Remifentanil (BioDeep_00000002029)
Secondary id: BioDeep_00000398454
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
3-(4-Methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester
化学式: C20H28N2O5 (376.1998118)
中文名称: 瑞芬太尼
谱图信息:
最多检出来源 Homo sapiens(urine) 50%
分子结构信息
SMILES: CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC(=O)OC)CC1)C(=O)OC
InChI: InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3
描述信息
Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist. Hence, it causes a reduction in sympathetic nervous system tone, respiratory depression and analgesia.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AH - Opioid anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:8802
- KEGG: C08021
- KEGGdrug: D08473
- PubChem: 60815
- HMDB: HMDB0015036
- Metlin: METLIN66781
- DrugBank: DB00899
- ChEMBL: CHEMBL1005
- Wikipedia: Remifentanil
- MeSH: Remifentanil
- chemspider: 54803
- CAS: 132875-61-7
- PMhub: MS000001707
- PubChem: 10221
- NIKKAJI: J423.836B
- KNApSAcK: 8802
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhenming Kang, Guoshao Zhu, Changsheng Su, Kai Zeng, Shunyuan Li, Xiaodan Wu. Differential effects of remifentanil and sufentanil anesthesia on post-operative pain and cognitive functions.
International immunopharmacology.
2022 Jul; 108(?):108888. doi:
10.1016/j.intimp.2022.108888. [PMID: 35729829] - Nicole Wylie, Lee Beale, Ian Westley. Consistency of remifentanil concentrations in propofol-Remifentanil infusions. A laboratory-based study.
Paediatric anaesthesia.
2022 06; 32(6):727-731. doi:
10.1111/pan.14427. [PMID: 35234322] - Jun Okuda, Takeshi Suzuki, Kenta Wakaizumi, Jungo Kato, Takashige Yamada, Hiroshi Morisaki. Effects of Thoracic Epidural Anesthesia on Systemic and Local Inflammatory Responses in Patients Undergoing Lung Cancer Surgery: A Randomized Controlled Trial.
Journal of cardiothoracic and vascular anesthesia.
2022 05; 36(5):1380-1386. doi:
10.1053/j.jvca.2021.08.026. [PMID: 34518101] - M-X Yang, Z-Z Wu, X-Y Liao, B-L Zhang, X Chen, Y Wu, J-D Lin. Remifentanil reduces multiple organ and energy metabolism disturbances in a rat sepsis model.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2022 Feb; 73(1):. doi:
10.26402/jpp.2022.1.08. [PMID: 35639040] - Youqing Li, Jiangping Yu, Mingmin Zhang, Meng Jia. Clinical Application of Remifentanil Combined with Sevoflurane in Manual Reduction of Humeral Supracondylar Fracture in Children.
Computational and mathematical methods in medicine.
2022; 2022(?):2410433. doi:
10.1155/2022/2410433. [PMID: 35844458] - Xiaojun Li, Zhenping Gui, Huizi Liu, Shaojie Qian, Yanan Jia, Xiaopan Luo. Remifentanil pretreatment ameliorates H/R-induced cardiac microvascular endothelial cell dysfunction by regulating the PI3K/Akt/HIF-1α signaling pathway.
Bioengineered.
2021 12; 12(1):7872-7881. doi:
10.1080/21655979.2021.1969843. [PMID: 34612779] - Tae Kyun Kim. Obesity and anesthetic pharmacology: simulation of target-controlled infusion models of propofol and remifentanil.
Korean journal of anesthesiology.
2021 12; 74(6):478-487. doi:
10.4097/kja.21345. [PMID: 34407372] - Ping-Ping Jiang, Yan-Xia Guo, Xiao-Lin Yang, Juan Xu, Dan Wang. Effects of different remifentanil target concentrations on MACBAR of sevoflurane in patients with liver dysfunction under carbon dioxide pneumoperitoneum stimulus: A randomized controlled trial.
Journal of clinical pharmacy and therapeutics.
2021 Dec; 46(6):1776-1783. doi:
10.1111/jcpt.13524. [PMID: 34514614] - Dan Wang, Juan Xu, Xiao-Lin Yang, Yan-Xia Guo, Ping-Ping Jiang, Guo-Yuan Zhang. Effects of different plasma target concentrations of remifentanil on the MACBAR of sevoflurane in children with laparoscopic surgery.
BMC anesthesiology.
2021 09; 21(1):231. doi:
10.1186/s12871-021-01453-z. [PMID: 34560835] - L Van Hese, E Cuypers, T Theys, A Absalom, S Rex. Comparison of predicted and real propofol and remifentanil concentrations in plasma and brain tissue during target-controlled infusion: a reply.
Anaesthesia.
2021 06; 76(6):861-862. doi:
10.1111/anae.15452. [PMID: 33662142] - Y Luo, L Wang, G W Li, Z Y Yang, X Z Lin. [Dexmedetomidine up-regulates peripheral blood microRNA 183 to improve remifentanil-related hyperalgesia].
Zhonghua yi xue za zhi.
2021 May; 101(17):1246-1249. doi:
10.3760/cma.j.cn112137-20200825-02467. [PMID: 34865393] - Analía I Alet, Marcus V Batista da Silva, Horacio V Castellini, Nicolás A Alet, Bibiana D Riquelme. In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium.
Microvascular research.
2021 05; 135(?):104132. doi:
10.1016/j.mvr.2021.104132. [PMID: 33421433] - Sirkku Ahlström, Paula Bergman, Ritva Jokela, Linda Ottensmann, Ari Ahola-Olli, Matti Pirinen, Klaus T Olkkola, Mari A Kaunisto, Eija Kalso. First genome-wide association study on rocuronium dose requirements shows association with SLCO1A2.
British journal of anaesthesia.
2021 May; 126(5):949-957. doi:
10.1016/j.bja.2021.01.029. [PMID: 33676726] - Hyung-Been Yhim, Hyung-Min Oh, Hyun-Kyu Yoon, Yong Hwy Kim, Hee-Pyoung Park. A Retrospective Observational Study of the Neuroendocrine Stress Response in Patients Undergoing Endoscopic Transsphenoidal Surgery for Removal of Pituitary Adenomas: Total Intravenous Versus Balanced Anesthesia.
Journal of neurosurgical anesthesiology.
2021 Apr; 33(2):137-146. doi:
10.1097/ana.0000000000000638. [PMID: 31453876] - Natsuki Akashi, Yusuke Murahata, Masahumi Hosokawa, Yoshiaki Hikasa, Yoshiharu Okamoto, Tomohiro Imagawa. Cardiovascular and renal effects of constant rate infusions of remifentanil, dexmedetomidine and their combination in dogs anesthetized with sevoflurane.
The Journal of veterinary medical science.
2021 Mar; 83(2):285-296. doi:
10.1292/jvms.20-0457. [PMID: 33310997] - Linda Y Tang, Jingping Wang. Response to 'Systematic Application of Rapid Sequence Intubation With Remifentanil During COVID-19 Pandemic'.
Seminars in cardiothoracic and vascular anesthesia.
2021 03; 25(1):76. doi:
10.1177/1089253220943026. [PMID: 32696727] - Sergio Bevilacqua, Vanessa Bottari, Ilaria Galeotti. Systematic Application of Rapid Sequence Intubation With Remifentanil During COVID-19 Pandemic.
Seminars in cardiothoracic and vascular anesthesia.
2021 Mar; 25(1):74-75. doi:
10.1177/1089253220941369. [PMID: 32664787] - Sandra Funcke, Hans O Pinnschmidt, Charlotte Brinkmann, Stefan Wesseler, Burkhard Beyer, Marlene Fischer, Rainer Nitzschke. Nociception level-guided opioid administration in radical retropubic prostatectomy: a randomised controlled trial.
British journal of anaesthesia.
2021 02; 126(2):516-524. doi:
10.1016/j.bja.2020.09.051. [PMID: 33228979] - Elizabeth Jabbour, Carsten Fütterer, Sebastian Zach, Anna-Isabelle Kälsch, Michael Keese, Nuh N Rahbari, Bernhard K Krämer, Kay G Schwenke. Implantation of a peritoneal dialysis catheter in patients with ESRD using local anesthesia and Remifentanil.
PloS one.
2021; 16(11):e0259351. doi:
10.1371/journal.pone.0259351. [PMID: 34735524] - Ning Yang, Ming Yang, Wenping Peng, Siwen Zhao, Jie Bao, Mingzhang Zuo. Comparison of anesthesia effects between closed-loop and open-loop target controlled infusion of propofol using the bispectral index in abdominal surgery.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2020 Dec; 45(12):1419-1424. doi:
10.11817/j.issn.1672-7347.2020.190489. [PMID: 33472997] - Jean Jung, Allan Kolodziej, Elise Pape, Michael Bisch, Lucie Javot, Valérie Gibaja, Jean-Yves Jouzeau, Julien Scala-Bertola, Nicolas Gambier. Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.
Forensic science international.
2020 Dec; 317(?):110437. doi:
10.1016/j.forsciint.2020.110437. [PMID: 33007729] - Daneele Thorpe, Ryan T Lacy, Justin C Strickland. Acquisition of remifentanil self-administration: Enhanced in female rats but no effect of adolescent stress exposure.
Pharmacology, biochemistry, and behavior.
2020 12; 199(?):173038. doi:
10.1016/j.pbb.2020.173038. [PMID: 32910927] - Zhiqiang Yu, Peijun Zhang, Haiyun Wang, Li Zhang, Wei Wei, Wenqian Fang, Xingbo Mu. Effects of dexmedetomidine versus remifentanil on mothers and neonates during cesarean section under general anesthesia.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2020 Dec; 164(4):417-424. doi:
10.5507/bp.2019.055. [PMID: 31762471] - Anthony R Absalom, Ann E Rigby-Jones, Andrew R Rushton, J Robert Sneyd. De-mystifying the 'Mixifusor'.
Paediatric anaesthesia.
2020 12; 30(12):1292-1298. doi:
10.1111/pan.14039. [PMID: 33051933] - L Van Hese, T Theys, A R Absalom, S Rex, E Cuypers. Comparison of predicted and real propofol and remifentanil concentrations in plasma and brain tissue during target-controlled infusion: a prospective observational study.
Anaesthesia.
2020 12; 75(12):1626-1634. doi:
10.1111/anae.15125. [PMID: 32506561] - Rongsheng Zhou, Shuang Li, Xiaopeng Mei, Tao Jiang, Qiang Wang. Remifentanil up-regulates HIF1α expression to ameliorate hepatic ischaemia/reperfusion injury via the ZEB1/LIF axis.
Journal of cellular and molecular medicine.
2020 11; 24(22):13196-13207. doi:
10.1111/jcmm.15929. [PMID: 32996684] - Douglas J Eleveld, Pieter Colin, Anthony R Absalom, Michel M R F Struys. Target-controlled-infusion models for remifentanil dosing consistent with approved recommendations.
British journal of anaesthesia.
2020 10; 125(4):483-491. doi:
10.1016/j.bja.2020.05.051. [PMID: 32654750] - Yi-Heng Liu, Xiao-Bing Hu, Xia-Min Yang, Ying-Wei Wang, Meng Deng. Comparing remifentanil and sufentanil in stress reduction during neurosurgery: a randomised controlled trial.
International journal of clinical pharmacy.
2020 Oct; 42(5):1326-1334. doi:
10.1007/s11096-020-01094-1. [PMID: 32686050] - Matthew Stewart, Adam Thaler, Patrick Hunt, Leonard Estephan, Maurits Boon, Colin Huntley. Preferential use of total intravenous anesthesia in ambulatory otolaryngology surgery during the COVID-19 pandemic.
American journal of otolaryngology.
2020 Sep; 41(5):102570. doi:
10.1016/j.amjoto.2020.102570. [PMID: 32505994] - Dirk J Bosch, Matijs V Meurs, Rianne M Jongman, Peter Heeringa, Wayel H Abdulahad, Michel M R F Struys. Effects of propofol and dexmedetomidine with and without remifentanil on serum cytokine concentrations in healthy volunteers: a post hoc analysis.
British journal of anaesthesia.
2020 09; 125(3):267-274. doi:
10.1016/j.bja.2020.05.039. [PMID: 32660717] - Laura N Hannivoort, Anthony R Absalom, Michel M R F Struys. The role of pharmacokinetics and pharmacodynamics in clinical anaesthesia practice.
Current opinion in anaesthesiology.
2020 Aug; 33(4):483-489. doi:
10.1097/aco.0000000000000881. [PMID: 32530894] - Kohei Fukuta, Asuka Kasai, Noriko Niki, Yuki Ishikawa, Ryosuke Kawanishi, Nami Kakuta, Yoko Sakai, Yasuo M Tsutsumi, Katsuya Tanaka. The effect of 1\% glucose loading on metabolism in the elderly patients during remifentanil-induced anesthesia: a randomized controlled trial.
BMC anesthesiology.
2020 06; 20(1):143. doi:
10.1186/s12871-020-01061-3. [PMID: 32505171] - Gonul Sagiroglu, Ayse Baysal. Continuous intravenous versus intermittent bolus midazolam with remifentanil during arteriovenous fistula placement with monitored anesthesia care in chronic renal failure patients: a randomized controlled trial.
Annals of Saudi medicine.
2020 May; 40(3):175-182. doi:
10.5144/0256-4947.2020.175. [PMID: 32493052] - Sang Hwan Ji, Ji Hyun Lee, Joo Youn Cho, Hwa Suk Kim, Young Eun Jang, Eun Hee Kim, Jin Tae Kim, Hee Soo Kim. External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old.
Journal of Korean medical science.
2020 03; 35(11):e70. doi:
10.3346/jkms.2020.35.e70. [PMID: 32193901] - Egidijus Semenas, Maria Lönnemark, Pär Dahlman, Michael Hultström, Mats Eriksson. Analgesic effects of dexmedetomidine and remifentanil on periprocedural pain during percutaneous ablation of renal carcinoma.
Upsala journal of medical sciences.
2020 Feb; 125(1):52-57. doi:
10.1080/03009734.2020.1720047. [PMID: 32067572] - Jungchan Park, Seung-Hwa Lee, Jong-Hwan Lee, Jeong Jin Min, Ji-Hye Kwon, Ah-Ran Oh, Keumhee Carriere, Joonghyun Ahn. Volatile versus total intravenous anesthesia for 30-day mortality following non-cardiac surgery in patients with preoperative myocardial injury.
PloS one.
2020; 15(9):e0238661. doi:
10.1371/journal.pone.0238661. [PMID: 32915840] - Marija S Kutlesic, Gordana Kocic, Ranko M Kutlesic. [The effects of remifentanil used during cesarean section on oxidative stress markers in correlation with maternal hemodynamics and neonatal outcome: a randomized controlled trial].
Brazilian journal of anesthesiology (Elsevier).
2019 Nov; 69(6):537-545. doi:
10.1016/j.bjan.2019.05.005. [PMID: 31796304] - Ru Ouyang, Haijing Ren, Wei Liu, Xi Yuan, Enjun Lei. Remifentanil inhibits the traumatic stress response in emergent trauma surgery.
Journal of clinical laboratory analysis.
2019 Oct; 33(8):e22971. doi:
10.1002/jcla.22971. [PMID: 31373418] - Brian J Anderson, Oliver Bagshaw. Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children.
Anesthesiology.
2019 07; 131(1):164-185. doi:
10.1097/aln.0000000000002657. [PMID: 30920966] - Michael C Montana, Lindsay Juriga, Anshuman Sharma, Evan D Kharasch. Opioid Sensitivity in Children with and without Obstructive Sleep Apnea.
Anesthesiology.
2019 06; 130(6):936-945. doi:
10.1097/aln.0000000000002664. [PMID: 30870164] - Heleen J Blussé van Oud-Alblas, Margreke J E Brill, Mariska Y M Peeters, Dick Tibboel, Meindert Danhof, Catherijne A J Knibbe. Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints.
BMC anesthesiology.
2019 01; 19(1):15. doi:
10.1186/s12871-019-0684-z. [PMID: 30669968] - Qiang Jia, Fen Tian, Wei-Na Duan, Yi-Fan Jia, Hua-Xin Wang, Zhong-Yuan Xia. Effects of Dezocine-Remifentanil Intravenous Anaesthesia on Perioperative Signs, Serum TNF-&aipha; and IL-6 in Liver Cancer Patients undergoing Radiofrequency Ablation.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jan; 29(1):4-7. doi:
10.29271/jcpsp.2019.01.4. [PMID: 30630559] - Suchun Ding, Hongzhong Ma, Gao Wang, Zhenyu Yu, Kezhong Li, Aijie Huang. Effect of Remifentanil Combined Anesthesia on Cytokines and Oxidative Stress in Patients undergoing Laparoscopic Surgery for Colon Cancer.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jan; 29(1):8-11. doi:
10.29271/jcpsp.2019.01.8. [PMID: 30630560] - Mohamed R El-Tahan, Samah El Kenany, Ehsan M Abdelaty, Eiad A Ramzy. Comparison of the effects of low doses of dexmedetomidine and remifentanil on the maternal hemodynamic changes during caesarean delivery in patients with severe preeclampsia: a randomized trial.
Minerva anestesiologica.
2018 12; 84(12):1343-1351. doi:
10.23736/s0375-9393.18.12312-1. [PMID: 29516705] - J Li, H-P Hu, Y Li, W Shao, J-Z Zhang, L-M Wang. Influences of remifentanil on myocardial ischemia-reperfusion injury and the expressions of Bax and Bcl-2 in rats.
European review for medical and pharmacological sciences.
2018 12; 22(24):8951-8960. doi:
10.26355/eurrev_201812_16665. [PMID: 30575939] - Mohamed Said Nakhli, Mohamed Kahloul, Taieb Guizani, Chekib Zedini, Ajmi Chaouch, Walid Naija. Intravenous lidocaine as adjuvant to general anesthesia in renal surgery.
The Libyan journal of medicine.
2018 Dec; 13(1):1433418. doi:
10.1080/19932820.2018.1433418. [PMID: 29433385] - Ping-Chen, Qing-Song Lin, Xian-Zhong Lin. Optimal concentration of the transversus abdominis plane block in enhanced recovery after surgery protocols for patients of advanced age undergoing laparoscopic rectal cancer surgery.
The Journal of international medical research.
2018 Nov; 46(11):4437-4446. doi:
10.1177/0300060518790699. [PMID: 30111216] - Daan J Reesink, J M W Scheltema, M M Barendrecht, A E Boeken Kruger, A Jansonius, J Wiltink, F van der Windt. Extracorporeal shock wave lithotripsy under intravenous sedation for treatment of urolithiasis.
Scandinavian journal of urology.
2018 Oct; 52(5-6):453-458. doi:
10.1080/21681805.2018.1524398. [PMID: 30451054] - Shigeru Maeda, Tsugunobu Andoh, Rieko Onishi, Yumiko Tomoyasu, Hitoshi Higuchi, Takuya Miyawaki. Remifentanil suppresses increase in interleukin-6 mRNA in the brain by inhibiting cyclic AMP synthesis.
Journal of anesthesia.
2018 10; 32(5):731-739. doi:
10.1007/s00540-018-2548-y. [PMID: 30167784] - Monica Simeoni, Chao Chen. Population Pharmacokinetic Modelling for Estimation of Remifentanil Metabolic-Ratio Using Non-steady-State Concentrations under Rapidly Adaptive Dosing.
Pharmaceutical research.
2018 Sep; 35(11):216. doi:
10.1007/s11095-018-2508-0. [PMID: 30255401] - Tao Yan, Guo-Hua Zhang, Bao-Na Wang, Li Sun, Hui Zheng. Effects of propofol/remifentanil-based total intravenous anesthesia versus sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β and prognosis after breast cancer surgery: a prospective, randomized and controlled study.
BMC anesthesiology.
2018 09; 18(1):131. doi:
10.1186/s12871-018-0588-3. [PMID: 30243294] - Hélène I Morue, Shalini Raj-Lawrence, Sarah Saxena, Anne Delbaere, Edgard Engelman, Luc A Barvais. Placebo versus low-dose ketamine infusion in addition to remifentanil target-controlled infusion for conscious sedation during oocyte retrieval: A double-blinded, randomised controlled trial.
European journal of anaesthesiology.
2018 09; 35(9):667-674. doi:
10.1097/eja.0000000000000826. [PMID: 29757924] - Luis I Cortínez, Brian J Anderson. Advances in pharmacokinetic modeling: target controlled infusions in the obese.
Current opinion in anaesthesiology.
2018 Aug; 31(4):415-422. doi:
10.1097/aco.0000000000000619. [PMID: 29794852] - Wataru Sakai, Yusuke Yoshikawa, Michiaki Yamakage. In reply: Why remifentanil?.
Journal of anesthesia.
2018 06; 32(3):459. doi:
10.1007/s00540-018-2487-7. [PMID: 29616346] - Guillermo Lema. …why remifentanil?.
Journal of anesthesia.
2018 06; 32(3):458. doi:
10.1007/s00540-018-2488-6. [PMID: 29594514] - Seokha Yoo, Karam Nam, Won Ho Kim. Association between remifentanil and acute kidney injury.
Journal of anesthesia.
2018 04; 32(2):306. doi:
10.1007/s00540-018-2450-7. [PMID: 29327277] - L-Q Ren, X-X Sun, Y Guan. Effects of sevoflurane or propofol combined with remifentanil anesthesia on clinical efficacy and stress response in pregnant women with pregnancy-induced hypertension.
European review for medical and pharmacological sciences.
2018 03; 22(6):1825-1829. doi:
10.26355/eurrev_201803_14602. [PMID: 29630132] - Özcan Pişkin, Hilal Ayoğlu. Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats.
Cardiovascular toxicology.
2018 02; 18(1):56-62. doi:
10.1007/s12012-017-9413-3. [PMID: 28540470] - Cui Cui, Fang Yu, Suqing Yin, Yuting Yang, Yingfu Jiao, Chiwai Cheung, Xiaomin Wang, Bo Qi, Yaling Liu, Peiying Li, Weifeng Yu, Jie Xiao, Liqun Yang. Remifentanil Preconditioning Attenuates Hepatic Ischemia-Reperfusion Injury in Rats via Neuronal Activation in Dorsal Vagal Complex.
Mediators of inflammation.
2018; 2018(?):3260256. doi:
10.1155/2018/3260256. [PMID: 29861656] - Wataru Sakai, Yusuke Yoshikawa, Naoyuki Hirata, Michiaki Yamakage. Effect of remifentanil during cardiopulmonary bypass on incidence of acute kidney injury after cardiac surgery.
Journal of anesthesia.
2017 Dec; 31(6):895-902. doi:
10.1007/s00540-017-2419-y. [PMID: 29086014] - Karim Nasseri, Shoaleh Shami, Mousa Shirmohammadi, Farzad Sarshivi, Negin Ghadami. The Effect of Remifentanil on Succinylcholine Induced Changes in Serum Potassium and Creatine Kinase: A Prospective Randomized Double blind Study.
Acta bio-medica : Atenei Parmensis.
2017 10; 88(3):276-280. doi:
10.23750/abm.v88i3.4845. [PMID: 29083331] - Y J Cho, W Y Jo, H Oh, C-H Koo, J Oh, J-Y Cho, K-S Yu, Y Jeon, T K Kim. Performance of the Minto model for the target-controlled infusion of remifentanil during cardiopulmonary bypass.
Anaesthesia.
2017 Oct; 72(10):1196-1205. doi:
10.1111/anae.14019. [PMID: 28891056] - Asunción Romero, Juan-Antonio García-Carmona, María-Luisa Laorden, Margarita M Puig. Role of CRF1 receptor in post-incisional plasma extravasation and nociceptive responses in mice.
Toxicology and applied pharmacology.
2017 10; 332(?):121-128. doi:
10.1016/j.taap.2017.04.021. [PMID: 28434951] - Rathvirak Ing, Ngai Liu, Thierry Chazot, Julien Fessler, Jean François Dreyfus, Marc Fischler, Morgan Le Guen. Nociceptive stimulation during Macintosh direct laryngoscopy compared with McGrath Mac videolaryngoscopy: A randomized trial using indirect evaluation using an automated administration of propofol and remifentanil.
Medicine.
2017 Sep; 96(38):e8087. doi:
10.1097/md.0000000000008087. [PMID: 28930848] - Xiaochun Zheng, Liling Wan, Fei Gao, Jianghu Chen, Wenshao Tu. [Effect of ear point embedding on plasma and effect site concentrations of propofol-remifentanil in elderly patients after target-controlled induction].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2017 Aug; 37(8):869-873. doi:
10.13703/j.0255-2930.2017.08.017. [PMID: 29231349] - Zhang Hao, Hou Yali, Li Xiangjun, Dong Fusheng, Lin Ruihua. [Comparison between propofol and propofol-remifentanil sedation under target-controlled infusion for impacted supernumerary teeth extraction surgery for children].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology.
2017 Aug; 35(4):408-412. doi:
10.7518/hxkq.2017.04.013. [PMID: 28853509] - Liguo Hu, Jianhui Pan, Shantang Zhang, Jinjing Yu, Keqiang He, Shuhua Shu, Ruiting Wang. Propofol in combination with remifentanil for cesarean section: Placental transfer and effect on mothers and newborns at different induction to delivery intervals.
Taiwanese journal of obstetrics & gynecology.
2017 Aug; 56(4):521-526. doi:
10.1016/j.tjog.2016.09.010. [PMID: 28805611] - Kentaro Ouchi, Kazuna Sugiyama. [Remifentanil does not increase urine output during oral surgery, contrary to its effect during other surgeries - a cohort study].
Revista brasileira de anestesiologia.
2017 Jul; 67(4):342-346. doi:
10.1016/j.bjan.2015.12.012. [PMID: 28410819] - Qi Zhang, Ya-Nan Li, Yang-Yang Guo, Chun-Ping Yin, Fang Gao, Xi Xin, Shu-Ping Huo, Xiu-Li Wang, Qiu-Jun Wang. Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly: A prospective, randomized, controlled trial.
Medicine.
2017 Jun; 96(26):e7375. doi:
10.1097/md.0000000000007375. [PMID: 28658163] - Maya Mikami, Yi Zhang, Benjamin Kim, Tilla S Worgall, Harald Groeben, Charles W Emala. Dexmedetomidine's inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation.
BMC anesthesiology.
2017 03; 17(1):52. doi:
10.1186/s12871-017-0345-z. [PMID: 28356076] - Kwon Hui Seo, Jin Woo Choi, Hong Soo Jung, Hansol Yoo, Jin Deok Joo. The Effects of Remifentanil on Expression of High Mobility Group Box 1 in Septic Rats.
Journal of Korean medical science.
2017 Mar; 32(3):542-551. doi:
10.3346/jkms.2017.32.3.542. [PMID: 28145661] - Nobuyuki Matsuura, Taiki Okamura, Satoko Ide, Tatsuya Ichinohe. Remifentanil Reduces Blood Loss During Orthognathic Surgery.
Anesthesia progress.
2017; 64(1):3-7. doi:
10.2344/anpr-63-03-04. [PMID: 28128659] - Changxi Shi, Yue Liu, Wei Zhang, Yishan Lei, Cui'e Lu, Rao Sun, Yu'e Sun, Ming Jiang, Xiaoping Gu, Zhengliang Ma. Intraoperative electroacupuncture relieves remifentanil-induced postoperative hyperalgesia via inhibiting spinal glial activation in rats.
Molecular pain.
2017 Jan; 13(?):1744806917725636. doi:
10.1177/1744806917725636. [PMID: 28825338] - Tomohiro Chaki, Yuko Nawa, Keishi Tamashiro, Eri Mizuno, Naoyuki Hirata, Michiaki Yamakage. Remifentanil prevents increases of blood glucose and lactate levels during cardiopulmonary bypass in pediatric cardiac surgery.
Annals of cardiac anaesthesia.
2017 Jan; 20(1):33-37. doi:
10.4103/0971-9784.197827. [PMID: 28074792] - E Erkılıç, E Kesimci, F Alaybeyoğlu, I Kılınç, R Tural, A Yazgan, T Gümüş, A Sepici Dinçel, E G Dumlu, O Kanbak. Does remifentanil attenuate renal ischemia-reperfusion injury better than dexmedetomidine in rat kidney?.
Drug design, development and therapy.
2017; 11(?):677-683. doi:
10.2147/dddt.s126701. [PMID: 28331287] - Germano De Cosmo, Flaminio Sessa, Federico Fiorini, Elisabetta Congedo. Effect of remifentanil and fentanyl on postoperative cognitive function and cytokines level in elderly patients undergoing major abdominal surgery.
Journal of clinical anesthesia.
2016 Dec; 35(?):40-46. doi:
10.1016/j.jclinane.2016.07.016. [PMID: 27871564] - Ting Xu, Min Li, Cheng Ni, Xiang-Yang Guo. Dexmedetomidine versus remifentanil for sedation during awake intubation using a Shikani optical stylet: a randomized, double-blinded, controlled trial.
BMC anesthesiology.
2016 08; 16(1):52. doi:
10.1186/s12871-016-0219-9. [PMID: 27484783] - Yan Li, Lingzhong Meng, Yuming Peng, Hui Qiao, Lanjun Guo, Ruquan Han, Adrian W Gelb. Effects of Dexmedetomidine on motor- and somatosensory-evoked potentials in patients with thoracic spinal cord tumor: a randomized controlled trial.
BMC anesthesiology.
2016 08; 16(1):51. doi:
10.1186/s12871-016-0217-y. [PMID: 27484701] - Jose D Bolanos, Montserrat Vallverdu, Pere Caminal, Daniel F Valencia, Xavi Borrat, Pedro L Gambus, Jose F Valencia. Assessment of sedation-analgesia by means of Poincaré analysis of the electroencephalogram.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference.
2016 Aug; 2016(?):6425-6428. doi:
10.1109/embc.2016.7592199. [PMID: 28269717] - Makoto Sato, Chika Kikuchi, Tomoki Sasakawa, Takayuki Kunisawa. Effects of remifentanil on the sphincter of Oddi in a 3-year-old child: a case report.
Journal of clinical anesthesia.
2016 Aug; 32(?):262-4. doi:
10.1016/j.jclinane.2016.02.039. [PMID: 27290986] - Ruth Edry, Vasile Recea, Yuri Dikust, Daniel I Sessler. Preliminary Intraoperative Validation of the Nociception Level Index: A Noninvasive Nociception Monitor.
Anesthesiology.
2016 Jul; 125(1):193-203. doi:
10.1097/aln.0000000000001130. [PMID: 27171828] - Mineto Kamata, Joseph D Tobias. Remifentanil: applications in neonates.
Journal of anesthesia.
2016 06; 30(3):449-60. doi:
10.1007/s00540-015-2134-5. [PMID: 26758072] - Tatjana Bevans, Cassandra Deering-Rice, Chris Stockmann, Alan Light, Christopher Reilly, Derek J Sakata. Inhaled Remifentanil in Rodents.
Anesthesia and analgesia.
2016 06; 122(6):1831-8. doi:
10.1213/ane.0000000000001228. [PMID: 26974021] - Jacob Schaff, Robert Maniker. Anesthetic management of donor nephrectomy for a recipient with history of malignant hyperthermia: avoiding a transferred trigger.
Journal of clinical anesthesia.
2016 Jun; 31(?):259-62. doi:
10.1016/j.jclinane.2016.01.034. [PMID: 27185722] - Eirini Sklika, Konstantinos Kalimeris, Despina Perrea, Nikolaos Stavropoulos, Georgia Kostopanagiotou, Paraskevi Matsota. REMIFENTANIL VS FENTANYL DURING DAY CASE DENTAL SURGERY IN PEOPLE WITH SPECIAL NEEDS: A COMPARATIVE, PILOT STUDY OF THEIR EFFECT ON STRESS RESPONSE AND POSTOPERATIVE PAIN.
Middle East journal of anaesthesiology.
2016 06; 23(5):509-15. doi:
. [PMID: 27487636] - X-L Zhi, C-Y Li, M Xue, Y Hu, Y Ji. Changes in cognitive function due to combined propofol and remifentanil treatment are associated with phosphorylation of Tau in the hippocampus, abnormal total water and calcium contents of the brain, and elevated serum S100β levels.
European review for medical and pharmacological sciences.
2016 05; 20(10):2156-62. doi:
. [PMID: 27249618] - Christian Bohris, Christian G Stief, Frank Strittmatter. Improvement of SWL Efficacy: Reduction of the Respiration-Induced Kidney Motion by Using an Abdominal Compression Plate.
Journal of endourology.
2016 Apr; 30(4):411-6. doi:
10.1089/end.2015.0681. [PMID: 26558296] - Jacqueline A Hannam, Xavier Borrat, Iñaki F Trocóniz, José F Valencia, Erik W Jensen, Angela Pedroso, Jenifer Muñoz, Sergi Castellví-Bel, Antoni Castells, Pedro L Gambús. Modeling Respiratory Depression Induced by Remifentanil and Propofol during Sedation and Analgesia Using a Continuous Noninvasive Measurement of pCO2.
The Journal of pharmacology and experimental therapeutics.
2016 Mar; 356(3):563-73. doi:
10.1124/jpet.115.226977. [PMID: 26660440] - Ning Yang, Yun Yue, Jonathan Z Pan, Ming-Zhang Zuo, Yu Shi, Shu-Zhen Zhou, Wen-Ping Peng, Jian-Dong Gao. Changes in the Bispectral Index in Response to Loss of Consciousness and No Somatic Movement to Nociceptive Stimuli in Elderly Patients.
Chinese medical journal.
2016 Feb; 129(4):410-6. doi:
10.4103/0366-6999.176083. [PMID: 26879014] - Toshiyuki Handa, Takaaki Onodera, Yoshifumi Honda, Yoshihiko Koukita, Tatsuya Ichinohe. Propofol-remifentanil is More Effective than Propofol-fentanyl in Decreasing Intraoperative Blood Loss during Sagittal Split Ramus Osteotomy.
The Bulletin of Tokyo Dental College.
2016; 57(3):169-73. doi:
10.2209/tdcpublication.2016-0100. [PMID: 27665694] - Hale Sayan-Ozacmak, Veysel Haktan Ozacmak, Inci Turan, Figen Barut, Volkan Hanci. Pretreatment with remifentanil protects against the reduced-intestinal contractility related to the ischemia and reperfusion injury in rat.
Brazilian journal of anesthesiology (Elsevier).
2015 Nov; 65(6):483-90. doi:
10.1016/j.bjane.2013.09.007. [PMID: 26614146] - Suzane L Beier, Cláudio R S Mattoso, Antonio J A Aguiar, Pedro T G Vianna, Flavio Massone. Hemodynamic effects of target-controlled infusion of propofol alone or in combination with a constant-rate infusion of remifentanil in dogs.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2015 Oct; 79(4):309-15. doi:
NULL. [PMID: 26424912] - Xiaohua Liu, Zhiying Pan, Diansan Su, Zhongwei Yang, Beijie Zheng, Xiangrui Wang, Jie Tian. Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling.
Transplantation.
2015 Oct; 99(10):2109-17. doi:
10.1097/tp.0000000000000737. [PMID: 25919765] - Takahiro Moriyama, Akira Matsunaga, Osamu Nagata, Kei Enohata, Tomomi Kamikawaji, Erika Uchino, Yuichi Kanmura. Effective method of continuous rocuronium administration based on effect-site concentrations using a pharmacokinetic/pharmacodynamic model during propofol-remifentanil anesthesia.
Journal of anesthesia.
2015 Aug; 29(4):593-9. doi:
10.1007/s00540-015-1991-2. [PMID: 25725779] - Aslı Demir, Fatma Meric Yılmaz, Cavit Ceylan, Omer Gokhan Doluoglu, Perihan Uçar, Cevdet Züngün, Cigdem Yildirim Guclu, Utku Ünal, Umit Karadeniz, Eren Günertem, Gokhan Lafci, Kerim Çağlı, Ayşegül Özgök. A comparison of the effects of ketamine and remifentanil on renal functions in coronary artery bypass graft surgery.
Renal failure.
2015 Jun; 37(5):819-26. doi:
10.3109/0886022x.2015.1015390. [PMID: 25707524] - Plínio C Leal, Reinaldo Salomão, Milena K C Brunialti, Rioko K Sakata. Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study.
Journal of clinical anesthesia.
2015 Jun; 27(4):331-7. doi:
10.1016/j.jclinane.2015.02.002. [PMID: 25910532] - Remco A Koster, Hugo E M Vereecke, Ben Greijdanus, Daan J Touw, Michel M R F Struys, Jan Willem C Alffenaar. Analysis of remifentanil with liquid chromatography-tandem mass spectrometry and an extensive stability investigation in EDTA whole blood and acidified EDTA plasma.
Anesthesia and analgesia.
2015 Jun; 120(6):1235-41. doi:
10.1213/ane.0000000000000643. [PMID: 25692453] - Seung-Hyun Lee, Joo-Dong Kim, Sol-Ah Park, Chung-Sik Oh, Seong-Hyop Kim. Effects of µ-Opioid Receptor Gene Polymorphism on Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia with Remifentanil: Double Blinded Randomized Trial.
Journal of Korean medical science.
2015 May; 30(5):651-7. doi:
10.3346/jkms.2015.30.5.651. [PMID: 25931799] - Mari Tsutsui, Sayaka Ishigaki, Ayana Kanaya, Saori Kawaguchi, Takahiro Ogura. [The Effect of Preoperative Oral Rehydration on Hemodynamic Changes during Induction of Anesthesia and Intraoperative Fluid Management].
Masui. The Japanese journal of anesthesiology.
2015 Apr; 64(4):362-7. doi:
NULL. [PMID: 26419096]