Fluvoxamine (BioDeep_00000001988)

 

Secondary id: BioDeep_00000405825

human metabolite blood metabolite


代谢物信息卡片


(2-aminoethoxy)({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene})amine

化学式: C15H21F3N2O2 (318.1555042)
中文名称: 氟伏沙明
谱图信息: 最多检出来源 Homo sapiens(blood) 99.71%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Fluvoxamine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/fluvoxamine (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000001988). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COCCCC/C(=N\OCCN)/c1ccc(cc1)C(F)(F)F
InChI: InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3

描述信息

Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients. It was launched in the US in December 1994 and in Japan in June 1999. As of the end of 1995, more than 10 million patients worldwide have been treated with fluvoxamine.
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065689 - Cytochrome P-450 CYP2C19 Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AB - Selective serotonin reuptake inhibitors
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
CONFIDENCE standard compound; INTERNAL_ID 8519
D049990 - Membrane Transport Modulators
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

44 个代谢物同义名

(2-aminoethoxy)({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene})amine; 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine; Pharmascience brand OF fluvoxamine maleate; Neuraxpharm brand OF fluvoxamine maleate; Stadapharm brand OF fluvoxamine maleate; Ratiopharm brand OF fluvoxamine maleate; Merck dura brand OF fluvoxamine maleate; Betapharm brand OF fluvoxamine maleate; Novopharm brand OF fluvoxamine maleate; Nu-pharm brand OF fluvoxamine maleate; Nu pharm brand OF fluvoxamine maleate; Declimed brand OF fluvoxamine maleate; Geminis brand OF fluvoxamine maleate; Solvay brand OF fluvoxamine maleate; Aliud brand OF fluvoxamine maleate; Fluvoxamine maleate, (e)-isomer; Fluvoxamine, (Z)-isomer; Fluvoxamin neuraxpharm; Fluvoxamin-neuraxpharm; Fluvoxamin-ratiopharm; Fluvoxamin ratiopharm; Geminis, fluvoxamina; Fluvoxamine maleate; Fluvoxamina geminis; Ratio fluvoxamine; Ratio-fluvoxamine; Fluvoxamin stada; Novo fluvoxamine; Novo-fluvoxamine; Fluvoxamin beta; PMS Fluvoxamine; PMS-Fluvoxamine; Nu-fluvoxamine; Fluvoxamine-CR; Nu fluvoxamine; Fluvoxamin al; Fluvoxamine; Fluvoxadura; Floxyfral; Dumirox; Faverin; Desiflu; Fevarin; Luvox



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Furong Zhang, Wenting Gong, Zhou Cui, Jing Li, Yuanyuan Lu. Rhabdomyolysis in a male adolescent associated with monotherapy of fluvoxamine. European journal of hospital pharmacy : science and practice. 2022 Dec; ?(?):. doi: 10.1136/ejhpharm-2022-003533. [PMID: 36460460]
  • Wen Wen, Chen Chen, Jiake Tang, Chunyi Wang, Mengyun Zhou, Yongran Cheng, Xiang Zhou, Qi Wu, Xingwei Zhang, Zhanhui Feng, Mingwei Wang, Qin Mao. Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19：a meta-analysis. Annals of medicine. 2022 12; 54(1):516-523. doi: 10.1080/07853890.2022.2034936. [PMID: 35118917]
  • Wei Zheng, He-Li Sun, Hong Cai, Qinge Zhang, Chee H Ng, Yu-Tao Xiang. Antidepressants for COVID-19: A systematic review. Journal of affective disorders. 2022 06; 307(?):108-114. doi: 10.1016/j.jad.2022.03.059. [PMID: 35339571]
  • Takuya Nagashima, Takashi Hayakawa, Hayato Akimoto, Kimino Minagawa, Yasuo Takahashi, Satoshi Asai. Identifying Antidepressants Less Likely to Cause Hyponatremia: Triangulation of Retrospective Cohort, Disproportionality, and Pharmacodynamic Studies. Clinical pharmacology and therapeutics. 2022 06; 111(6):1258-1267. doi: 10.1002/cpt.2573. [PMID: 35258103]
  • Vladimir Trkulja. Fluvoxamine for COVID-19 ICU patients?. British journal of clinical pharmacology. 2022 05; 88(5):2454-2455. doi: 10.1111/bcp.15166. [PMID: 35132670]
  • Sapan Bhuta, Waleed Khokher, Nithin Kesireddy, Saffa Iftikhar, Azizullah Beran, Mohammed Mhanna, Neha J Patel, Mitra Patel, Cameron Burmeister, Ragheb Assaly. Fluvoxamine in Nonhospitalized Patients With Acute COVID-19 Infection and the Lack of Efficacy in Reducing Rates of Hospitalization, Mechanical Ventilation, and Mortality in Placebo-Controlled Trials: A Systematic Review and Meta-Analysis. American journal of therapeutics. 2022 May; 29(3):e298-e304. doi: 10.1097/mjt.0000000000001496. [PMID: 35383578]
  • Peter Manu. Fluvoxamine for Acute COVID-19 Infection: Weak Hypothesis, Predictable Failure. American journal of therapeutics. 2022 May; 29(3):e342-e343. doi: 10.1097/mjt.0000000000001502. [PMID: 35383592]
  • Udo Bonnet, Georg Juckel. COVID-19 Outcomes: Does the Use of Psychotropic Drugs Make a Difference? Accumulating Evidence of a Beneficial Effect of Antidepressants-A Scoping Review. Journal of clinical psychopharmacology. 2022 May; 42(3):284-292. doi: 10.1097/jcp.0000000000001543. [PMID: 35420565]
  • Xiaoxing Wang, Martin E Dowty, Ann Wouters, Svitlana Tatulych, Carol A Connell, Vu H Le, Sakambari Tripathy, Melissa T O'Gorman, Jennifer A Winton, Natalie Yin, Hernan Valdez, Bimal K Malhotra. Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals. European journal of drug metabolism and pharmacokinetics. 2022 May; 47(3):419-429. doi: 10.1007/s13318-021-00745-6. [PMID: 35226304]
  • Martina Calusic, Robert Marcec, Lea Luksa, Ivan Jurkovic, Natasa Kovac, Slobodan Mihaljevic, Robert Likic. Safety and efficacy of fluvoxamine in COVID-19 ICU patients: An open label, prospective cohort trial with matched controls. British journal of clinical pharmacology. 2022 05; 88(5):2065-2073. doi: 10.1111/bcp.15126. [PMID: 34719789]
  • Ahmed Hassab Errasoul, Mohammed A Alarabi. Factors predicting serum clozapine levels in Middle Eastern patients: an observational study. BMC psychiatry. 2022 04; 22(1):269. doi: 10.1186/s12888-022-03910-6. [PMID: 35428222]
  • Janna K Duong, Romina A Nand, Aarti Patel, Oscar Della Pasqua, Annette S Gross. A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity. Pharmacology research & perspectives. 2022 04; 10(2):e00946. doi: 10.1002/prp2.946. [PMID: 35307978]
  • Todd C Lee, Simone Vigod, Émilie Bortolussi-Courval, Ryan Hanula, David R Boulware, Eric J Lenze, Angela M Reiersen, Emily G McDonald. Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis. JAMA network open. 2022 04; 5(4):e226269. doi: 10.1001/jamanetworkopen.2022.6269. [PMID: 35385087]
  • Yazhou Sun, Weiguo Wan, Xin Zhao, Xueyu Han, Tianxin Ye, Xiaoli Chen, Qian Ran, Xiukun Wang, Xin Liu, Chuan Qu, Shaobo Shi, Cui Zhang, Bo Yang. Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension. Bioengineered. 2022 04; 13(4):10843-10856. doi: 10.1080/21655979.2022.2065953. [PMID: 35473584]
  • Yaeko Hashimoto, Takuji Suzuki, Kenji Hashimoto. Mechanisms of action of fluvoxamine for COVID-19: a historical review. Molecular psychiatry. 2022 04; 27(4):1898-1907. doi: 10.1038/s41380-021-01432-3. [PMID: 34997196]
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  • Peter E Wu, Emily Austin, Derek Leong. Title Not Available. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2022 03; 194(11):E437-E438. doi: 10.1503/cmaj.220011-f. [PMID: 35314448]
  • Catia Marzolini, Fiona Marra, Alison Boyle, Saye Khoo, David J Back. Fluvoxamine for the treatment of COVID-19. The Lancet. Global health. 2022 03; 10(3):e331. doi: 10.1016/s2214-109x(21)00592-1. [PMID: 35180411]
  • Michael G Dodds, Eileen B Doyle, Angela M Reiersen, Fran Brown, Craig R Rayner. Fluvoxamine for the treatment of COVID-19. The Lancet. Global health. 2022 03; 10(3):e332. doi: 10.1016/s2214-109x(22)00006-7. [PMID: 35180412]
  • Gilmar Reis, Edward Mills. Fluvoxamine for the treatment of COVID-19 - Author's reply. The Lancet. Global health. 2022 03; 10(3):e333. doi: 10.1016/s2214-109x(21)00588-x. [PMID: 35180413]
  • Hyun Kim, Shannon Manzi, Joseph Gonzelez-Heydrich, Jonathan Picker. Fluvoxamine for the treatment of COVID-19. The Lancet. Global health. 2022 03; 10(3):e330. doi: 10.1016/s2214-109x(22)00003-1. [PMID: 35180410]
  • David R Boulware, Mahsa Abassi. Fluvoxamine for the treatment of COVID-19. The Lancet. Global health. 2022 03; 10(3):e329. doi: 10.1016/s2214-109x(21)00590-8. [PMID: 35180409]
  • Peter E Wu, Emily Austin, Derek Leong. Fluvoxamine for symptomatic outpatients with COVID-19. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2022 02; 194(7):E258. doi: 10.1503/cmaj.220011. [PMID: 35045990]
  • Eric J Lenze, Angela M Reiersen, Shelley N Facente. Authors' Reply to Mazza et al.: 'Fluvoxamine for the Early Treatment of SARS‑CoV‑2 Infection: A Review of Current Evidence'. Drugs. 2022 02; 82(3):353-354. doi: 10.1007/s40265-022-01681-8. [PMID: 35150436]
  • Mario Gennaro Mazza, Benedetta Vai, Livia De Picker, Francesco Benedetti, Raffaella Zanardi. Comment on: 'Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence'. Drugs. 2022 02; 82(3):349-351. doi: 10.1007/s40265-022-01682-7. [PMID: 35150437]
  • Yaeko Hashimoto, Takuji Suzuki, Kenji Hashimoto. Old drug fluvoxamine, new hope for COVID-19. European archives of psychiatry and clinical neuroscience. 2022 Feb; 272(1):161-163. doi: 10.1007/s00406-021-01326-z. [PMID: 34476589]
  • Konrad Rejdak, Paweł Grieb. Fluvoxamine and Amantadine: Central Nervous System Acting Drugs Repositioned for COVID-19 as Early Intervention. Current neuropharmacology. 2022; 20(4):777-781. doi: 10.2174/1570159x19666210729123734. [PMID: 34325642]
  • Otavio Berwanger. Fluvoxamine for outpatients with COVID-19: where do we stand?. The Lancet. Global health. 2022 01; 10(1):e2-e3. doi: 10.1016/s2214-109x(21)00501-5. [PMID: 34717819]
  • Philip L Hooper. Heme oxygenase agonists-fluvoxamine, melatonin-are efficacious therapy for Covid-19. Cell stress & chaperones. 2022 01; 27(1):3-4. doi: 10.1007/s12192-021-01246-w. [PMID: 34846631]
  • Konstantinos I Papadopoulos, Warachaya Sutheesophon, Tar-Choon Aw. Anti-SARS-CoV-2 Action of Fluvoxamine may be Mediated by Endothelial Nitric Oxide Synthase. Pharmacopsychiatry. 2022 01; 55(1):57. doi: 10.1055/a-1641-0357. [PMID: 34555857]
  • Gilmar Reis, Eduardo Augusto Dos Santos Moreira-Silva, Daniela Carla Medeiros Silva, Lehana Thabane, Aline Cruz Milagres, Thiago Santiago Ferreira, Castilho Vitor Quirino Dos Santos, Vitoria Helena de Souza Campos, Ana Maria Ribeiro Nogueira, Ana Paula Figueiredo Guimaraes de Almeida, Eduardo Diniz Callegari, Adhemar Dias de Figueiredo Neto, Leonardo Cançado Monteiro Savassi, Maria Izabel Campos Simplicio, Luciene Barra Ribeiro, Rosemary Oliveira, Ofir Harari, Jamie I Forrest, Hinda Ruton, Sheila Sprague, Paula McKay, Alla V Glushchenko, Craig R Rayner, Eric J Lenze, Angela M Reiersen, Gordon H Guyatt, Edward J Mills. Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial. The Lancet. Global health. 2022 01; 10(1):e42-e51. doi: 10.1016/s2214-109x(21)00448-4. [PMID: 34717820]
  • Abir T El-Alfy, Kristin Busse. Fluvoxamine and COVID-19. WMJ : official publication of the State Medical Society of Wisconsin. 2022; 121(?):P2. doi: NULL. [PMID: 35671339]
  • Shelley N Facente, Angela M Reiersen, Eric J Lenze, David R Boulware, Jeffrey D Klausner. Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence. Drugs. 2021 Dec; 81(18):2081-2089. doi: 10.1007/s40265-021-01636-5. [PMID: 34851510]
  • Allan H Young. Repurposing psychopharmacology: A two-way street?. Journal of psychopharmacology (Oxford, England). 2021 12; 35(12):1439-1440. doi: 10.1177/02698811211064648. [PMID: 34872403]
  • Tomiko Oskotsky, Ivana Maric, Alice Tang, Boris Oskotsky, Ronald J Wong, Nima Aghaeepour, Marina Sirota, David K Stevenson. Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants. JAMA network open. 2021 11; 4(11):e2133090. doi: 10.1001/jamanetworkopen.2021.33090. [PMID: 34779847]
  • Nicolas Hoertel. Do the Selective Serotonin Reuptake Inhibitor Antidepressants Fluoxetine and Fluvoxamine Reduce Mortality Among Patients With COVID-19?. JAMA network open. 2021 11; 4(11):e2136510. doi: 10.1001/jamanetworkopen.2021.36510. [PMID: 34779851]
  • Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter. Prostaglandins, leukotrienes, and essential fatty acids. 2021 09; 172(?):102323. doi: 10.1016/j.plefa.2021.102323. [PMID: 34392133]
  • Jakub Staroń, Wojciech Pietruś, Ryszard Bugno, Rafał Kurczab, Grzegorz Satała, Dawid Warszycki, Tomasz Lenda, Anna Wantuch, Adam S Hogendorf, Agata Hogendorf, Beata Duszyńska, Andrzej J Bojarski. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. European journal of medicinal chemistry. 2021 Aug; 220(?):113533. doi: 10.1016/j.ejmech.2021.113533. [PMID: 34049262]
  • Thang L Pham, Azucena H Kakazu, Jiucheng He, Robert Nshimiyimana, Nicos A Petasis, Bokkyoo Jun, Nicolas G Bazan, Haydee E P Bazan. Elucidating the structure and functions of Resolvin D6 isomers on nerve regeneration with a distinctive trigeminal transcriptome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 08; 35(8):e21775. doi: 10.1096/fj.202100686r. [PMID: 34245621]
  • Michael Zastrozhin, Valentin Skryabin, Valeriy Smirnov, Anastasiya Zastrozhina, Elena Grishina, Kristina Ryzhikova, Irina Bure, Pavel Golovinskii, Sergey Koporov, Evgeniy Bryun, Dmitry Sychev. Effect of Genetic Polymorphism of the CYP2D6 Gene on the Efficacy and Safety of Fluvoxamine in Major Depressive Disorder. American journal of therapeutics. 2021 Jun; 29(1):e26-e33. doi: 10.1097/mjt.0000000000001388. [PMID: 34117140]
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