheng Lou, Wei Li, Qin Hu. Influence of cefoperazone and azithromycin on the pharmacokinetics of pazufloxacin in rats. European journal of drug metabolism and pharmacokinetics. 2007 Oct; 32(4):219-23. doi: 10.1007/bf03191007. [PMID: 18348471]
  • Shenghui Fu, Zhongfang Liu, Shaopu Liu, Jangtao Liu, Aoer Yi. Study on the resonance Rayleigh scattering spectra of the interactions of palladium (II)-cephalosporins chelates with 4,5-dibromofluorescein and their analytical applications. Analytica chimica acta. 2007 Sep; 599(2):271-8. doi: 10.1016/j.aca.2007.07.071. [PMID: 17870290]