Bisoprolol (BioDeep_00000001910)

 

Secondary id: BioDeep_00000397909

human metabolite blood metabolite


代谢物信息卡片


1-[(propan-2-yl)amino]-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol

化学式: C18H31NO4 (325.2253)
中文名称: 比索洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 10.19%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
InChI: InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3

描述信息

Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Bisoprolol is structurally similar to metoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At lower doses (less than 20 mg daily), bisoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with daily doses of 20 mg or greater. Unlike propranolol and pindolol, bisoprolol does not exhibit membrane-stabilizing or sympathomimetic activity. Bisoprolol possesses a single chiral centre and is administered as a racemic mixture. Only l-bisoprolol exhibits significant β-blocking activity.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3013
CONFIDENCE standard compound; INTERNAL_ID 8595
CONFIDENCE standard compound; INTERNAL_ID 2677

同义名列表

25 个代谢物同义名

1-[(propan-2-yl)amino]-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol; (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol; (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol; (+-)-1-((a-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol; (+-)-1-((Α-(2-isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol; 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol; Bisoprolol fumarate (1:1) salt, (+-)-isomer; Bisoprolol fumarate (2:1) salt, (+-)-isomer; Merck brand OF bisoprolol fumarate; Bisoprolol methanesulfonate salt; Bisoprolol, fumarate (1:1) salt; Bisoprolol, fumarate (2:1) salt; Hydrochloride, bisoprolol; Bisoprolol hydrochloride; Bisoprolol hemifumarate; Bisoprolol, (+-)-isomer; Bisoprolol, (-)-isomer; Fumarate, bisoprolol; Bisoprolol Fumarate; Bisoprolol fumerate; Bisoprololum; BISOPROLOL; Concor; Bisoprolol; Bisoprolol



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ACE, AXIN2, CYP2D6, CYP3A4, EDN1, NR3C2, PIK3CA
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 ADRB2
Endoplasmic reticulum membrane 4 CYP1B1, CYP2D6, CYP3A4, NR3C2
Nucleus 3 ADRB2, AXIN2, NR3C2
cytosol 3 AXIN2, NR3C2, PIK3CA
centrosome 1 AXIN2
nucleoplasm 1 NR3C2
Cell membrane 8 ABCB1, ACE, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, TNF
lamellipodium 1 PIK3CA
Multi-pass membrane protein 7 ABCB1, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, CACNA1I
cell surface 2 ABCB1, TNF
Golgi apparatus 1 ADRB2
Golgi membrane 1 INS
neuronal cell body 1 TNF
Lysosome 2 ACE, ADRB2
endosome 2 ACE, ADRB2
plasma membrane 12 ABCB1, ACE, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AXIN2, CACNA1I, PIK3CA, REN, TNF
Membrane 9 ABCB1, ACE, ADRB2, AGTR1, CACNA1I, CYP1B1, CYP2D6, CYP3A4, REN
apical plasma membrane 2 ABCB1, ADRB2
extracellular exosome 2 ABCB1, ACE
endoplasmic reticulum 1 CYP2D6
extracellular space 7 ACE, CRP, EDN1, IL6, INS, REN, TNF
perinuclear region of cytoplasm 1 PIK3CA
Schaffer collateral - CA1 synapse 1 ADRB1
intercalated disc 1 PIK3CA
mitochondrion 2 CYP1B1, CYP2D6
intracellular membrane-bounded organelle 3 CYP1B1, CYP2D6, CYP3A4
Microsome membrane 3 CYP1B1, CYP2D6, CYP3A4
Single-pass type I membrane protein 1 ACE
Secreted 6 ACE, CRP, EDN1, IL6, INS, REN
extracellular region 7 ACE, CRP, EDN1, IL6, INS, REN, TNF
Single-pass membrane protein 1 CYP2D6
basal part of cell 1 EDN1
external side of plasma membrane 2 ACE, TNF
beta-catenin destruction complex 1 AXIN2
Early endosome 2 ADRB1, ADRB2
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
receptor complex 3 ADRB2, ADRB3, NR3C2
chromatin 1 NR3C2
phagocytic cup 1 TNF
brush border membrane 1 ACE
sperm midpiece 1 ACE
endosome lumen 1 INS
basal plasma membrane 1 ACE
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
voltage-gated calcium channel complex 1 CACNA1I
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 2 ADRB1, ADRB2
clathrin-coated endocytic vesicle membrane 1 ADRB2
external side of apical plasma membrane 1 ABCB1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kamal Sharma, Hardik Desai, Neha Sharm, Mukesh Laddha, Kalpesh Hansora, Prashant Vazirani. To Evaluate the 'Real World' Clinical Performance of Bisoprolol in Post-Myocardial Infarction with Left Ventricular Dysfunction: Tenacity Study. The Journal of the Association of Physicians of India. 2022 Apr; 70(4):11-12. doi: . [PMID: 35443400]
  • Joshua Wong, Sameer Sharma, Jessica V Yao, Anuradha Aggarwal, Leeanne Grigg. COVID-19 mRNA vaccine (Comirnaty)-induced myocarditis. The Medical journal of Australia. 2022 02; 216(3):122-123. doi: 10.5694/mja2.51394. [PMID: 35075640]
  • Ahmed Mohamed Youssef, Hesham Abdallah Elghoneimy, Maged Wasfy Helmy, Ahmed Mokhtar Abdelazeem, Noha Mahmoud El-Khodary. Effect of amlodipine versus bisoprolol in hypertensive patients on maintenance hemodialysis: A randomized controlled trial. Medicine. 2021 Dec; 100(51):e28322. doi: 10.1097/md.0000000000028322. [PMID: 34941131]
  • Tommaso D'Angelo, Antonino Cattafi, Maria Ludovica Carerj, Christian Booz, Giorgio Ascenti, Giuseppe Cicero, Alfredo Blandino, Silvio Mazziotti. Myocarditis After SARS-CoV-2 Vaccination: A Vaccine-Induced Reaction?. The Canadian journal of cardiology. 2021 10; 37(10):1665-1667. doi: 10.1016/j.cjca.2021.05.010. [PMID: 34118375]
  • Yuji Takahashi, Tomohiro Sonoo, Hidehiko Nakano, Hiromu Naraba, Hideki Hashimoto, Kensuke Nakamura. The influence of edema on the bisoprolol blood concentration after bisoprolol dermal patch application: A case-control study. Medicine. 2021 Sep; 100(38):e27354. doi: 10.1097/md.0000000000027354. [PMID: 34559159]
  • Melanie McGinlay, Sam Straw, Jacob Jagger, Bako Nouri, John Gierula, Klaus K Witte. Impact of the COVID-19 pandemic on the management of chronic heart failure. Reviews in cardiovascular medicine. 2021 06; 22(2):271-276. doi: 10.31083/j.rcm2202034. [PMID: 34258895]
  • Joyce S Macwan, Grace Fraczkiewicz, Mauro Bertolino, Phillip Krüger, Sheila-Annie Peters. Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol. CPT: pharmacometrics & systems pharmacology. 2021 06; 10(6):622-632. doi: 10.1002/psp4.12634. [PMID: 34080804]
  • Philippe Bégin, Jeannie Callum, Nancy M Heddle, Richard Cook, Michelle P Zeller, Alan Tinmouth, Dean A Fergusson, Melissa M Cushing, Marshall J Glesby, Michaël Chassé, Dana V Devine, Nancy Robitalle, Renée Bazin, Nadine Shehata, Andrés Finzi, Allison McGeer, Damon C Scales, Lisa Schwartz, Alexis F Turgeon, Ryan Zarychanski, Nick Daneman, Richard Carl, Luiz Amorim, Caroline Gabe, Martin Ellis, Bruce S Sachais, Kent Cadogan Loftsgard, Erin Jamula, Julie Carruthers, Joanne Duncan, Kayla Lucier, Na Li, Yang Liu, Chantal Armali, Amie Kron, Dimpy Modi, Marie-Christine Auclair, Sabrina Cerro, Meda Avram, Donald M Arnold. Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial. Trials. 2021 May; 22(1):323. doi: 10.1186/s13063-021-05235-3. [PMID: 33947446]
  • Rod J Azadan, Nadia H Agha, Hawley E Kunz, Forrest L Baker, Preteesh L Mylabathula, Tracy A Ledoux, Daniel P O'Connor, Charles R Pedlar, Richard J Simpson. The effects of normoxic endurance exercise on erythropoietin (EPO) production and the impact of selective β1 and non-selective β1 + β2 adrenergic receptor blockade. European journal of applied physiology. 2021 May; 121(5):1499-1511. doi: 10.1007/s00421-020-04558-4. [PMID: 33646423]
  • Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 05; 77(5):704-712. doi: 10.1053/j.ajkd.2020.07.023. [PMID: 33010357]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Peter McGranaghan, Anshul Saxena, Hans-Dirk Düngen, Muni Rubens, Sandeep Appunni, Joseph Salami, Emir Veledar, Philipp Lacour, Florian Blaschke, Danilo Obradovic, Goran Loncar, Elvis Tahirovic, Frank Edelmann, Burkert Pieske, Tobias Daniel Trippel. Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure. Scientific reports. 2021 04; 11(1):8164. doi: 10.1038/s41598-021-87776-w. [PMID: 33854188]
  • Jing Wang, Jing Liu, Liang Xie, Xiaomin Cai, Xiaohua Ma, Jianbin Gong. Bisoprolol, a β1 antagonist, protects myocardial cells from ischemia-reperfusion injury via PI3K/AKT/GSK3β pathway. Fundamental & clinical pharmacology. 2020 Dec; 34(6):708-720. doi: 10.1111/fcp.12562. [PMID: 32363697]
  • Marina Krasnova, Alexander Kulikov, Sergey Okovityi, Dmitry Ivkin, Andrey Karpov, Elena Kaschina, Alexey Smirnov. Comparative efficacy of empagliflozin and drugs of baseline therapy in post-infarct heart failure in normoglycemic rats. Naunyn-Schmiedeberg's archives of pharmacology. 2020 09; 393(9):1649-1658. doi: 10.1007/s00210-020-01873-7. [PMID: 32377771]
  • Takuto Arita, Shinya Suzuki, Yuko Kato, Hiroto Kano, Junji Yajima, Shunsuke Matsuno, Takayuki Otsuka, Hiroaki Semba, Tokuhisa Uejima, Yuji Oikawa, Kazuyuki Nagashima, Naoharu Yagi, Koichi Sagara, Gen Tanabe, Takeshi Yamashita. Association Between Dose and Plasma Concentration of Bisoprolol in Patients with Heart Failure (CVI ARO 6). International heart journal. 2020 Jul; 61(4):748-754. doi: 10.1536/ihj.20-052. [PMID: 32684605]
  • Masaya Shinohara, Ryou Wada, Shintaro Yao, Kensuke Yano, Katsuya Akitsu, Hideki Koike, Toshio Kinoshita, Hitomi Yuzawa, Takeya Suzuki, Tadashi Fujino, Takanori Ikeda. Comparison of the Transdermal Bisoprolol Patch with Oral Bisoprolol Fumarate Administration as a Therapeutic Agent for Idiopathic Frequent Premature Ventricular Contractions. International heart journal. 2020 May; 61(3):510-516. doi: 10.1536/ihj.19-643. [PMID: 32418969]
  • Sven Fikenzer, Kati Fikenzer, Ulrich Laufs, Roberto Falz, Antina Schulze, Martin Busse. Effects of cardioselective beta-blockade on plasma catecholamines and performance during different forms of exercise. The Journal of sports medicine and physical fitness. 2020 Apr; 60(4):643-649. doi: 10.23736/s0022-4707.19.10225-3. [PMID: 31818057]
  • Takuto Arita, Shinya Suzuki, Yuko Kato, Hiroto Kano, Junji Yajima, Shunsuke Matsuno, Takayuki Otsuka, Hiroaki Semba, Tokuhisa Uejima, Yuji Oikawa, Kazuyuki Nagashima, Naoharu Yagi, Koichi Sagara, Gen Tanabe, Takeshi Yamashita. Association between bisoprolol plasma concentration and worsening of heart failure: (CVI ARO 6). Drug metabolism and pharmacokinetics. 2020 Apr; 35(2):228-237. doi: 10.1016/j.dmpk.2020.01.002. [PMID: 32044255]
  • Frantisek Nehaj, Juraj Sokol, Jela Ivankova, Michal Mokan, Marian Mokan. Effect of Bisoprolol on the Level of Dabigatran. American journal of therapeutics. 2020 Mar; 27(2):e159-e164. doi: 10.1097/mjt.0000000000000786. [PMID: 30074534]
  • Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis. Recent advances in understanding and managing resistant/refractory hypertension. F1000Research. 2020; 9(?):. doi: 10.12688/f1000research.21669.1. [PMID: 32201574]
  • Sarah Al Fawaz, Mohammad Al Deeb, James L Huffman, Naji A Al Kholaif, Fiona Garlich, Ryan Chuang. A Case of Status Epilepticus and Transient Stress Cardiomyopathy Associated with Smoking the Synthetic Psychoactive Cannabinoid, UR-144. The American journal of case reports. 2019 Dec; 20(?):1902-1906. doi: 10.12659/ajcr.918918. [PMID: 31857571]
  • O B Kuzmin, N N Buchneva, V V Zhezha, S V Serdyuk. [Uncontrolled Arterial Hypertension: Kidney, Neurohormonal Imbalance, and Approaches to Antihypertensive Drug Therapy]. Kardiologiia. 2019 Dec; 59(12):64-71. doi: 10.18087/cardio.2019.12.n547. [PMID: 31849313]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121793. doi: 10.1016/j.jchromb.2019.121793. [PMID: 31629310]
  • Maurizio Sessa, Annamaria Mascolo, Daniel Bech Rasmussen, Kristian Kragholm, Magnus Thorsten Jensen, Liberata Sportiello, Concetta Rafaniello, Giuseppe Michele Tari, Claudia Pagliaro, Morten Andersen, Francesco Rossi, Annalisa Capuano. Beta-blocker choice and exchangeability in patients with heart failure and chronic obstructive pulmonary disease: an Italian register-based cohort study. Scientific reports. 2019 08; 9(1):11465. doi: 10.1038/s41598-019-47967-y. [PMID: 31391573]
  • Kazuyoshi Kakehi, Yoshitaka Iwanaga, Heitaro Watanabe, Takashi Sonobe, Tsuyoshi Akiyama, Shuji Shimizu, Hiromi Yamamoto, Shunichi Miyazaki. Modulation of Sympathetic Activity and Innervation With Chronic Ivabradine and β-Blocker Therapies: Analysis of Hypertensive Rats With Heart Failure. Journal of cardiovascular pharmacology and therapeutics. 2019 07; 24(4):387-396. doi: 10.1177/1074248419829168. [PMID: 30786751]
  • Hiroyuki Tsutsui, Shin-Ichi Momomura, Tohru Masuyama, Yoshihiko Saito, Issei Komuro, Toyoaki Murohara, Shintaro Kinugawa. Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction　- The CIBIS-J Trial. Circulation journal : official journal of the Japanese Circulation Society. 2019 05; 83(6):1269-1277. doi: 10.1253/circj.cj-18-1199. [PMID: 30956267]
  • Ahmad Abdulrahman Almeman, Yasir Ahmed Beshir, Ahmad Hamad Aldosary. Comparison of the Effects of Metoprolol and Bisoprolol on Lipid and Glucose Profiles in Cardiovascular Patients. Current drug safety. 2019; 14(1):27-30. doi: 10.2174/1574886313666181029101247. [PMID: 30370856]
  • Chaoying Hu, Xiao Hu, Chunhua Wang, Zirun Zhao, Dan Gao, Xiaoping Chen, Dongli Zhou, Yue Huang, Lin Li, Lan Zhang. Bioequivalence and Pharmacokinetics of Bisoprolol-Amlodipine 5 mg/5 mg Combination Tablet versus Bisoprolol 5 mg Tablet and Amlodipine 5 mg Tablet: An Open-Label, Randomized, Two-Sequence Crossover Study in Healthy Chinese Subjects. Clinical drug investigation. 2018 Dec; 38(12):1145-1154. doi: 10.1007/s40261-018-0700-y. [PMID: 30232699]
  • Hanqing Zhao, Chao Liu, Degong Yang, Xiaocao Wan, Rui Shang, Peng Quan, Liang Fang. Molecular mechanism of ion-pair releasing from acrylic pressure sensitive adhesive containing carboxyl group: Roles of doubly ionic hydrogen bond in the controlled release process of bisoprolol ion-pair. Journal of controlled release : official journal of the Controlled Release Society. 2018 11; 289(?):146-157. doi: 10.1016/j.jconrel.2018.09.024. [PMID: 30268589]
  • Richard Myles Turner, Vanessa Fontana, Mark Bayliss, Sarah Whalley, Anahi Santoyo Castelazo, Munir Pirmohamed. Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 159(?):272-281. doi: 10.1016/j.jpba.2018.06.062. [PMID: 30005242]
  • Andrzej Madej, Józefa Dąbek, Michał Majewski, Justyna Szuta. Effect of perindopril and bisoprolol on IL-2, INF-γ, hs-CRP and T-cell stimulation and correlations with blood pressure in mild and moderate hypertension. International journal of clinical pharmacology and therapeutics. 2018 Sep; 56(9):393-399. doi: 10.5414/cp203249. [PMID: 29809132]
  • Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. The lancet. Diabetes & endocrinology. 2018 06; 6(6):464-475. doi: 10.1016/s2213-8587(18)30071-8. [PMID: 29655877]
  • Alvin Tieu, Thomas J Velenosi, Andrew S Kucey, Matthew A Weir, Bradley L Urquhart. β-Blocker Dialyzability in Maintenance Hemodialysis Patients: A Randomized Clinical Trial. Clinical journal of the American Society of Nephrology : CJASN. 2018 04; 13(4):604-611. doi: 10.2215/cjn.07470717. [PMID: 29519953]
  • Maurizio Sessa, Annamaria Mascolo, Rikke Nørmark Mortensen, Mikkel Porsborg Andersen, Giuseppe Massimo Claudio Rosano, Annalisa Capuano, Francesco Rossi, Gunnar Gislason, Henrik Enghusen-Poulsen, Christian Torp-Pedersen. Relationship between heart failure, concurrent chronic obstructive pulmonary disease and beta-blocker use: a Danish nationwide cohort study. European journal of heart failure. 2018 03; 20(3):548-556. doi: 10.1002/ejhf.1045. [PMID: 29159953]
  • Elizabeth do Espirito Santo Cestário, Letícia Aparecida Barufi Fernandes, Luiz Tadeu Giollo-Júnior, Jéssica Rodrigues Roma Uyemura, Camila Suemi Sato Matarucco, Manoel Idelfonso Paz Landim, Luciana Neves Cosenso-Martin, Lúcia Helena Bonalume Tácito, Heitor Moreno, José Fernando Vilela-Martin, Juan Carlos Yugar-Toledo. Resistant Hypertension On Treatment (ResHypOT): sequential nephron blockade compared to dual blockade of the renin-angiotensin-aldosterone system plus bisoprolol in the treatment of resistant arterial hypertension - study protocol for a randomized controlled trial. Trials. 2018 Feb; 19(1):101. doi: 10.1186/s13063-017-2343-3. [PMID: 29433578]
  • Valentina N Nikolic, Slobodan M Jankovic, Marina Deljanin-Ilic, Sanja S Stojanovic, Miroslav Lj Nikolic, Slavoljub Zivanovic, Dragana Stokanovic, Tatjana Jevtovic-Stoimenov, Jasmina R Milovanovic. Population Pharmacokinetic Analysis of Bisoprolol in Patients with Stable Coronary Artery Disease. European journal of drug metabolism and pharmacokinetics. 2018 Feb; 43(1):35-44. doi: 10.1007/s13318-017-0414-1. [PMID: 28577178]
  • Nadia H Agha, Forrest L Baker, Hawley E Kunz, Rachel Graff, Rod Azadan, Chad Dolan, Mitzi S Laughlin, Chitra Hosing, Melissa M Markofski, Richard A Bond, Catherine M Bollard, Richard J Simpson. Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β2-adrenergic receptor. Brain, behavior, and immunity. 2018 02; 68(?):66-75. doi: 10.1016/j.bbi.2017.10.001. [PMID: 29017969]
  • Ali Sigaroudi, Martina Kinzig, Oliver Wahl, Christoph Stelzer, Michael Schroeter, Uwe Fuhr, Ulrike Holzgrabe, Fritz Sörgel. Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples. Pharmacology. 2018; 101(1-2):29-34. doi: 10.1159/000480091. [PMID: 28930747]
  • Marcel van Gelderen, Matthias Stölzel, John Meijer, Virginie Kerbusch, Christiane Collins, Cees Korstanje. An Exploratory Study in Healthy Male Subjects of the Mechanism of Mirabegron-Induced Cardiovascular Effects. Journal of clinical pharmacology. 2017 Dec; 57(12):1534-1544. doi: 10.1002/jcph.952. [PMID: 28618007]
  • David J Polhemus, Rishi K Trivedi, Juan Gao, Zhen Li, Amy L Scarborough, Traci T Goodchild, Kurt J Varner, Huijing Xia, Frank W Smart, Daniel R Kapusta, David J Lefer. Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney. Journal of the American College of Cardiology. 2017 Oct; 70(17):2139-2153. doi: 10.1016/j.jacc.2017.08.056. [PMID: 29050562]
  • Poonam Malik, Ravi Bhushan. Development of liquid chromatographic methods for enantioseparation and sensitive detection of β-adrenolytics/β2-agonists in human plasma using a single enantiomer reagent. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Sep; 1061-1062(?):117-122. doi: 10.1016/j.jchromb.2017.06.041. [PMID: 28732286]
  • Tianlun Yang, Yinong Jiang, Yuming Hao, Shuxian Zhou, Xinjuan Xu, Baiming Qu, Xue Lin, Tianrong Ma. Comparison of bisoprolol to a metoprolol CR/ZOK tablet for control of heart rate and blood pressure in mild-to-moderate hypertensive patients: the CREATIVE study. Hypertension research : official journal of the Japanese Society of Hypertension. 2017 Jan; 40(1):79-86. doi: 10.1038/hr.2016.101. [PMID: 27534738]
  • Simone Hansmann, Adam Darwich, Alison Margolskee, Leon Aarons, Jennifer Dressman. Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models. The Journal of pharmacy and pharmacology. 2016 Dec; 68(12):1501-1515. doi: 10.1111/jphp.12618. [PMID: 27781273]
  • Katja Cvan Trobec, Iztok Grabnar, Mojca Kerec Kos, Tomaz Vovk, Jurij Trontelj, Stefan D Anker, Giuseppe Rosano, Mitja Lainscak. Bisoprolol pharmacokinetics and body composition in patients with chronic heart failure: a longitudinal study. European journal of clinical pharmacology. 2016 Jul; 72(7):813-22. doi: 10.1007/s00228-016-2041-1. [PMID: 26996442]
  • Aleksander Skoczylas, Grzegorz Piecha, Andrzej Więcek. Effects of antihypertensive treatment on plasma apelin, resistin, and visfatin concentrations. Polskie Archiwum Medycyny Wewnetrznej. 2016 Apr; 126(4):243-53. doi: 10.20452/pamw.3390. [PMID: 27129086]
  • Heitaro Watanabe, Yoshitaka Iwanaga, Yuki Miyaji, Hiromi Yamamoto, Shunichi Miyazaki. Renal denervation mitigates cardiac remodeling and renal damage in Dahl rats: a comparison with β-receptor blockade. Hypertension research : official journal of the Japanese Society of Hypertension. 2016 Apr; 39(4):217-26. doi: 10.1038/hr.2015.133. [PMID: 26631854]
  • Chao-Hsiun Tang, Chia-Chen Wang, Tso-Hsiao Chen, Chuang-Ye Hong, Yuh-Mou Sue. Prognostic Benefits of Carvedilol, Bisoprolol, and Metoprolol Controlled Release/Extended Release in Hemodialysis Patients with Heart Failure: A 10-Year Cohort. Journal of the American Heart Association. 2016 Jan; 5(1):. doi: 10.1161/jaha.115.002584. [PMID: 26738790]
  • Valentina N Nikolic, Slobodan M Jankovic, Zorica M Dimitrijevic, Miodrag J Sokolovic, Branislav R Andric, Dejan S Petrovic, Tatjana Jevtovic-Stoimenov, Slavoljub Zivanovic, Jasmina R Milovanovic. Population Pharmacokinetics of Bisoprolol in Hemodialysis Patients with Hypertension. Pharmacology. 2016; 97(3-4):134-7. doi: 10.1159/000443179. [PMID: 26736018]
  • Joanna Giebułtowicz, Grzegorz Kojro, Katarzyna Buś-Kwaśnik, Piotr J Rudzki, Ryszard Marszałek, Andrzej Leś, Piotr Wroczyński. Cloud-point extraction is compatible with liquid chromatography coupled to electrospray ionization mass spectrometry for the determination of bisoprolol in human plasma. Journal of chromatography. A. 2015 Dec; 1423(?):39-46. doi: 10.1016/j.chroma.2015.10.076. [PMID: 26572051]
  • Bryan Williams, Thomas M MacDonald, Steve Morant, David J Webb, Peter Sever, Gordon McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Jackie Salsbury, Isla Mackenzie, Sandosh Padmanabhan, Morris J Brown. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet (London, England). 2015 Nov; 386(10008):2059-2068. doi: 10.1016/s0140-6736(15)00257-3. [PMID: 26414968]
  • Gu Fugen, Hao Duo, Meng Gendalai, Wu Chunzhi, Wang Yi. Preparation of bisoprolol fumarate nasal spray and its nasal delivery in rats. Pakistan journal of pharmaceutical sciences. 2015 Nov; 28(6):2173-8. doi: NULL. [PMID: 26639509]
  • E V Denesiuk. [EFFICACY OF STANDARD TWO-YEAR COMPREHENSIVE THERAPY TO ACHIEVE TARGET BLOOD PRESSURE AND REGRESSION DEGREES OF REMODELING OF THE LEFT VENTRICULAR HYPERTROPHY IN PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION WITH COMORBID HYPERTENSION]. Likars'ka sprava. 2015 Oct; ?(7-8):22-9. doi: ". [PMID: 27491146]
  • Hassan M Albishri, Deia Abd El-Hady, Roaa A Tayeb. Cyclodextrin Micellar LC for Direct Selective Analysis of Combined Dosage Drugs in Urine. Journal of chromatographic science. 2015 Aug; 53(7):1123-30. doi: 10.1093/chromsci/bmu174. [PMID: 25540291]
  • Kazuo Eguchi, Satoshi Hoshide, Kazuomi Kario. Effects of Celiprolol and Bisoprolol on Blood Pressure, Vascular Stiffness, and Baroreflex Sensitivity. American journal of hypertension. 2015 Jul; 28(7):858-67. doi: 10.1093/ajh/hpu245. [PMID: 25577782]
  • Gautam R Shroff, Charles A Herzog. β-Blockers in dialysis patients: a nephrocardiology perspective. Journal of the American Society of Nephrology : JASN. 2015 Apr; 26(4):774-6. doi: 10.1681/asn.2014080831. [PMID: 25359873]
  • Wilton A van Klei. [Which is the preferred perioperative beta-blocker?]. Nederlands tijdschrift voor geneeskunde. 2015; 159(?):A9798. doi: NULL. [PMID: 26732221]
  • Jochen Springer, Anika Tschirner, Arash Haghikia, Stephan von Haehling, Hind Lal, Aleksandra Grzesiak, Elena Kaschina, Sandra Palus, Mareike Pötsch, Karoline von Websky, Berthold Hocher, Celine Latouche, Frederic Jaisser, Lars Morawietz, Andrew J S Coats, John Beadle, Josep M Argiles, Thomas Thum, Gabor Földes, Wolfram Doehner, Denise Hilfiker-Kleiner, Thomas Force, Stefan D Anker. Prevention of liver cancer cachexia-induced cardiac wasting and heart failure. European heart journal. 2014 Apr; 35(14):932-41. doi: 10.1093/eurheartj/eht302. [PMID: 23990596]
  • Mauro Contini, Anna Apostolo, Gaia Cattadori, Stefania Paolillo, Annamaria Iorio, Erika Bertella, Elisabetta Salvioni, Marina Alimento, Stefania Farina, Pietro Palermo, Monica Loguercio, Valentina Mantegazza, Marlus Karsten, Susanna Sciomer, Damiano Magrì, Cesare Fiorentini, Piergiuseppe Agostoni. Multiparametric comparison of CARvedilol, vs. NEbivolol, vs. BIsoprolol in moderate heart failure: the CARNEBI trial. International journal of cardiology. 2013 Oct; 168(3):2134-40. doi: 10.1016/j.ijcard.2013.01.277. [PMID: 23506636]
  • Valentina N Nikolic, Tatjana Jevtovic-Stoimenov, Radmila Velickovic-Radovanović, Stevan Ilic, Marina Deljanin-Ilic, Dragan Marinkovic, Svetlana Apostolović, Dragana Stanojevic, Slavoljub Zivanovic, Nikola Stefanovic, Srdjan Pesic, Dejana Ruzic Zecevic, Jasmina R Milovanovic, Slobodan M Jankovic. Population pharmacokinetics of bisoprolol in patients with chronic heart failure. European journal of clinical pharmacology. 2013 Apr; 69(4):859-65. doi: 10.1007/s00228-012-1427-y. [PMID: 23093041]
  • Kazuya Ishida, Asuka Horie, Maki Nishimura, Masato Taguchi, Nozomu Fujii, Takashi Nozawa, Hiroshi Inoue, Yukiya Hashimoto. Variability of bioavailability and intestinal absorption characteristics of bisoprolol. Drug metabolism and pharmacokinetics. 2013; 28(6):491-6. doi: 10.2133/dmpk.dmpk-13-rg-017. [PMID: 23719964]
  • Huichao Chang, Jinyin Li, Ji Li, Xiaoduo Guan, Fanlu Sun, Zhongzhi Qian, Kaishun Bi, Guorong Fan. Simultaneous determination of amlodipine and bisoprolol in rat plasma by a liquid chromatography/tandem mass spectrometry method and its application in pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2012 Dec; 71(?):104-10. doi: 10.1016/j.jpba.2012.08.012. [PMID: 22947502]
  • Katarzyna Bus-Kwasnik, Hanna Ksycinska, Andrzej Les, Krystyna Serafin-Byczak, Piotr J Rudzki, Jerzy Raszek, Tomasz Lazowski, Agnieszka Bielak, Andrzej Wybraniec. Bioequivalence and pharmacokinetics of two 10-mg bisoprolol formulations as film-coated tablets in healthy white volunteers: a randomized, crossover, open-label, 2-period, single-dose, fasting study. International journal of clinical pharmacology and therapeutics. 2012 Dec; 50(12):909-19. doi: 10.5414/cp201726. [PMID: 23006443]
  • Guo-fu Li, Kun Wang, Rui Chen, Hao-ru Zhao, Jin Yang, Qing-shan Zheng. Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling. Acta pharmacologica Sinica. 2012 Nov; 33(11):1359-71. doi: 10.1038/aps.2012.103. [PMID: 23085739]
  • Sevgi Tatar Ulu, Zeynep Aydoğmuş. An HPLC method for the determination of bisoprolol in human plasma and its application to a pharmacokinetic study. Journal of chromatographic science. 2012 Aug; 50(7):615-9. doi: 10.1093/chromsci/bms056. [PMID: 22553280]
  • G Rengo, A Lymperopoulos, C Zincarelli, Gd Femminella, D Liccardo, G Pagano, C de Lucia, A Cannavo, P Gargiulo, N Ferrara, P Perrone Filardi, Wj Koch, D Leosco. Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α(2) -adrenoceptor-catecholamine production axis in heart failure. British journal of pharmacology. 2012 Aug; 166(8):2430-40. doi: 10.1111/j.1476-5381.2012.01972.x. [PMID: 22519418]
  • Arzu Onay-Besikci, Elif Suzmecelik, A Tanju Ozcelikay. Carvedilol suppresses fatty acid oxidation and stimulates glycolysis in C2C12 cells. Canadian journal of physiology and pharmacology. 2012 Aug; 90(8):1087-93. doi: 10.1139/y2012-015. [PMID: 22524679]
  • Marek Rajzer, Wiktoria Wojciechowska, Kalina Kawecka-Jaszcz, Anetta Undas. Plasma fibrin clot properties in arterial hypertension and their modification by antihypertensive medication. Thrombosis research. 2012 Jul; 130(1):99-103. doi: 10.1016/j.thromres.2011.08.022. [PMID: 21917299]
  • Timo P Hiltunen, Kimmo Kontula. Clinical and molecular approaches to individualize antihypertensive drug therapy. Annals of medicine. 2012 Jun; 44 Suppl 1(?):S23-9. doi: 10.3109/07853890.2012.679960. [PMID: 22713145]
  • Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J Paul Fawcett, Jingkai Gu, Limei Zhao. Determination of landiolol, an ultra-short-acting β₁-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 891-892(?):7-11. doi: 10.1016/j.jchromb.2011.12.024. [PMID: 22418070]
  • Bryan Wai, Leighton G Kearney, David L Hare, Michelle Ord, Louise M Burrell, Piyush M Srivastava. Beta blocker use in subjects with type 2 diabetes mellitus and systolic heart failure does not worsen glycaemic control. Cardiovascular diabetology. 2012 Feb; 11(?):14. doi: 10.1186/1475-2840-11-14. [PMID: 22330091]
  • Andrzej Madej, Aleksandra Bołdys, Lukasz Bułdak, Krzysztof Labuzek, Marcin Basiak, Bogusław Okopień. Short-term antihypertensive therapy lowers the C-reactive protein level. Postepy higieny i medycyny doswiadczalnej (Online). 2012 Feb; 66(?):78-84. doi: . [PMID: 22371409]
  • Kati M Donner, Timo P Hiltunen, Tuula Hannila-Handelberg, Timo Suonsyrjä, Kimmo Kontula. STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men. Hypertension research : official journal of the Japanese Society of Hypertension. 2012 Jan; 35(1):107-14. doi: 10.1038/hr.2011.166. [PMID: 21993215]
  • Gábor Eros, Petra Hartmann, Szilvia Berkó, Eszter Csizmazia, Erzsébet Csányi, Anita Sztojkov-Ivanov, István Németh, Piroska Szabó-Révész, István Zupkó, Lajos Kemény. A novel murine model for the in vivo study of transdermal drug penetration. TheScientificWorldJournal. 2012; 2012(?):543536. doi: 10.1100/2012/543536. [PMID: 22272176]
  • Gastone Leonetti, Colin G Egan. Use of carvedilol in hypertension: an update. Vascular health and risk management. 2012; 8(?):307-22. doi: 10.2147/vhrm.s31578. [PMID: 22661898]
  • Raymond R Tjandrawinata, Effi Setiawati, Danang Agung Yunaidi, Iwan Dwi Santoso, Arini Setiawati, Liana W Susanto. Bioequivalence study of two formulations of bisoprolol fumarate film-coated tablets in healthy subjects. Drug design, development and therapy. 2012; 6(?):311-6. doi: 10.2147/dddt.s36567. [PMID: 23139624]
  • Hoyoun Won, Seok-Min Kang, Min-Jeong Shin, Jaewon Oh, Namki Hong, Sungha Park, Sang-Hak Lee, Yangsoo Jang, Namsik Chung. Plasma adiponectin concentration and its association with metabolic syndrome in patients with heart failure. Yonsei medical journal. 2012 Jan; 53(1):91-8. doi: 10.3349/ymj.2012.53.1.91. [PMID: 22187237]
  • M N Mamedov. [Broadened indications for the use of selective β-adrenoblockers]. Kardiologiia. 2012; 52(5):74-6. doi: ". [PMID: 22839590]
  • Sheng-Kui Feng. [Observation on curative effect of glomerular pathological proteinuria treated with heat-producing needling]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2012 Jan; 32(1):8-12. doi: . [PMID: 22295812]
  • Nicoletta Riva, Gregory Y H Lip. Nebivolol for the treatment of heart failure. Expert opinion on investigational drugs. 2011 Dec; 20(12):1733-46. doi: 10.1517/13543784.2011.625011. [PMID: 21980961]
  • M A Morsy. Protective effect of lisinopril on hepatic ischemia/reperfusion injury in rats. Indian journal of pharmacology. 2011 Nov; 43(6):652-5. doi: 10.4103/0253-7613.89820. [PMID: 22144768]
  • K M Mahmoud, A S Ammar. Effect of N-acetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: a randomized controlled trial. Acta anaesthesiologica Scandinavica. 2011 Sep; 55(8):1015-21. doi: 10.1111/j.1399-6576.2011.02492.x. [PMID: 22092168]
  • Mohammed F Abdul-Mohsen. Medical angioplasty - hope and expectations: an optimistic overview. Journal of family & community medicine. 2011 Sep; 18(3):101-10. doi: 10.4103/2230-8229.90007. [PMID: 22175036]
  • Marja Lahti, Jenny-Maria Brozinski, Antti Jylhä, Leif Kronberg, Aimo Oikari. Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout. Environmental toxicology and chemistry. 2011 Jun; 30(6):1403-11. doi: 10.1002/etc.501. [PMID: 21337612]
  • N I Vinnik, L A Kutsenko, N L Kutsenko, I L Solokhina, M V Mikitiuk, T V Mamontova, I P Kaĭdashev. [The effectiveness of pioglitazone in the treatment of patients with coronary heart disease on the background of metabolic syndrome]. Likars'ka sprava. 2011 Apr; ?(3-4):71-8. doi: ". [PMID: 22416367]
  • Alessandro Inno, Michele Basso, Fabio M Vecchio, Valentina A Marsico, Eleonora Cerchiaro, Ettore D'Argento, Cinzia Bagalà, Carlo Barone. Anastrozole-related acute hepatitis with autoimmune features: a case report. BMC gastroenterology. 2011 Mar; 11(?):32. doi: 10.1186/1471-230x-11-32. [PMID: 21453541]
  • Neil A Smart, Alf I Larsen, John P Le Maitre, Almir S Ferraz. Effect of exercise training on interleukin-6, tumour necrosis factor alpha and functional capacity in heart failure. Cardiology research and practice. 2011 Feb; 2011(?):532620. doi: 10.4061/2011/532620. [PMID: 21403878]
  • Song Zhang, Ben He, Steven Goldstein, Junbo Ge, Zuyue Wang, George Ruiz. Changes in adiponectin expression in acute myocardial infarction rats and the significance of bisoprolol intervention. Canadian journal of physiology and pharmacology. 2011 Feb; 89(2):109-15. doi: 10.1139/y10-113. [PMID: 21326342]
  • Gaofeng Liu, Yan Liu, Rui Liu, Feng Dong, Zhiren Zhang. Effects of Flos carthami on CYP2D6 and on the Pharmacokinetics of Metoprolol in Rats. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):207076. doi: 10.1155/2011/207076. [PMID: 21127727]
  • N I Vinnik, I P Kaĭdashev. [Clinical description of effectiveness of pioglitazone in a complex therapy of patients with ischemic heart disease on background of metabolic syndrome]. Likars'ka sprava. 2011 Jan; ?(1-2):82-9. doi: NULL. [PMID: 21954640]
  • A Drechsler, W Kirch. [Urinary bladder tuberculosis and bacillus calmette-guérin instillation: reduced efficacy of bisoprolol in hypertension]. Aktuelle Urologie. 2010 Nov; 41(6):372-4. doi: 10.1055/s-0030-1262676. [PMID: 21082517]
  • S Reddy, A Bahl, K K Talwar. Congestive heart failure in Indians: how do we improve diagnosis & management?. The Indian journal of medical research. 2010 Nov; 132(?):549-60. doi: NULL. [PMID: 21150007]
  • Oskar Gonzalez, Gorka Iriarte, Estitxu Rico, Nerea Ferreirós, Miren Itxaso Maguregui, Rosa Maria Alonso, Rosa Maria Jiménez. LC-MS/MS method for the determination of several drugs used in combined cardiovascular therapy in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(28):2685-92. doi: 10.1016/j.jchromb.2010.07.026. [PMID: 20846917]
  • A Drechsler, W Kirch. [Urinary bladder tuberculosis and Bacillus Calmette-Guérin instillation: reduced efficacy of bisoprolol in hypertension]. Deutsche medizinische Wochenschrift (1946). 2010 Oct; 135(40):1968-70. doi: 10.1055/s-0030-1263343. [PMID: 20922637]
  • Li Zhang, Xiaoli Su, Chenggong Zhang, Li Ouyang, Qingji Xie, Ming Ma, Shouzhuo Yao. Extraction and preconcentration of beta-blockers in human urine for analysis with high performance liquid chromatography by means of carrier-mediated liquid phase microextraction. Talanta. 2010 Aug; 82(3):984-92. doi: 10.1016/j.talanta.2010.06.003. [PMID: 20678656]
  • Inder S Anand, Anita Deswal, Dean J Kereiakes, Das Purkayastha, Dion H Zappe. Comparison of once-daily versus twice-daily dosing of valsartan in patients with chronic stable heart failure. Vascular health and risk management. 2010 Aug; 6(?):449-55. doi: NULL. [PMID: 20730060]
  • Gang-Yi Liu, Wei Wang, Jing-Ying Jia, Chuan Lu, Yan-Mei Liu, Meng-Qi Zhang, Yun Liu, Shui-Jun Li, Chen Yu. Liquid chromatography tandem mass spectrometry method for determination of bisoprolol in human plasma using d5-bisoprolol as the internal standard. Biomedical chromatography : BMC. 2010 Jun; 24(6):574-80. doi: 10.1002/bmc.1329. [PMID: 19810009]
  • Davide Castagno, Pardeep S Jhund, John J V McMurray, James D Lewsey, Erland Erdmann, Faiez Zannad, Willem J Remme, José L Lopez-Sendon, Philippe Lechat, Ferenc Follath, Christer Höglund, Viacheslav Mareev, Zygmunt Sadowski, Ricardo J Seabra-Gomes, Henry J Dargie. Improved survival with bisoprolol in patients with heart failure and renal impairment: an analysis of the cardiac insufficiency bisoprolol study II (CIBIS-II) trial. European journal of heart failure. 2010 Jun; 12(6):607-16. doi: 10.1093/eurjhf/hfq038. [PMID: 20354032]
  • D H J Elder, M Pauriah, C C Lang, J Shand, I B A Menown, B D W C K Sin, S Gupta, S G Duckett, W Foster, D Zachariah, P R Kalra. Is there a Failure to Optimize theRapy in anGina pEcToris (FORGET) study?. QJM : monthly journal of the Association of Physicians. 2010 May; 103(5):305-10. doi: 10.1093/qjmed/hcq011. [PMID: 20181676]