Cetiedil (BioDeep_00001871534)

Main id: BioDeep_00000009578

 


代谢物信息卡片


2-(azepan-1-yl)ethyl 2-cyclohexyl-2-thiophen-3-ylacetate

化学式: C20H31NO2S (349.2075)
中文名称: 西替地尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCCN(CC1)CCOC(=O)C(C2CCCCC2)C3=CSC=C3
InChI: InChI=1S/C20H31NO2S/c22-20(23-14-13-21-11-6-1-2-7-12-21)19(18-10-15-24-16-18)17-8-4-3-5-9-17/h10,15-17,19H,1-9,11-14H2

描述信息

C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D006401 - Hematologic Agents > D000986 - Antisickling Agents
ATC code: C04AX26

同义名列表

3 个代谢物同义名

2-(azepan-1-yl)ethyl 2-cyclohexyl-2-thiophen-3-ylacetate; Cetiedil; Cetiedil



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 CHAT, MYLK
Peripheral membrane protein 1 ACHE
Nucleus 3 ACHE, CHAT, MPO
cytosol 3 CHAT, KCNN4, MYLK
nucleoplasm 2 ATP2B1, MPO
Cell membrane 3 ACHE, ATP2B1, KCNN4
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
ruffle membrane 1 KCNN4
Multi-pass membrane protein 5 ATP2B1, CACNA1I, CATSPER3, KCNN4, SLC18A3
Synapse 4 ACHE, ATP2B1, CHAT, MYLK
cell surface 1 ACHE
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 ACHE
neuromuscular junction 1 ACHE
neuronal cell body 1 KCNN4
presynaptic membrane 1 ATP2B1
Lysosome 1 MPO
acrosomal vesicle 1 CATSPER3
plasma membrane 8 ACHE, ATP2B1, CACNA1I, CATSPER3, F2, KCNN4, MYLK, SLC18A3
synaptic vesicle membrane 2 ATP2B1, SLC18A3
terminal bouton 1 SLC18A3
Membrane 4 ACHE, ATP2B1, CACNA1I, KCNN4
basolateral plasma membrane 1 ATP2B1
extracellular exosome 3 ATP2B1, F2, MPO
endoplasmic reticulum 1 CATSPER3
extracellular space 3 ACHE, F2, MPO
perinuclear region of cytoplasm 1 ACHE
intracellular membrane-bounded organelle 2 ATP2B1, MPO
Secreted 2 ACHE, F2
extracellular region 3 ACHE, F2, MPO
Extracellular side 1 ACHE
motile cilium 1 CATSPER3
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 2 ATP2B1, SLC18A3
actin cytoskeleton 1 MYLK
vesicle 1 KCNN4
Cell projection, lamellipodium 1 MYLK
Cell projection, ruffle membrane 1 KCNN4
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 F2
secretory granule 1 MPO
lateral plasma membrane 1 ATP2B1
neuron projection 2 CHAT, KCNN4
cell projection 1 ATP2B1
blood microparticle 1 F2
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
Cell projection, cilium, flagellum membrane 1 CATSPER3
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
stress fiber 1 MYLK
azurophil granule 1 MPO
voltage-gated potassium channel complex 1 KCNN4
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
voltage-gated calcium channel complex 1 CACNA1I
azurophil granule lumen 1 MPO
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 SLC18A3
phagocytic vesicle lumen 1 MPO
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
synaptic cleft 1 ACHE
AP-1 adaptor complex 1 SLC18A3
AP-2 adaptor complex 1 SLC18A3
photoreceptor ribbon synapse 1 ATP2B1
clathrin-sculpted acetylcholine transport vesicle membrane 1 SLC18A3
[Isoform H]: Cell membrane 1 ACHE
CatSper complex 1 CATSPER3


文献列表

  • B S Jensen, D Strobaek, P Christophersen, T D Jorgensen, C Hansen, A Silahtaroglu, S P Olesen, P K Ahring. Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel. The American journal of physiology. 1998 09; 275(3):C848-56. doi: 10.1152/ajpcell.1998.275.3.c848. [PMID: 9730970]
  • J Giannettini, M Chauvet, M Dell'Amico, M Bourdeaux. Influence of cetiedil on erythrocyte membrane microviscosity and acetylcholinesterase activity. Pharmacological research. 1992 Jan; 25(1):31-41. doi: 10.1016/s1043-6618(05)80062-3. [PMID: 1738756]
  • M P Dube, F B Davis, P J Davis, S D Blas. Bepridil and cetiedil reversibly inhibit thyroid hormone stimulation in vitro of human red cell Ca2+-ATPase activity. Molecular endocrinology (Baltimore, Md.). 1987 Feb; 1(2):168-71. doi: 10.1210/mend-1-2-168. [PMID: 2970587]
  • C Narasimhan, L W Fung. Molecular properties of cetiedil and its interactions with erythrocyte membranes. Journal of pharmaceutical sciences. 1986 Jul; 75(7):654-9. doi: 10.1002/jps.2600750707. [PMID: 3020225]
  • E P Orringer, J R Powell, R E Cross, J F Rogers, O Wojcieszyn, J C Phillips, J Reed, K T Ng, L R Berkowitz. A single-dose pharmacokinetic study of the antisickling agent cetiedil. Clinical pharmacology and therapeutics. 1986 Mar; 39(3):276-81. doi: 10.1038/clpt.1986.39. [PMID: 3512147]
  • M L Holland, K T Ng. Automated capillary gas chromatographic assay using nitrogen-phosphorus detection for the determination of cetiedil in plasma. Journal of chromatography. 1985 Nov; 345(1):178-83. doi: 10.1016/0378-4347(85)80151-1. [PMID: 4086578]
  • H Kohzaki, K Kakinuma, T Asakura, T Yamakawa. Effects of cetiedil on the oxidative metabolism of activated polymorphonuclear leucocytes. British journal of haematology. 1985 Jul; 60(3):531-9. doi: 10.1111/j.1365-2141.1985.tb07450.x. [PMID: 4015989]
  • J D Henderson, V N Mankad, T M Glenn, Y W Cho. Gas chromatographic analysis of cetiedil, a candidate antisickling agent, in human plasma with nitrogen-sensitive detection. Journal of pharmaceutical sciences. 1984 Dec; 73(12):1748-51. doi: 10.1002/jps.2600731222. [PMID: 6527249]
  • C Larousse, M F Kergueris, Y Le Normand, J Visset. Research on the eventual enzymatic induction activity of cetiedil in rat and man. International journal of clinical pharmacology, therapy, and toxicology. 1980; 18(5):195-9. doi: NULL. [PMID: 7390670]