DPCPX (BioDeep_00001871441)
Main id: BioDeep_00000009523
代谢物信息卡片
8-Cyclopentyl-1,3-dipropylxanthine
化学式: C16H24N4O2 (304.18991639999996)
中文名称: 1,3-二丙基-8-环戊基黄嘌呤
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3
InChI: InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
描述信息
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].
同义名列表
4 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:73282
- KEGG: C13709
- PubChem: 1329
- DrugBank: DB12946
- ChEMBL: CHEMBL183
- CAS: 102146-07-6
- PubChem: 586298
- NIKKAJI: J126.311K
- medchemexpress: HY-100937
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Carolin Torregroza, Chiara O Glashoerster, Katharina Feige, Martin Stroethoff, Annika Raupach, André Heinen, Markus W Hollmann, Ragnar Huhn. Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.
International journal of molecular sciences.
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The international journal of neuropsychopharmacology.
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Cell reports.
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Canadian journal of physiology and pharmacology.
2006 Nov; 84(11):1177-84. doi:
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European journal of pharmacology.
2006 Oct; 548(1-3):29-35. doi:
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Hepatology (Baltimore, Md.).
2006 Oct; 44(4):813-22. doi:
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Kidney international.
2006 Aug; 70(4):675-81. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Jul; 21(7):1961-5. doi:
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American journal of physiology. Renal physiology.
2006 Jun; 290(6):F1367-75. doi:
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Planta medica.
2006 Jun; 72(7):579-83. doi:
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The Journal of pharmacology and experimental therapeutics.
2006 Feb; 316(2):530-8. doi:
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Neuroscience.
2006; 138(4):1195-203. doi:
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Journal of neurochemistry.
2005 Dec; 95(5):1421-37. doi:
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European journal of pharmacology.
2005 Oct; 523(1-3):16-24. doi:
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Hypertension (Dallas, Tex. : 1979).
2005 Oct; 46(4):780-6. doi:
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British journal of pharmacology.
2005 Oct; 146(4):604-11. doi:
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American journal of physiology. Renal physiology.
2005 Aug; 289(2):F369-76. doi:
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005 Jul; 25(27):6286-95. doi:
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British journal of pharmacology.
2005 Apr; 144(8):1109-17. doi:
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The Journal of pharmacy and pharmacology.
2005 Mar; 57(3):399-404. doi:
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Acta pharmacologica Sinica.
2005 Feb; 26(2):160-5. doi:
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The international journal of biochemistry & cell biology.
2005 Jan; 37(1):155-65. doi:
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The Journal of pharmacology and experimental therapeutics.
2005 Jan; 312(1):27-34. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2004 Dec; 370(6):492-9. doi:
10.1007/s00210-004-0999-1. [PMID: 15558241] - Per Liss, Per-Ola Carlsson, Fredrik Palm, Peter Hansell. Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat.
European radiology.
2004 Jul; 14(7):1297-302. doi:
10.1007/s00330-003-2167-2. [PMID: 14714138] - Hui-Jie Ma, Hui-Juan Ma, Yi-Xian Liu, Qing-Shan Wang. Injection of adenosine into the renal artery activates spontaneous activity of renal afferent nerve fibers.
Sheng li xue bao : [Acta physiologica Sinica].
2004 Apr; 56(2):192-7. doi:
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American journal of physiology. Renal physiology.
2004 Feb; 286(2):F298-306. doi:
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Journal of the American Society of Nephrology : JASN.
2004 Jan; 15(1):102-11. doi:
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The Journal of clinical investigation.
2003 Dec; 112(12):1895-905. doi:
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Circulation research.
2003 Oct; 93(8):759-66. doi:
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Brain research.
2003 Oct; 987(1):49-58. doi:
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Pediatric research.
2003 Sep; 54(3):400-5. doi:
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Annals of nuclear medicine.
2003 Sep; 17(6):457-62. doi:
10.1007/bf03006434. [PMID: 14575379] - Dan Shi, William L Padgett, John W Daly. Caffeine analogs: effects on ryanodine-sensitive calcium-release channels and GABAA receptors.
Cellular and molecular neurobiology.
2003 Jun; 23(3):331-47. doi:
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Planta medica.
2003 Apr; 69(4):332-6. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2003 Mar; 54(1):109-20. doi:
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Molecular pharmacology.
2003 Feb; 63(2):342-50. doi:
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American journal of physiology. Renal physiology.
2002 Dec; 283(6):F1216-25. doi:
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Biochemical pharmacology.
2002 Oct; 64(8):1201-6. doi:
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Journal of natural products.
2002 Oct; 65(10):1479-85. doi:
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