Nafoxidine (BioDeep_00001875142)

Main id: BioDeep_00000009765

 


代谢物信息卡片


Nafoxidine

化学式: C29H31NO2 (425.2354666)
中文名称: 萘福昔定
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC2=C(C=C1)C(=C(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)OCCN5CCCC5
InChI: InChI=1S/C29H31NO2/c1-31-26-14-16-28-24(21-26)11-15-27(22-7-3-2-4-8-22)29(28)23-9-12-25(13-10-23)32-20-19-30-17-5-6-18-30/h2-4,7-10,12-14,16,21H,5-6,11,15,17-20H2,1H3

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C1971 - Angiogenesis Activator Inhibitor
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents
C1892 - Chemopreventive Agent

同义名列表

1 个代谢物同义名

Nafoxidine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • A K Loomis, P Thomas. Binding characteristics of estrogen receptor (ER) in Atlantic croaker (Micropogonias undulatus) testis: different affinity for estrogens and xenobiotics from that of hepatic ER. Biology of reproduction. 1999 Jul; 61(1):51-60. doi: 10.1095/biolreprod61.1.51. [PMID: 10377031]
  • G G Kuiper, B Carlsson, K Grandien, E Enmark, J Häggblad, S Nilsson, J A Gustafsson. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997 Mar; 138(3):863-70. doi: 10.1210/endo.138.3.4979. [PMID: 9048584]
  • M Sato, M K Rippy, H U Bryant. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1996 Jun; 10(8):905-12. doi: 10.1096/fasebj.10.8.8666168. [PMID: 8666168]
  • H Wiseman, B Halliwell. Tamoxifen and related compounds protect against lipid peroxidation in isolated nuclei: relevance to the potential anticarcinogenic benefits of breast cancer prevention and therapy with tamoxifen?. Free radical biology & medicine. 1994 Nov; 17(5):485-8. doi: 10.1016/0891-5849(94)90176-7. [PMID: 7835756]
  • M S Wisel, J K Datta, R N Saxena. Effects of anti-estrogens on early pregnancy in guinea pigs. International journal of fertility and menopausal studies. 1994 May; 39(3):156-63. doi: NULL. [PMID: 7920752]
  • H Wiseman. The antioxidant action of a pure antioestrogen: ability to inhibit lipid peroxidation compared to tamoxifen and 17 beta-oestradiol and relevance to its anticancer potential. Biochemical pharmacology. 1994 Feb; 47(3):493-8. doi: 10.1016/0006-2952(94)90180-5. [PMID: 8117317]
  • M Miyagi, H Aoyama, M Morishita, Y Iwamoto. Effects of sex hormones on chemotaxis of human peripheral polymorphonuclear leukocytes and monocytes. Journal of periodontology. 1992 Jan; 63(1):28-32. doi: 10.1902/jop.1992.63.1.28. [PMID: 1552459]
  • J R Pasqualini, C Sumida, N Giambiagi. Pharmacodynamic and biological effects of anti-estrogens in different models. Journal of steroid biochemistry. 1988 Oct; 31(4B):613-43. doi: 10.1016/0022-4731(88)90013-1. [PMID: 3059059]
  • A Khar, A M Ali. Serum protects HeLa cells from antiestrogen effects in culture. European journal of cancer & clinical oncology. 1987 Jun; 23(6):761-3. doi: 10.1016/0277-5379(87)90275-6. [PMID: 3653194]
  • B S Leung. Mode of estrogen action on cell proliferation in CAMA-1 cells: III. Effect of antiestrogen. Anticancer research. 1987 Mar; 7(2):219-25. doi: NULL. [PMID: 3592635]
  • W C Chang, H H Tai. Induction of a decrease in renal NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity by estradiol in rats. Biochemical pharmacology. 1985 Jun; 34(12):2073-6. doi: 10.1016/0006-2952(85)90397-1. [PMID: 4004926]
  • G N Wade, J M Gray, T J Bartness. Gonadal influences on adiposity. International journal of obesity. 1985; 9 Suppl 1(?):83-92. doi: ". [PMID: 4066126]
  • C K Osborne, D H Boldt, P Estrada. Human breast cancer cell cycle synchronization by estrogens and antiestrogens in culture. Cancer research. 1984 Apr; 44(4):1433-9. doi: NULL. [PMID: 6704960]
  • D R Mann, M S Blank, R Sridaran, V D Castracane, C Eldridge, D C Collins. Influence of anti-oestrogens on gonadotrophin secretion in control and ACTH-infused immature rats. Acta endocrinologica. 1984 Mar; 105(3):308-13. doi: 10.1530/acta.0.1050308. [PMID: 6322494]
  • H Nogami. Fine-structural heterogeneity and morphologic changes in rat pituitary prolactin cells after estrogen and testosterone treatment. Cell and tissue research. 1984; 237(2):195-202. doi: 10.1007/bf00217136. [PMID: 6478487]
  • T Alhadi, B K Vonderhaar. Induction of cryptic lactogenic hormone binding in livers of adult female mice treated neonatally with estradiol or nafoxidine. Endocrinology. 1982 Jan; 110(1):254-9. doi: 10.1210/endo-110-1-254. [PMID: 6274621]
  • S K Roy, J Sengupta, B C Paria, S K Manchanda. In vitro inhibiton of trophoblast maturation and expansion of early rat blastocysts by an oestrogen antagonist. Acta endocrinologica. 1982 Jan; 99(1):129-35. doi: 10.1530/acta.0.0990129. [PMID: 7058672]
  • J van Marle, J Lindeman, A T Ariens, W Labruyère, J van Weeren-Kramer. Estrogen receptors in human breast cancer. I. Specificity of the histochemical localization of estrogen receptors using an estrogen-albumin FITC complex. Virchows Archiv. B, Cell pathology including molecular pathology. 1982; 40(1):17-25. doi: NULL. [PMID: 6126951]
  • L L Stolbach, C B Begg, T Hall, J Horton. Treatment of renal carcinoma: a phase III randomized trial of oral medroxyprogesterone (Provera), hydroxyurea, and nafoxidine. Cancer treatment reports. 1981 Jul; 65(7-8):689-92. doi: . [PMID: 6454485]
  • S K Roy, J Sengupta, S K Manchanda. Rat embryo development in vitro. Acta endocrinologica. 1981 Apr; 96(4):546-51. doi: 10.1530/acta.0.0960546. [PMID: 7211109]
  • M A Kneifel, B S Katzenellenbogen. Comparative effects of estrogen and antiestrogen on plasma renin substrate levels and hepatic estrogen receptors in the rat. Endocrinology. 1981 Feb; 108(2):545-52. doi: 10.1210/endo-108-2-545. [PMID: 7004858]
  • J Sengupta, S K Roy, S K Manchanda. Hormonal control of implantation: a possible role of lysosomal function in the embryo-uterus interaction. Journal of steroid biochemistry. 1979 Jul; 11(1C):729-44. doi: 10.1016/0022-4731(79)90007-4. [PMID: 491641]
  • L G Feun, A Drelichman, A Singhakowinta, V K Vaitkevicius, N Oishi. Phase II study of nafoxidine in the therapy for advanced renal carcinoma. Cancer treatment reports. 1979 Jan; 63(1):149-50. doi: . [PMID: 369688]
  • S A Li, J J Li. Estrogen-induced progesterone receptor in the Syrian hamster kidney. I. Modulation by antiestrogens and androgens. Endocrinology. 1978 Dec; 103(6):2119-28. doi: 10.1210/endo-103-6-2119. [PMID: 748036]
  • A H Dodge. Fine structural, G-6-PD isoenzyme, and HaLV gs antigen studies of poly I/C and antiestrogen treated DES-induced hamster renal tumors. European journal of cancer. 1977 Dec; 13(12):1377-87. doi: 10.1016/0014-2964(77)90150-5. [PMID: 598385]
  • L Chan, R L Jackson, A R Means. Female steroid hormones and lipoprotein synthesis in the cockerel: effects of progesterone and nafoxidine on the estrogenic stimulation of very low density lipoproteins (VLDL) synthesis. Endocrinology. 1977 Jun; 100(6):1636-43. doi: 10.1210/endo-100-6-1636. [PMID: 192542]
  • S S Legha, M Slavik, S K Carter. Nafoxidine--an antiestrogen for the treatment of breast cancer. Cancer. 1976 Oct; 38(4):1535-41. doi: 10.1002/1097-0142(197610)38:4<1535::aid-cncr2820380415>3.0.co;2-m. [PMID: 991075]
  • S Legha, F M Muggia. Letter: Antiestrogens in the treatment of cancer. Annals of internal medicine. 1976 Jun; 84(6):751. doi: 10.7326/0003-4819-84-6-751_1. [PMID: 937894]
  • J Uriel, D Bouillon, C Aussel, M Dupiers. Alpha-fetoprotein: the major high-affinity estrogen binder in rat uterine cytosols. Proceedings of the National Academy of Sciences of the United States of America. 1976 May; 73(5):1452-6. doi: 10.1073/pnas.73.5.1452. [PMID: 58416]
  • C Lazier. (3H)-estradiol binding by chick liver nuclear extracts: mechanism of increase in binding following estradiol injection. Steroids. 1975 Sep; 26(3):281-98. doi: 10.1016/0039-128x(75)90075-6. [PMID: 173044]
  • E Engelsman, J C Heuson, J Blonk Van Der Wijst, A Drochmans, H Maass, F Cheix, L G Sobrinho, H Nowakowski. Controlled clinical trial of L-dopa and nafoxidine in advanced breast cancer: an E.O.R.T.C. study. British medical journal. 1975 Jun; 2(5973):714-5. doi: 10.1136/bmj.2.5973.714. [PMID: 1095122]
  • P A Nickerson. Fat accumulation in tha adrenal gland: effect of oestradiol benzoate on the zona reticularis of the Mongolian gerbil adrenal gland. Pathologia Europaea. 1975; 10(4):287-97. doi: . [PMID: 174051]
  • P Antonio, M Gabaldón, T Lacomba, A Juan. Effect of the antiestrogen nafoxidine on the occurrence of estrogen-dependent renal tumors in hamster. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1974 Nov; 6(6):522-4. doi: 10.1055/s-0028-1093802. [PMID: 4217760]
  • E V Jensen, P I Brecher, S Mohla, E R DeSombre. Receptor transformation in estrogen action. Acta endocrinologica. Supplementum. 1974; 191(?):159-72. doi: 10.1530/acta.0.077s0159. [PMID: 4375378]
  • A Gorins, A Netter, M L'Hermite. [Prolactin: radioimmunologic levels and changes under ethinyl estradiol and nafoxidine in advanced breast cancers in women]. Annales d'endocrinologie. 1973 Sep; 34(5):601-2. doi: . [PMID: 4794619]