PTERIDINE (BioDeep_00001869137)
Main id: BioDeep_00000006541
代谢物信息卡片
PTERIDINE
化学式: C6H4N4 (132.0435944)
中文名称: 喋啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=C2C(=N1)C=NC=N2
InChI: InChI=1S/C6H4N4/c1-2-9-6-5(8-1)3-7-4-10-6/h1-4H
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:27601
- KEGG: C07581
- PubChem: 1043
- MeSH: Pteridines
- CAS: 91-18-9
- PubChem: 9783
- NIKKAJI: J100.476J
- RefMet: Pteridine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Song Liu, Yu Hou, Ya-Jun Shi, Nan Zhang, Yi-Guang Hu, Wen-Ming Chen, Ji-Liang Zhang. Triphenyltin induced darker body coloration by disrupting melanocortin system and pteridine metabolic pathway in a reef fish, Amphiprion ocellaris.
Ecotoxicology and environmental safety.
2024 Apr; 274(?):116177. doi:
10.1016/j.ecoenv.2024.116177. [PMID: 38461573] - Ahmed H Hassan, Christian Ihling, Claudio Iacobucci, Panagiotis L Kastritis, Andrea Sinz, Tobias Kruse. The structural principles underlying molybdenum insertase complex assembly.
Protein science : a publication of the Protein Society.
2023 Aug; ?(?):e4753. doi:
10.1002/pro.4753. [PMID: 37572332] - Jan-Niklas Weber, Rieke Minner-Meinen, Maria Behnecke, Rebekka Biedendieck, Veit G Hänsch, Thomas W Hercher, Christian Hertweck, Lena van den Hout, Lars Knüppel, Simon Sivov, Jutta Schulze, Ralf-R Mendel, Robert Hänsch, David Kaufholdt. Moonlighting Arabidopsis molybdate transporter 2 family and GSH-complex formation facilitate molybdenum homeostasis.
Communications biology.
2023 08; 6(1):801. doi:
10.1038/s42003-023-05161-x. [PMID: 37532778] - Kevin D Oliphant, Robin R Fettig, Jennifer Snoozy, Ralf R Mendel, Kurt Warnhoff. Obtaining the necessary molybdenum cofactor for sulfite oxidase activity in the nematode Caenorhabditis elegans surprisingly involves a dietary source.
The Journal of biological chemistry.
2023 01; 299(1):102736. doi:
10.1016/j.jbc.2022.102736. [PMID: 36423681] - Gyeongmin Lee, Hyo Rin Kang, Aro Kim, Jong-Hyeon Park, Min Ja Lee, Su-Mi Kim. Antiviral effect of vesatolimod (GS-9620) against foot-and-mouth disease virus both in vitro and invivo.
Antiviral research.
2022 09; 205(?):105384. doi:
10.1016/j.antiviral.2022.105384. [PMID: 35863499] - Ichiro Wakabayashi, Mikio Marumo. Evidence for Indoxyl Sulfate as an Inducer of Oxidative Stress in Patients With Diabetes.
In vivo (Athens, Greece).
2022 Jul; 36(4):1790-1794. doi:
10.21873/invivo.12893. [PMID: 35738626] - Ronen Spiegel, Bernd C Schwahn, Liza Squires, Nils Confer. Molybdenum cofactor deficiency: A natural history.
Journal of inherited metabolic disease.
2022 05; 45(3):456-469. doi:
10.1002/jimd.12488. [PMID: 35192225] - Lindsey Rasmussen, Zachary Foulks, Jiandong Wu, Casey Burton, Honglan Shi. Establishing pteridine metabolism in a progressive isogenic breast cancer cell model - part II.
Metabolomics : Official journal of the Metabolomic Society.
2022 04; 18(5):27. doi:
10.1007/s11306-022-01885-9. [PMID: 35482254] - Lindsey Rasmussen, Zachary Foulks, Casey Burton, Honglan Shi. Establishing pteridine metabolism in a progressive isogenic breast cancer cell model.
Metabolomics : Official journal of the Metabolomic Society.
2021 12; 18(1):2. doi:
10.1007/s11306-021-01861-9. [PMID: 34919200] - Corinna Probst, Jing Yang, Joern Krausze, Thomas W Hercher, Casseday P Richers, Thomas Spatzal, Khadanand Kc, Logan J Giles, Douglas C Rees, Ralf R Mendel, Martin L Kirk, Tobias Kruse. Mechanism of molybdate insertion into pterin-based molybdenum cofactors.
Nature chemistry.
2021 08; 13(8):758-765. doi:
10.1038/s41557-021-00714-1. [PMID: 34183818] - Sharon A Riddler, Michael Para, Constance A Benson, Anthony Mills, Moti Ramgopal, Edwin DeJesus, Cynthia Brinson, Joshua Cyktor, Jana Jacobs, Dianna Koontz, John W Mellors, Gregory M Laird, Terri Wrin, Heena Patel, Susan Guo, Jeffrey Wallin, Jillian Boice, Liao Zhang, Rita Humeniuk, Rebecca Begley, Polina German, Hiba Graham, Romas Geleziunas, Diana M Brainard, Devi SenGupta. Vesatolimod, a Toll-like Receptor 7 Agonist, Induces Immune Activation in Virally Suppressed Adults Living With Human Immunodeficiency Virus-1.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 06; 72(11):e815-e824. doi:
10.1093/cid/ciaa1534. [PMID: 33043969] - Andrew S Terker, Ming-Zhi Zhang, Raymond C Harris. Staying Connected: Transcriptomics in the Search for Novel Diabetic Kidney Disease Treatments.
Diabetes.
2021 02; 70(2):326-327. doi:
10.2337/dbi20-0042. [PMID: 33472948] - Lu Zhang, Zichen Wang, Ruijie Liu, Zhengzhe Li, Jennifer Lin, Megan L Wojciechowicz, Jiyi Huang, Kyung Lee, Avi Ma'ayan, John Cijiang He. Connectivity Mapping Identifies BI-2536 as a Potential Drug to Treat Diabetic Kidney Disease.
Diabetes.
2021 02; 70(2):589-602. doi:
10.2337/db20-0580. [PMID: 33067313] - Jie Zhou, Qifan Yang, Lisen Lu, Zhan Tuo, Zhexing Shou, Jing Cheng. PLK1 Inhibition Induces Immunogenic Cell Death and Enhances Immunity against NSCLC.
International journal of medical sciences.
2021; 18(15):3516-3525. doi:
10.7150/ijms.60135. [PMID: 34522178] - Simon J Mayr, Ralf-R Mendel, Guenter Schwarz. Molybdenum cofactor biology, evolution and deficiency.
Biochimica et biophysica acta. Molecular cell research.
2021 01; 1868(1):118883. doi:
10.1016/j.bbamcr.2020.118883. [PMID: 33017596] - Thomas W Hercher, Joern Krausze, Jing Yang, Martin L Kirk, Tobias Kruse. Identification and characterisation of the Volvox carteri Moco carrier protein.
Bioscience reports.
2020 11; 40(11):. doi:
10.1042/bsr20202351. [PMID: 33084886] - Hui Chen, Su-Xiang Guo, Sai Zhang, Xiao-Dan Li, Hao Wang, Xiao-Wei Li. MiRNA-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway.
The Kaohsiung journal of medical sciences.
2020 Nov; 36(11):869-877. doi:
10.1002/kjm2.12260. [PMID: 32583575] - Joern Krausze, Thomas W Hercher, Archna Archna, Tobias Kruse. The structure of the Moco carrier protein from Rippkaea orientalis.
Acta crystallographica. Section F, Structural biology communications.
2020 Sep; 76(Pt 9):453-463. doi:
10.1107/s2053230x20011073. [PMID: 32880594] - Ichiro Wakabayashi, Mamoru Nakanishi, Makoto Ohki, Akira Suehiro, Kagehiro Uchida. A simple and useful method for evaluation of oxidative stress in vivo by spectrofluorometric estimation of urinary pteridines.
Scientific reports.
2020 07; 10(1):11223. doi:
10.1038/s41598-020-67681-4. [PMID: 32641855] - Yumi Nakai, Akiko Maruyama-Nakashita. Biosynthesis of Sulfur-Containing Small Biomolecules in Plants.
International journal of molecular sciences.
2020 May; 21(10):. doi:
10.3390/ijms21103470. [PMID: 32423011] - Wei Tan, Tian-Hua Liao, Jin Wang, Yu Ye, Yu-Chen Wei, Hao-Kui Zhou, Youli Xiao, Xiao-Yang Zhi, Zhi-Hui Shao, Liang-Dong Lyu, Guo-Ping Zhao. A recently evolved diflavin-containing monomeric nitrate reductase is responsible for highly efficient bacterial nitrate assimilation.
The Journal of biological chemistry.
2020 04; 295(15):5051-5066. doi:
10.1074/jbc.ra120.012859. [PMID: 32111737] - Eman H Yousef, Mohamed E El-Mesery, Maha R Habeeb, Laila A Eissa. Polo-like kinase 1 as a promising diagnostic biomarker and potential therapeutic target for hepatocellular carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2020 Apr; 42(4):1010428320914475. doi:
10.1177/1010428320914475. [PMID: 32252611] - Thomas W Hercher, Joern Krausze, Sven Hoffmeister, Dagmar Zwerschke, Thomas Lindel, Wulf Blankenfeldt, Ralf R Mendel, Tobias Kruse. Insights into the Cnx1E catalyzed MPT-AMP hydrolysis.
Bioscience reports.
2020 01; 40(1):. doi:
10.1042/bsr20191806. [PMID: 31860061] - Xiao Lv, Xiaoxiao Yang, Mei-Miao Zhan, Peichang Cao, Shihong Zheng, Ruijun Peng, Jihong Han, Zhouling Xie, Zhengchao Tu, Chenzhong Liao. Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold.
European journal of medicinal chemistry.
2019 Dec; 184(?):111769. doi:
10.1016/j.ejmech.2019.111769. [PMID: 31629162] - Alanna C Green, Darren Lath, Katie Hudson, Brant Walkley, Jennifer M Down, Robert Owen, Holly R Evans, Julia Paton-Hough, Gwendolen C Reilly, Michelle A Lawson, Andrew D Chantry. TGFβ Inhibition Stimulates Collagen Maturation to Enhance Bone Repair and Fracture Resistance in a Murine Myeloma Model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2019 12; 34(12):2311-2326. doi:
10.1002/jbmr.3859. [PMID: 31442332] - Elena Bekerman, Joseph Hesselgesser, Brian Carr, Mark Nagel, Magdeleine Hung, Adele Wang, Lance Stapleton, Agneta von Gegerfelt, Hanne Andersen Elyard, Jeffrey D Lifson, Romas Geleziunas. PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy.
Antimicrobial agents and chemotherapy.
2019 11; 63(11):. doi:
10.1128/aac.01163-19. [PMID: 31501143] - Arkadiusz Zupok, Michal Gorka, Beata Siemiatkowska, Aleksandra Skirycz, Silke Leimkühler. Iron-Dependent Regulation of Molybdenum Cofactor Biosynthesis Genes in Escherichia coli.
Journal of bacteriology.
2019 09; 201(17):. doi:
10.1128/jb.00382-19. [PMID: 31235512] - Gregory Q Del Prete, W Gregory Alvord, Yuan Li, Claire Deleage, Mukta Nag, Kelli Oswald, James A Thomas, Cathi Pyle, William J Bosche, Vicky Coalter, Adam Wiles, Rodney Wiles, Brian Berkemeier, Michael Hull, Elizabeth Chipriano, Lorna Silipino, Randy Fast, Jacob Kiser, Rebecca Kiser, Tyler Malys, Joshua Kramer, Matthew W Breed, Charles M Trubey, Jacob D Estes, Tiffany L Barnes, Joseph Hesselgesser, Romas Geleziunas, Jeffrey D Lifson. TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia.
JCI insight.
2019 06; 4(11):. doi:
10.1172/jci.insight.127717. [PMID: 31167974] - Karthik Dhananjayan, Felix Irrgang, Ritesh Raju, David G Harman, Chris Moran, Velandai Srikanth, Gerald Münch. Determination of glyoxal and methylglyoxal in serum by UHPLC coupled with fluorescence detection.
Analytical biochemistry.
2019 05; 573(?):51-66. doi:
10.1016/j.ab.2019.02.014. [PMID: 30796906] - Ralf R Mendel, Thomas W Hercher. Harvesting Moco.
Nature chemical biology.
2019 05; 15(5):429-430. doi:
10.1038/s41589-019-0257-y. [PMID: 30911176] - Xiaofei Xin, Feng Lin, Qiyue Wang, Lifang Yin, Ram I Mahato. ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer.
ACS applied materials & interfaces.
2019 Apr; 11(16):14647-14659. doi:
10.1021/acsami.9b02756. [PMID: 30933478] - Xin Liu, Jing Wang, Yang Yu, Lina Kong, Yimei Liu, Zhiqi Liu, Hongyu Li, Piwei Wei, Minglong Liu, Hai Zhou, Qingyun Bu, Jun Fang. Identification and characterization of the rice pre-harvest sprouting mutants involved in molybdenum cofactor biosynthesis.
The New phytologist.
2019 04; 222(1):275-285. doi:
10.1111/nph.15607. [PMID: 30471121] - Manuel Tejada-Jimenez, Alejandro Chamizo-Ampudia, Victoria Calatrava, Aurora Galvan, Emilio Fernandez, Angel Llamas. From the Eukaryotic Molybdenum Cofactor Biosynthesis to the Moonlighting Enzyme mARC.
Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
10.3390/molecules23123287. [PMID: 30545001] - Jessie Bong, Kerry M Loomes, Bin Lin, Jonathan M Stephens. New approach: Chemical and fluorescence profiling of NZ honeys.
Food chemistry.
2018 Nov; 267(?):355-367. doi:
10.1016/j.foodchem.2017.07.065. [PMID: 29934178] - Shunsuke Watanabe, Muneo Sato, Yuji Sawada, Maho Tanaka, Akihiro Matsui, Yuri Kanno, Masami Yokota Hirai, Motoaki Seki, Atsushi Sakamoto, Mitsunori Seo. Arabidopsis molybdenum cofactor sulfurase ABA3 contributes to anthocyanin accumulation and oxidative stress tolerance in ABA-dependent and independent ways.
Scientific reports.
2018 11; 8(1):16592. doi:
10.1038/s41598-018-34862-1. [PMID: 30413758] - K Agarwal, S H Ahn, M Elkhashab, A H Lau, A Gaggar, A Bulusu, X Tian, A L Cathcart, J Woo, G M Subramanian, P Andreone, H J Kim, W L Chuang, M H Nguyen. Safety and efficacy of vesatolimod (GS-9620) in patients with chronic hepatitis B who are not currently on antiviral treatment.
Journal of viral hepatitis.
2018 11; 25(11):1331-1340. doi:
10.1111/jvh.12942. [PMID: 29851204] - Xin Xiong, Yuanyuan Zhang, Wenjing Zhang. Simultaneous determination of twelve polar pteridines including dihydro- and tetrahydropteridine in human urine by hydrophilic interaction liquid chromatography with tandem mass spectrometry.
Biomedical chromatography : BMC.
2018 Aug; 32(8):e4244. doi:
10.1002/bmc.4244. [PMID: 29575016] - Joern Krausze, Thomas W Hercher, Dagmar Zwerschke, Martin L Kirk, Wulf Blankenfeldt, Ralf R Mendel, Tobias Kruse. The functional principle of eukaryotic molybdenum insertases.
The Biochemical journal.
2018 05; 475(10):1739-1753. doi:
10.1042/bcj20170935. [PMID: 29717023] - Carolina Boni, Andrea Vecchi, Marzia Rossi, Diletta Laccabue, Tiziana Giuberti, Arianna Alfieri, Pietro Lampertico, Glenda Grossi, Floriana Facchetti, Maurizia R Brunetto, Barbara Coco, Daniela Cavallone, Alessandra Mangia, Rosanna Santoro, Valeria Piazzolla, Audrey Lau, Anuj Gaggar, G Mani Subramanian, Carlo Ferrari. TLR7 Agonist Increases Responses of Hepatitis B Virus-Specific T Cells and Natural Killer Cells in Patients With Chronic Hepatitis B Treated With Nucleos(T)Ide Analogues.
Gastroenterology.
2018 05; 154(6):1764-1777.e7. doi:
10.1053/j.gastro.2018.01.030. [PMID: 29378197] - Qian Zhang, Binbin Zhao, Xin Chen, Nan Song, Jing Wu, Guangchao Li, Pin Yu, Yunlin Han, Jiangning Liu, Chuan Qin. GS-9620 inhibits enterovirus 71 replication mainly through the NF-κB and PI3K-AKT signaling pathways.
Antiviral research.
2018 05; 153(?):39-48. doi:
10.1016/j.antiviral.2018.02.002. [PMID: 29425831] - Li Li, Vivian Barry, Stephane Daffis, Congrong Niu, Erik Huntzicker, Dorothy M French, Igor Mikaelian, Robert E Lanford, William E Delaney, Simon P Fletcher. Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.
Journal of hepatology.
2018 05; 68(5):912-921. doi:
10.1016/j.jhep.2017.12.008. [PMID: 29247724] - Belén P Solans, Angèle Fleury, Matthias Freiwald, Holger Fritsch, Karin Haug, Iñaki F Trocóniz. Population Pharmacokinetics of Volasertib Administered in Patients with Acute Myeloid Leukaemia as a Single Agent or in Combination with Cytarabine.
Clinical pharmacokinetics.
2018 03; 57(3):379-392. doi:
10.1007/s40262-017-0566-9. [PMID: 28631179] - Harry L A Janssen, Maurizia R Brunetto, Yoon Jun Kim, Carlo Ferrari, Benedetta Massetto, Anh-Hoa Nguyen, Adarsh Joshi, Jacky Woo, Audrey H Lau, Anuj Gaggar, G Mani Subramanian, Eric M Yoshida, Sang Hoon Ahn, Naoky C S Tsai, Scott Fung, Edward J Gane. Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B.
Journal of hepatology.
2018 03; 68(3):431-440. doi:
10.1016/j.jhep.2017.10.027. [PMID: 29104121] - Simon Julius Mayr, Jörn Oliver Sass, Julia Vry, Janbernd Kirschner, Irina Mader, Jan-Bernd Hövener, Jochen Reiss, José Angel Santamaria-Araujo, Günter Schwarz, Sarah Catharina Grünert. A mild case of molybdenum cofactor deficiency defines an alternative route of MOCS1 protein maturation.
Journal of inherited metabolic disease.
2018 03; 41(2):187-196. doi:
10.1007/s10545-018-0138-7. [PMID: 29368224] - Inga Kruse, Andrew E Maclean, Lionel Hill, Janneke Balk. Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria.
The Biochemical journal.
2018 01; 475(2):495-509. doi:
10.1042/bcj20170559. [PMID: 29247140] - Mi-Yeon Jeon, Kyoung-Jin Min, Seon Min Woo, Seung Un Seo, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon. Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression.
International journal of molecular sciences.
2017 Nov; 18(12):. doi:
10.3390/ijms18122568. [PMID: 29186071] - Anne Klewe, Tobias Kruse, Thomas Lindel. Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A.
Chemistry (Weinheim an der Bergstrasse, Germany).
2017 Aug; 23(47):11230-11233. doi:
10.1002/chem.201702274. [PMID: 28688127] - Marie O Pohl, Jessica von Recum-Knepper, Ariel Rodriguez-Frandsen, Caroline Lanz, Emilio Yángüez, Stephen Soonthornvacharin, Thorsten Wolff, Sumit K Chanda, Silke Stertz. Identification of Polo-like kinases as potential novel drug targets for influenza A virus.
Scientific reports.
2017 08; 7(1):8629. doi:
10.1038/s41598-017-08942-7. [PMID: 28819179] - Angel Llamas, Alejandro Chamizo-Ampudia, Manuel Tejada-Jimenez, Aurora Galvan, Emilio Fernandez. The molybdenum cofactor enzyme mARC: Moonlighting or promiscuous enzyme?.
BioFactors (Oxford, England).
2017 Jul; 43(4):486-494. doi:
10.1002/biof.1362. [PMID: 28497908] - Jesús Fernández-Sainz, Pedro J Pacheco-Liñán, José M Granadino-Roldán, Iván Bravo, Andrés Garzón, Jaime Rubio-Martínez, José Albaladejo. Binding of the anticancer drug BI-2536 to human serum albumin. A spectroscopic and theoretical study.
Journal of photochemistry and photobiology. B, Biology.
2017 Jul; 172(?):77-87. doi:
10.1016/j.jphotobiol.2017.05.016. [PMID: 28531794] - Ewa Niedzialkowska, Beata Mrugała, Agnieszka Rugor, Mateusz P Czub, Anna Skotnicka, Julien J H Cotelesage, Graham N George, Maciej Szaleniec, Wladek Minor, Krzysztof Lewiński. Optimization of overexpression of a chaperone protein of steroid C25 dehydrogenase for biochemical and biophysical characterization.
Protein expression and purification.
2017 Jun; 134(?):47-62. doi:
10.1016/j.pep.2017.03.019. [PMID: 28343996] - Katherine D'Amico, Melanie J Filiatrault. The conserved hypothetical protein PSPTO_3957 is essential for virulence in the plant pathogen Pseudomonas syringae pv. tomato DC3000.
FEMS microbiology letters.
2017 04; 364(8):. doi:
10.1093/femsle/fnx004. [PMID: 28073812] - Gianpiero Vigani, Dario Di Silvestre, Anna Maria Agresta, Silvia Donnini, Pierluigi Mauri, Christian Gehl, Florian Bittner, Irene Murgia. Molybdenum and iron mutually impact their homeostasis in cucumber (Cucumis sativus) plants.
The New phytologist.
2017 Feb; 213(3):1222-1241. doi:
10.1111/nph.14214. [PMID: 27735062] - Joern Krausze, Corinna Probst, Ute Curth, Joachim Reichelt, Sayantan Saha, David Schafflick, Dirk W Heinz, Ralf R Mendel, Tobias Kruse. Dimerization of the plant molybdenum insertase Cnx1E is required for synthesis of the molybdenum cofactor.
The Biochemical journal.
2017 01; 474(1):163-178. doi:
10.1042/bcj20160846. [PMID: 27803248] - Ayse Basak Engin, Atilla Engin. The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity.
Advances in experimental medicine and biology.
2017; 960(?):511-527. doi:
10.1007/978-3-319-48382-5_22. [PMID: 28585214] - Carla Duncan, Frances B Jamieson, JoLynn Troudt, Linda Izzo, Helle Bielefeldt-Ohmann, Angelo Izzo, Carolina Mehaffy. Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion.
PloS one.
2017; 12(6):e0179996. doi:
10.1371/journal.pone.0179996. [PMID: 28650996] - David Kaufholdt, Christin-Kirsty Baillie, Martin H Meyer, Oliver D Schwich, Ulrike L Timmerer, Lydia Tobias, Daniela van Thiel, Robert Hänsch, Ralf R Mendel. Identification of a protein-protein interaction network downstream of molybdenum cofactor biosynthesis in Arabidopsis thaliana.
Journal of plant physiology.
2016 Dec; 207(?):42-50. doi:
10.1016/j.jplph.2016.10.002. [PMID: 27792900] - Iain C Clark, Matt Youngblut, Gillian Jacobsen, Kelly M Wetmore, Adam Deutschbauer, Lauren Lucas, John D Coates. Genetic dissection of chlorate respiration in Pseudomonas stutzeri PDA reveals syntrophic (per)chlorate reduction.
Environmental microbiology.
2016 10; 18(10):3342-3354. doi:
10.1111/1462-2920.13068. [PMID: 26411776] - Megan M Kaneda, Paola Cappello, Abraham V Nguyen, Natacha Ralainirina, Chanae R Hardamon, Philippe Foubert, Michael C Schmid, Ping Sun, Evangeline Mose, Michael Bouvet, Andrew M Lowy, Mark A Valasek, Roman Sasik, Francesco Novelli, Emilio Hirsch, Judith A Varner. Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.
Cancer discovery.
2016 08; 6(8):870-85. doi:
10.1158/2159-8290.cd-15-1346. [PMID: 27179037] - Casey Burton, Honglan Shi, Yinfa Ma. Development of a high-performance liquid chromatography - Tandem mass spectrometry urinary pterinomics workflow.
Analytica chimica acta.
2016 Jul; 927(?):72-81. doi:
10.1016/j.aca.2016.05.005. [PMID: 27237839] - Joanna Jakubiczka-Smorag, Jose Angel Santamaria-Araujo, Imke Metz, Avadh Kumar, Samy Hakroush, Wolfgang Brueck, Guenter Schwarz, Peter Burfeind, Jochen Reiss, Lukasz Smorag. Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.
Human genetics.
2016 07; 135(7):813-26. doi:
10.1007/s00439-016-1676-4. [PMID: 27138983] - Benjamin J Daniels, Gordana Prijic, Sarah Meidinger, Kerry M Loomes, Jonathan M Stephens, Ralf C Schlothauer, Daniel P Furkert, Margaret A Brimble. Isolation, Structural Elucidation, and Synthesis of Lepteridine From Ma̅nuka (Leptospermum scoparium) Honey.
Journal of agricultural and food chemistry.
2016 Jun; 64(24):5079-84. doi:
10.1021/acs.jafc.6b01596. [PMID: 27210444] - Xin Xiong, Yanmeng Liu. Chromatographic behavior of 12 polar pteridines in hydrophilic interaction chromatography using five different HILIC columns coupled with tandem mass spectrometry.
Talanta.
2016 Apr; 150(?):493-502. doi:
10.1016/j.talanta.2015.12.066. [PMID: 26838435] - David Kaufholdt, Christin-Kirsty Baillie, Rolf Bikker, Valentin Burkart, Christian-Alexander Dudek, Linn von Pein, Martin Rothkegel, Ralf R Mendel, Robert Hänsch. The molybdenum cofactor biosynthesis complex interacts with actin filaments via molybdenum insertase Cnx1 as anchor protein in Arabidopsis thaliana.
Plant science : an international journal of experimental plant biology.
2016 Mar; 244(?):8-18. doi:
10.1016/j.plantsci.2015.12.011. [PMID: 26810449] - Jeroen Van Daele, Dieter Blancquaert, Filip Kiekens, Dominique Van Der Straeten, Willy E Lambert, Christophe P Stove. Degradation and interconversion of plant pteridines during sample preparation and ultra-high performance liquid chromatography-tandem mass spectrometry.
Food chemistry.
2016 Mar; 194(?):1189-98. doi:
10.1016/j.foodchem.2015.08.098. [PMID: 26471671] - Boonyanoot Chaiyosang, Kwanjai Kanokmedhakul, Jaursup Boonmak, Sujittra Youngme, Veerapol Kukongviriyapan, Kasem Soytong, Somdej Kanokmedhakul. A new lumazine peptide penilumamide E from the fungus Aspergillus terreus.
Natural product research.
2016; 30(9):1017-24. doi:
10.1080/14786419.2015.1101107. [PMID: 26518160] - M Zvarik, D Martinicky, L Hunakova, L Sikurova. Differences in pteridine urinary levels in patients with malignant and benign ovarian tumors in comparison with healthy individuals.
Journal of photochemistry and photobiology. B, Biology.
2015 Dec; 153(?):191-7. doi:
10.1016/j.jphotobiol.2015.09.019. [PMID: 26414289] - Edward J Gane, Young-Suk Lim, Stuart C Gordon, Kumar Visvanathan, Eric Sicard, Richard N Fedorak, Stuart Roberts, Benedetta Massetto, Zhishen Ye, Stefan Pflanz, Kimberly L Garrison, Anuj Gaggar, G Mani Subramanian, John G McHutchison, Shyamasundaran Kottilil, Bradley Freilich, Carla S Coffin, Wendy Cheng, Yoon Jun Kim. The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection.
Journal of hepatology.
2015 Aug; 63(2):320-8. doi:
10.1016/j.jhep.2015.02.037. [PMID: 25733157] - Hao Qiang Yu, Yuan Yuan Zhang, Tai Ming Yong, Yan Ping Liu, Shu Feng Zhou, Feng Ling Fu, Wan Chen Li. Cloning and functional validation of molybdenum cofactor sulfurase gene from Ammopiptanthus nanus.
Plant cell reports.
2015 Jul; 34(7):1165-76. doi:
10.1007/s00299-015-1775-z. [PMID: 25721201] - Stephan Menne, Daniel B Tumas, Katherine H Liu, Linta Thampi, Dalal AlDeghaither, Betty H Baldwin, Christine A Bellezza, Paul J Cote, Jim Zheng, Randall Halcomb, Abigail Fosdick, Simon P Fletcher, Stephane Daffis, Li Li, Peng Yue, Grushenka H I Wolfgang, Bud C Tennant. Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B.
Journal of hepatology.
2015 Jun; 62(6):1237-45. doi:
10.1016/j.jhep.2014.12.026. [PMID: 25559326] - Ralf R Mendel, Silke Leimkühler. The biosynthesis of the molybdenum cofactors.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2015 Mar; 20(2):337-47. doi:
10.1007/s00775-014-1173-y. [PMID: 24980677] - Gilbert Reibnegger, Dietmar Fuchs. A comment to 'normalization of urinary pteridines by urine specific gravity for early cancer detection' [Clin. Chim. Acta 435 (2014) 42-47].
Clinica chimica acta; international journal of clinical chemistry.
2015 Jan; 438(?):418-9. doi:
10.1016/j.cca.2014.08.032. [PMID: 25195006] - Eric Lawitz, Daniel Gruener, Thomas Marbury, John Hill, Lynn Webster, David Hassman, Anh-Hoa Nguyen, Stefan Pflanz, Erik Mogalian, Anuj Gaggar, Benedetta Massetto, G Mani Subramanian, John G McHutchison, Ira M Jacobson, Bradley Freilich, Maribel Rodriguez-Torres. Safety, pharmacokinetics and pharmacodynamics of the oral toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C.
Antiviral therapy.
2015; 20(7):699-708. doi:
10.3851/imp2845. [PMID: 25105516] - Yinfa Ma, Casey Burton, Honglan Shi. A rebuttal to 'A comment to 'Normalization of urinary pteridines by urine specific gravity for early cancer detection' [Clin. Chim. Acta 435 (2014) 42-47]'.
Clinica chimica acta; international journal of clinical chemistry.
2015 Jan; 438(?):415-7. doi:
10.1016/j.cca.2014.08.044. [PMID: 25245674] - Eleni Pontiki, Dimitra Hadjipavlou-Litina, Alexandros Patsilinakos, Trang M Tran, Charles M Marson. Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties.
Future medicinal chemistry.
2015; 7(14):1937-51. doi:
10.4155/fmc.15.104. [PMID: 26423719] - Zheng Zhou, Hongli He, Luping Ma, Xiaoqian Yu, Qian Mi, Jingsong Pang, Guixiang Tang, Bao Liu. Overexpression of a GmCnx1 gene enhanced activity of nitrate reductase and aldehyde oxidase, and boosted mosaic virus resistance in soybean.
PloS one.
2015; 10(4):e0124273. doi:
10.1371/journal.pone.0124273. [PMID: 25886067] - E Martín Tornero, I Durán Merás, A Espinosa-Mansilla. HPLC determination of serum pteridine pattern as biomarkers.
Talanta.
2014 Oct; 128(?):319-26. doi:
10.1016/j.talanta.2014.04.052. [PMID: 25059167] - Audrey Lamora, Julie Talbot, Gwenola Bougras, Jérôme Amiaud, Marion Leduc, Julie Chesneau, Julien Taurelle, Verena Stresing, Marie Cécile Le Deley, Marie Françoise Heymann, Dominique Heymann, Françoise Redini, Franck Verrecchia. Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 Oct; 20(19):5097-112. doi:
10.1158/1078-0432.ccr-13-3191. [PMID: 25107916] - Casey Burton, Honglan Shi, Yinfa Ma. Normalization of urinary pteridines by urine specific gravity for early cancer detection.
Clinica chimica acta; international journal of clinical chemistry.
2014 Aug; 435(?):42-7. doi:
10.1016/j.cca.2014.04.022. [PMID: 24792383] - Ramu Rajasekaran, Prakasarao Aruna, Dornadula Koteeswaran, Munusamy Baludavid, Singaravelu Ganesan. Synchronous luminescence spectroscopic characterization of urine of normal subjects and cancer patients.
Journal of fluorescence.
2014 Jul; 24(4):1199-205. doi:
10.1007/s10895-014-1401-4. [PMID: 24832355] - H Tomšíková, P Solich, L Nováková. Sample preparation and UHPLC-FD analysis of pteridines in human urine.
Journal of pharmaceutical and biomedical analysis.
2014 Jul; 95(?):265-72. doi:
10.1016/j.jpba.2014.03.012. [PMID: 24704455] - Corinna Probst, Phillip Ringel, Verena Boysen, Lisette Wirsing, Mariko Matsuda Alexander, Ralf R Mendel, Tobias Kruse. Genetic characterization of the Neurospora crassa molybdenum cofactor biosynthesis.
Fungal genetics and biology : FG & B.
2014 May; 66(?):69-78. doi:
10.1016/j.fgb.2014.02.004. [PMID: 24569084] - Gudrun Ott, Debora Reichmann, Cornelia Boerger, Ingolf Cascorbi, Florian Bittner, Ralf-Rainer Mendel, Thomas Kunze, Bernd Clement, Antje Havemeyer. Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Apr; 42(4):718-25. doi:
10.1124/dmd.113.055202. [PMID: 24423752] - Abigail Fosdick, Jim Zheng, Stefan Pflanz, Christian R Frey, Joseph Hesselgesser, Randall L Halcomb, Grushenka Wolfgang, Daniel B Tumas. Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses.
The Journal of pharmacology and experimental therapeutics.
2014 Jan; 348(1):96-105. doi:
10.1124/jpet.113.207878. [PMID: 24133297] - Casey Burton, Honglan Shi, Yinfa Ma. Simultaneous detection of six urinary pteridines and creatinine by high-performance liquid chromatography-tandem mass spectrometry for clinical breast cancer detection.
Analytical chemistry.
2013 Nov; 85(22):11137-45. doi:
10.1021/ac403124a. [PMID: 24138137] - Yuanyuan Liu, Li Xiong, Ying Chang, Jianying Tang, Wei Ang, Tao Yang, Weiyi Pi, Xiaoyan Yang, Weiwei Ye, Youfu Luo, Zhenling Wang. Phosphoinositide 3-kinase δ/γ inhibition does not prevent concanavalin A-induced hepatitis.
Molecular medicine reports.
2013 Nov; 8(5):1305-10. doi:
10.3892/mmr.2013.1649. [PMID: 23969545] - Yinfa Ma, Casey Burton. Pteridine detection in urine: the future of cancer diagnostics?.
Biomarkers in medicine.
2013 Oct; 7(5):679-81. doi:
10.2217/bmm.13.88. [PMID: 24044558] - L Fan, P Li, Z Yin, G Fu, D J Liao, Y Liu, J Zhu, Y Zhang, L Wang, Q Yan, Y Guo, C Shao, G Huang, Z Wang. Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma.
British journal of cancer.
2013 Sep; 109(5):1137-46. doi:
10.1038/bjc.2013.463. [PMID: 23942078] - H Tomšíková, P Tomšík, P Solich, L Nováková. Determination of pteridines in biological samples with an emphasis on their stability.
Bioanalysis.
2013 Sep; 5(18):2307-26. doi:
10.4155/bio.13.194. [PMID: 24053245] - Yajun Li, Jiachang Zhang, Juan Zhang, Ling Hao, Jinping Hua, Liusheng Duan, Mingcai Zhang, Zhaohu Li. Expression of an Arabidopsis molybdenum cofactor sulphurase gene in soybean enhances drought tolerance and increases yield under field conditions.
Plant biotechnology journal.
2013 Aug; 11(6):747-58. doi:
10.1111/pbi.12066. [PMID: 23581509] - Robert E Lanford, Bernadette Guerra, Deborah Chavez, Luis Giavedoni, Vida L Hodara, Kathleen M Brasky, Abigail Fosdick, Christian R Frey, Jim Zheng, Grushenka Wolfgang, Randall L Halcomb, Daniel B Tumas. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.
Gastroenterology.
2013 Jun; 144(7):1508-17, 1517.e1. doi:
10.1053/j.gastro.2013.02.003. [PMID: 23415804] - Phillip Ringel, Joern Krausze, Joop van den Heuvel, Ute Curth, Antonio J Pierik, Stephanie Herzog, Ralf R Mendel, Tobias Kruse. Biochemical characterization of molybdenum cofactor-free nitrate reductase from Neurospora crassa.
The Journal of biological chemistry.
2013 May; 288(20):14657-14671. doi:
10.1074/jbc.m113.457960. [PMID: 23539622] - Ralf R Mendel. The molybdenum cofactor.
The Journal of biological chemistry.
2013 May; 288(19):13165-72. doi:
10.1074/jbc.r113.455311. [PMID: 23539623] - N Shaemningwar Moyon, Mullah Muhaiminul Islam, Smritakshi Phukan, Sivaprasad Mitra. Fluorescence modulation and associative behavior of lumazine in hydrophobic domain of micelles and bovine serum albumin.
Journal of photochemistry and photobiology. B, Biology.
2013 Apr; 121(?):37-45. doi:
10.1016/j.jphotobiol.2013.02.008. [PMID: 23501728] - M Zvarik, D Martinicky, L Hunakova, I Lajdova, L Sikurova. Fluorescence characteristics of human urine from normal individuals and ovarian cancer patients.
Neoplasma.
2013; 60(5):533-7. doi:
10.4149/neo_2013_069. [PMID: 23790172] - Uri Lopatin, Grushenka Wolfgang, Daniel Tumas, Christian R Frey, Carol Ohmstede, Joseph Hesselgesser, Brian Kearney, Lisa Moorehead, G Mani Subramanian, John G McHutchison. Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist.
Antiviral therapy.
2013; 18(3):409-18. doi:
10.3851/imp2548. [PMID: 23416308] - Yuji Shimura, Junya Kuroda, Masaki Ri, Hisao Nagoshi, Mio Yamamoto-Sugitani, Tsutomu Kobayashi, Miki Kiyota, Ryuko Nakayama, Shinsuke Mizutani, Yoshiaki Chinen, Natsumi Sakamoto, Yosuke Matsumoto, Shigeo Horiike, Yukimasa Shiotsu, Shinsuke Iida, Masafumi Taniwaki. RSK2(Ser227) at N-terminal kinase domain is a potential therapeutic target for multiple myeloma.
Molecular cancer therapeutics.
2012 Dec; 11(12):2600-9. doi:
10.1158/1535-7163.mct-12-0605. [PMID: 23012246] - A Jiménez Girón, E Martín-Tornero, M C Hurtado Sánchez, I Durán Merás, A Espinosa Mansilla. A simple HPLC-ESI-MS method for the direct determination of ten pteridinic biomarkers in human urine.
Talanta.
2012 Nov; 101(?):465-72. doi:
10.1016/j.talanta.2012.09.061. [PMID: 23158350] - Philippa B Mills, Emma J Footitt, Serkan Ceyhan, Paula J Waters, Cornelis Jakobs, Peter T Clayton, Eduard A Struys. Urinary AASA excretion is elevated in patients with molybdenum cofactor deficiency and isolated sulphite oxidase deficiency.
Journal of inherited metabolic disease.
2012 Nov; 35(6):1031-6. doi:
10.1007/s10545-012-9466-1. [PMID: 22403017]