Ifosfamide (BioDeep_00000002193)

 

Secondary id: BioDeep_00000398868

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

化学式: C7H15Cl2N2O2P (260.024816)
中文名称: 异环磷酰胺
谱图信息: 最多检出来源 Homo sapiens(blood) 1.46%

分子结构信息

SMILES: C1CN(CCCl)P(=O)(NCCCl)OC1
InChI: InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)

描述信息

Ifosfamide is only found in individuals that have used or taken this drug. It is a positional isomer of cyclophosphamide which is active as an alkylating agent and an immunosuppressive agent. [PubChem]The exact mechanism of ifosfamide has not been determined, but appears to be similar to other alkylating agents. Ifosfamide requires biotransformation in the liver by mixed-function oxidases (cytochrome P450 system) before it becomes active. After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily through the alkylation of DNA, done by attaching the N-7 position of guanine to its reactive electrophilic groups. The formation of inter and intra strand cross-links in the DNA results in cell death.
CONFIDENCE standard compound; INTERNAL_ID 895; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7346; ORIGINAL_PRECURSOR_SCAN_NO 7344
CONFIDENCE standard compound; INTERNAL_ID 895; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7289; ORIGINAL_PRECURSOR_SCAN_NO 7287
CONFIDENCE standard compound; INTERNAL_ID 895; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7327; ORIGINAL_PRECURSOR_SCAN_NO 7323
CONFIDENCE standard compound; INTERNAL_ID 895; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7274; ORIGINAL_PRECURSOR_SCAN_NO 7272
CONFIDENCE standard compound; INTERNAL_ID 895; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7310; ORIGINAL_PRECURSOR_SCAN_NO 7308
CONFIDENCE standard compound; INTERNAL_ID 895; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7330; ORIGINAL_PRECURSOR_SCAN_NO 7329
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AA - Nitrogen mustard analogues
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2683
CONFIDENCE standard compound; INTERNAL_ID 2723
D009676 - Noxae > D000477 - Alkylating Agents

同义名列表

20 个代谢物同义名

3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2lambda5-oxazaphosphinan-2-one; Ifosfamide sterile; Isophosphamide; I-phosphamide; Iphosphamide; Isofosfamide; Ifosfamidum; Iphosphamid; Iso endoxan; Asta Z 4942; Ifosphamide; Iso-endoxan; ifosfamide; Isosfamide; Ifsofamide; Ifosfamida; Ifosfamid; Holoxan; Ifex



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

  • Ifosfamide Action Pathway: Ifosfamide + Oxygen + Water ⟶ 2-Dechloroethylifosfamide + 3-Dechloroethylifosfamide + Chloroacetaldehyde + Hydrogen peroxide
  • Ifosfamide Metabolism Pathway: Ifosfamide + Oxygen + Water ⟶ 2-Dechloroethylifosfamide + 3-Dechloroethylifosfamide + Chloroacetaldehyde + Hydrogen peroxide

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mai M Younis, Iriny M Ayoub, Mina Y George, Nada M Mostafa, Omayma A Eldahshan. In vivo hepatoprotective and nephroprotective effects of Stenocarpus sinuatus leaf extract against ifosfamide-induced toxicity in rats. Archiv der Pharmazie. 2024 Feb; 357(2):e2300438. doi: 10.1002/ardp.202300438. [PMID: 37984852]
  • Ahmad Salimi, Saleh Khezri, Sepideh Azizian, Vida Kamrani, Nima Amir Jahadi, Mehdi Shahedi. Evaluation of in vitro effects of ifosfamide drug on mitochondrial functions using isolated mitochondria obtained from vital organs. Journal of biochemical and molecular toxicology. 2023 Nov; ?(?):e23570. doi: 10.1002/jbt.23570. [PMID: 37929796]
  • Abdollah Arjmand, Melika Mashhadi, Armin Kaveh, Farzaneh Kamranfar, Enayatollah Seydi, Jalal Pourahmad. Mitochondrial Transplantation Therapy against Ifosfamide Induced Toxicity on Rat Renal Proximal Tubular Cells. Drug research. 2023 Feb; 73(2):113-120. doi: 10.1055/a-1967-2066. [PMID: 36395822]
  • Pengfei Hu, Jinchi Ying, Yusu Wang, Tiantian Jiang, Zheng Pan, Chen Zhao, Jiping Li, Chunyi Li. Extracellular Vesicles Derived From 3D Cultured Antler Stem Cells Serve as a New Drug Vehicle in Osteosarcoma Treatment. Cell transplantation. 2023 Jan; 32(?):9636897231219830. doi: 10.1177/09636897231219830. [PMID: 38102784]
  • Ahmad Salimi, Mohammad Shabani, Hossein Mohammadi, Vahid Sudi. Intraperitoneal pretreatment of ellagic acid and chrysin alleviate ifosfamide-induced neurotoxicity, but betanin induces death in male wistar rats. Human & experimental toxicology. 2023 Jan; 42(?):9603271221147883. doi: 10.1177/09603271221147883. [PMID: 36951984]
  • Selim Çomaklı, Fatih Mehmet Kandemir, Sefa Küçükler, Selçuk Özdemir. Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB/p53 and Bcl-2 expression. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2022 Aug; 97(6):423-432. doi: 10.1080/10520295.2021.2021449. [PMID: 35037524]
  • Eline Verscheure, Matteo Creta, Dorian Vanneste, Jeroen Vanoirbeek, Meziane Zakia, Taleb Abdesselam, Robin Lebegge, Katrien Poels, Manosij Ghosh, Radu-Corneliu Duca, Lode Godderis. Quantification of three antineoplastic agents in urine using the UniSpray ionisation source. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Aug; 1205(?):123331. doi: 10.1016/j.jchromb.2022.123331. [PMID: 35752139]
  • Saliha Sarfraz, Haleema Saeed. Feasibility and safety of outpatient administration of ifosfamide and etoposide for pediatric patients with Ewing sarcoma in a resource-limited setting amid the COVID-19 pandemic. Pediatric blood & cancer. 2022 05; 69(5):e29595. doi: 10.1002/pbc.29595. [PMID: 35234343]
  • Cindy Banh, Kendall Valsvik, Alejandra Arredondo, Kassie Notbohm, Emad Elquza, Hani Babiker, Andrew Kraft, Alejandro Recio Boiles, Daniel Persky, Alicia Ortega, Ali McBride. Transitioning ifosfamide chemotherapy regimens to the ambulatory setting: reviewing cost savings and safety profile. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2022 Mar; 30(3):2755-2766. doi: 10.1007/s00520-021-06653-4. [PMID: 34825982]
  • Alissa Groenendijk, Harm van Tinteren, Yilin Jiang, Ronald R de Krijger, Gordan M Vujanic, Jan Godzinski, Christian Rübe, Jens-Peter Schenk, Carlo Morosi, Kathy Pritchard-Jones, Reem Al-Saadi, Sucheta J Vaidya, Arnauld C Verschuur, Gema L Ramírez-Villar, Norbert Graf, Beatriz de Camargo, Jarno Drost, Daniela Perotti, Marry M van den Heuvel-Eibrink, Jesper Brok, Filippo Spreafico, Annelies M C Mavinkurve-Groothuis. Outcome of SIOP patients with low- or intermediate-risk Wilms tumour relapsing after initial vincristine and actinomycin-D therapy only - the SIOP 93-01 and 2001 protocols. European journal of cancer (Oxford, England : 1990). 2022 03; 163(?):88-97. doi: 10.1016/j.ejca.2021.12.014. [PMID: 35042071]
  • Yun Jung Bae, Hyojin Kim, Wonjae Cha, Byung Se Choi. Primary pharyngeal synovial sarcoma in a pediatric patient: A case report. Medicine. 2021 Dec; 100(52):e28411. doi: 10.1097/md.0000000000028411. [PMID: 34967377]
  • Jill N Modi, Sarah K Cimino. Incidence of ifosfamide induced encephalopathy in patients receiving concomitant fosaprepitant. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2021 Dec; 27(8):1891-1895. doi: 10.1177/1078155220971794. [PMID: 33166244]
  • Alice Paul, Anita Duncan, Justine Bacchetta, Laurence Dubourg, Perrine Marec-Bérard, Corentin Tanné. Chronic kidney disease consecutive to chemotherapy for chondroblastic osteosarcoma: A report on 6 pediatric cases. Nephrologie & therapeutique. 2021 Dec; 17(7):543-546. doi: 10.1016/j.nephro.2021.05.004. [PMID: 34229968]
  • Hyoung-Yun Han, Mi-Sun Choi, Seokjoo Yoon, Je-Won Ko, Sang-Kyum Kim, Tae-Won Kim. Investigation of Ifosfamide Toxicity Induces Common Upstream Regulator in Liver and Kidney. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212201. [PMID: 34830083]
  • Antoine Villa, Mathieu Molimard, Dunia Sakr, Régis Lassalle, Emmanuelle Bignon, Béatrice Martinez, Magali Rouyer, Simone Mathoulin-Pelissier, Isabelle Baldi, Catherine Verdun-Esquer, Mireille Canal-Raffin. Nurses' internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study. International archives of occupational and environmental health. 2021 Nov; 94(8):1839-1850. doi: 10.1007/s00420-021-01706-x. [PMID: 34021808]
  • Noriko Yamaguchi, Yoshinobu Hamada, Risa Inagaki, Kohei Nemoto, Hideyuki Yoshitomi, Satoshi Takakura. Successful salvage treatment with paclitaxel, ifosfamide, and cisplatin in a patient with methotrexate-resistant gestational trophoblastic neoplasia who developed hypersensitivity reaction to etoposide. The journal of obstetrics and gynaecology research. 2021 Oct; 47(10):3737-3741. doi: 10.1111/jog.14945. [PMID: 34278664]
  • Shruti Gupta, Ignacio Portales-Castillo, Amir Daher, Abhijat Kitchlu. Conventional Chemotherapy Nephrotoxicity. Advances in chronic kidney disease. 2021 09; 28(5):402-414.e1. doi: 10.1053/j.ackd.2021.08.001. [PMID: 35190107]
  • Shinya Shimizu, Yuichi Hayashi, Shohei Nishida, Hironori Fujii, Mitsuhiro Nakamura, Nobuaki Yoshikura, Akihito Nagano, Junichi Kitagawa, Nobuhiro Kanemura, Kosuke Mizutani, Ryo Kobayashi, Takuma Ishihara, Hideki Hayashi, Takayoshi Shimohata, Tadashi Sugiyama, Akio Suzuki. Albumin-bilirubin score for predicting neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy. Journal of clinical pharmacy and therapeutics. 2021 Jun; 46(3):794-799. doi: 10.1111/jcpt.13355. [PMID: 33393716]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Christine Chevreau, Christophe Massard, Aude Flechon, Rémy Delva, Gwenaëlle Gravis, Jean-Pierre Lotz, Jacques-Olivier Bay, Marine Gross-Goupil, Karim Fizazi, Loïc Mourey, Angelo Paci, Jérôme Guitton, Fabienne Thomas, Bénédicte Lelièvre, Joseph Ciccolini, Sotheara Moeung, Yohan Gallois, Pascale Olivier, Stéphane Culine, Thomas Filleron, Etienne Chatelut. Multicentric phase II trial of TI-CE high-dose chemotherapy with therapeutic drug monitoring of carboplatin in patients with relapsed advanced germ cell tumors. Cancer medicine. 2021 04; 10(7):2250-2258. doi: 10.1002/cam4.3687. [PMID: 33675184]
  • Shazia Ilyas, Raheela Tabasum, Ali Iftikhar, Mamoona Nazir, Amina Hussain, Aroosha Hussain, Muhammad Sajjad Ali, Farooq Saleem, Uzma Saleem, Matheus Froeyen, Iskandar Abdullah, Muhammad Usman Mirza, Sarfraz Ahmad. Effect of Berberis vulgaris L. root extract on ifosfamide-induced in vivo toxicity and in vitro cytotoxicity. Scientific reports. 2021 01; 11(1):1708. doi: 10.1038/s41598-020-80579-5. [PMID: 33462261]
  • Marie Lambert, Melanie White-Koning, Mathieu Alonso, Arnaud Garnier, Gwennaelle Alphonsa, Chloé Puiseux, Caroline Munzer, Joseph Berthier, Laurence Malard, Marlène Pasquet, Etienne Chatelut. Plasma cystatin C is a marker of renal glomerular injury in children treated with cisplatin or ifosfamide. Pediatric blood & cancer. 2021 01; 68(1):e28747. doi: 10.1002/pbc.28747. [PMID: 33058496]
  • Matthew R Trendowski, Heather E Wheeler, Omar El-Charif, Darren R Feldman, Robert J Hamilton, David J Vaughn, Chunkit Fung, Christian Kollmannsberger, Lawrence H Einhorn, Lois B Travis, M Eileen Dolan. Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 12; 26(24):6550-6558. doi: 10.1158/1078-0432.ccr-20-2682. [PMID: 32998964]
  • Marie Palamini, Annick Dufour, Roxane Therrien, Jean-François Delisle, Geneviève Mercier, Sébastien Gagné, Nicolas Caron, Jean-François Bussières. Quantification of healthcare workers' exposure to cyclophosphamide, ifosfamide, methotrexate, and 5-fluorouracil by 24-h urine assay: A descriptive pilot study. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2020 Dec; 26(8):1864-1870. doi: 10.1177/1078155220907129. [PMID: 32138611]
  • Dacheng Jin, Meng Chen, Bing Wang, Yunjiu Gou. Mediastinal desmoplastic small round cell tumor. Medicine. 2020 Oct; 99(44):e22921. doi: 10.1097/md.0000000000022921. [PMID: 33126354]
  • R L G Gonçalves, F V M Cunha, B P S Sousa-Neto, L S A Oliveira, M E Lopes, D C Rezende, I J O Sousa, K M Nogueira, L K M Souza, J V R Medeiros, D V T Wong, V M P Pereira, R C P Lima-Júnior, D P Sousa, C P C Oliveira, F R C Almeida, Francisco de Assis Oliveira. α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2020 10; 393(10):1835-1848. doi: 10.1007/s00210-020-01869-3. [PMID: 32415495]
  • Andreza Negreli Santos, Rodrigo Juliano Oliveira, Lucas Roberto Pessatto, Roberto da Silva Gomes, Carlos Alberto Ferreira de Freitas. Biomonitoring of pharmacists and nurses at occupational risk from handling antineoplastic agents. The International journal of pharmacy practice. 2020 Oct; 28(5):506-511. doi: 10.1111/ijpp.12590. [PMID: 31663186]
  • Kazuto Imai, Toshinari Yamasaki, Hiromasa Sakamoto, Kiyonao Nakamura, Takashi Mizowaki, Osamu Ogawa, Teruyoshi Aoyama. [A Case of Primary Ewing Sarcoma of the Kidney Treated with Multidisciplinary Approach]. Hinyokika kiyo. Acta urologica Japonica. 2020 Sep; 66(9):297-302. doi: 10.14989/actauroljap_66_9_297. [PMID: 32988166]
  • Cristina Bouzas, Maria Del Mar Bibiloni, Alicia Julibert, Miguel Ruiz-Canela, Jordi Salas-Salvadó, Dolores Corella, Maria Dolors Zomeño, Dora Romaguera, Jesús Vioque, Ángel M Alonso-Gómez, Julia Wärnberg, J Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J Tinahones, José Lapetra, Xavier Pintó, Antonio García Ríos, Aurora Bueno-Cavanillas, José J Gaforio, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín-Sánchez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Cesar Ignacio Fernandez-Lázaro, Nerea Becerra-Tomás, Ignacio Manuel Gimenez-Alba, Julia Muñoz, Marga Morey, Alejandro Oncina-Canovas, Lucas Tojal-Sierra, Jéssica Pérez-López, Itziar Abete, Tamara Casañas-Quintana, Sara Castro-Barquero, M Rosa Bernal-López, José Manuel Santos-Lozano, Ana Galera, Escarlata Angullo-Martinez, F Javier Basterra-Gortari, Josep Basora, Carmen Saiz, Olga Castañer, Marian Martín, Leyre Notario-Barandiarán, María C Belló-Mora, Carmen Sayón-Orea, Jesús García-Gavilán, Albert Goday, Josep A Tur. Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study. Nutrients. 2020 Jul; 12(7):. doi: 10.3390/nu12072114. [PMID: 32708828]
  • Atsuko Watanabe, Atsuhiko Ohta, Takashi Fujino, Erika Hidawa, Yuko Akioka, Junki Koike, Ryuhei Tanaka. [Pathological Findings of Chronic Effects Observed in the Kidneys Exposed to Antineoplastic Agents in Two Adolescent Patients]. Gan to kagaku ryoho. Cancer & chemotherapy. 2020 Jul; 47(7):1129-1131. doi: . [PMID: 32668868]
  • Pramod K Kalambate, Dhanjai, Ankita Sinha, Yankai Li, Yue Shen, Yunhui Huang. An electrochemical sensor for ifosfamide, acetaminophen, domperidone, and sumatriptan based on self-assembled MXene/MWCNT/chitosan nanocomposite thin film. Mikrochimica acta. 2020 06; 187(7):402. doi: 10.1007/s00604-020-04366-9. [PMID: 32572633]
  • Amir Kiani, Shadi Heydari Nik, Adineh Khodadoost, Ahmad Salimi, Jalal Pourahmad. Trifluoperazine an Antipsychotic Drug and Inhibitor of Mitochondrial Permeability Transition Protects Cytarabine and Ifosfamide-Induced Neurotoxicity. Drug research. 2020 Jun; 70(6):265-272. doi: 10.1055/a-1154-8672. [PMID: 32365382]
  • Takumi Shiraishi, Terukazu Nakamura, Toshiya Takamura, Masakatsu Oishi, Takeshi Yamada, Yasuhiro Yamada, Takashi Ueda, Atsuko Fujihara, Fumiya Hongo, Koji Okihara, Osamu Ukimura. Less nephrotoxicity of paclitaxel and ifosfamide plus nedaplatin for refractory or relapsed germ cell tumors in patients with impaired renal function. International journal of urology : official journal of the Japanese Urological Association. 2020 Feb; 27(2):134-139. doi: 10.1111/iju.14147. [PMID: 31701563]
  • Hamit Çelik, Sefa Kucukler, Selim Çomaklı, Selçuk Özdemir, Cuneyt Caglayan, Ahmet Yardım, Fatih Mehmet Kandemir. Morin attenuates ifosfamide-induced neurotoxicity in rats via suppression of oxidative stress, neuroinflammation and neuronal apoptosis. Neurotoxicology. 2020 01; 76(?):126-137. doi: 10.1016/j.neuro.2019.11.004. [PMID: 31722249]
  • Mohammad Mehdi Ommati, Omid Farshad, Vahid Ghanbarinejad, Hamid Reza Mohammadi, Mousavi Khadijeh, Azarpira Negar, Mahboubi Zahra, Farshid Ilkhaninasab, Leila Moezi, Reza Heidari. The Nephroprotective Role of Carnosine Against Ifosfamide-Induced Renal Injury and Electrolytes Imbalance is Mediated Via the Regulation of Mitochondrial Function and Alleviation of Oxidative Stress. Drug research. 2020 Jan; 70(1):49-56. doi: 10.1055/a-1017-5085. [PMID: 31671464]
  • Eduardo Madrigal-Bujaidar, Edilberto Pérez-Montoya, Sandra García-Medina, José Melesio Cristóbal-Luna, José A Morales-González, Eduardo Osiris Madrigal-Santillán, Rogelio Paniagua-Pérez, Isela Álvarez-González. Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin. Scientific reports. 2019 11; 9(1):16621. doi: 10.1038/s41598-019-53204-3. [PMID: 31719649]
  • Antoine Villa, Mathieu Molimard, Emmanuelle Bignon, Béatrice Martinez, Magali Rouyer, Simone Mathoulin-Pelissier, Isabelle Baldi, Catherine Verdun-Esquer, Mireille Canal-Raffin. Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross-sectional multicentre descriptive study. BMJ open. 2019 11; 9(11):e033040. doi: 10.1136/bmjopen-2019-033040. [PMID: 31712349]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Esmee Cm Kooijmans, Arend Bökenkamp, Nic S Tjahjadi, Jesse M Tettero, Eline van Dulmen-den Broeder, Helena Jh van der Pal, Margreet A Veening. Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer. The Cochrane database of systematic reviews. 2019 03; 3(?):CD008944. doi: 10.1002/14651858.cd008944.pub3. [PMID: 30855726]
  • Jie Xiong, Guifang Zhao, Shengli Yang, Jing Chen. Efficacy, Tolerability and Pharmacokinetic Impact of Aprepitant in Sarcoma Patients Receiving Ifosfamide and Doxorubicin Chemotherapy: A Randomized Controlled Trial. Advances in therapy. 2019 02; 36(2):355-364. doi: 10.1007/s12325-018-0862-2. [PMID: 30607545]
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