Bradykinin (BioDeep_00001868546)
Main id: BioDeep_00000004411
代谢物信息卡片
Bradykinin
化学式: C50H73N15O11 (1059.5613707999998)
中文名称: 缓激肽
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(=O)O
InChI: InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
描述信息
A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
COVID info from WikiPathways
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain[1][2][3][4][5].
同义名列表
1 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:3165
- KEGG: C00306
- PubChem: 439201
- DrugBank: DB12126
- ChEMBL: CHEMBL406291
- MeSH: Bradykinin
- CAS: 58-82-2
- MetaboLights: MTBLC3165
- PubChem: 3600
- 3DMET: B01212
- NIKKAJI: J10.684D
- RefMet: Bradykinin
- medchemexpress: HY-P0206
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 69489 Pelophylax bedriagae: 10.1016/0304-4165(90)90140-R
- 45623 Pelophylax lessonae: 10.1016/0304-4165(90)90140-R
- 8407 Rana temporaria: 10.1016/S0196-9781(96)00339-7
- 69489 Pelophylax bedriagae: 10.1016/0304-4165(90)90140-R
- 45623 Pelophylax lessonae: 10.1016/0304-4165(90)90140-R
- 8407 Rana temporaria: 10.1016/S0196-9781(96)00339-7
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ibeth Guevara-Lora, Maria Sordyl, Anna Niewiarowska-Sendo, Grazyna Bras, Edyta Korbut, Joanna Goralska, Malgorzata Malczewska-Malec, Bogdan Solnica, Andrzej Kozik. The effect of bradykinin on the pro-inflammatory response of human adipocytes.
Acta biochimica Polonica.
2022 Jul; 69(3):495-505. doi:
10.18388/abp.2020_6389. [PMID: 35810482] - Igor Maciel Souza-Silva, Cristiane Amorim de Paula, Lucas Bolais-Ramos, Anderson Kenedy Santos, Filipe Alex da Silva, Vívian Louise Soares de Oliveira, Isabella Domingos da Rocha, Maísa Mota Antunes, Lídia Pereira Barbosa Cordeiro, Vanessa Pereira Teixeira, Sérgio Ricardo Aluotto Scalzo Júnior, Adriana Campezatto Raabe, Pedro Pires Goulart Guimaraes, Flávio Almeida Amaral, Jarbas Magalhães Resende, Marco Antônio Peliky Fontes, Gustavo Batista Menezes, Silvia Guatimosim, Robson Augusto Souza Santos, Thiago Verano-Braga. Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptors.
British journal of pharmacology.
2022 06; 179(12):3061-3077. doi:
10.1111/bph.15790. [PMID: 34978069] - Pei-Suen Tsou, Chenyang Lu, Mikel Gurrea-Rubio, Sei Muraoka, Phillip L Campbell, Qi Wu, Ellen N Model, Matthew E Lind, Sirapa Vichaikul, Megan N Mattichak, William D Brodie, Jonatan L Hervoso, Sarah Ory, Camila I Amarista, Rida Pervez, Lucas Junginger, Mustafa Ali, Gal Hodish, Morgan M O'Mara, Jeffrey H Ruth, Aaron M Robida, Andrew J Alt, Chengxin Zhang, Andrew G Urquhart, Jeffrey N Lawton, Kevin C Chung, Tristan Maerz, Thomas L Saunders, Vincent E Groppi, David A Fox, M Asif Amin. Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1.
The Journal of clinical investigation.
2022 06; 132(11):. doi:
10.1172/jci151827. [PMID: 35439173] - S Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem M Mohammed, Dennis R Phillips, James C Whisstock, Adam J Quek, Edward P Feener, Ruby H P Law, David Gailani. A mechanism for hereditary angioedema caused by a lysine 311-to-glutamic acid substitution in plasminogen.
Blood.
2022 05; 139(18):2816-2829. doi:
10.1182/blood.2021012945. [PMID: 35100351] - Pierre Malchair, Aurema Otero, Jordi Giol, Xavier Solanich, Thiago Carnaval, Alonso Fernández-Nistal, Ana Sánchez-Gabriel, Carmen Montoto, Ramon Lleonart, Sebastián Videla. A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID).
Trials.
2022 Apr; 23(1):303. doi:
10.1186/s13063-022-06219-7. [PMID: 35413921] - Jordi Giol, Javier Jacob, Ferrán Llopis, Ramón Lleonart, Fernando Ruiz Esteve, Pierre Malchair. Exceptional treatment of COVID-19 pneumonia with icatibant.
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.
2022 04; 34(2):159-160. doi:
NULL. [PMID: 35275476] - Amanda Mathis, Mark Sale, Melanie Cornpropst, William P Sheridan, Shu Chin Ma. Population pharmacokinetic modeling and simulations of berotralstat for prophylactic treatment of attacks of hereditary angioedema.
Clinical and translational science.
2022 04; 15(4):1027-1035. doi:
10.1111/cts.13233. [PMID: 35212456] - Angela Strain. Angioedema of the tongue due to haloperidol.
The American journal of emergency medicine.
2022 Mar; 53(?):284.e5-284.e6. doi:
10.1016/j.ajem.2021.09.039. [PMID: 34620528] - Simone König, Christian Engl, Malte Bayer, Fabiola Escolano-Lozano, Heike Rittner, Cora Rebhorn, Frank Birklein. Substance P Serum Degradation in Complex Regional Pain Syndrome - Another Piece of the Puzzle?.
The journal of pain.
2022 03; 23(3):501-507. doi:
10.1016/j.jpain.2021.10.005. [PMID: 34678467] - Manuele Figueiredo da Silva, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Luana Heimfarth, Paulo Ricardo Martins-Filho, Jullyana de Souza Siqueira Quintans, Lucindo José Quintans-Júnior. Bradykinin-target therapies in SARS-CoV-2 infection: current evidence and perspectives.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 03; 395(3):275-283. doi:
10.1007/s00210-022-02206-6. [PMID: 35089406] - Paula Busse, Allen Kaplan. Specific Targeting of Plasma Kallikrein for Treatment of Hereditary Angioedema: A Revolutionary Decade.
The journal of allergy and clinical immunology. In practice.
2022 03; 10(3):716-722. doi:
10.1016/j.jaip.2021.11.011. [PMID: 34838707] - Marina Fandaros, Kusumam Joseph, Allen P Kaplan, David A Rubenstein, Berhane Ghebrehiwet, Wei Yin. gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema.
Inflammation.
2022 Feb; 45(1):116-128. doi:
10.1007/s10753-021-01532-w. [PMID: 34494203] - Olav Rogde Gramstad, Sai Priya Sarma Kandanur, Michael Etscheid, Erik Waage Nielsen, Sandip Mahadev Kanse. Factor VII activating protease (FSAP) is not essential in the pathophysiology of angioedema in patients with C1 inhibitor deficiency.
Molecular immunology.
2022 02; 142(?):95-104. doi:
10.1016/j.molimm.2021.11.019. [PMID: 34973499] - Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Zih-Yao Yu, Chuen-Mao Yang. Anti-Inflammatory Effects of Rhamnetin on Bradykinin-Induced Matrix Metalloproteinase-9 Expression and Cell Migration in Rat Brain Astrocytes.
International journal of molecular sciences.
2022 Jan; 23(2):. doi:
10.3390/ijms23020609. [PMID: 35054789] - Sara AlMarabeh, Eric F Lucking, Ken D O'Halloran, Mohammed H Abdulla. Intrarenal pelvic bradykinin-induced sympathoexcitatory reno-renal reflex is attenuated in rats exposed to chronic intermittent hypoxia.
Journal of hypertension.
2022 01; 40(1):46-64. doi:
10.1097/hjh.0000000000002972. [PMID: 34433765] - Na Zhang, Yanan Huo, Chen Yao, Jie Sun, Yafeng Zhang. The Effect of the Angiotensin-Converting Enzyme Inhibitor on Bone Health in Castrated Hypertensive Rats Is Mediated via the Kinin-Kallikrein System.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2022; 2022(?):9067167. doi:
10.1155/2022/9067167. [PMID: 35814865] - Frank L van de Veerdonk, Evangelos Giamarellos-Bourboulis, Peter Pickkers, Lennie Derde, Helen Leavis, Reinout van Crevel, Job J Engel, W Joost Wiersinga, Alexander P J Vlaar, Manu Shankar-Hari, Tom van der Poll, Marc Bonten, Derek C Angus, Jos W M van der Meer, Mihai G Netea. A guide to immunotherapy for COVID-19.
Nature medicine.
2022 01; 28(1):39-50. doi:
10.1038/s41591-021-01643-9. [PMID: 35064248] - Aisha Tabassum, Mohammad Shahid Iqbal, Sadia Sultan, Raghad Ali Alhuthali, Deena Ismail Alshubaili, Raghad Salah Sayyam, Lama Mohammed Abyad, Ahmed H Qasem, Ahmad F Arbaeen. Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID-19.
Mediators of inflammation.
2022; 2022(?):7423537. doi:
10.1155/2022/7423537. [PMID: 35153624] - Amanda A de Oliveira, Ander Vergara, Xiaopu Wang, John C Vederas, Gavin Y Oudit. Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists.
Peptides.
2022 01; 147(?):170697. doi:
10.1016/j.peptides.2021.170697. [PMID: 34801627] - Deepraj Paul, Suresh K Mohankumar, Rhian S Thomas, Chai B Kheng, Duraiswamy Basavan. Potential Implications of Angiotensin-converting Enzyme 2 Blockades on Neuroinflammation in SARS-CoV-2 Infection.
Current drug targets.
2022; 23(4):364-372. doi:
10.2174/1389450122666211103165837. [PMID: 34732115] - Nhung Pham, Finterly Hu, Chris T Evelo, Martina Kutmon. Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients.
Frontiers in immunology.
2022; 13(?):963357. doi:
10.3389/fimmu.2022.963357. [PMID: 36189295] - Sonja Oehmcke-Hecht, Peggy Berlin, Brigitte Müller-Hilke, Bernd Kreikemeyer, Praveen Vasudevan, Larissa Henze, Valeria Khaimov, Brigitte Vollmar, Robert David, Claudia Maletzki. The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jan; 145(?):112429. doi:
10.1016/j.biopha.2021.112429. [PMID: 34801854] - Enrique Alfaro, Elena Díaz-García, Sara García-Tovar, Ester Zamarrón, Alberto Mangas, Raúl Galera, Kapil Nanwani-Nanwani, Rebeca Pérez-de-Diego, Eduardo López-Collazo, Francisco García-Río, Carolina Cubillos-Zapata. Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity.
Frontiers in immunology.
2022; 13(?):909342. doi:
10.3389/fimmu.2022.909342. [PMID: 35812405] - Soumya Panigrahi, Tamal Goswami, Brian Ferrari, Christopher J Antonelli, Douglas A Bazdar, Hannah Gilmore, Michael L Freeman, Michael M Lederman, Scott F Sieg. SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis.
Microbiology spectrum.
2021 12; 9(3):e0073521. doi:
10.1128/spectrum.00735-21. [PMID: 34935423] - Xuan-Ming Guo, Maruti Balaso Yadav, Mahjabin Khan, Chao-Wei Hao, Cheng-Yuan Lin, Tao Huang, Jiang Wu, Bao-Min Fan, Zhao-Xiang Bian. Bradykinin-Potentiating Peptide-Paclitaxel Conjugate Directed at Ectopically Expressed Angiotensin-Converting Enzyme in Triple-Negative Breast Cancer.
Journal of medicinal chemistry.
2021 12; 64(23):17051-17062. doi:
10.1021/acs.jmedchem.1c00705. [PMID: 34699215] - Mayara Alves Amorim, Janiana Raíza Jentsch Matias de Oliveira, Vitor Hélio Souza Oliveira, Daniela Almeida Cabrini, Michel Fleith Otuki, Eunice André. Role of nitric oxide, bradykinin B2 receptor, and TRPV1 in the airway alterations caused by simvastatin in rats.
European journal of pharmacology.
2021 Dec; 912(?):174591. doi:
10.1016/j.ejphar.2021.174591. [PMID: 34710369] - Sarah A S Alves, Lucas S Florentino, Douglas E Teixeira, Rodrigo P Silva-Aguiar, Diogo B Peruchetti, Ana Carolina Oliveira, Julio Scharfstein, María-Paz Marzolo, Ana Acacia S Pinheiro, Celso Caruso-Neves. Surface megalin expression is a target to the inhibitory effect of bradykinin on the renal albumin endocytosis.
Peptides.
2021 12; 146(?):170646. doi:
10.1016/j.peptides.2021.170646. [PMID: 34500007] - Victor Leyva-Grado, Pavel Pugach, Nazlie Sadeghi-Latefi. A novel anti-inflammatory treatment for bradykinin-induced sore throat or pharyngitis.
Immunity, inflammation and disease.
2021 12; 9(4):1321-1335. doi:
10.1002/iid3.479. [PMID: 34153179] - Camila Lopes Veronez, Sandra C Christiansen, Tukisa D Smith, Marc A Riedl, Bruce L Zuraw. COVID-19 and hereditary angioedema: Incidence, outcomes, and mechanistic implications.
Allergy and asthma proceedings.
2021 Nov; 42(6):506-514. doi:
10.2500/aap.2021.42.210083. [PMID: 34871158] - Simone König, Nico Steinebrey, Myriam Herrnberger, Fabiola Escolano-Lozano, Tanja Schlereth, Cora Rebhorn, Frank Birklein. Reduced serum protease activity in Complex Regional Pain Syndrome: The impact of angiotensin-converting enzyme and carboxypeptidases.
Journal of pharmaceutical and biomedical analysis.
2021 Oct; 205(?):114307. doi:
10.1016/j.jpba.2021.114307. [PMID: 34392129] - D Pecori, P Della Siega, E Sozio, E Barbano, L Mazzoran, A Zanichelli, F Sbrana, I Federico, F Bassi, M Fabris, I Vendramin, R Sbrojavacca, C Tascini. Icatibant in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Case Report.
Journal of investigational allergology & clinical immunology.
2021 Oct; 31(5):451-452. doi:
10.18176/jiaci.0659. [PMID: 33275101] - A Cesoni Marcelli, S Loffredo, A Petraroli, L Carucci, I Mormile, A L Ferrara, G Spadaro, A Genovese, M Bova. Nailfold Videocapillaroscopy Findings in Bradykinin-Mediated Angioedema.
Journal of investigational allergology & clinical immunology.
2021 Oct; 31(5):404-416. doi:
10.18176/jiaci.0524. [PMID: 32301440] - Yu-Ling Yin, Chenyu Ye, Fulai Zhou, Jia Wang, Dehua Yang, Wanchao Yin, Ming-Wei Wang, H Eric Xu, Yi Jiang. Molecular basis for kinin selectivity and activation of the human bradykinin receptors.
Nature structural & molecular biology.
2021 09; 28(9):755-761. doi:
10.1038/s41594-021-00645-y. [PMID: 34518695] - Raffi Tachdjian, Douglas T Johnston. Angioedema: differential diagnosis and acute management.
Postgraduate medicine.
2021 Sep; 133(7):765-770. doi:
10.1080/00325481.2021.1945219. [PMID: 34134576] - V V Neroev, N B Chesnokova, O A Kost, T D Okhotsimskaya, T A Pavlenko, O V Beznos, P V Binevsky, O A Lisovskaya. [Bradykinin and angiotensin-converting enzyme in serum of patients with diabetic retinopathy and the prognosis of diabetic macular edema development (pilot study)].
Problemy endokrinologii.
2021 08; 67(4):13-19. doi:
10.14341/probl12762. [PMID: 34533010] - Blas Larrauri, C Garren Hester, Haixiang Jiang, Vojislav D Miletic, Alejandro Malbran, Konrad Bork, Allen Kaplan, Michael Frank. Analysis of cold activation of the contact system in hereditary angioedema with normal C1 inhibitor.
Molecular immunology.
2021 08; 136(?):150-160. doi:
10.1016/j.molimm.2021.06.009. [PMID: 34153620] - Fernanda Barrinha Fernandes, Adriana Barrinha Fernandes, Andreia Cristina Silva Febba, Ana Paula Oliveira Leite, Cleber Aparecido Leite, Maria Sylvia Souza Vitalle, Flavia Fernandes Jung, Dulce Elena Casarini. Association of Ang-(1-7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents.
Hypertension research : official journal of the Japanese Society of Hypertension.
2021 08; 44(8):969-977. doi:
10.1038/s41440-021-00618-0. [PMID: 33568792] - Lauré M Fijen, Konrad Bork, Danny M Cohn. Current and Prospective Targets of Pharmacologic Treatment of Hereditary Angioedema Types 1 and 2.
Clinical reviews in allergy & immunology.
2021 Aug; 61(1):66-76. doi:
10.1007/s12016-021-08832-x. [PMID: 33423210] - Samantha L Cooper, Eleanor Boyle, Sophie R Jefferson, Calum R A Heslop, Pirathini Mohan, Gearry G J Mohanraj, Hamza A Sidow, Rory C P Tan, Stephen J Hill, Jeanette Woolard. Role of the Renin-Angiotensin-Aldosterone and Kinin-Kallikrein Systems in the Cardiovascular Complications of COVID-19 and Long COVID.
International journal of molecular sciences.
2021 Jul; 22(15):. doi:
10.3390/ijms22158255. [PMID: 34361021] - Hassan Madkhali, Amer Tarawneh, Zulfiqar Ali, Hoang V Le, Stephen J Cutler, Ikhlas A Khan, Zia Shariat-Madar. Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144126. [PMID: 34299400] - Devasahayam Arokia Balaya Rex, Sumaithangi Thattai Arun Kumar, Prashant Kumar Modi, Thottethodi Subrahmanya Keshava Prasad. Broadening COVID-19 Interventions to Drug Innovation: Neprilysin Pathway as a Friend, Foe, or Promising Molecular Target?.
Omics : a journal of integrative biology.
2021 07; 25(7):408-416. doi:
10.1089/omi.2021.0080. [PMID: 34191617] - Jorge F Giani, Luciana C Veiras, Justin Z Y Shen, Ellen A Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A Gonzalez-Villalobos, Kenneth E Bernstein. Novel roles of the renal angiotensin-converting enzyme.
Molecular and cellular endocrinology.
2021 06; 529(?):111257. doi:
10.1016/j.mce.2021.111257. [PMID: 33781839] - Camila Lopes Veronez, Agatha Ribeiro Mendes, Caroliny Souza Leite, Caio Perez Gomes, Anete Sevciovic Grumach, João Bosco Pesquero. The Panorama of Primary Angioedema in the Brazilian Population.
The journal of allergy and clinical immunology. In practice.
2021 06; 9(6):2293-2304.e5. doi:
10.1016/j.jaip.2020.11.039. [PMID: 33276216] - Steven de Maat, Kusumam Joseph, Coen Maas, Allen P Kaplan. Blood Clotting and the Pathogenesis of Types I and II Hereditary Angioedema.
Clinical reviews in allergy & immunology.
2021 Jun; 60(3):348-356. doi:
10.1007/s12016-021-08837-6. [PMID: 33956309] - Tanja Gangnus, Bjoern B Burckhardt. Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system.
Analytical and bioanalytical chemistry.
2021 May; 413(11):2971-2984. doi:
10.1007/s00216-021-03231-9. [PMID: 33693976] - Stephanie A Wilczynski, Camilla F Wenceslau, Cameron G McCarthy, R Clinton Webb. A Cytokine/Bradykinin Storm Comparison: What Is the Relationship Between Hypertension and COVID-19?.
American journal of hypertension.
2021 04; 34(4):304-306. doi:
10.1093/ajh/hpaa217. [PMID: 33877321] - Bożena Bądzyńska, Iwona Baranowska, Janusz Sadowski. Further evidence against the role renal medullary perfusion in short-term control of arterial pressure in normotensive and mildly or overtly hypertensive rats.
Pflugers Archiv : European journal of physiology.
2021 04; 473(4):623-631. doi:
10.1007/s00424-021-02534-1. [PMID: 33651165] - Cameron G McCarthy, Stephanie Wilczynski, Camilla F Wenceslau, R Clinton Webb. A new storm on the horizon in COVID-19: Bradykinin-induced vascular complications.
Vascular pharmacology.
2021 04; 137(?):106826. doi:
10.1016/j.vph.2020.106826. [PMID: 33358968] - Guohui Yang, Pengfei Yao, Shengli Ma, Chi Zhang. Bradykinin Activates the Bradykinin B2 Receptor to Ameliorate Neuronal Injury in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury.
ACS chemical neuroscience.
2021 03; 12(6):1031-1038. doi:
10.1021/acschemneuro.1c00054. [PMID: 33621043] - Habib Haybar, Mahmood Maniati, Najmaldin Saki, Zeinab Deris Zayeri. COVID-19: imbalance of multiple systems during infection and importance of therapeutic choice and dosing of cardiac and anti-coagulant therapies.
Molecular biology reports.
2021 Mar; 48(3):2917-2928. doi:
10.1007/s11033-021-06333-w. [PMID: 33837899] - Vardan T Karamyan. Between two storms, vasoactive peptides or bradykinin underlie severity of COVID-19?.
Physiological reports.
2021 03; 9(5):e14796. doi:
10.14814/phy2.14796. [PMID: 33687143] - Mehrdad Alikhani, Amir Javadi, Mahdi Aalikhani. Des-Arg9 bradykinin and bradykinin potentially trigger cytokine storm in patients with COVID-19.
Iranian journal of immunology : IJI.
2021 03; 18(1):93-94. doi:
10.22034/iji.2021.89684.1962. [PMID: 33787518] - George Kroumpouzos. Cutaneous manifestations of COVID-19: An unusual presentation with edematous plaques and pruritic, erythematous papules, and comment on the role of bradykinin storm and its therapeutic implications.
Dermatologic therapy.
2021 Mar; 34(2):e14753. doi:
10.1111/dth.14753. [PMID: 33406308] - Eli Mansour, Andre C Palma, Raisa G Ulaf, Luciana C Ribeiro, Ana Flavia Bernardes, Thyago A Nunes, Marcus V Agrela, Bruna Bombassaro, Milena Monfort-Pires, Rafael L Camargo, Eliana P Araujo, Natalia S Brunetti, Alessandro S Farias, Antônio Luís E Falcão, Thiago Martins Santos, Plinio Trabasso, Rachel P Dertkigil, Sergio S Dertkigil, Maria Luiza Moretti, Licio A Velloso. Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin-Kallikrein System in Severe COVID-19.
Viruses.
2021 02; 13(2):. doi:
10.3390/v13020309. [PMID: 33669276] - Tanja Gangnus, Bjoern B Burckhardt. Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19.
Scientific reports.
2021 02; 11(1):3061. doi:
10.1038/s41598-021-82191-7. [PMID: 33542252] - Arnold Lee. Berotralstat: First Approval.
Drugs.
2021 Feb; 81(3):405-409. doi:
10.1007/s40265-021-01475-4. [PMID: 33646555] - T Caballero. Treatment of Hereditary Angioedema.
Journal of investigational allergology & clinical immunology.
2021 Feb; 31(1):1-16. doi:
10.18176/jiaci.0653. [PMID: 33602658] - Ahmed S Gouda, Bruno Mégarbane. Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19?.
Drug development research.
2021 02; 82(1):38-48. doi:
10.1002/ddr.21732. [PMID: 32761647] - Allen P Kaplan, Berhane Ghebrehiwet. Pathways for bradykinin formation and interrelationship with complement as a cause of edematous lung in COVID-19 patients.
The Journal of allergy and clinical immunology.
2021 Feb; 147(2):507-509. doi:
10.1016/j.jaci.2020.10.025. [PMID: 33129885] - Lyvia Lintzmaier Petiz, Talita Glaser, Julio Scharfstein, Mariusz Z Ratajczak, Henning Ulrich. P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation.
Stem cell reviews and reports.
2021 02; 17(1):241-252. doi:
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Trials.
2021 Jan; 22(1):71. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2021 01; 118(3):. doi:
10.1073/pnas.2014810118. [PMID: 33397811] - Yuehuan Wu, Cong Fu, Bing Li, Chang Liu, Zhi He, Xing-Er Li, Ailing Wang, Genshan Ma, Yuyu Yao. Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway.
Journal of diabetes research.
2021; 2021(?):6626627. doi:
10.1155/2021/6626627. [PMID: 34557552] - Anete S Grumach, Camila L Veronez, Dorottya Csuka, Henriette Farkas. Angioedema Without Wheals: Challenges in Laboratorial Diagnosis.
Frontiers in immunology.
2021; 12(?):785736. doi:
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The Journal of biological chemistry.
2021 Jan; 296(?):100329. doi:
10.1016/j.jbc.2021.100329. [PMID: 33497625] - Patricia Gomez-Gutierrez, Juan J Perez. Discovery of a Bradykinin B2 Partial Agonist Profile of Raloxifene in a Drug Repurposing Campaign.
International journal of molecular sciences.
2020 Dec; 22(1):. doi:
10.3390/ijms22010257. [PMID: 33383825] - Sándor Sipka, Attila Tóth, Sándor Sipka. Age-dependent possible role of contact-activated blood coagulation factor XII as a potential contributor to the “bradykinin storm” in COVID-19 patients.
Orvosi hetilap.
2020 12; 161(50):2099-2103. doi:
10.1556/650.2020.32075. [PMID: 33310922] - T Vanassche, M M Engelen, Q Van Thillo, J Wauters, J Gunst, C Wouters, C Vandenbriele, S Rex, L Liesenborghs, A Wilmer, P Meersseman, G Van den Berghe, D Dauwe, G Verbeke, M Thomeer, T Fivez, D Mesotten, D Ruttens, L Heytens, I Dapper, S Tuyls, B De Tavernier, P Verhamme. A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico study.
Trials.
2020 Dec; 21(1):1005. doi:
10.1186/s13063-020-04878-y. [PMID: 33298149] - Janiana Raíza Jentsch Matias de Oliveira, Mayara Alves Amorim, Eunice André. The role of TRPA1 and TRPV4 channels in bronchoconstriction and plasma extravasation in airways of rats treated with captopril.
Pulmonary pharmacology & therapeutics.
2020 12; 65(?):102004. doi:
10.1016/j.pupt.2021.102004. [PMID: 33610768] - Shou Ping Guan, Raymond Chee Seong Seet, Brian K Kennedy. Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?.
Ageing research reviews.
2020 12; 64(?):101201. doi:
10.1016/j.arr.2020.101201. [PMID: 33157320] - Suzanne Zwaveling, Roy Gerth van Wijk, Faiz Karim. Pulmonary edema in COVID-19: Explained by bradykinin?.
The Journal of allergy and clinical immunology.
2020 12; 146(6):1454-1455. doi:
10.1016/j.jaci.2020.08.038. [PMID: 33077247] - Tsong-Hai Lee, Pei-Shan Liu, Ming-Ming Tsai, Jiun-Liang Chen, Su-Jane Wang, Hsi-Lung Hsieh. The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling.
Cell communication and signaling : CCS.
2020 11; 18(1):185. doi:
10.1186/s12964-020-00680-0. [PMID: 33228717] - Betty Diamond, Bruce T Volpe, Sonya VanPatten, Yousef Al Abed. SARS-CoV-2 and interferon blockade.
Molecular medicine (Cambridge, Mass.).
2020 11; 26(1):103. doi:
10.1186/s10020-020-00231-w. [PMID: 33167852] - Soltan A Ebrahimi. Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS-CoV-2.
Drug development research.
2020 11; 81(7):765-767. doi:
10.1002/ddr.21676. [PMID: 32337769] - Yi Wang, Jean-Francois Marier, Nastya Kassir, Colin Chang, Patrick Martin. Pharmacokinetics, Pharmacodynamics, and Exposure-Response of Lanadelumab for Hereditary Angioedema.
Clinical and translational science.
2020 11; 13(6):1208-1216. doi:
10.1111/cts.12806. [PMID: 32407574] - Seyyed Mohammad Ghahestani, Elaheh Shahab, Sara Karimi, Mohammad Hamidi Madani. Methylene blue may have a role in the treatment of COVID-19.
Medical hypotheses.
2020 Nov; 144(?):110163. doi:
10.1016/j.mehy.2020.110163. [PMID: 33254484] - Tanja Gangnus, Bjoern B Burckhardt. Improving sensitivity for the targeted LC-MS/MS analysis of the peptide bradykinin using a design of experiments approach.
Talanta.
2020 Oct; 218(?):121134. doi:
10.1016/j.talanta.2020.121134. [PMID: 32797891] - Steven de Maat, Quirijn de Mast, A H Jan Danser, Frank L van de Veerdonk, Coen Maas. Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection.
Seminars in thrombosis and hemostasis.
2020 10; 46(7):835-837. doi:
10.1055/s-0040-1712960. [PMID: 32526773] - Emma L Robinson, Kanar Alkass, Olaf Bergmann, Janet J Maguire, H Llewelyn Roderick, Anthony P Davenport. Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.
Journal of molecular and cellular cardiology.
2020 10; 147(?):88-91. doi:
10.1016/j.yjmcc.2020.08.009. [PMID: 32818486] - Mehdi Mahmudpour, Jamshid Roozbeh, Mohsen Keshavarz, Shokrollah Farrokhi, Iraj Nabipour. COVID-19 cytokine storm: The anger of inflammation.
Cytokine.
2020 09; 133(?):155151. doi:
10.1016/j.cyto.2020.155151. [PMID: 32544563] - Yuan Gao, Yixin Han, Xiaoyu Zhang, Qiaoling Fei, Ruijuan Qi, Rui Hou, Runlan Cai, Cheng Peng, Yun Qi. Penicillin causes non-allergic anaphylaxis by activating the contact system.
Scientific reports.
2020 08; 10(1):14160. doi:
10.1038/s41598-020-71083-x. [PMID: 32843685] - Frank L van de Veerdonk, Ilse J E Kouijzer, Aline H de Nooijer, Hans G van der Hoeven, Coen Maas, Mihai G Netea, Roger J M Brüggemann. Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19.
JAMA network open.
2020 08; 3(8):e2017708. doi:
10.1001/jamanetworkopen.2020.17708. [PMID: 32789513] - Gloria Valdés, Stephanie Acuña, Daniela Schneider, Rita Ortíz, Oslando Padilla. Bradykinin Exerts Independent Effects on Trophoblast Invasion and Blood Pressure in Pregnant Guinea Pigs.
Reproductive sciences (Thousand Oaks, Calif.).
2020 08; 27(8):1648-1655. doi:
10.1007/s43032-020-00195-6. [PMID: 32430711] - Kamala Vanarsa, Jared Henderson, Sanam Soomro, Ling Qin, Ting Zhang, Nicole Jordan, Chaim Putterman, Irene Blanco, Ramesh Saxena, Chandra Mohan. Upregulation of Proinflammatory Bradykinin Peptides in Systemic Lupus Erythematosus and Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950).
2020 07; 205(2):369-376. doi:
10.4049/jimmunol.1801167. [PMID: 32540998] - Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow, Daniel Jacobson. A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm.
eLife.
2020 07; 9(?):. doi:
10.7554/elife.59177. [PMID: 32633718] - Joseph A Roche, Renuka Roche. A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 06; 34(6):7265-7269. doi:
10.1096/fj.202000967. [PMID: 32359101] - Pradeep K Singh, Zu-Lin Chen, Dhiman Ghosh, Sidney Strickland, Erin H Norris. Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer's patients.
Neurobiology of disease.
2020 06; 139(?):104833. doi:
10.1016/j.nbd.2020.104833. [PMID: 32173555] - Maria Bova, Chiara Suffritti, Valeria Bafunno, Stefania Loffredo, Giorgia Cordisco, Stefano Del Giacco, Tiziana Maria Angela De Pasquale, Davide Firinu, Maurizio Margaglione, Vincenzo Montinaro, Angelica Petraroli, Anna Radice, Luisa Brussino, Andrea Zanichelli, Alessandra Zoli, Marco Cicardi. Impaired control of the contact system in hereditary angioedema with normal C1-inhibitor.
Allergy.
2020 06; 75(6):1394-1403. doi:
10.1111/all.14160. [PMID: 31860755] - Zhentao Zhang, Guodong Lv, Liang Du. Avicularin Reduces the Expression of Mediators of Inflammation and Oxidative Stress in Bradykinin-Treated MG-63 Human Osteoblastic Osteosarcoma Cells.
Medical science monitor : international medical journal of experimental and clinical research.
2020 May; 26(?):e921957. doi:
10.12659/msm.921957. [PMID: 32463805] - Seyed-Mohammad Ghahestani, Javad Mahmoudi, Sakineh Hajebrahimi, Amir-Babak Sioofy-Khojine, Hanieh Salehi-Pourmehr, Fatemeh Sadeghi-Ghyassi, Hadi Mostafaei. Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios: Is Bradykinin Sneaking out of Our Sight?.
Iranian journal of allergy, asthma, and immunology.
2020 May; 19(S1):13-17. doi:
10.18502/ijaai.v19i(s1.r1).2850. [PMID: 32534506] - Raffi Tachdjian, Karin E Johnson, Deborah Casso, Susan A Oliveria, Giovanna Devercelli, Gagan Jain. Real-world cohort study of adult and pediatric patients treated for hereditary angioedema in the United States.
Allergy and asthma proceedings.
2020 05; 41(3):172-182. doi:
10.2500/aap.2020.41.200011. [PMID: 32375961] - Hilary Longhurst, Henriette Farkas. Biological therapy in hereditary angioedema: transformation of a rare disease.
Expert opinion on biological therapy.
2020 05; 20(5):493-501. doi:
10.1080/14712598.2020.1724280. [PMID: 31994957] - Florian Stehlin, Camillo Ribi. [Hereditary angioedema due to C1-esterase inhibitor deficiency : novel approaches].
Revue medicale suisse.
2020 Apr; 16(689):675-678. doi:
. [PMID: 32270933] - Michihiro Hide, Atsushi Fukunaga, Junichi Maehara, Kazunori Eto, James Hao, Moshe Vardi, Yuji Nomoto. Efficacy, pharmacokinetics, and safety of icatibant for the treatment of Japanese patients with an acute attack of hereditary angioedema: A phase 3 open-label study.
Allergology international : official journal of the Japanese Society of Allergology.
2020 Apr; 69(2):268-273. doi:
10.1016/j.alit.2019.08.012. [PMID: 31672405] - Katarzyna Piotrowicz-Wójcik, Grzegorz Porebski. Life-threatening laryngeal attacks in hereditary angioedema patients.
Otolaryngologia polska = The Polish otolaryngology.
2020 Mar; 74(2):1-5. doi:
10.5604/01.3001.0014.0619. [PMID: 32308206] - Chantal C Clark, Zonne L M Hofman, Wariya Sanrattana, Lyanne den Braven, Steven de Maat, Coen Maas. The Fibronectin Type II Domain of Factor XII Ensures Zymogen Quiescence.
Thrombosis and haemostasis.
2020 Mar; 120(3):400-411. doi:
10.1055/s-0039-3402760. [PMID: 31940673] - Zonne L M Hofman, Mignon T van den Elzen, Jeffrey Kuijpers, Steven de Maat, C Erik Hack, André C Knulst, Heike Röckmann, Coen Maas. Evidence for bradykinin release in chronic spontaneous urticaria.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2020 03; 50(3):343-351. doi:
10.1111/cea.13558. [PMID: 31899843] - Ehsan Gholamreza-Fahimi, Marion Bisha, Janina Hahn, Ulrich Straßen, Michael Krybus, Farbod Khosravani, Thomas K Hoffmann, Thomas Hohlfeld, Jens Greve, Murat Bas, Sören Twarock, Georg Kojda. Cyclooxygenase activity in bradykinin-induced dermal extravasation. A study in mice and humans.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Mar; 123(?):109797. doi:
10.1016/j.biopha.2019.109797. [PMID: 31874445] - Krystyna Obtułowicz, Joanna Góralska, Anna Bogdali, Wojciech Dyga, Aleksander Obtułowicz, Dorota Myszkowska, Monika Ziemianin, Anna Gruca, Bogdan Solnica, Ewa Czarnobilska. Bradykinin and oxidative stress in patients with hereditary angioedema due to C1 inhibitor deficiency.
Polish archives of internal medicine.
2020 02; 130(2):79-88. doi:
10.20452/pamw.15138. [PMID: 31933486]