GW 0742 (BioDeep_00001871658)
Main id: BioDeep_00000010796
代谢物信息卡片
{4-[({2-[3-Fluoro-4-(Trifluoromethyl)phenyl]-4-Methyl-1,3-Thiazol-5-Yl}methyl)sulfanyl]-2-Methylphenoxy}acetic Acid
化学式: C21H17F4NO3S2 (471.058594)
中文名称: GW0742
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC(=C(C=C3)C(F)(F)F)F)C)OCC(=O)O
InChI: InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)
描述信息
GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:79991
- KEGG: C15625
- KEGGdrug: D70682
- PubChem: 9934458
- ChEMBL: CHEMBL38508
- CAS: 317318-84-6
- PubChem: 17396615
- PDB-CCD: GW0
- NIKKAJI: J2.054.791J
- medchemexpress: HY-13928
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cigdem Sahin, Lilia Magomedova, Thais A M Ferreira, Jiabao Liu, Jens Tiefenbach, Priscilla S Alves, Fellipe J G Queiroz, Andressa S de Oliveira, Mousumi Bhattacharyya, Julie Grouleff, Patrícia C N Nogueira, Edilberto R Silveira, Daniel C Moreira, José Roberto Souza de Almeida Leite, Guilherme D Brand, David Uehling, Gennady Poda, Henry Krause, Carolyn L Cummins, Luiz A S Romeiro. Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.
Journal of medicinal chemistry.
2022 02; 65(3):1961-1978. doi:
10.1021/acs.jmedchem.1c01542. [PMID: 35089724] - Zongtao Zhou, Qiang Ren, Shixuan Jiao, Zongyu Cai, Xinqian Geng, Liming Deng, Bin Wang, Lijun Hu, Luyong Zhang, Ying Yang, Zheng Li. Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents.
European journal of medicinal chemistry.
2022 Feb; 229(?):114061. doi:
10.1016/j.ejmech.2021.114061. [PMID: 34954593] - Xingming Hou, Clemens Malainer, Atanas G Atanasov, Elke H Heiß, Verena M Dirsch, Limei Wang, KeWei Wang. Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice.
Journal of natural products.
2021 12; 84(12):3110-3116. doi:
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Neurochemical research.
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International journal of molecular sciences.
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Journal of cellular physiology.
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PloS one.
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Canadian journal of diabetes.
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2013 Nov; 45(12):880-6. doi:
10.1055/s-0033-1348317. [PMID: 23803968] - Jens C de Groot, Christopher Weidner, Joern Krausze, Ken Kawamoto, Frank C Schroeder, Sascha Sauer, Konrad Büssow. Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ.
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Mediators of inflammation.
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Experimental & molecular medicine.
2012 Oct; 44(10):578-85. doi:
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Journal of clinical biochemistry and nutrition.
2011 Jul; 49(1):42-9. doi:
10.3164/jcbn.10-139. [PMID: 21765606] - Basilia Zingarelli, Giovanna Piraino, Paul W Hake, Michael O'Connor, Alvin Denenberg, Hongkuan Fan, James A Cook. Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.
The American journal of pathology.
2010 Oct; 177(4):1834-47. doi:
10.2353/ajpath.2010.091010. [PMID: 20709805] - Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Salvatore Cuzzocrea. GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury.
Journal of leukocyte biology.
2010 Aug; 88(2):291-301. doi:
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Shock (Augusta, Ga.).
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Hepatology (Baltimore, Md.).
2008 Aug; 48(2):432-41. doi:
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Atherosclerosis.
2005 Jul; 181(1):29-37. doi:
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