Quinine (BioDeep_00000002037)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product Volatile Flavor Compounds


代谢物信息卡片


(R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol

化学式: C20H24N2O2 (324.18376839999996)
中文名称: 金鸡纳霜, 奎宁, DSSTox_GSID_44280
谱图信息: 最多检出来源 Homo sapiens(blood) 2.55%

分子结构信息

SMILES: C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12
InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1

描述信息

Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy. It has a role as an antimalarial, a muscle relaxant and a non-narcotic analgesic. It is a conjugate base of a quinine(1+). It derives from a hydride of an (8S)-cinchonan.
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Quinine is an Antimalarial.
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.
Quinine is a natural product found in Cinchona calisaya, Cinchona officinalis, and other organisms with data available.
Quinine is a quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Quinine is an alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
See also: Quinine Sulfate (active moiety of); Quinine salicylate (active moiety of); Quinine arsenite (active moiety of) ... View More ...
Quinine is an alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. [PubChem].
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BC - Methanolquinolines
A cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
It is used in tonics and bitter drinks
[Raw Data] CB141_Quinine_pos_10eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_20eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_40eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_50eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_30eV_CB000051.txt
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].

同义名列表

113 个代谢物同义名

(R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol; (R)-[(4S,5R,7S)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]-oct-2-yl](6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol; Quinine, suitable for fluorescence, anhydrous, >=98.0\\% (dried material, NT); (R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxy-4-quinolinyl)methanol; (1R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol; (R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol; 2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-; alpha-(6-Methoxy-4-quinoyl)-5-vinyl-2-quinclidinemethanol; Quinine, certified reference material, TraceCERT(R); Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-, sulfate; Fawns and mcallan brand OF quinine bisulfate; Fawns and mcallan brand OF quinine sulfate; (3alpha,8alpha,9R)-6-methoxycinchonan-9-ol; Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-; Cinchonan-9-ol, 6-methoxy-, (8-alpha,9R)-; Cinchonan-9-ol, 6-methoxy-, (8alpha,9R)-; Quinsan (*2:1 Sulfate salt*), dihydrate; Innotech brand OF quinine hydrochloride; Quinamm (*2:1 Sulfate salt*), dihydrate; (R)-(-)-Quinine, 6-methoxycinchonidine; Lafran brand OF quinine hydrochloride; Biquinate (*Bisulfate heptathydrate*); (8.alpha.,9R)-6-Methoxycinchonan-9-ol; Quine (*2:1 Sulfate salt*, dihydrate); (8-alpha,9R)-6-Methoxycinchonan-9-ol; (9R)-6-methoxy-8alpha-cinchonan-9-ol; Dentojel (*Bisulfate heptathydrate*); Cinchonan-9-ol, 6-methoxy-, (8a,9R)-; Alphapharm brand OF quinine sulfate; Aventis brand OF quinine bisulfate; Prosana brand OF quinine bisulfate; Hoechst brand OF quinine sulfate; Plough brand OF quinine sulfate; (8S,9R)-6-Methoxycinchonan-9-ol; Odan brand OF quinine sulfate; Foy brand OF quinine sulfate; Cinchonan-9-ol, 6-methoxy-; 6-Methoxycinchonan-9-ol; Hydrochloride, Quinine; Quinine tannate [USP]; CHININUM PURUM [HPUS]; 6-Methoxycinchonidine; Quinine Hydrochloride; 6-Methoxycinchonine; Quinine, Anhydrous; quinine bisulphate; Bisulfate, Quinine; Quinoline alkaloid; Sulphate, Quinine; Quinine anhydrous; Quinine bisulfate; Quinineanhydrous; Quinine sulphate; Quinine [BAN:NF]; Sulfate, Quinine; Quinine, tannate; QUININE [WHO-DD]; QUININE (MART.); Quinine Sulfate; UNII-26MX5YAL2R; (8S,9R)-Quinine; UNII-A7V27PHC7A; QUININE [MART.]; QUININE [VANDF]; Chinin [German]; (R)-(-)-quinine; Chininum purum; Quinine Lafran; Tox21_112389_1; QUININE [HSDB]; Kinder Quinina; QUININE [INCI]; Quinine, 90\\%; QUININE [MI]; Coco-Quinine; Quinine-Odan; Tox21_112389; (-)-Quinine; (-)quinine; A7V27PHC7A; Quinoctal; Quinbisan; Quinbisul; Qualaquin; Biquinate; Legatrim; Surquina; chininum; Quinimax; Chinine; Aflukin; Quindan; Quinsul; Quinsan; Quinine; Quinson; Myoquin; Quinamm; Rezquin; quinina; Chinin; Strema; QI9; Conquinine; Quinine; DSSTox_GSID_44280



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

87 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Muhammad Irfan Waris, Yanyuan Lei, Guojun Qi, Ziying Guan, Abdul Rashied, Jie Chen, Lihua Lyu. The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds. Insect science. 2024 Apr; 31(2):448-468. doi: 10.1111/1744-7917.13301. [PMID: 38010036]
  • Cécile Ficko, Pierre-Louis Conan. [Malaria in 2022: clinical and therapeutic aspects]. Medecine tropicale et sante internationale. 2023 06; 3(2):. doi: 10.48327/mtsi.v3i2.2023.378. [PMID: 37525671]
  • Louis H Miller, Jesus Rojas-Jaimes, Leanne M Low, Gilberto Corbellini. What Historical Records Teach Us about the Discovery of Quinine. The American journal of tropical medicine and hygiene. 2023 01; 108(1):7-11. doi: 10.4269/ajtmh.22-0404. [PMID: 36410328]
  • Ning Wen, Ping-Shun Song, Lin Ni, Juan Chen. Tannic acid-aminopropyltriethoxysilane co-deposition modified polymer membrane for α-glucosidase immobilization. Journal of chromatography. A. 2022 Nov; 1683(?):463550. doi: 10.1016/j.chroma.2022.463550. [PMID: 36219969]
  • Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi. Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats. BMC immunology. 2022 10; 23(1):50. doi: 10.1186/s12865-022-00519-y. [PMID: 36261807]
  • M G Semedo, A L Pereira, J R Pita. Cinchona bark and quinine in the Portuguese official pharmacopoeias (1794-2001). Die Pharmazie. 2022 09; 77(7):278-285. doi: 10.1691/ph.2022.2034. [PMID: 36199186]
  • Ryuta Asaumi, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Kunal S Taskar, Yuichi Sugiyama. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. CPT: pharmacometrics & systems pharmacology. 2022 07; 11(7):919-933. doi: 10.1002/psp4.12807. [PMID: 35570332]
  • Rajinder Bhardwaj, Julie L Collins, Joseph Stringfellow, Jennifer Madonia, Matt S Anderson, Jeri-Anne Finley, David A Stock, Vladimir Coric, Robert Croop, Richard Bertz. P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects. Clinical pharmacology in drug development. 2022 07; 11(7):889-897. doi: 10.1002/cpdd.1088. [PMID: 35304977]
  • Peyman Rezaie, Vida Bitarafan, Braden D Rose, Kylie Lange, Jens F Rehfeld, Michael Horowitz, Christine Feinle-Bisset. Quinine Effects on Gut and Pancreatic Hormones and Antropyloroduodenal Pressures in Humans-Role of Delivery Site and Sex. The Journal of clinical endocrinology and metabolism. 2022 06; 107(7):e2870-e2881. doi: 10.1210/clinem/dgac182. [PMID: 35325161]
  • Nourhan M Abd El-Aziz, Ibrahim Khalifa, Amira M G Darwish, Ahmed N Badr, Huda Aljumayi, El-Sayed Hafez, Mohamed G Shehata. Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092662. [PMID: 35566014]
  • Tatsuya Kokawa, Hiroyuki Yamamoto, Mitsuaki Itoh, Akira Shimane, Hiroya Kawai, Tomofumi Takaya. Fever-Related Ventricular Fibrillation　- Potential Adverse Effect of SARS-CoV-2 Vaccination in Patients With Brugada Syndrome. Circulation journal : official journal of the Japanese Circulation Society. 2022 Feb; 86(3):474. doi: 10.1253/circj.cj-21-0750. [PMID: 34615807]
  • Xiuliang Dai, Xiangjiao Yi, Yufeng Wang, Wei Xia, Jianguo Tao, Jun Wu, Dengshun Miao, Li Chen. PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice. Frontiers in endocrinology. 2022; 13(?):781404. doi: 10.3389/fendo.2022.781404. [PMID: 35340329]
  • Teerachat Sae-Heng, Rajith Kumar Reddy Rajoli, Marco Siccardi, Juntra Karbwang, Kesara Na-Bangchang. Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. CPT: pharmacometrics & systems pharmacology. 2022 01; 11(1):104-115. doi: 10.1002/psp4.12737. [PMID: 34730282]
  • Alexander Burashnikov, Hector Barajas-Martinez, Robert Cox, Mark A Demitrack, Michael J Fossler, Michael Kramer, Robert B Kleiman, Peter Kowey, Charles Antzelevitch. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk. Heart rhythm. 2021 12; 18(12):2177-2186. doi: 10.1016/j.hrthm.2021.08.028. [PMID: 34481984]
  • Yong-Jia Chen, Kun-Yuan Ma, Sha-Sha Du, Zhi-Jun Zhang, Tian-Lin Wu, Yu Sun, Ying-Qian Liu, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, Chen Tang. Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids. Journal of agricultural and food chemistry. 2021 Oct; 69(41):12156-12170. doi: 10.1021/acs.jafc.1c05677. [PMID: 34623798]
  • Daniel M Gelfman. Reflections on quinine and its importance in dermatology today. Clinics in dermatology. 2021 Sep; 39(5):900-903. doi: 10.1016/j.clindermatol.2021.08.017. [PMID: 34785019]
  • M G Semedo, A L Pereira, J R Pita. The influence of German science on Cinchona and quinine research in Portugal in the second half of the 19th century. Die Pharmazie. 2021 08; 76(8):396-402. doi: 10.1691/ph.2021.1050. [PMID: 34412740]
  • J V Joviano-Santos, A Santos-Miranda, E A Neri, M H Fonseca-Alaniz, J E Krieger, A C Pereira, D Roman-Campos. SCN5A compound heterozygosity mutation in Brugada syndrome: Functional consequences and the implication for pharmacological treatment. Life sciences. 2021 Aug; 278(?):119646. doi: 10.1016/j.lfs.2021.119646. [PMID: 34048814]
  • Inoussa Sanané, Judith Legrand, Christine Dillmann, Frédéric Marion-Poll. High-Throughput Feeding Bioassay for Lepidoptera Larvae. Journal of chemical ecology. 2021 Jul; 47(7):642-652. doi: 10.1007/s10886-021-01290-x. [PMID: 34331170]
  • Wout Verbeure, Eveline Deloose, Joran Tóth, Jens F Rehfeld, Lukas Van Oudenhove, Inge Depoortere, Jan Tack. The endocrine effects of bitter tastant administration in the gastrointestinal system: intragastric versus intraduodenal administration. American journal of physiology. Endocrinology and metabolism. 2021 07; 321(1):E1-E10. doi: 10.1152/ajpendo.00636.2020. [PMID: 34029163]
  • Braden D Rose, Vida Bitarafan, Peyman Rezaie, Penelope C E Fitzgerald, Michael Horowitz, Christine Feinle-Bisset. Comparative Effects of Intragastric and Intraduodenal Administration of Quinine on the Plasma Glucose Response to a Mixed-Nutrient Drink in Healthy Men: Relations with Glucoregulatory Hormones and Gastric Emptying. The Journal of nutrition. 2021 06; 151(6):1453-1461. doi: 10.1093/jn/nxab020. [PMID: 33704459]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Maximilian Große, Natalia Ruetalo, Mirjam Layer, Dan Hu, Ramona Businger, Sascha Rheber, Christian Setz, Pia Rauch, Janina Auth, Maria Fröba, Ekkehard Brysch, Michael Schindler, Ulrich Schubert. Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2. Viruses. 2021 04; 13(4):. doi: 10.3390/v13040647. [PMID: 33918670]
  • M Schneider, F Dron, E Cuinet, F Woehrlé. Comparative pharmacokinetic profile of cimicoxib in dogs and cats after IV administration. Veterinary journal (London, England : 1997). 2021 Apr; 270(?):105625. doi: 10.1016/j.tvjl.2021.105625. [PMID: 33641805]
  • Francesco Trenti, Kotaro Yamamoto, Benke Hong, Christian Paetz, Yoko Nakamura, Sarah E O'Connor. Early and Late Steps of Quinine Biosynthesis. Organic letters. 2021 03; 23(5):1793-1797. doi: 10.1021/acs.orglett.1c00206. [PMID: 33625237]
  • Federico Noto, Sandra Recuero, Julián Valencia, Beatrice Saporito, Domenico Robbe, Sergi Bonet, Augusto Carluccio, Marc Yeste. Inhibition of Potassium Channels Affects the Ability of Pig Spermatozoa to Elicit Capacitation and Trigger the Acrosome Exocytosis Induced by Progesterone. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041992. [PMID: 33671466]
  • Tianjiao Lin, Jingyu Song, Xinting Pan, Youdong Wan, Ziqian Wu, Shaoyan Lv, Liangyu Mi, Yunyun Wang, Fei Tian. Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis. Medical science monitor : international medical journal of experimental and clinical research. 2021 Feb; 27(?):e927968. doi: 10.12659/msm.927968. [PMID: 33582700]
  • Mutaib M Mashraqi, Navaneet Chaturvedi, Qamre Alam, Saleh Alshamrani, Mosa M Bahnass, Khurshid Ahmad, Amany I Alqosaibi, Mashael M Alnamshan, Syed Sayeed Ahmad, Mirza Masroor Ali Beg, Abha Mishra, Sibhghatulla Shaikh, Syed Mohd Danish Rizvi. Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030582. [PMID: 33499241]
  • Wei Wei, Xingyue Wu, Chaoyuan Jin, Tong Mu, Guorong Gu, Min Min, Sucheng Mu, Yi Han. Predictive Significance of the Prognostic Nutritional Index (PNI) in Patients with Severe COVID-19. Journal of immunology research. 2021; 2021(?):9917302. doi: 10.1155/2021/9917302. [PMID: 34337084]
  • Andrew D S Duncan, Simona Hapca, Nicosha De Souza, Daniel Morales, Samira Bell. Quinine exposure and the risk of acute kidney injury: a population-based observational study of older people. Age and ageing. 2020 10; 49(6):1042-1047. doi: 10.1093/ageing/afaa079. [PMID: 32463438]
  • Aurelie Vandenbeuch, Courtney E Wilson, Sue C Kinnamon. Optogenetic Activation of Type III Taste Cells Modulates Taste Responses. Chemical senses. 2020 10; 45(7):533-539. doi: 10.1093/chemse/bjaa044. [PMID: 32582939]
  • A G Tolkushin, E A Luchinin, M E Kholovnya-Voloskova, A A Zavyalov. [History of aminoquinoline preparations: from cinchona bark to chloroquine and hydroxychloroquinon]. Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny. 2020 Oct; 28(Special Issue):1118-1122. doi: 10.32687/0869-866x-2020-28-s2-1118-1122. [PMID: 33219768]
  • Ingrid Berling, Joshua D King, Greene Shepherd, Robert S Hoffman, Badria Alhatali, Valery Lavergne, Darren M Roberts, Sophie Gosselin, Gabrielle Wilson, Thomas D Nolin, Marc Ghannoum. Extracorporeal Treatment for Chloroquine, Hydroxychloroquine, and Quinine Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. Journal of the American Society of Nephrology : JASN. 2020 10; 31(10):2475-2489. doi: 10.1681/asn.2020050564. [PMID: 32963091]
  • Dong Ye, Anna Harder, Zhizhou Fang, Manuel Weinheimer, Loic Laplanche, Mario Mezler. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening. Pharmaceutical research. 2020 Sep; 37(10):194. doi: 10.1007/s11095-020-02895-9. [PMID: 32918191]
  • Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. [PMID: 32690433]
  • Davoud Kianifard, Seyyed Maysam Mousavi Shoar, Ahmed Aly, Leila Kianifard, Farhad Rezaee. Administration of Nicotine Exacerbates the Quinine-induced Structural and Functional Alterations of Testicular Tissue in Adult Rats: An Experimental Study. Urology journal. 2020 Jul; 18(1):103-110. doi: 10.22037/uj.v16i7.5884. [PMID: 32748385]
  • Victoria V Golovchenko, Shinen Naranmandakh, Jamsranjav Ganbaatar, Artur Yu Prilepskii, Gennady L Burygin, Alexander O Chizhov, Alexander S Shashkov. Structural investigation and comparative cytotoxic activity of water-soluble polysaccharides from fruit bodies of the medicinal fungus quinine conk. Phytochemistry. 2020 Jul; 175(?):112313. doi: 10.1016/j.phytochem.2020.112313. [PMID: 32353551]
  • Mauricio A García, Danae Contreras, Pablo M González. Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability. Pharmaceutical research. 2020 Jun; 37(7):121. doi: 10.1007/s11095-020-02824-w. [PMID: 32514792]
  • X J Wang, Y S Yang, K Shen, J Wang, F Han, G F Wu, Y Li, X Z Bai, L Luo, D H Hu. [Effects and mechanism of pyrroloquinoline quinine on mitochondrial function and cell survival of rat bone marrow mesenchymal stem cells under oxidative stress]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2020 May; 36(5):378-387. doi: 10.3760/cma.j.cn501120-20190806-00335. [PMID: 32456375]
  • Hans Friedrich Stabenau, Changyu Shen, Larisa G Tereshchenko, Jonathan W Waks. Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil. Heart rhythm. 2020 03; 17(3):460-467. doi: 10.1016/j.hrthm.2019.09.017. [PMID: 31539628]
  • Nataly Allasi Canales, Tobias Nikolaj Gress Hansen, Claus Cornett, Kim Walker, Felix Driver, Alexandre Antonelli, Carla Maldonado, Mark Nesbitt, Christopher J Barnes, Nina Rønsted. Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies. Journal of ethnopharmacology. 2020 Mar; 249(?):112375. doi: 10.1016/j.jep.2019.112375. [PMID: 31698039]
  • Vida Bitarafan, Penelope C E Fitzgerald, Tanya J Little, Wolfgang Meyerhof, Karen L Jones, Tongzhi Wu, Michael Horowitz, Christine Feinle-Bisset. Intragastric administration of the bitter tastant quinine lowers the glycemic response to a nutrient drink without slowing gastric emptying in healthy men. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 02; 318(2):R263-R273. doi: 10.1152/ajpregu.00294.2019. [PMID: 31774306]
  • Zhiping Che, Jinming Yang, Di Sun, Yuee Tian, Shengming Liu, Xiaomin Lin, Jia Jiang, Genqiang Chen. Combinatorial Synthesis of Novel 9R-Acyloxyquinine Derivatives as Insecticidal Agents. Combinatorial chemistry & high throughput screening. 2020; 23(2):111-118. doi: 10.2174/1386207323666200120112714. [PMID: 31958039]
  • Franklin Mogo Kom, Martin Paul Baane, Marius Mbody, Moussa Abame Sanda, Bi Ndongo Bilong, Francis Ateba Ndongo, Jean-Marc Mben Ii. COVID-19 mimics endemic tropical diseases at an early stage: a report of two symptomatic COVID-19 patients treated in a polymerase chain reaction void zone in Cameroon. The Pan African medical journal. 2020; 37(?):212. doi: 10.11604/pamj.2020.37.212.25545. [PMID: 33520051]
  • Jakub Staroń, Rafał Kurczab, Dawid Warszycki, Grzegorz Satała, Martyna Krawczyk, Ryszard Bugno, Tomasz Lenda, Piotr Popik, Adam S Hogendorf, Agata Hogendorf, Krzysztof Dubiel, Mikołaj Matłoka, Rafał Moszczyński-Pętkowski, Jerzy Pieczykolan, Maciej Wieczorek, Paweł Zajdel, Andrzej J Bojarski. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. European journal of medicinal chemistry. 2020 Jan; 185(?):111857. doi: 10.1016/j.ejmech.2019.111857. [PMID: 31734022]
  • Julie Iven, Jessica R Biesiekierski, Dongxing Zhao, Eveline Deloose, Owen G O'Daly, Inge Depoortere, Jan Tack, Lukas Van Oudenhove. Intragastric quinine administration decreases hedonic eating in healthy women through peptide-mediated gut-brain signaling mechanisms. Nutritional neuroscience. 2019 Dec; 22(12):850-862. doi: 10.1080/1028415x.2018.1457841. [PMID: 29607741]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Kanae Nishimura, Noboru Okamura, Tetsutaro Kimachi, Jun Haginaka. Evaluation of molecularly imprinted polymers for chlorpromazine and bromopromazine prepared by multi-step swelling and polymerization method-The application for the determination of chlorpromazine and its metabolites in rat plasma by column-switching LC. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):248-255. doi: 10.1016/j.jpba.2019.05.063. [PMID: 31181487]
  • Hong Shen, Ming Yao, Michael Sinz, Punit Marathe, A David Rodrigues, Mingshe Zhu. Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins. Molecular pharmaceutics. 2019 09; 16(9):4065-4076. doi: 10.1021/acs.molpharmaceut.9b00472. [PMID: 31335150]
  • Anna Svedberg, Svante Vikingsson, Anders Vikström, Niels Hornstra, Magnus Kentson, Eva Branden, Hirsh Koyi, Bengt Bergman, Henrik Gréen. Erlotinib treatment induces cytochrome P450 3A activity in non-small cell lung cancer patients. British journal of clinical pharmacology. 2019 08; 85(8):1704-1709. doi: 10.1111/bcp.13953. [PMID: 30945322]
  • F Azadmehr, K Zarei. Fabrication of an imprinted electrochemical sensor from l-tyrosine, 3-methyl-4-nitrophenol and gold nanoparticles for quinine determination. Bioelectrochemistry (Amsterdam, Netherlands). 2019 Jun; 127(?):59-67. doi: 10.1016/j.bioelechem.2019.01.001. [PMID: 30703737]
  • Jay W Mason, David G Strauss, Martino Vaglio, Fabio Badilini. Correction of the QRS duration for heart rate. Journal of electrocardiology. 2019 May; 54(?):1-4. doi: 10.1016/j.jelectrocard.2019.02.005. [PMID: 30782546]
  • Kai Wu, Yi Yao, Fang Chen, Mingxing Xu, Guangquan Lu, Tingting Jiang, Ziyu Liu, Weixing Du, Fang Li, Rugui Li, Huabing Tan, Jian Li. Analysis of Plasmodium falciparum Na+/H+ exchanger (pfnhe1) polymorphisms among imported African malaria parasites isolated in Wuhan, Central China. BMC infectious diseases. 2019 Apr; 19(1):354. doi: 10.1186/s12879-019-3921-7. [PMID: 31035938]
  • Dietrich Mebs, Cora Wunder, Stefan W Toennes. Coping with noxious effects of quinine by praying mantids (Mantodea) and spiders (Araneae). Toxicon : official journal of the International Society on Toxinology. 2019 Apr; 162(?):57-60. doi: 10.1016/j.toxicon.2019.03.017. [PMID: 30904569]
  • Shoji Maehara, Andria Agusta, Yoshimi Tokunaga, Hirotaka Shibuya, Toshiyuki Hata. Endophyte composition and Cinchona alkaloid production abilities of Cinchona ledgeriana cultivated in Japan. Journal of natural medicines. 2019 Mar; 73(2):431-438. doi: 10.1007/s11418-018-1273-z. [PMID: 30552602]
  • Jinrong Li, Christian H Lemon. Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 02; 39(9):1631-1648. doi: 10.1523/jneurosci.2000-18.2018. [PMID: 30606758]
  • Naohiro Imura, Masamichi Ae, Rin Hoshino, Masami Abe, Tatsuya Yamamuro, Keisuke Oyama, Yasuo Oyama. Membrane hyperpolarization and depolarization of rat thymocytes by azoxystrobin, a post harvest fungicide. Chemico-biological interactions. 2019 Feb; 300(?):35-39. doi: 10.1016/j.cbi.2019.01.006. [PMID: 30629953]
  • Ana Leonor Pardo Campos Godoy, Natália Valadares de Moraes, Jhohann Richard de Lima Benzi, Vera Lucia Lanchote. Changes in tramadol enantioselective pharmacokinetics and metabolism in rats with experimental diabetes treated or not with insulin. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Feb; 128(?):97-102. doi: 10.1016/j.ejps.2018.11.032. [PMID: 30502451]
  • Shinsaku Yoshitomi, Yukitoshi Takahashi, Tokito Yamaguchi, Taikan Oboshi, Asako Horino, Hiroko Ikeda, Katsumi Imai, Tohru Okanishi, Mitsuko Nakashima, Hirotomo Saitsu, Naomichi Matsumoto, Jun Yoshimoto, Takako Fujita, Atsushi Ishii, Shinichi Hirose, Yushi Inoue. Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations. Epileptic disorders : international epilepsy journal with videotape. 2019 Feb; 21(1):48-54. doi: 10.1684/epd.2019.1026. [PMID: 30782581]
  • Chee Tung Tai, Hong Heng See. Rapid quantification of quinine by multi-stacking in a portable microchip electrophoresis system. Electrophoresis. 2019 02; 40(3):455-461. doi: 10.1002/elps.201800398. [PMID: 30450561]
  • Qiong Wang, Haiyun Wang, Youyan Zhong, Qiang Zhang. Drug-Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats. Drug design, development and therapy. 2019; 13(?):4207-4213. doi: 10.2147/dddt.s226948. [PMID: 31849452]
  • Stephy George, Margarita Taburyanskaya, Vicky Lewis. Probable drug-drug interaction between dabigatran and quinidine resulting in thrombin time rebound despite multiple idarucizumab doses. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2019 Jan; 30(1):42-46. doi: 10.1097/mbc.0000000000000782. [PMID: 30431448]
  • Kenta Watanabe, Tadashi Tsubouchi, Toru Yamada, Eiichi Hinoi, Izuru Miyawaki. Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors. The Journal of toxicological sciences. 2019; 44(7):441-457. doi: 10.2131/jts.44.441. [PMID: 31270301]
  • Mastaneh Sharafi, Shristi Rawal, Maria Luz Fernandez, Tania B Huedo-Medina, Valerie B Duffy. Taste phenotype associates with cardiovascular disease risk factors via diet quality in multivariate modeling. Physiology & behavior. 2018 10; 194(?):103-112. doi: 10.1016/j.physbeh.2018.05.005. [PMID: 29746892]
  • Travis W Grim, Scarlet Jinhong Park, Cullen L Schmid, Robert B Laprairie, Michael Cameron, Laura M Bohn. The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes. Drug and alcohol dependence. 2018 10; 191(?):195-202. doi: 10.1016/j.drugalcdep.2018.05.034. [PMID: 30138791]
  • Ashish Dogra, Shipra Bhatt, Asmita Magotra, Anjna Sharma, Pankul Kotwal, Abhishek Gour, Priya Wazir, Gurdarshan Singh, Utpal Nandi. Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long-term use. Phytotherapy research : PTR. 2018 Oct; 32(10):1967-1974. doi: 10.1002/ptr.6123. [PMID: 29806225]
  • Anke Di, Shiqin Xiong, Zhiming Ye, R K Subbarao Malireddi, Satoshi Kometani, Ming Zhong, Manish Mittal, Zhigang Hong, Thirumala-Devi Kanneganti, Jalees Rehman, Asrar B Malik. The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation. Immunity. 2018 07; 49(1):56-65.e4. doi: 10.1016/j.immuni.2018.04.032. [PMID: 29958799]
  • Hadi Molanaei, Abdul Rashid Qureshi, Olof Heimbürger, Bengt Lindholm, Ulf Diczfalusy, Björn Anderstam, Leif Bertilsson, Peter Stenvinkel. Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients. BMC pharmacology & toxicology. 2018 06; 19(1):33. doi: 10.1186/s40360-018-0221-6. [PMID: 29941014]
  • Adele Murauer, Markus Ganzera. Quantitative determination of major alkaloids in Cinchona bark by Supercritical Fluid Chromatography. Journal of chromatography. A. 2018 Jun; 1554(?):117-122. doi: 10.1016/j.chroma.2018.04.038. [PMID: 29699870]
  • Kazuki Harada, Hidekazu Sakaguchi, Shoko Sada, Rika Ishida, Yuki Hayasaka, Takashi Tsuboi. Bitter tastant quinine modulates glucagon-like peptide-1 exocytosis from clonal GLUTag enteroendocrine L cells via actin reorganization. Biochemical and biophysical research communications. 2018 06; 500(3):723-730. doi: 10.1016/j.bbrc.2018.04.143. [PMID: 29684353]
  • Juan G Ripoll, Mahrukh S Rizvi, Rebecca L King, Craig E Daniels. Severe Babesia microti infection presenting as multiorgan failure in an immunocompetent host. BMJ case reports. 2018 May; 2018(?):. doi: 10.1136/bcr-2018-224647. [PMID: 29848533]
  • Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers. Journal of pharmacological and toxicological methods. 2018 Mar; 90(?):58-66. doi: 10.1016/j.vascn.2017.12.003. [PMID: 29274391]
  • Sarah M Tindall, Cindy Vallières, Dev H Lakhani, Farida Islahudin, Kang-Nee Ting, Simon V Avery. Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials. Scientific reports. 2018 02; 8(1):2464. doi: 10.1038/s41598-018-20816-0. [PMID: 29410428]
  • Ryutaro Matsui, Ryutaro Hattori, Youhei Usami, Masumi Koyama, Yuki Hirayama, Emi Matsuba, Yukiya Hashimoto. Functional characteristics of a renal H+/lipophilic cation antiport system in porcine LLC-PK1 cells and rats. Drug metabolism and pharmacokinetics. 2018 Feb; 33(1):96-102. doi: 10.1016/j.dmpk.2017.11.313. [PMID: 29338932]
  • Graziela Scheuer Gomes, Tamara Ramos Maciel, Eduarda Martini Piegas, Luana Roberta Michels, Letícia Marques Colomé, Rodrigo José Freddo, Daiana Silva de Ávila, Andre Gundel, Sandra Elisa Haas. Optimization of Curcuma Oil/Quinine-Loaded Nanocapsules for Malaria Treatment. AAPS PharmSciTech. 2018 Feb; 19(2):551-564. doi: 10.1208/s12249-017-0854-6. [PMID: 28875471]
  • David Aguilera-Alonso, Eva María López Medina, Teresa Del Rosal, Julián Villota Arrieta, Luis Escosa-García, Milagros García-Hortelano. Acalculous Cholecystitis in a Pediatric Patient With Plasmodium Falciparum Infection: A Case Report and Literature Review. The Pediatric infectious disease journal. 2018 02; 37(2):e43-e45. doi: 10.1097/inf.0000000000001734. [PMID: 28787387]
  • Saul A Mullen, Patrick W Carney, Annie Roten, Michael Ching, Paul A Lightfoot, Leonid Churilov, Umesh Nair, Melody Li, Samuel F Berkovic, Steven Petrou, Ingrid E Scheffer. Precision therapy for epilepsy due to KCNT1 mutations: A randomized trial of oral quinidine. Neurology. 2018 01; 90(1):e67-e72. doi: 10.1212/wnl.0000000000004769. [PMID: 29196578]
  • E Deloose, M Corsetti, L Van Oudenhove, I Depoortere, J Tack. Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2018 Jan; 30(1):. doi: 10.1111/nmo.13171. [PMID: 28776826]
  • Khan Muhammad Baloch, Khan Usmanghani, Ejaz Mohiuddin, Tasneem Qureshi, Muhammad Daniyal, Muhammad Ibrar Shinwari. A randomized, control and comparative study of polyherbal formulation use for Malaria (Plasmodium falciparum). Pakistan journal of pharmaceutical sciences. 2018 Jan; 31(1(Suppl.)):291-297. doi: ". [PMID: 29386156]
  • Zay Myo Htet, Mahzuz Karim. A Catastrophic Consequence of Cramp. Acute medicine. 2018; 17(1):50-52. doi: NULL. [PMID: 29589607]
  • Javier Franco-Pérez, Joaquín Manjarrez-Marmolejo, Cesar Rodríguez-Balderas, Nelly Castro, Paola Ballesteros-Zebadua. Quinine and carbenoxolone enhance the anticonvulsant activity of some classical antiepileptic drugs. Neurological research. 2018 Jan; 40(1):26-33. doi: 10.1080/01616412.2017.1384092. [PMID: 28988516]
  • Evaren E Page, Dustin J Little, Sara K Vesely, James N George. Quinine-Induced Thrombotic Microangiopathy: A Report of 19 Patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2017 Nov; 70(5):686-695. doi: 10.1053/j.ajkd.2017.05.023. [PMID: 28780041]
  • Caitlin McIntyre, Rory McQuillan, Chaim Bell, Marisa Battistella. Targeted Deprescribing in an Outpatient Hemodialysis Unit: A Quality Improvement Study to Decrease Polypharmacy. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2017 Nov; 70(5):611-618. doi: 10.1053/j.ajkd.2017.02.374. [PMID: 28416321]
  • John I Glendinning, Joyce Tang, Ana Paula Morales Allende, Bruce P Bryant, Lisa Youngentob, Steven L Youngentob. Fetal alcohol exposure reduces responsiveness of taste nerves and trigeminal chemosensory neurons to ethanol and its flavor components. Journal of neurophysiology. 2017 08; 118(2):1198-1209. doi: 10.1152/jn.00108.2017. [PMID: 28490641]
  • Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy, Frédérick Gay, Camille Roussel, Stéphane Jauréguiberry, Claire Perillaud, Dominique Langui, Sylvestre Biligui, Nathalie Chartrel, Audrey Mérens, Eric Kendjo, Aniruddha Ghose, Md Mahtab Uddin Hassan, Md Amir Hossain, Hugh W F Kingston, Katherine Plewes, Arjen M Dondorp, Martin Danis, Sandrine Houzé, Serge Bonnefoy, Marc Thellier, Charles J Woodrow, Pierre A Buffet. Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis. Science translational medicine. 2017 07; 9(397):. doi: 10.1126/scitranslmed.aaf9377. [PMID: 28679662]
  • Olasupo Stephen Adeniyi, Olubiyi Vincent Makinde, Emmanuel Titus Friday, Samuel Babafemi Olaleye. Effects of quinine on gastric ulcer healing in Wistar rats. Journal of complementary & integrative medicine. 2017 Jun; 14(4):. doi: 10.1515/jcim-2016-0132. [PMID: 28665790]
  • Subramanyam J Tantry, Shankar D Markad, Vikas Shinde, Jyothi Bhat, Gayathri Balakrishnan, Amit K Gupta, Anisha Ambady, Anandkumar Raichurkar, Chaitanyakumar Kedari, Sreevalli Sharma, Naina V Mudugal, Ashwini Narayan, C N Naveen Kumar, Robert Nanduri, Sowmya Bharath, Jitendar Reddy, Vijender Panduga, K R Prabhakar, Karthikeyan Kandaswamy, Ramanatha Saralaya, Parvinder Kaur, Neela Dinesh, Supreeth Guptha, Kirsty Rich, David Murray, Helen Plant, Marian Preston, Helen Ashton, Darren Plant, Jarrod Walsh, Peter Alcock, Kathryn Naylor, Matthew Collier, James Whiteaker, Robert E McLaughlin, Meenakshi Mallya, Manoranjan Panda, Suresh Rudrapatna, Vasanthi Ramachandran, Radha Shandil, Vasan K Sambandamurthy, Khisi Mdluli, Christopher B Cooper, Harvey Rubin, Takahiro Yano, Pravin Iyer, Shridhar Narayanan, Stefan Kavanagh, Kakoli Mukherjee, V Balasubramanian, Vinayak P Hosagrahara, Suresh Solapure, Sudha Ravishankar, Shahul Hameed P. Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis. Journal of medicinal chemistry. 2017 02; 60(4):1379-1399. doi: 10.1021/acs.jmedchem.6b01358. [PMID: 28075132]
  • Margarete do Socorro Mendonça Gomes, José Luiz Fernandes Vieira, Álvaro Augusto Ribeiro D'Almeida Couto, Vanja Suely Calvosa D'Almeida Couto, Michelle Valéria Dias Ferreira Vieira, Francis Christian da Silva Pereira, Ricado Luiz Dantas Machado. Recurrence of Plasmodium falciparum after treatment with quinine and doxycycline in the Amazon basin. Tropical medicine & international health : TM & IH. 2017 02; 22(2):133-138. doi: 10.1111/tmi.12813. [PMID: 27862676]
  • Zhou Meng, Harma Ellens, Joe Bentz. Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells. Drug metabolism and disposition: the biological fate of chemicals. 2017 02; 45(2):190-197. doi: 10.1124/dmd.116.072140. [PMID: 27856526]
  • G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria. Journal of the Royal Society of Medicine. 2017 Feb; 110(2):73-82. doi: 10.1177/0141076816688411. [PMID: 28169590]
  • Mohammad Fawad Ansari, Faisal Hayat, Afreen Inam, Fatima Kathrada, Robyn L van Zyl, Maureen Coetzee, Kamal Ahmad, Dongyun Shin, Amir Azam. New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):460-465. doi: 10.1016/j.bmcl.2016.12.043. [PMID: 28027871]
  • Rao Mukkavilli, Gajanan Jadhav, Subrahmanyam Vangala. Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines. Current pharmaceutical biotechnology. 2017; 18(14):1151-1158. doi: 10.2174/1389201019666180308091855. [PMID: 29521222]
  • G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria. Journal of the Royal Society of Medicine. 2017 Jan; 110(1):31-40. doi: 10.1177/0141076816681421. [PMID: 28106483]
  • Atthanee Jeeyapant, Hugh W Kingston, Katherine Plewes, Richard J Maude, Josh Hanson, M Trent Herdman, Stije J Leopold, Thatsanun Ngernseng, Prakaykaew Charunwatthana, Nguyen Hoan Phu, Aniruddha Ghose, M Mahtab Uddin Hasan, Caterina I Fanello, Md Abul Faiz, Tran Tinh Hien, Nicholas P J Day, Nicholas J White, Arjen M Dondorp. Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria. PloS one. 2017; 12(1):e0169307. doi: 10.1371/journal.pone.0169307. [PMID: 28052109]
  • Ricardo P Garay, George T Grossberg. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert opinion on investigational drugs. 2017 Jan; 26(1):121-132. doi: 10.1080/13543784.2017.1267726. [PMID: 27936965]
  • Valerie B Duffy, Shristi Rawal, Jeeha Park, Mark H Brand, Mastaneh Sharafi, Bradley W Bolling. Characterizing and improving the sensory and hedonic responses to polyphenol-rich aronia berry juice. Appetite. 2016 12; 107(?):116-125. doi: 10.1016/j.appet.2016.07.026. [PMID: 27457970]
  • Miki Fukao, Eri Kondo, Hiroki Nishino, Ryutaro Hattori, Asuka Horie, Yukiya Hashimoto. Presence of an H+/Quinidine Antiport System in Madin-Darby Canine Kidney Cells. European journal of drug metabolism and pharmacokinetics. 2016 Dec; 41(6):819-824. doi: 10.1007/s13318-015-0314-1. [PMID: 26628429]
  • J Wang. The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition. Clinical pharmacology and therapeutics. 2016 Nov; 100(5):489-499. doi: 10.1002/cpt.442. [PMID: 27506881]
  • Andrea Hubeny, Markus Keiser, Stefan Oswald, Gabriele Jedlitschky, Heyo K Kroemer, Werner Siegmund, Markus Grube. Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. Drug metabolism and disposition: the biological fate of chemicals. 2016 10; 44(10):1562-8. doi: 10.1124/dmd.116.069807. [PMID: 27504015]