(2S)-3-hydroxypropane-1,2-diyl didecanoate (BioDeep_00001869261)

Main id: BioDeep_00000005128

 


代谢物信息卡片


(2S)-3-hydroxypropane-1,2-diyl didecanoate

化学式: C23H44O5 (400.3189)
中文名称: 1,2-二癸酰基-sn-甘油
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCC
InChI: InChI=1S/C23H44O5/c1-3-5-7-9-11-13-15-17-22(25)27-20-21(19-24)28-23(26)18-16-14-12-10-8-6-4-2/h21,24H,3-20H2,1-2H3/t21-/m0/s1

描述信息

同义名列表

2 个代谢物同义名

(2S)-3-hydroxypropane-1,2-diyl didecanoate; (2S)-3-Hydroxy-1,2-propanediyl didecanoate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 CAT, CYP1A1, EGFR, FPR1, MAPK14, MAPK3, NCF1, ODC1, PRKX, RAC1, RHOA, SPRR1B
Peripheral membrane protein 3 CYP1A1, CYP1B1, NCF1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 5 CYP1A1, CYP1B1, EGFR, RAC1, RHOA
Nucleus 7 EGFR, MAPK14, MAPK3, MPO, PRKX, RAC1, RHOA
cytosol 9 CAT, LIPE, MAPK14, MAPK3, NCF1, ODC1, RAC1, RHOA, SPRR1B
dendrite 2 NCF1, RAC1
trans-Golgi network 1 RAC1
nucleoplasm 5 MAPK14, MAPK3, MPO, NRG1, PRKX
Cell membrane 6 EGFR, FPR1, LIPE, NRG1, RAC1, RHOA
Lipid-anchor 2 RAC1, RHOA
Cytoplasmic side 3 NCF1, RAC1, RHOA
Cleavage furrow 1 RHOA
lamellipodium 2 RAC1, RHOA
ruffle membrane 3 EGFR, RAC1, RHOA
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 FPR1
Synapse 1 RAC1
cell cortex 2 RAC1, RHOA
cell junction 2 EGFR, RHOA
cell surface 1 EGFR
glutamatergic synapse 6 EGFR, MAPK14, MAPK3, NRG1, RAC1, RHOA
Golgi apparatus 1 MAPK3
Golgi membrane 1 EGFR
lysosomal membrane 1 EGF
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 NCF1
postsynapse 2 RAC1, RHOA
Cytoplasm, cytosol 2 LIPE, NCF1
Lysosome 1 MPO
endosome 2 EGFR, RHOA
plasma membrane 9 EGF, EGFR, F2, FPR1, MAPK3, NCF1, NRG1, RAC1, RHOA
Membrane 9 CAT, CYP1B1, EGF, EGFR, FPR1, LIPE, NCF1, NRG1, RAC1
apical plasma membrane 2 EGFR, NRG1
basolateral plasma membrane 1 EGFR
caveola 2 LIPE, MAPK3
extracellular exosome 6 CAT, EGF, F2, MPO, RAC1, RHOA
extracellular space 7 CSF3, EGF, EGFR, F2, MPO, NRG1, PNLIP
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 1 EGFR
mitochondrion 5 CAT, CYP1A1, CYP1B1, MAPK14, MAPK3
protein-containing complex 2 CAT, EGFR
intracellular membrane-bounded organelle 4 CAT, CYP1A1, CYP1B1, MPO
Microsome membrane 2 CYP1A1, CYP1B1
Single-pass type I membrane protein 2 EGFR, NRG1
Secreted 5 CSF3, F2, NRG1, PNLIP, RAC1
extracellular region 9 CAT, CSF3, EGF, F2, MAPK14, MPO, NRG1, PNLIP, RAC1
cytoplasmic side of plasma membrane 2 NCF1, RHOA
mitochondrial matrix 1 CAT
nuclear membrane 1 EGFR
dendritic spine 2 RAC1, RHOA
cytoplasmic vesicle 1 RAC1
midbody 1 RHOA
Early endosome 1 MAPK3
vesicle 1 RHOA
Cell projection, lamellipodium 2 RAC1, RHOA
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 EGFR
Cell junction, focal adhesion 1 MAPK3
focal adhesion 5 CAT, EGFR, MAPK3, RAC1, RHOA
Peroxisome 1 CAT
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 F2
secretory granule 1 MPO
nuclear speck 1 MAPK14
Late endosome 1 MAPK3
receptor complex 1 EGFR
cell periphery 1 RHOA
cytoskeleton 3 MAPK3, RAC1, RHOA
cytoplasmic ribonucleoprotein granule 1 RAC1
spindle pole 1 MAPK14
Cytoplasm, cell cortex 1 RHOA
blood microparticle 1 F2
nuclear envelope 1 MAPK3
Recycling endosome membrane 1 RAC1
Lipid droplet 1 LIPE
Membrane, caveola 2 LIPE, MAPK3
Cornified envelope 1 SPRR1B
Cell projection, dendrite 2 RAC1, RHOA
Melanosome 1 RAC1
pseudopodium 1 MAPK3
basal plasma membrane 1 EGFR
azurophil granule 1 MPO
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
secretory granule membrane 3 FPR1, RAC1, RHOA
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, MAPK3
platelet alpha granule lumen 1 EGF
azurophil granule membrane 1 FPR1
azurophil granule lumen 1 MPO
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
phagocytic vesicle lumen 1 MPO
ficolin-1-rich granule membrane 3 FPR1, RAC1, RHOA
apical junction complex 1 RHOA
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 CSF3
catalase complex 1 CAT
NADPH oxidase complex 2 NCF1, RAC1
phagolysosome 1 NCF1


文献列表

  • Adriano L Souza, Felippe J Pavinatto, Luciano Caseli, Diogo Volpati, Paulo B Miranda, Osvaldo N Oliveira. Chitosan does not inhibit enzymatic action of human pancreatic lipase in Langmuir monolayers of 1,2-didecanoyl-glycerol (DDG). Colloids and surfaces. B, Biointerfaces. 2014 Nov; 123(?):870-7. doi: 10.1016/j.colsurfb.2014.10.040. [PMID: 25466463]
  • Anaïs Bénarouche, Vanessa Point, Frédéric Carrière, Jean-François Cavalier. Using the reversible inhibition of gastric lipase by Orlistat for investigating simultaneously lipase adsorption and substrate hydrolysis at the lipid-water interface. Biochimie. 2014 Jun; 101(?):221-31. doi: 10.1016/j.biochi.2014.01.019. [PMID: 24508576]
  • Ikram Jemel, Ahmed Fendri, Youssef Gargouri, Sofiane Bezzine. Kinetic properties of dromedary pancreatic lipase: a comparative study on emulsified and monomolecular substrate. Colloids and surfaces. B, Biointerfaces. 2009 May; 70(2):238-42. doi: 10.1016/j.colsurfb.2008.12.035. [PMID: 19195852]
  • Angela Bourbon Freie, Francine Ferrato, Frédéric Carrière, Mark E Lowe. Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. The Journal of biological chemistry. 2006 Mar; 281(12):7793-800. doi: 10.1074/jbc.m512984200. [PMID: 16431912]
  • Pamela J Mansfield, Vania Hinkovska-Galcheva, Shannon S Carey, James A Shayman, Laurence A Boxer. Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. Blood. 2002 Feb; 99(4):1434-41. doi: 10.1182/blood.v99.4.1434. [PMID: 11830497]
  • E M Raeder, P J Mansfield, V Hinkovska-Galcheva, L Kjeldsen, J A Shayman, L A Boxer. Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation. Blood. 1999 Jan; 93(2):686-93. doi: . [PMID: 9885231]
  • M Aoubala, M Ivanova, I Douchet, A De Caro, R Verger. Interfacial binding of human gastric lipase to lipid monolayers, measured with an ELISA. Biochemistry. 1995 Aug; 34(34):10786-93. doi: 10.1021/bi00034a011. [PMID: 7545008]
  • K J Mills, S H Reynolds, R C Smart. Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes. Carcinogenesis. 1993 Dec; 14(12):2645-8. doi: 10.1093/carcin/14.12.2645. [PMID: 8269640]
  • S Ransac, Y Gargouri, H Moreau, R Verger. Inactivation of pancreatic and gastric lipases by tetrahydrolipstatin and alkyl-dithio-5-(2-nitrobenzoic acid). A kinetic study with 1,2-didecanoyl-sn-glycerol monolayers. European journal of biochemistry. 1991 Dec; 202(2):395-400. doi: 10.1111/j.1432-1033.1991.tb16387.x. [PMID: 1761041]
  • C Dahlgren, P Follin. Degranulation in human neutrophils primes the cells for subsequent responsiveness to the chemoattractant N-formylmethionylleucylphenylalanine but does not increase the sensitivity of the NADPH-oxidase to an intracellular calcium rise. Biochimica et biophysica acta. 1990 Apr; 1052(1):42-6. doi: 10.1016/0167-4889(90)90055-i. [PMID: 2157502]
  • R C Smart, K J Mills, L A Hansen, A H Conney. Synthetic lipid second messenger sn-1,2-didecanoylglycerol: a complete tumor promoter in mouse skin. Cancer research. 1989 Aug; 49(16):4455-8. doi: . [PMID: 2743335]
  • Y Gargouri, G Pieroni, F Ferrato, R Verger. Human gastric lipase. A kinetic study with dicaprin monolayers. European journal of biochemistry. 1987 Nov; 169(1):125-9. doi: 10.1111/j.1432-1033.1987.tb13588.x. [PMID: 3678230]
  • Y Gargouri, G Pieroni, C Rivière, A Sugihara, L Sarda, R Verger. Inhibition of lipases by proteins. A kinetic study with dicaprin monolayers. The Journal of biological chemistry. 1985 Feb; 260(4):2268-73. doi: . [PMID: 4038705]