Benzamil (BioDeep_00001875818)
Main id: BioDeep_00000009554
代谢物信息卡片
Benzamil
化学式: C13H14ClN7O (319.0948)
中文名称: 盐酸苯甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
InChI: InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:34558
- KEGG: C13751
- PubChem: 108107
- ChEMBL: CHEMBL212579
- CAS: 2898-76-2
- PubChem: 586340
- NIKKAJI: J346.598E
- KNApSAcK: 34558
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Liga Skarda, Julia Kowal, Kaspar P Locher. Structure of the Human Cholesterol Transporter ABCG1.
Journal of molecular biology.
2021 10; 433(21):167218. doi:
10.1016/j.jmb.2021.167218. [PMID: 34461069] - Niklas Ayasse, Peder Berg, Jesper Frank Andersen, Samuel Levi Svendsen, Mads V Sørensen, Natalya U Fedosova, I Jeanette Lynch, Charles S Wingo, Jens Leipziger. Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases.
American journal of physiology. Renal physiology.
2021 04; 320(4):F596-F607. doi:
10.1152/ajprenal.00444.2020. [PMID: 33554781] - Niklas Ayasse, Peder Berg, Jens Leipziger, Mads Vaarby Sørensen. ENaC expression correlates with the acute furosemide-induced K+ excretion.
Physiological reports.
2021 01; 9(1):e14668. doi:
10.14814/phy2.14668. [PMID: 33410279] - Ali Sassi, Yubao Wang, Alexandra Chassot, Olga Komarynets, Isabelle Roth, Valérie Olivier, Gilles Crambert, Eva Dizin, Emilie Boscardin, Edith Hummler, Eric Feraille. Interaction between Epithelial Sodium Channel γ-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct.
Journal of the American Society of Nephrology : JASN.
2020 05; 31(5):1009-1023. doi:
10.1681/asn.2019080790. [PMID: 32245797] - Reham H Soliman, Jermaine G Johnston, Eman Y Gohar, Crystal M Taylor, David M Pollock. Greater natriuretic response to ENaC inhibition in male versus female Sprague-Dawley rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 02; 318(2):R418-R427. doi:
10.1152/ajpregu.00060.2019. [PMID: 31913682] - Hong Zheng, Xuefei Liu, Kenichi Katsurada, Kaushik P Patel. Renal denervation improves sodium excretion in rats with chronic heart failure: effects on expression of renal ENaC and AQP2.
American journal of physiology. Heart and circulatory physiology.
2019 11; 317(5):H958-H968. doi:
10.1152/ajpheart.00299.2019. [PMID: 31490733] - Mads Vaarby Sørensen, Bidisha Saha, Iben Skov Jensen, Peng Wu, Niklas Ayasse, Catherine E Gleason, Samuel Levi Svendsen, Wen-Hui Wang, David Pearce. Potassium acts through mTOR to regulate its own secretion.
JCI insight.
2019 04; 5(?):. doi:
10.1172/jci.insight.126910. [PMID: 31013253] - Anastasia V Sudarikova, Valeria Y Vasileva, Irina O Vassilieva, Yuri A Negulyaev, Elena A Morachevskaya, Vladislav I Chubinskiy-Nadezhdin. Extracellular protease trypsin activates amiloride-insensitive sodium channels in human leukemia cells.
Journal of cellular biochemistry.
2019 01; 120(1):461-469. doi:
10.1002/jcb.27402. [PMID: 30203535] - Rikke Ydegaard, Henrik Andersen, Christina S Oxlund, Ib A Jacobsen, Pernille B L Hansen, Jonathan F Jürgensen, Antonio Augusto Peluso, Paul M Vanhoutte, Mette Staehr, Per Svenningsen, Boye L Jensen. The acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and mice.
Acta physiologica (Oxford, England).
2019 01; 225(1):e13189. doi:
10.1111/apha.13189. [PMID: 30240139] - Masayoshi Nanami, Truyen D Pham, Young Hee Kim, Baoli Yang, Roy L Sutliff, Olivier Staub, Janet D Klein, Karen I Lopez-Cayuqueo, Regine Chambrey, Annie Y Park, Xiaonan Wang, Vladimir Pech, Jill W Verlander, Susan M Wall. The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression.
Journal of the American Society of Nephrology : JASN.
2018 06; 29(6):1706-1719. doi:
10.1681/asn.2017080826. [PMID: 29773687] - Autumn N Harris, P Richard Grimm, Hyun-Wook Lee, Eric Delpire, Lijuan Fang, Jill W Verlander, Paul A Welling, I David Weiner. Mechanism of Hyperkalemia-Induced Metabolic Acidosis.
Journal of the American Society of Nephrology : JASN.
2018 05; 29(5):1411-1425. doi:
10.1681/asn.2017111163. [PMID: 29483157] - Jonathan M Berman, Elena Mironova, James D Stockand. Physiological regulation of the epithelial Na+ channel by casein kinase II.
American journal of physiology. Renal physiology.
2018 03; 314(3):F367-F372. doi:
10.1152/ajprenal.00469.2017. [PMID: 29021227] - Rie Marunaka, Akiyuki Taruno, Toshiro Yamamoto, Narisato Kanamura, Yoshinori Marunaka. Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 50(1):363-377. doi:
10.1159/000494012. [PMID: 30308504] - Hong Wang, Cesar A Romero, J X Masjoan Juncos, Sumit R Monu, Edward L Peterson, Oscar A Carretero. Effect of salt intake on afferent arteriolar dilatation: role of connecting tubule glomerular feedback (CTGF).
American journal of physiology. Renal physiology.
2017 Dec; 313(6):F1209-F1215. doi:
10.1152/ajprenal.00320.2017. [PMID: 28835421] - Oleg Palygin, Vladislav Levchenko, Daria V Ilatovskaya, Tengis S Pavlov, Oleh M Pochynyuk, Howard J Jacob, Aron M Geurts, Matthew R Hodges, Alexander Staruschenko. Essential role of Kir5.1 channels in renal salt handling and blood pressure control.
JCI insight.
2017 09; 2(18):. doi:
10.1172/jci.insight.92331. [PMID: 28931751] - Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Yusuke Sata, Michael James Turner, Masafumi Fukumitsu, Hiromi Yamamoto, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi. Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits.
The journal of physiological sciences : JPS.
2017 Sep; 67(5):587-593. doi:
10.1007/s12576-016-0489-5. [PMID: 27660058] - Kaustubh Sharma, Masudul Haque, Richard Guidry, Yoichi Ueta, Ryoichi Teruyama. Effect of dietary salt intake on epithelial Na+ channels (ENaC) in vasopressin magnocellular neurosecretory neurons in the rat supraoptic nucleus.
The Journal of physiology.
2017 09; 595(17):5857-5874. doi:
10.1113/jp274856. [PMID: 28714095] - I S Jensen, C K Larsen, J Leipziger, M V Sørensen. Na(+) dependence of K(+) -induced natriuresis, kaliuresis and Na(+) /Cl(-) cotransporter dephosphorylation.
Acta physiologica (Oxford, England).
2016 09; 218(1):49-61. doi:
10.1111/apha.12707. [PMID: 27172453] - Nathan A Zaidman, Angela Panoskaltsis-Mortari, Scott M O'Grady. Differentiation of human bronchial epithelial cells: role of hydrocortisone in development of ion transport pathways involved in mucociliary clearance.
American journal of physiology. Cell physiology.
2016 08; 311(2):C225-36. doi:
10.1152/ajpcell.00073.2016. [PMID: 27306366] - Sujay V Kharade, Daniel Flores, Craig W Lindsley, Lisa M Satlin, Jerod S Denton. ROMK inhibitor actions in the nephron probed with diuretics.
American journal of physiology. Renal physiology.
2016 04; 310(8):F732-F737. doi:
10.1152/ajprenal.00423.2015. [PMID: 26661652] - Pia Jeggle, Verena Hofschröer, Martina Maase, Marko Bertog, Kristina Kusche-Vihrog. Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2016 Jan; 30(1):45-53. doi:
10.1096/fj.14-259606. [PMID: 26324851] - Tengis S Pavlov, Daria V Ilatovskaya, Oleg Palygin, Vladislav Levchenko, Oleh Pochynyuk, Alexander Staruschenko. Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium.
Journal of visualized experiments : JoVE.
2015 Sep; ?(103):. doi:
10.3791/53035. [PMID: 26381526] - Masayoshi Nanami, Vladimir Pech, Yoskaly Lazo-Fernandez, Alan M Weinstein, Susan M Wall. ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. II. Bafilomycin-sensitive H+ secretion.
American journal of physiology. Renal physiology.
2015 Aug; 309(3):F259-68. doi:
10.1152/ajprenal.00120.2015. [PMID: 26017972] - Hong Wang, Martin A D'Ambrosio, YiLin Ren, Sumit R Monu, Pablo Leung, Kristopher Kutskill, Jeffrey L Garvin, Branislava Janic, Edward L Peterson, Oscar A Carretero. Tubuloglomerular and connecting tubuloglomerular feedback during inhibition of various Na transporters in the nephron.
American journal of physiology. Renal physiology.
2015 May; 308(9):F1026-31. doi:
10.1152/ajprenal.00605.2014. [PMID: 25715987] - P Richard Grimm, Yoskaly Lazo-Fernandez, Eric Delpire, Susan M Wall, Susan G Dorsey, Edward J Weinman, Richard Coleman, James B Wade, Paul A Welling. Integrated compensatory network is activated in the absence of NCC phosphorylation.
The Journal of clinical investigation.
2015 May; 125(5):2136-50. doi:
10.1172/jci78558. [PMID: 25893600] - Koji Ito, Yoshitaka Hirooka, Kenji Sunagawa. Cardiac sympathetic afferent stimulation induces salt-sensitive sympathoexcitation through hypothalamic epithelial Na+ channel activation.
American journal of physiology. Heart and circulatory physiology.
2015 Mar; 308(5):H530-9. doi:
10.1152/ajpheart.00586.2014. [PMID: 25527778] - Kelly A Hyndman, Vladislav Bugaj, Elena Mironova, James D Stockand, Jennifer S Pollock. NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.
American journal of physiology. Renal physiology.
2015 Feb; 308(3):F244-51. doi:
10.1152/ajprenal.00596.2013. [PMID: 25391901] - Tengis S Pavlov, Vladislav Levchenko, Daria V Ilatovskaya, Oleg Palygin, Alexander Staruschenko. Impaired epithelial Na+ channel activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats.
Pediatric research.
2015 Jan; 77(1-1):64-9. doi:
10.1038/pr.2014.145. [PMID: 25279988] - YiLin Ren, Martin A D'Ambrosio, Jeffrey L Garvin, Pablo Leung, Kristopher Kutskill, Hong Wang, Edward L Peterson, Oscar A Carretero. Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30.
American journal of physiology. Renal physiology.
2014 Aug; 307(4):F427-34. doi:
10.1152/ajprenal.00072.2014. [PMID: 24966088] - Crystal A West, Weiquing Han, Ningjun Li, Shyama M E Masilamani. Renal epithelial sodium channel is critical for blood pressure maintenance and sodium balance in the normal late pregnant rat.
Experimental physiology.
2014 May; 99(5):816-23. doi:
10.1113/expphysiol.2013.076273. [PMID: 24563165] - Robert W Hunter, Eilidh Craigie, Natalie Z M Homer, John J Mullins, Matthew A Bailey. Acute inhibition of NCC does not activate distal electrogenic Na+ reabsorption or kaliuresis.
American journal of physiology. Renal physiology.
2014 Feb; 306(4):F457-67. doi:
10.1152/ajprenal.00339.2013. [PMID: 24402096] - Hong Wang, Martin A D'Ambrosio, Jeffrey L Garvin, Yilin Ren, Oscar A Carretero. Connecting tubule glomerular feedback in hypertension.
Hypertension (Dallas, Tex. : 1979).
2013 Oct; 62(4):738-45. doi:
10.1161/hypertensionaha.113.01846. [PMID: 23959547] - I Jeanette Lynch, Amanda K Welch, Donald E Kohan, Brian D Cain, Charles S Wingo. Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct.
American journal of physiology. Renal physiology.
2013 Aug; 305(4):F568-73. doi:
10.1152/ajprenal.00613.2012. [PMID: 23698114] - Vladimir Pech, Monika Thumova, Sergey I Dikalov, Edith Hummler, Bernard C Rossier, David G Harrison, Susan M Wall. Nitric oxide reduces Cl⁻ absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism.
American journal of physiology. Renal physiology.
2013 Jun; 304(11):F1390-7. doi:
10.1152/ajprenal.00292.2012. [PMID: 23515718] - Tengis S Pavlov, Vladislav Levchenko, Paul M O'Connor, Daria V Ilatovskaya, Oleg Palygin, Takefumi Mori, David L Mattson, Andrey Sorokin, Julian H Lombard, Allen W Cowley, Alexander Staruschenko. Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension.
Journal of the American Society of Nephrology : JASN.
2013 Jun; 24(7):1053-62. doi:
10.1681/asn.2012080839. [PMID: 23599382] - Seong-Ki Lee, Walter F Boron, Mark D Parker. Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits.
American journal of physiology. Renal physiology.
2013 Apr; 304(7):F883-99. doi:
10.1152/ajprenal.00612.2012. [PMID: 23324180] - Lijun Li, R Mayuri Garikepati, Susanna Tsukerman, Donald Kohan, James B Wade, Swasti Tiwari, Carolyn M Ecelbarger. Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct.
American journal of physiology. Renal physiology.
2013 Feb; 304(3):F279-88. doi:
10.1152/ajprenal.00161.2012. [PMID: 23195676] - Vladimir Pech, Monika Thumova, Young Hee Kim, Diana Agazatian, Edith Hummler, Bernard C Rossier, Alan M Weinstein, Masayoshi Nanami, Susan M Wall. ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.
American journal of physiology. Renal physiology.
2012 Jul; 303(1):F45-55. doi:
10.1152/ajprenal.00030.2012. [PMID: 22496413] - Hong Wang, Martin A D'Ambrosio, Jeffrey L Garvin, Yilin Ren, Oscar A Carretero. Connecting tubule glomerular feedback mediates acute tubuloglomerular feedback resetting.
American journal of physiology. Renal physiology.
2012 May; 302(10):F1300-4. doi:
10.1152/ajprenal.00673.2011. [PMID: 22357913] - Meghana M Pandit, Kevin A Strait, Toshio Matsuda, Donald E Kohan. Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production.
American journal of physiology. Renal physiology.
2012 May; 302(10):F1325-30. doi:
10.1152/ajprenal.00034.2012. [PMID: 22357920] - Chih-Jen Cheng, German Lozano, Michel Baum. Prenatal programming of rat cortical collecting tubule sodium transport.
American journal of physiology. Renal physiology.
2012 Mar; 302(6):F674-8. doi:
10.1152/ajprenal.00633.2011. [PMID: 22189946] - Ryoichi Teruyama, Mayumi Sakuraba, Lori L Wilson, Narine E J Wandrey, William E Armstrong. Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.
American journal of physiology. Endocrinology and metabolism.
2012 Feb; 302(3):E273-85. doi:
10.1152/ajpendo.00407.2011. [PMID: 22045317] - Reno C Reyes, Alexei Verkhratsky, Vladimir Parpura. Plasmalemmal Na+/Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes.
ASN neuro.
2012 Jan; 4(1):. doi:
10.1042/an20110059. [PMID: 22268447] - Gail A Reif, Tamio Yamaguchi, Emily Nivens, Hiroyuki Fujiki, Cibele S Pinto, Darren P Wallace. Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin.
American journal of physiology. Renal physiology.
2011 Nov; 301(5):F1005-13. doi:
10.1152/ajprenal.00243.2011. [PMID: 21816754] - F Enning, H Murck, J-C Krieg, H Vedder. Hypericum perforatum differentially affects corticosteroid receptor-mRNA expression in human monocytic U-937 cells.
Journal of psychiatric research.
2011 Sep; 45(9):1170-7. doi:
10.1016/j.jpsychires.2011.03.007. [PMID: 21570090] - Hong Zheng, Xuefei Liu, U S Rao, Kaushik P Patel. Increased renal ENaC subunits and sodium retention in rats with chronic heart failure.
American journal of physiology. Renal physiology.
2011 Mar; 300(3):F641-9. doi:
10.1152/ajprenal.00254.2010. [PMID: 21159737] - Kristina Kusche-Vihrog, Katarina Urbanova, Anja Blanqué, Marianne Wilhelmi, Hermann Schillers, Katrin Kliche, Hermann Pavenstädt, Eva Brand, Hans Oberleithner. C-reactive protein makes human endothelium stiff and tight.
Hypertension (Dallas, Tex. : 1979).
2011 Feb; 57(2):231-7. doi:
10.1161/hypertensionaha.110.163444. [PMID: 21149827] - Hongyu Wu, Lihe Chen, Qiaoling Zhou, Wenzheng Zhang. AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells.
PloS one.
2011; 6(11):e27429. doi:
10.1371/journal.pone.0027429. [PMID: 22087315] - H Wang, J L Garvin, M A D'Ambrosio, Y Ren, O A Carretero. Connecting tubule glomerular feedback antagonizes tubuloglomerular feedback in vivo.
American journal of physiology. Renal physiology.
2010 Dec; 299(6):F1374-8. doi:
10.1152/ajprenal.00403.2010. [PMID: 20826574] - Crystal West, Zheng Zhang, Geoffrey Ecker, Shyama M E Masilamani. Increased renal alpha-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Nov; 299(5):R1326-32. doi:
10.1152/ajpregu.00082.2010. [PMID: 20686170] - Yilin Ren, Martin A D'Ambrosio, Jeffrey L Garvin, Oscar A Carretero. Angiotensin II enhances connecting tubule glomerular feedback.
Hypertension (Dallas, Tex. : 1979).
2010 Oct; 56(4):636-42. doi:
10.1161/hypertensionaha.110.153692. [PMID: 20696981] - Kye Won Park, Hironori Waki, Sung-Pil Choi, Ki-Moon Park, Peter Tontonoz. The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.
Journal of lipid research.
2010 Sep; 51(9):2775-84. doi:
10.1194/jlr.m008490. [PMID: 20519739] - Endre Sulyok, József Pál, Zsolt Vajda, Roy Steier, Tamás Dóczi. Benzamil prevents brain water accumulation in hyponatraemic rats.
Acta neurochirurgica.
2009 Sep; 151(9):1121-5. doi:
10.1007/s00701-009-0354-x. [PMID: 19415169] - Marleen L A Kortenoeven, Yuedan Li, Stephen Shaw, Hans-Peter Gaeggeler, Bernard C Rossier, Jack F M Wetzels, Peter M T Deen. Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.
Kidney international.
2009 Jul; 76(1):44-53. doi:
10.1038/ki.2009.91. [PMID: 19367330] - Shengzhou Wu, Krzysztof L Hyrc, Krista L Moulder, Ying Lin, Timothy Warmke, B Joy Snider. Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors.
Journal of neurochemistry.
2009 Jun; 109(5):1225-36. doi:
10.1111/j.1471-4159.2009.06037.x. [PMID: 19476541] - Koji Ito, Yoshitaka Hirooka, Kenji Sunagawa. Acquisition of brain Na sensitivity contributes to salt-induced sympathoexcitation and cardiac dysfunction in mice with pressure overload.
Circulation research.
2009 Apr; 104(8):1004-11. doi:
10.1161/circresaha.108.188995. [PMID: 19299647] - Kalyan V Srinivas, Sujit K Sikdar. Epileptiform activity induces distance-dependent alterations of the Ca2+ extrusion mechanism in the apical dendrites of subicular pyramidal neurons.
The European journal of neuroscience.
2008 Dec; 28(11):2195-212. doi:
10.1111/j.1460-9568.2008.06519.x. [PMID: 19046366] - Hon Kit Wong, Peter O Bauer, Masaru Kurosawa, Anand Goswami, Chika Washizu, Yoko Machida, Asako Tosaki, Mizuki Yamada, Thomas Knöpfel, Takemichi Nakamura, Nobuyuki Nukina. Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism.
Human molecular genetics.
2008 Oct; 17(20):3223-35. doi:
10.1093/hmg/ddn218. [PMID: 18658163] - Xuemei Wang, Kosuke Takeya, Philip I Aaronson, Kathy Loutzenhiser, Rodger Loutzenhiser. Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response.
American journal of physiology. Renal physiology.
2008 Jul; 295(1):F272-82. doi:
10.1152/ajprenal.00200.2007. [PMID: 18495800] - Alessandra Cantone, Xinbo Yang, Qingshang Yan, Gerhard Giebisch, Steven C Hebert, Tong Wang. Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity.
American journal of physiology. Renal physiology.
2008 Jun; 294(6):F1366-72. doi:
10.1152/ajprenal.00608.2007. [PMID: 18385266] - Veerendra K Madala Halagappa, Swasti Tiwari, Shahla Riazi, Xinqun Hu, Carolyn M Ecelbarger. Chronic candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker rat.
American journal of physiology. Renal physiology.
2008 May; 294(5):F1222-31. doi:
10.1152/ajprenal.00604.2007. [PMID: 18305093] - Xiao-Qing Dai, Alkarim Ramji, Yan Liu, Qiang Li, Edward Karpinski, Xing-Zhen Chen. Inhibition of TRPP3 channel by amiloride and analogs.
Molecular pharmacology.
2007 Dec; 72(6):1576-85. doi:
10.1124/mol.107.037150. [PMID: 17804601] - Shinsaku Tokuda, Naomi Niisato, Yoshinori Marunaka. Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells.
Biochemical and biophysical research communications.
2007 Nov; 363(3):566-71. doi:
10.1016/j.bbrc.2007.08.187. [PMID: 17888879] - Naomi Niisato, Akiyuki Taruno, Yoshinori Marunaka. Aldosterone-induced modification of osmoregulated ENaC trafficking.
Biochemical and biophysical research communications.
2007 Sep; 361(1):162-8. doi:
10.1016/j.bbrc.2007.07.002. [PMID: 17658480] - Swasti Tiwari, Lina Nordquist, Veerendra K Madala Halagappa, Carolyn A Ecelbarger. Trafficking of ENaC subunits in response to acute insulin in mouse kidney.
American journal of physiology. Renal physiology.
2007 Jul; 293(1):F178-85. doi:
10.1152/ajprenal.00447.2006. [PMID: 17389677] - Melissa A Fowler, Kyriaki Sidiropoulou, Emin D Ozkan, Christopher W Phillips, Donald C Cooper. Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.
PloS one.
2007 Jun; 2(6):e573. doi:
10.1371/journal.pone.0000573. [PMID: 17593972] - Vladimír Pech, Young Hee Kim, Alan M Weinstein, Lorraine A Everett, Truyen D Pham, Susan M Wall. Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism.
American journal of physiology. Renal physiology.
2007 Mar; 292(3):F914-20. doi:
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American journal of physiology. Renal physiology.
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American journal of physiology. Renal physiology.
2006 May; 290(5):F1055-64. doi:
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European journal of medical research.
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American journal of physiology. Renal physiology.
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American journal of physiology. Renal physiology.
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American journal of physiology. Renal physiology.
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