Quinine (BioDeep_00000002037)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


(R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol

化学式: C20H24N2O2 (324.1838)
中文名称: 金鸡纳霜, 奎宁, DSSTox_GSID_44280
谱图信息: 最多检出来源 Homo sapiens(otcml) 12.58%

分子结构信息

SMILES: C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12
InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1

描述信息

Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy. It has a role as an antimalarial, a muscle relaxant and a non-narcotic analgesic. It is a conjugate base of a quinine(1+). It derives from a hydride of an (8S)-cinchonan.
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Quinine is an Antimalarial.
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.
Quinine is a natural product found in Cinchona calisaya, Cinchona officinalis, and other organisms with data available.
Quinine is a quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Quinine is an alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
See also: Quinine Sulfate (active moiety of); Quinine salicylate (active moiety of); Quinine arsenite (active moiety of) ... View More ...
Quinine is an alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. [PubChem].
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BC - Methanolquinolines
A cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
It is used in tonics and bitter drinks
[Raw Data] CB141_Quinine_pos_10eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_20eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_40eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_50eV_CB000051.txt
[Raw Data] CB141_Quinine_pos_30eV_CB000051.txt
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].

同义名列表

113 个代谢物同义名

(R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol; (R)-[(4S,5R,7S)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]-oct-2-yl](6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol; Quinine, suitable for fluorescence, anhydrous, >=98.0\\% (dried material, NT); (R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxy-4-quinolinyl)methanol; (1R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol; (R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol; 2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-; alpha-(6-Methoxy-4-quinoyl)-5-vinyl-2-quinclidinemethanol; Quinine, certified reference material, TraceCERT(R); Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-, sulfate; Fawns and mcallan brand OF quinine bisulfate; Fawns and mcallan brand OF quinine sulfate; (3alpha,8alpha,9R)-6-methoxycinchonan-9-ol; Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-; Cinchonan-9-ol, 6-methoxy-, (8-alpha,9R)-; Cinchonan-9-ol, 6-methoxy-, (8alpha,9R)-; Quinsan (*2:1 Sulfate salt*), dihydrate; Innotech brand OF quinine hydrochloride; Quinamm (*2:1 Sulfate salt*), dihydrate; (R)-(-)-Quinine, 6-methoxycinchonidine; Lafran brand OF quinine hydrochloride; Biquinate (*Bisulfate heptathydrate*); (8.alpha.,9R)-6-Methoxycinchonan-9-ol; Quine (*2:1 Sulfate salt*, dihydrate); (8-alpha,9R)-6-Methoxycinchonan-9-ol; (9R)-6-methoxy-8alpha-cinchonan-9-ol; Dentojel (*Bisulfate heptathydrate*); Cinchonan-9-ol, 6-methoxy-, (8a,9R)-; Alphapharm brand OF quinine sulfate; Aventis brand OF quinine bisulfate; Prosana brand OF quinine bisulfate; Hoechst brand OF quinine sulfate; Plough brand OF quinine sulfate; (8S,9R)-6-Methoxycinchonan-9-ol; Odan brand OF quinine sulfate; Foy brand OF quinine sulfate; Cinchonan-9-ol, 6-methoxy-; 6-Methoxycinchonan-9-ol; Hydrochloride, Quinine; Quinine tannate [USP]; CHININUM PURUM [HPUS]; 6-Methoxycinchonidine; Quinine Hydrochloride; 6-Methoxycinchonine; Quinine, Anhydrous; quinine bisulphate; Bisulfate, Quinine; Quinoline alkaloid; Sulphate, Quinine; Quinine anhydrous; Quinine bisulfate; Quinineanhydrous; Quinine sulphate; Quinine [BAN:NF]; Sulfate, Quinine; Quinine, tannate; QUININE [WHO-DD]; QUININE (MART.); Quinine Sulfate; UNII-26MX5YAL2R; (8S,9R)-Quinine; UNII-A7V27PHC7A; QUININE [MART.]; QUININE [VANDF]; Chinin [German]; (R)-(-)-quinine; Chininum purum; Quinine Lafran; Tox21_112389_1; QUININE [HSDB]; Kinder Quinina; QUININE [INCI]; Quinine, 90\\%; QUININE [MI]; Coco-Quinine; Quinine-Odan; Tox21_112389; (-)-Quinine; (-)quinine; A7V27PHC7A; Quinoctal; Quinbisan; Quinbisul; Qualaquin; Biquinate; Legatrim; Surquina; chininum; Quinimax; Chinine; Aflukin; Quindan; Quinsul; Quinsan; Quinine; Quinson; Myoquin; Quinamm; Rezquin; quinina; Chinin; Strema; QI9; Conquinine; Quinine; DSSTox_GSID_44280



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

87 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, AXIN2, CA1, CYP2C19, CYP2C9, CYP2D6, HDGFL2, SLC9A1
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 5 CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6
Nucleus 3 AXIN2, HDGFL2, ITGB3
cytosol 2 AXIN2, CA1
centrosome 1 AXIN2
nucleoplasm 2 ITGB3, SLC9A1
Cell membrane 4 ABCB1, GJD2, ITGB3, SLC9A1
lamellipodium 1 SLC9A1
ruffle membrane 1 ITGB3
Multi-pass membrane protein 6 ABCB1, CATSPER3, GJD2, KCNA3, SLC9A1, TAS2R38
Synapse 2 GJD2, ITGB3
cell surface 5 ABCB1, GP1BA, ITGA2B, ITGB3, SLC9A1
glutamatergic synapse 2 ITGB3, KCNA3
presynaptic membrane 1 KCNA3
acrosomal vesicle 1 CATSPER3
plasma membrane 14 ABCB1, AXIN2, CATSPER3, CYP2C19, CYP2C9, GCG, GJD2, GP1BA, GP9, ITGA2B, ITGB3, KCNA3, SLC9A1, TAS2R38
Membrane 10 ABCB1, CYP1B1, CYP2D6, GP1BA, GP9, ITGA2B, ITGB3, KCNA3, SLC9A1, TAS2R38
apical plasma membrane 3 ABCB1, ITGB3, SLC9A1
axon 1 KCNA3
basolateral plasma membrane 1 SLC9A1
extracellular exosome 6 ABCB1, CA1, GP1BA, ITGA2B, ITGB3, SLC9A1
endoplasmic reticulum 2 CATSPER3, CYP2D6
extracellular space 3 GCG, GP1BA, IL6
perinuclear region of cytoplasm 2 KCNA3, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 3 CYP1B1, CYP2D6, SLC9A1
protein-containing complex 1 ITGB3
intracellular membrane-bounded organelle 5 CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6
Microsome membrane 4 CYP1A2, CYP1B1, CYP2C9, CYP2D6
Single-pass type I membrane protein 3 GP9, ITGA2B, ITGB3
Secreted 2 GCG, IL6
extracellular region 2 GCG, IL6
Single-pass membrane protein 1 CYP2D6
motile cilium 1 CATSPER3
external side of plasma membrane 3 GP1BA, ITGA2B, ITGB3
T-tubule 1 SLC9A1
beta-catenin destruction complex 1 AXIN2
cell-cell junction 1 ITGB3
postsynaptic membrane 2 ITGB3, KCNA3
Apical cell membrane 1 ABCB1
Membrane raft 2 KCNA3, SLC9A1
Cell junction, focal adhesion 1 ITGB3
focal adhesion 3 ITGA2B, ITGB3, SLC9A1
extracellular matrix 1 GP1BA
Cell junction, gap junction 1 GJD2
connexin complex 1 GJD2
Postsynaptic cell membrane 1 ITGB3
receptor complex 1 ITGB3
blood microparticle 1 ITGA2B
Basolateral cell membrane 1 SLC9A1
microvillus membrane 1 ITGB3
[Isoform 2]: Cell membrane 1 KCNA3
Cell projection, cilium, flagellum membrane 1 CATSPER3
Melanosome 1 ITGB3
filopodium membrane 1 ITGB3
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 2 GCG, IL6
calyx of Held 1 KCNA3
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 KCNA3
platelet alpha granule membrane 2 ITGA2B, ITGB3
integrin complex 2 ITGA2B, ITGB3
lamellipodium membrane 1 ITGB3
[Glucagon-like peptide 1]: Secreted 1 GCG
alphav-beta3 integrin-vitronectin complex 1 ITGB3
alphav-beta3 integrin-IGF-1-IGF1R complex 1 ITGB3
Cell projection, lamellipodium membrane 1 ITGB3
alpha9-beta1 integrin-ADAM8 complex 1 ITGB3
alphav-beta3 integrin-HMGB1 complex 1 ITGB3
alphav-beta3 integrin-PKCalpha complex 1 ITGB3
glycinergic synapse 1 ITGB3
integrin alphaIIb-beta3 complex 2 ITGA2B, ITGB3
integrin alphav-beta3 complex 1 ITGB3
interleukin-6 receptor complex 1 IL6
glycoprotein Ib-IX-V complex 2 GP1BA, GP9
cation-transporting ATPase complex 1 SLC9A1
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
CatSper complex 1 CATSPER3


文献列表

  • Muhammad Irfan Waris, Yanyuan Lei, Guojun Qi, Ziying Guan, Abdul Rashied, Jie Chen, Lihua Lyu. The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds. Insect science. 2024 Apr; 31(2):448-468. doi: 10.1111/1744-7917.13301. [PMID: 38010036]
  • Cécile Ficko, Pierre-Louis Conan. [Malaria in 2022: clinical and therapeutic aspects]. Medecine tropicale et sante internationale. 2023 06; 3(2):. doi: 10.48327/mtsi.v3i2.2023.378. [PMID: 37525671]
  • Louis H Miller, Jesus Rojas-Jaimes, Leanne M Low, Gilberto Corbellini. What Historical Records Teach Us about the Discovery of Quinine. The American journal of tropical medicine and hygiene. 2023 01; 108(1):7-11. doi: 10.4269/ajtmh.22-0404. [PMID: 36410328]
  • Ning Wen, Ping-Shun Song, Lin Ni, Juan Chen. Tannic acid-aminopropyltriethoxysilane co-deposition modified polymer membrane for α-glucosidase immobilization. Journal of chromatography. A. 2022 Nov; 1683(?):463550. doi: 10.1016/j.chroma.2022.463550. [PMID: 36219969]
  • Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi. Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats. BMC immunology. 2022 10; 23(1):50. doi: 10.1186/s12865-022-00519-y. [PMID: 36261807]
  • M G Semedo, A L Pereira, J R Pita. Cinchona bark and quinine in the Portuguese official pharmacopoeias (1794-2001). Die Pharmazie. 2022 09; 77(7):278-285. doi: 10.1691/ph.2022.2034. [PMID: 36199186]
  • Ryuta Asaumi, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Kunal S Taskar, Yuichi Sugiyama. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. CPT: pharmacometrics & systems pharmacology. 2022 07; 11(7):919-933. doi: 10.1002/psp4.12807. [PMID: 35570332]
  • Rajinder Bhardwaj, Julie L Collins, Joseph Stringfellow, Jennifer Madonia, Matt S Anderson, Jeri-Anne Finley, David A Stock, Vladimir Coric, Robert Croop, Richard Bertz. P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects. Clinical pharmacology in drug development. 2022 07; 11(7):889-897. doi: 10.1002/cpdd.1088. [PMID: 35304977]
  • Peyman Rezaie, Vida Bitarafan, Braden D Rose, Kylie Lange, Jens F Rehfeld, Michael Horowitz, Christine Feinle-Bisset. Quinine Effects on Gut and Pancreatic Hormones and Antropyloroduodenal Pressures in Humans-Role of Delivery Site and Sex. The Journal of clinical endocrinology and metabolism. 2022 06; 107(7):e2870-e2881. doi: 10.1210/clinem/dgac182. [PMID: 35325161]
  • Nourhan M Abd El-Aziz, Ibrahim Khalifa, Amira M G Darwish, Ahmed N Badr, Huda Aljumayi, El-Sayed Hafez, Mohamed G Shehata. Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092662. [PMID: 35566014]
  • Tatsuya Kokawa, Hiroyuki Yamamoto, Mitsuaki Itoh, Akira Shimane, Hiroya Kawai, Tomofumi Takaya. Fever-Related Ventricular Fibrillation　- Potential Adverse Effect of SARS-CoV-2 Vaccination in Patients With Brugada Syndrome. Circulation journal : official journal of the Japanese Circulation Society. 2022 Feb; 86(3):474. doi: 10.1253/circj.cj-21-0750. [PMID: 34615807]
  • Xiuliang Dai, Xiangjiao Yi, Yufeng Wang, Wei Xia, Jianguo Tao, Jun Wu, Dengshun Miao, Li Chen. PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice. Frontiers in endocrinology. 2022; 13(?):781404. doi: 10.3389/fendo.2022.781404. [PMID: 35340329]
  • Teerachat Sae-Heng, Rajith Kumar Reddy Rajoli, Marco Siccardi, Juntra Karbwang, Kesara Na-Bangchang. Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. CPT: pharmacometrics & systems pharmacology. 2022 01; 11(1):104-115. doi: 10.1002/psp4.12737. [PMID: 34730282]
  • Alexander Burashnikov, Hector Barajas-Martinez, Robert Cox, Mark A Demitrack, Michael J Fossler, Michael Kramer, Robert B Kleiman, Peter Kowey, Charles Antzelevitch. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk. Heart rhythm. 2021 12; 18(12):2177-2186. doi: 10.1016/j.hrthm.2021.08.028. [PMID: 34481984]
  • Yong-Jia Chen, Kun-Yuan Ma, Sha-Sha Du, Zhi-Jun Zhang, Tian-Lin Wu, Yu Sun, Ying-Qian Liu, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, Chen Tang. Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids. Journal of agricultural and food chemistry. 2021 Oct; 69(41):12156-12170. doi: 10.1021/acs.jafc.1c05677. [PMID: 34623798]
  • Daniel M Gelfman. Reflections on quinine and its importance in dermatology today. Clinics in dermatology. 2021 Sep; 39(5):900-903. doi: 10.1016/j.clindermatol.2021.08.017. [PMID: 34785019]
  • M G Semedo, A L Pereira, J R Pita. The influence of German science on Cinchona and quinine research in Portugal in the second half of the 19th century. Die Pharmazie. 2021 08; 76(8):396-402. doi: 10.1691/ph.2021.1050. [PMID: 34412740]
  • J V Joviano-Santos, A Santos-Miranda, E A Neri, M H Fonseca-Alaniz, J E Krieger, A C Pereira, D Roman-Campos. SCN5A compound heterozygosity mutation in Brugada syndrome: Functional consequences and the implication for pharmacological treatment. Life sciences. 2021 Aug; 278(?):119646. doi: 10.1016/j.lfs.2021.119646. [PMID: 34048814]
  • Inoussa Sanané, Judith Legrand, Christine Dillmann, Frédéric Marion-Poll. High-Throughput Feeding Bioassay for Lepidoptera Larvae. Journal of chemical ecology. 2021 Jul; 47(7):642-652. doi: 10.1007/s10886-021-01290-x. [PMID: 34331170]
  • Wout Verbeure, Eveline Deloose, Joran Tóth, Jens F Rehfeld, Lukas Van Oudenhove, Inge Depoortere, Jan Tack. The endocrine effects of bitter tastant administration in the gastrointestinal system: intragastric versus intraduodenal administration. American journal of physiology. Endocrinology and metabolism. 2021 07; 321(1):E1-E10. doi: 10.1152/ajpendo.00636.2020. [PMID: 34029163]
  • Braden D Rose, Vida Bitarafan, Peyman Rezaie, Penelope C E Fitzgerald, Michael Horowitz, Christine Feinle-Bisset. Comparative Effects of Intragastric and Intraduodenal Administration of Quinine on the Plasma Glucose Response to a Mixed-Nutrient Drink in Healthy Men: Relations with Glucoregulatory Hormones and Gastric Emptying. The Journal of nutrition. 2021 06; 151(6):1453-1461. doi: 10.1093/jn/nxab020. [PMID: 33704459]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Maximilian Große, Natalia Ruetalo, Mirjam Layer, Dan Hu, Ramona Businger, Sascha Rheber, Christian Setz, Pia Rauch, Janina Auth, Maria Fröba, Ekkehard Brysch, Michael Schindler, Ulrich Schubert. Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2. Viruses. 2021 04; 13(4):. doi: 10.3390/v13040647. [PMID: 33918670]
  • M Schneider, F Dron, E Cuinet, F Woehrlé. Comparative pharmacokinetic profile of cimicoxib in dogs and cats after IV administration. Veterinary journal (London, England : 1997). 2021 Apr; 270(?):105625. doi: 10.1016/j.tvjl.2021.105625. [PMID: 33641805]
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