UNII:FU2EWB60RT (BioDeep_00001868295)

Main id: BioDeep_00000002294

 

PANOMIX_OTCML-2023 Industrial Pollutants Volatile Flavor Compounds


代谢物信息卡片


2-(((2-Ethylhexyl)oxy)carbonyl)benzoic acid

化学式: C16H22O4 (278.1518012)
中文名称: 邻苯二甲酸单(2-乙基己基)酯, 邻苯二甲酸单乙基己酯, 2-（（2-乙基己基）氧基）羰基）苯甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O
InChI: InChI=1S/C16H22O4/c1-3-5-8-12(4-2)11-20-16(19)14-10-7-6-9-13(14)15(17)18/h6-7,9-10,12H,3-5,8,11H2,1-2H3,(H,17,18)

描述信息

Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1].
Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1].

同义名列表

7 个代谢物同义名

2-(((2-Ethylhexyl)oxy)carbonyl)benzoic acid; UNII:FU2EWB60RT; MEHP; Phthalic acid mono-2-ethylhexyl ester; MEHPA; Mono-(2-ethylhexyl)phthalate; 2-(((2-Ethylhexyl)oxy)carbonyl)benzoic acid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu Hao, Xuan'en Tian, Fengmei Yan, Xiuqin Wang, Jing Huang, Ling Li. Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells. Ecotoxicology and environmental safety. 2024 Jun; 277(?):116394. doi: 10.1016/j.ecoenv.2024.116394. [PMID: 38663197]
  • Xia Wang, Dinggang Li, Xiangqin Zheng, Yifan Hong, Jie Zhao, Wei Deng, Mingxin Wang, Lianju Shen, Chunlan Long, Guanghui Wei, Shengde Wu. Di-(2-ethylhexyl) phthalate induces ferroptosis in prepubertal mouse testes via the lipid metabolism pathway. Environmental toxicology. 2024 Mar; 39(3):1747-1758. doi: 10.1002/tox.24065. [PMID: 38050670]
  • Yiyun Liu, Naima Hamid, Rakia Manzoor, Bao-Fu Zhang, Yan-Ling Liao, Jin-Xia Wang, De-Sheng Pei. PPARβ/δ-ANGPTL4 axis mediates the promotion of mono-2-ethylhexyl phthalic acid on MYCN-amplified neuroblastoma development. The Science of the total environment. 2024 Feb; 912(?):168949. doi: 10.1016/j.scitotenv.2023.168949. [PMID: 38042186]
  • Fulya Dal Yöntem, Sinem Ayaz, Şeyma Bulut, Ebru Hacıosmanoğlu Aldoğan, Müfide Aydoğan Ahbab. Endoplasmic reticulum stress and pro-inflammatory responses induced by phthalate metabolites monoethylhexyl phthalate and monobutyl phthalate in 1.1B4 pancreatic beta cells. Toxicology. 2024 Jan; 501(?):153695. doi: 10.1016/j.tox.2023.153695. [PMID: 38048874]
  • Sean M Harris, Anthony L Su, John F Dou, Rita Loch-Caruso, Elana R Elkin, Sammy Jaber, Kelly M Bakulski. Placental cell conditioned media modifies hematopoietic stem cell transcriptome invitro. Placenta. 2024 Jan; 145(?):117-125. doi: 10.1016/j.placenta.2023.12.016. [PMID: 38128222]
  • Minling Gao, Linsen Bai, Ling Xiao, Hongchang Peng, Qiaoting Chen, Weiwen Qiu, Zhengguo Song. Micro (nano)plastics and phthalate esters drive endophytic bacteria alteration and inhibit wheat root growth. The Science of the total environment. 2023 Oct; ?(?):167734. doi: 10.1016/j.scitotenv.2023.167734. [PMID: 37827310]
  • Qi Xu, Shuang Ding, Wen Qi, Xueting Zhang, Meng Zhang, Jiqiang Xing, Aipeng Ju, Liting Zhou, Lin Ye. JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students. Chemical research in toxicology. 2023 Apr; ?(?):. doi: 10.1021/acs.chemrestox.2c00365. [PMID: 37093692]
  • Yuezhu Zhang, Honghao Qian, Jia Wang, Ying Zhu, Xiaohan Miao, Xu Li, Jianli Yin, Ruxuan Zhang, Jiaming Ye, Chuanyi Huo, Weisen Zhao, Lin Ye. Di-(2-ethylhexyl) phthalate (DEHP) promoted hepatic lipid accumulation by activating Notch signaling pathway. Environmental toxicology. 2023 Mar; ?(?):. doi: 10.1002/tox.23792. [PMID: 36988346]
  • Samuel Thomas, William A Ricke, Lingjun Li. Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases. Chemical research in toxicology. 2023 Feb; 36(2):251-259. doi: 10.1021/acs.chemrestox.2c00328. [PMID: 36749316]
  • Huihua Yang, Yuming Zheng, Xuefeng Lai, Lei Zhao, Linlin Liu, Miao Liu, Wenting Guo, Liangle Yang, Qin Fang, Kejing Zhu, Wencan Dai, Wenhua Mei, Rui Zhu, Xiaomin Zhang. Associations of Urinary Phthalate Metabolites with Thyroid Function and the Mediated Role of Cytokines: A Panel Study of Healthy Children. Environmental science & technology. 2023 Feb; ?(?):. doi: 10.1021/acs.est.2c07656. [PMID: 36760168]
  • Yi Zhao, Hao Zhang, Jia-Gen Cui, Jia-Xin Wang, Ming-Shan Chen, Hao-Ran Wang, Xue-Nan Li, Jin-Long Li. Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor. Redox biology. 2023 02; 59(?):102584. doi: 10.1016/j.redox.2022.102584. [PMID: 36580806]
  • Hyunki Cho, Yohan Seol, Seungyun Baik, Baeckkyoung Sung, Chang Seon Ryu, Young Jun Kim. Mono(2-ethylhexyl) phthalate modulates lipid accumulation and reproductive signaling in Daphnia magna. Environmental science and pollution research international. 2022 Aug; 29(37):55639-55650. doi: 10.1007/s11356-022-19701-1. [PMID: 35320476]
  • Chien-Yu Lin, Ching-Way Chen, Hui-Ling Lee, Charlene Wu, Chikang Wang, Fung-Chang Sung, Ta-Chen Su. Global DNA methylation mediates the association between urine mono-2-ethylhexyl phthalate and serum apoptotic microparticles in a young Taiwanese population. The Science of the total environment. 2022 Feb; 808(?):152054. doi: 10.1016/j.scitotenv.2021.152054. [PMID: 34863772]
  • Miao Xu, Yongning Li, Xiaohong Wang, Qiannan Zhang, Lei Wang, Xin Zhang, Wenming Cui, Xiaomin Han, Ning Ma, Haishan Li, Hongyun Fang, Song Tang, Jingguang Li, Zhaoping Liu, Hui Yang, Xudong Jia. Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice. Environmental health perspectives. 2022 01; 130(1):17005. doi: 10.1289/ehp9373. [PMID: 35019730]
  • Yi-Zhen Yuan, Chong Ye, Jia-Hui Sun, Meng-Yuan Hu, Shao-Jie Huo, Yu-Ting Zhu, Su-Yun Xiang, Shu-Qin Yu. Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique. Toxicology and applied pharmacology. 2022 01; 434(?):115814. doi: 10.1016/j.taap.2021.115814. [PMID: 34843800]
  • Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Frontiers in cell and developmental biology. 2022; 10(?):1014243. doi: 10.3389/fcell.2022.1014243. [PMID: 36438553]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Karilyn E Sant, Hadley M Moreau, Larissa M Williams, Haydee M Jacobs, Anna M Bowsher, Jason D Boisvert, Roxanna M Smolowitz, Jacob Pantazis, Kate Annunziato, Malina Nguyen, Alicia Timme-Laragy. Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of developmental origins of health and disease. 2021 02; 12(1):132-140. doi: 10.1017/s2040174420000057. [PMID: 32063256]
  • Wen Qi, Qi Xu, Yixuan Xu, Zheng Wang, Liwei Yang, Shuangyu Guo, Yanbin Shi, Tianyang Zhao, Liting Zhou, Lin Ye. Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells. Ecotoxicology and environmental safety. 2021 Jan; 208(?):111472. doi: 10.1016/j.ecoenv.2020.111472. [PMID: 33091777]
  • Chun-Yu Lin, Chung-Hao Huang, Wen-Hung Wang, Jyrki Tenhunen, Ling-Chien Hung, Chi-Chou Lin, Yu-Cheng Chen, Yen-Hsu Chen, Wei-Ting Liao. Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses. Frontiers in immunology. 2021; 12(?):599345. doi: 10.3389/fimmu.2021.599345. [PMID: 33659001]
  • Luchen Yang, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong. Exposure to Di-2-ethylhexyl Phthalate and Benign Prostatic Hyperplasia, NHANES 2001-2008. Frontiers in endocrinology. 2021; 12(?):804457. doi: 10.3389/fendo.2021.804457. [PMID: 35095770]
  • Leyla Akın, Mustafa Kendirci, Figen Narin, Selim Kurtoğlu, Nihal Hatipoğlu, Ferhan Elmalı. Endocrine Disruptors and Polycystic Ovary Syndrome: Phthalates. Journal of clinical research in pediatric endocrinology. 2020 11; 12(4):393-400. doi: 10.4274/jcrpe.galenos.2020.2020.0037. [PMID: 32431137]
  • Jhih-Wei Hsu, Chung-Yi Nien, Szu-Ching Yeh, Feng-Yuan Tsai, Hsin-Wei Chen, Tzong-Shyuan Lee, Shen-Liang Chen, Yung-Hsi Kao, Tsui-Chun Tsou. Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Aug; 142(?):111487. doi: 10.1016/j.fct.2020.111487. [PMID: 32522588]
  • Sorour Ashari, Mohammad Karami, Mohammad Shokrzadeh, Morteza Ghandadi, Nasrin Ghassemi-Barghi, Ayat Dashti, Mohammad Ranaee, Hamidreza Mohammadi. The implication of mitochondrial dysfunction and mitochondrial oxidative damage in di (2-ethylhexyl) phthalate induced nephrotoxicity in both in vivo and in vitro models. Toxicology mechanisms and methods. 2020 Jul; 30(6):427-437. doi: 10.1080/15376516.2020.1758980. [PMID: 32312132]
  • Christina M Bailey-Hytholt, Tanaya Puranik, Anubhav Tripathi, Anita Shukla. Investigating interactions of phthalate environmental toxicants with lipid structures. Colloids and surfaces. B, Biointerfaces. 2020 Jun; 190(?):110923. doi: 10.1016/j.colsurfb.2020.110923. [PMID: 32199260]
  • Chang Gyun Park, Baeckkyoung Sung, Chang Seon Ryu, Young Jun Kim. Mono-(2-ethylhexyl) phthalate induces oxidative stress and lipid accumulation in zebrafish liver cells. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2020 Apr; 230(?):108704. doi: 10.1016/j.cbpc.2020.108704. [PMID: 31927120]
  • Qingqing Zhu, Jian Hou, Wenjun Yin, Fang Ye, Tian Xu, Juan Cheng, Zhiqiang Yu, Lin Wang, Jing Yuan. Associations of a mixture of urinary phthalate metabolites with blood lipid traits: A repeated-measures pilot study. Environmental pollution (Barking, Essex : 1987). 2020 Feb; 257(?):113509. doi: 10.1016/j.envpol.2019.113509. [PMID: 31767236]
  • Anna Mentor, Björn Brunström, Anna Mattsson, Maria Jönsson. Developmental exposure to a human relevant mixture of endocrine disruptors alters metabolism and adipogenesis in zebrafish (Danio rerio). Chemosphere. 2020 Jan; 238(?):124584. doi: 10.1016/j.chemosphere.2019.124584. [PMID: 31470313]
  • Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B Alarcon. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reproductive toxicology (Elmsford, N.Y.). 2020 01; 91(?):74-91. doi: 10.1016/j.reprotox.2019.10.004. [PMID: 31711903]
  • Sinem Akgül, Ünzile Sur, Yasemin Düzçeker, Aylin Balcı, Melis Pehlivantürk Kızılkan, Nuray Kanbur, Gürkan Bozdağ, Pınar Erkekoğlu, Ersin Gümüş, Belma Kocer-Gumusel, Orhan Derman. Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2019 Dec; 35(12):1084-1087. doi: 10.1080/09513590.2019.1630608. [PMID: 31219355]
  • Yuezhu Zhang, Shuyue Wang, Tianyang Zhao, Liwei Yang, Shuangyu Guo, Yanbin Shi, Xueting Zhang, Liting Zhou, Lin Ye. Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicology and environmental safety. 2019 Nov; 184(?):109611. doi: 10.1016/j.ecoenv.2019.109611. [PMID: 31491605]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Vladimíra Puklová, Tomáš Janoš, Lenka Sochorová, Adam Vavrouš, Karel Vrbík, Alena Fialová, Lenka Hanzlíková, Milena Černá. Exposure to Mixed Phthalates in Czech Preschool and School Children. Archives of environmental contamination and toxicology. 2019 Nov; 77(4):471-479. doi: 10.1007/s00244-019-00645-6. [PMID: 31214748]
  • Jhih-Wei Hsu, Szu-Ching Yeh, Feng-Yuan Tsai, Hsin-Wei Chen, Tsui-Chun Tsou. Fibroblast growth factor 21 secretion enhances glucose uptake in mono(2-ethylhexyl)phthalate-treated adipocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2019 Sep; 59(?):246-254. doi: 10.1016/j.tiv.2019.04.021. [PMID: 31009676]
  • Fei Wang, Chong Chang, Ruobi Li, Zhen Zhang, Hongmei Jiang, Ni Zeng, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Qing Wang. Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Toxicology. 2019 08; 424(?):152236. doi: 10.1016/j.tox.2019.06.007. [PMID: 31228551]
  • Jianying Bai, Zhen He, Yaofu Li, Xuexia Jiang, Hongmei Yu, Qing Tan. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environmental toxicology and pharmacology. 2019 Jul; 69(?):104-111. doi: 10.1016/j.etap.2019.04.004. [PMID: 31004931]
  • Isabel Kratochvil, Tommy Hofmann, Sandra Rother, Rita Schlichting, Rocco Moretti, Dieter Scharnweber, Vera Hintze, Beate I Escher, Jens Meiler, Stefan Kalkhof, Martin von Bergen. Mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) but not di(2-ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator-activated receptor γ. Rapid communications in mass spectrometry : RCM. 2019 May; 33 Suppl 1(?):75-85. doi: 10.1002/rcm.8258. [PMID: 30085373]
  • Li Zhu, Peng Duan, Xiuxue Hu, Yu Wang, Chunling Chen, Jiang Wan, Mengyi Dai, Xiaoling Liang, Junyi Li, Yan Tan. Exposure to cadmium and mono-(2-ethylhexyl) phthalate induce biochemical changes in rat liver, spleen, lung and kidney as determined by attenuated total reflection-Fourier transform infrared spectroscopy. Journal of applied toxicology : JAT. 2019 05; 39(5):783-797. doi: 10.1002/jat.3767. [PMID: 30680743]
  • Anastasia Repouskou, Emily Panagiotidou, Lydia Panagopoulou, Pernilla Larsdotter Bisting, Astrud R Tuck, Marcus O D Sjödin, Johan Lindberg, Evangelos Bozas, Joëlle Rüegg, Chris Gennings, Carl-Gustaf Bornehag, Pauliina Damdimopoulou, Antonios Stamatakis, Efthymia Kitraki. Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes. Scientific reports. 2019 04; 9(1):6424. doi: 10.1038/s41598-019-42377-6. [PMID: 31015488]
  • Wen Qi, Liting Zhou, Tianye Zhao, Shuang Ding, Qi Xu, Xu Han, Yaming Zhao, Xinyue Song, Tianyang Zhao, Xiaohan Zhang, Lin Ye. Effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate. Molecular and cellular endocrinology. 2019 03; 484(?):52-58. doi: 10.1016/j.mce.2019.01.012. [PMID: 30660700]
  • Jijun Shang, Jeanne Corriveau, Alexandre Champoux-Jenane, Julie Gagnon, Emmanuel Moss, Pierre Dumas, Eric Gaudreau, Jonathan Chevrier, Lorraine E Chalifour. Recovery From a Myocardial Infarction Is Impaired in Male C57bl/6 N Mice Acutely Exposed to the Bisphenols and Phthalates That Escape From Medical Devices Used in Cardiac Surgery. Toxicological sciences : an official journal of the Society of Toxicology. 2019 03; 168(1):78-94. doi: 10.1093/toxsci/kfy276. [PMID: 30398665]
  • Hussein Shoaito, Julia Petit, Audrey Chissey, Nicolas Auzeil, Jean Guibourdenche, Sophie Gil, Olivier Laprévote, Thierry Fournier, Séverine A Degrelle. The Role of Peroxisome Proliferator–Activated Receptor Gamma (PPARγ) in Mono(2-ethylhexyl) Phthalate (MEHP)-Mediated Cytotrophoblast Differentiation. Environmental health perspectives. 2019 Feb; 127(2):27003. doi: 10.1289/ehp3730. [PMID: 30810372]
  • Min Joo Kim, Shinje Moon, Byung-Chul Oh, Dawoon Jung, Kyungho Choi, Young Joo Park. Association Between Diethylhexyl Phthalate Exposure and Thyroid Function: A Meta-Analysis. Thyroid : official journal of the American Thyroid Association. 2019 02; 29(2):183-192. doi: 10.1089/thy.2018.0051. [PMID: 30588877]
  • Rosie M Martinez, Russ Hauser, Liming Liang, Abdallah Mansur, Michal Adir, Laura Dioni, Catherine Racowsky, Valentina Bollati, Andrea A Baccarelli, Ronit Machtinger. Urinary concentrations of phenols and phthalate metabolites reflect extracellular vesicle microRNA expression in follicular fluid. Environment international. 2019 02; 123(?):20-28. doi: 10.1016/j.envint.2018.11.043. [PMID: 30481674]
  • Gulru Gurdemir, Pinar Erkekoglu, Aylin Balci, Unzile Sur, Gizem Ozkemahli, Engin Tutkun, Hinc Yilmaz, Ali Asci, Belma Kocer-Gumusel. Oxidative Stress Parameters, Selenium Levels, DNA Damage, and Phthalate Levels in Plastic Workers. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2019; 38(3):253-270. doi: 10.1615/jenvironpatholtoxicoloncol.2019026470. [PMID: 31679312]
  • Prajakta Parag Pednekar, Rahul Krishnaji Gajbhiye, Anushree D Patil, Suchitra Vishwambhar Surve, Ajit Ganesh Datar, Geetha Dharmesh Balsarkar, Anahita R Chuahan, Geeta Ramesh Vanage. Estimation of plasma levels of bisphenol-A & phthalates in fertile & infertile women by gas chromatography-mass spectrometry. The Indian journal of medical research. 2018 Dec; 148(6):734-742. doi: 10.4103/ijmr.ijmr_2077_16. [PMID: 30778008]
  • Ronit Machtinger, Jia Zhong, Abdallah Mansur, Michal Adir, Catherine Racowsky, Russ Hauser, Kasey Brennan, Oskar Karlsson, Andrea A Baccarelli. Placental lncRNA Expression Is Associated With Prenatal Phthalate Exposure. Toxicological sciences : an official journal of the Society of Toxicology. 2018 05; 163(1):116-122. doi: 10.1093/toxsci/kfy013. [PMID: 29385630]
  • Chen-Yuan Chiu, Shih-Chun Sun, Chih-Kang Chiang, Ching-Chia Wang, Ding-Cheng Chan, Huang-Jen Chen, Shing-Hwa Liu, Rong-Sen Yang. Plasticizer di(2-ethylhexyl)phthalate interferes with osteoblastogenesis and adipogenesis in a mouse model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2018 04; 36(4):1124-1134. doi: 10.1002/jor.23740. [PMID: 28921615]
  • Munawar Hussain Soomro, Nour Baiz, Claire Philippat, Celine Vernet, Valerie Siroux, Cara Nichole Maesano, Shreosi Sanyal, Remy Slama, Carl-Gustaf Bornehag, Isabella Annesi-Maesano. Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study. Environmental health perspectives. 2018 02; 126(2):027002. doi: 10.1289/ehp1829. [PMID: 29398652]
  • Po-Chin Huang, Kai-Wei Liao, Jung-Wei Chang, Shiou-Hui Chan, Ching-Chang Lee. Characterization of phthalates exposure and risk for cosmetics and perfume sales clerks. Environmental pollution (Barking, Essex : 1987). 2018 Feb; 233(?):577-587. doi: 10.1016/j.envpol.2017.10.079. [PMID: 29102888]
  • Nataša Milošević, Nataša Milić, Dragana Živanović Bosić, Ivana Bajkin, Ivanka Perčić, Ludovico Abenavoli, Milica Medić Stojanoska. Potential influence of the phthalates on normal liver function and cardiometabolic risk in males. Environmental monitoring and assessment. 2017 Dec; 190(1):17. doi: 10.1007/s10661-017-6398-0. [PMID: 29234897]
  • Jennifer J Adibi, Yaqi Zhao, Lei V Zhan, Mirhan Kapidzic, Nicholas Larocque, Hannu Koistinen, Ilpo T Huhtaniemi, Ulf-Håkan Stenman. An Investigation of the Single and Combined Phthalate Metabolite Effects on Human Chorionic Gonadotropin Expression in Placental Cells. Environmental health perspectives. 2017 10; 125(10):107010. doi: 10.1289/ehp1539. [PMID: 29089286]
  • Han-Bin Huang, Chia-Jui Chuang, Pen-Hua Su, Chien-Wen Sun, Chien-Jen Wang, Ming-Tsang Wu, Shu-Li Wang. Prenatal and Childhood Exposure to Phthalate Diesters and Thyroid Function in a 9-Year Follow-up Birth Cohort Study: Taiwan Maternal and Infant Cohort Study. Epidemiology (Cambridge, Mass.). 2017 10; 28 Suppl 1(?):S10-S18. doi: 10.1097/ede.0000000000000722. [PMID: 29028671]
  • B Kolena, I Petrovičová, M Šidlovská, T Pilka, M Neuschlová, I Valentová, L' Rybanský, T Trnovec. Occupational phthalate exposure and health outcomes among hairdressing apprentices. Human & experimental toxicology. 2017 Oct; 36(10):1100-1112. doi: 10.1177/0960327116678295. [PMID: 27852937]
  • Anika Engel, Thorsten Buhrke, Francine Imber, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen. Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR. Toxicology letters. 2017 Aug; 277(?):54-63. doi: 10.1016/j.toxlet.2017.05.028. [PMID: 28571686]
  • Mangala Priya Viswanathan, Vigneswari Mullainadhan, Mayilvanan Chinnaiyan, Balasubramanian Karundevi. Effects of DEHP and its metabolite MEHP on insulin signalling and proteins involved in GLUT4 translocation in cultured L6 myotubes. Toxicology. 2017 07; 386(?):60-71. doi: 10.1016/j.tox.2017.05.005. [PMID: 28526321]
  • Szu-Ying Chen, Jing-Shiang Hwang, Fung-Chang Sung, Chien-Yu Lin, Chia-Jung Hsieh, Pau-Chung Chen, Ta-Chen Su. Mono-2-ethylhexyl phthalate associated with insulin resistance and lower testosterone levels in a young population. Environmental pollution (Barking, Essex : 1987). 2017 Jun; 225(?):112-117. doi: 10.1016/j.envpol.2017.03.037. [PMID: 28359975]
  • Zhansheng Wang, Minkun Shao, Yulu Liu. Promotion of Wilms' tumor cells migration and invasion by mono-2-ethyhexyl phthalate (MEHP) via activation of NF-κB signals. Chemico-biological interactions. 2017 May; 270(?):1-8. doi: 10.1016/j.cbi.2017.04.004. [PMID: 28390675]
  • Jennifer J Adibi, Jessie P Buckley, Myoung Keun Lee, Paige L Williams, Allan C Just, Yaqi Zhao, Hari K Bhat, Robin M Whyatt. Maternal urinary phthalates and sex-specific placental mRNA levels in an urban birth cohort. Environmental health : a global access science source. 2017 04; 16(1):35. doi: 10.1186/s12940-017-0241-5. [PMID: 28381288]
  • Sara Manteiga, Kyongbum Lee. Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways. Environmental health perspectives. 2017 04; 125(4):615-622. doi: 10.1289/ehp464. [PMID: 27384973]
  • Wei-Hsiang Chang, Meng-Hsing Wu, Hsien-An Pan, Pao-Lin Guo, Ching-Chang Lee. Semen quality and insulin-like factor 3: Associations with urinary and seminal levels of phthalate metabolites in adult males. Chemosphere. 2017 Apr; 173(?):594-602. doi: 10.1016/j.chemosphere.2017.01.056. [PMID: 28152410]
  • Xialin Hu, Yunyun Gu, Wenping Huang, Daqiang Yin. Phthalate monoesters as markers of phthalate contamination in wild marine organisms. Environmental pollution (Barking, Essex : 1987). 2016 Nov; 218(?):410-418. doi: 10.1016/j.envpol.2016.07.020. [PMID: 27435611]
  • Ayşe Derya Buluş, Ali Aşci, Pinar Erkekoglu, Aylin Balci, Nesibe Andiran, Belma Koçer-Gümüşel. The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty. Toxicology mechanisms and methods. 2016 Sep; 26(7):493-500. doi: 10.3109/15376516.2016.1158894. [PMID: 27451808]
  • Yongtong Zhu, Rui Hua, Yao Zhou, Hong Li, Song Quan, Yanhong Yu. Chronic exposure to mono-(2-ethylhexyl)-phthalate causes endocrine disruption and reproductive dysfunction in zebrafish. Environmental toxicology and chemistry. 2016 08; 35(8):2117-24. doi: 10.1002/etc.3369. [PMID: 26762230]
  • Astrid Mittermeier, Wolfgang Völkel, Hermann Fromme. Kinetics of the phthalate metabolites mono-2-ethylhexyl phthalate (MEHP) and mono-n-butyl phthalate (MnBP) in male subjects after a single oral dose. Toxicology letters. 2016 Jun; 252(?):22-8. doi: 10.1016/j.toxlet.2016.04.009. [PMID: 27091076]
  • Jessie P Buckley, Stephanie M Engel, Joseph M Braun, Robin M Whyatt, Julie L Daniels, Michelle A Mendez, David B Richardson, Yingying Xu, Antonia M Calafat, Mary S Wolff, Bruce P Lanphear, Amy H Herring, Andrew G Rundle. Prenatal Phthalate Exposures and Body Mass Index Among 4- to 7-Year-old Children: A Pooled Analysis. Epidemiology (Cambridge, Mass.). 2016 May; 27(3):449-58. doi: 10.1097/ede.0000000000000436. [PMID: 26745610]
  • Steven Jones, Annie Boisvert, Andrada Naghi, Françoise Hullin-Matsuda, Peter Greimel, Toshihide Kobayashi, Vassilios Papadopoulos, Martine Culty. Stimulatory effects of combined endocrine disruptors on MA-10 Leydig cell steroid production and lipid homeostasis. Toxicology. 2016 04; 355-356(?):21-30. doi: 10.1016/j.tox.2016.05.008. [PMID: 27181934]
  • Fatih Kardas, Ayse Kacar Bayram, Esra Demirci, Leyla Akin, Sevgi Ozmen, Mustafa Kendirci, Mehmet Canpolat, Didem Behice Oztop, Figen Narin, Hakan Gumus, Sefer Kumandas, Huseyin Per. Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis. Journal of child neurology. 2016 Apr; 31(5):629-35. doi: 10.1177/0883073815609150. [PMID: 26450281]
  • Huai-chih Chiang, Ya-Ting Kuo, Chih-Che Shen, Yi-Hua Lin, Shu-Li Wang, Tsui-Chun Tsou. Mono(2-ethylhexyl)phthalate accumulation disturbs energy metabolism of fat cells. Archives of toxicology. 2016 Mar; 90(3):589-601. doi: 10.1007/s00204-014-1446-9. [PMID: 25543134]
  • Yitao Pan, Jun Jing, Fengshou Dong, Qi Yao, Wei Zhang, Hongxia Zhang, Bing Yao, Jiayin Dai. Association between phthalate metabolites and biomarkers of reproductive function in 1066 Chinese men of reproductive age. Journal of hazardous materials. 2015 Dec; 300(?):729-736. doi: 10.1016/j.jhazmat.2015.08.011. [PMID: 26296076]
  • Cristian M Sobarzo, Nogueira de Morais Rosana, Lustig Livia, Denduchis Berta, Helena F Schteingart. Mono-(2-ethylhexyl) phthalate (MEHP) affects intercellular junctions of Sertoli cell: A potential role of oxidative stress. Reproductive toxicology (Elmsford, N.Y.). 2015 Dec; 58(?):203-12. doi: 10.1016/j.reprotox.2015.10.010. [PMID: 26498383]
  • Cinzia La Rocca, Sabrina Tait, Cristiana Guerranti, Luca Busani, Francesca Ciardo, Bruno Bergamasco, Guido Perra, Francesca Romana Mancini, Roberto Marci, Giulia Bordi, Donatella Caserta, Silvano Focardi, Massimo Moscarini, Alberto Mantovani. Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features. International journal of environmental research and public health. 2015 Oct; 12(10):12426-45. doi: 10.3390/ijerph121012426. [PMID: 26445054]
  • Milica Medic Stojanoska, Andrijana Milankov, Bojan Vukovic, Dejan Vukcevic, Jan Sudji, Ivana Bajkin, Nikola Curic, Tijana Icin, Branka Kovacev Zavisic, Natasa Milic. Do diethyl phthalate (DEP) and di-2-ethylhexyl phthalate (DEHP) influence the metabolic syndrome parameters? Pilot study. Environmental monitoring and assessment. 2015 Aug; 187(8):526. doi: 10.1007/s10661-015-4754-5. [PMID: 26210228]
  • Jianqiang Sun, Xiaoqin Wu, Jay Gan. Uptake and Metabolism of Phthalate Esters by Edible Plants. Environmental science & technology. 2015 Jul; 49(14):8471-8. doi: 10.1021/acs.est.5b01233. [PMID: 26090545]
  • L Yaghjyan, S Sites, Y Ruan, S-H Chang. Associations of urinary phthalates with body mass index, waist circumference and serum lipids among females: National Health and Nutrition Examination Survey 1999-2004. International journal of obesity (2005). 2015 Jun; 39(6):994-1000. doi: 10.1038/ijo.2015.8. [PMID: 25644057]
  • James Watt, Jennifer J Schlezinger. Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology. 2015 May; 331(?):66-77. doi: 10.1016/j.tox.2015.03.006. [PMID: 25777084]
  • Jer-Pei Fong, Fang-Jin Lee, I-Syuan Lu, Shi-Nian Uang, Ching-Chang Lee. Relationship between urinary concentrations of di(2-ethylhexyl) phthalate (DEHP) metabolites and reproductive hormones in polyvinyl chloride production workers. Occupational and environmental medicine. 2015 May; 72(5):346-53. doi: 10.1136/oemed-2014-102532. [PMID: 25637220]
  • Koichiro Adachi, Hiroshi Suemizu, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki. Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling. Environmental toxicology and pharmacology. 2015 May; 39(3):1067-73. doi: 10.1016/j.etap.2015.02.011. [PMID: 25867688]
  • Arianna Smerieri, Chiara Testa, Pietro Lazzeroni, Francesca Nuti, Enzo Grossi, Silvia Cesari, Luisa Montanini, Giuseppe Latini, Sergio Bernasconi, Anna Maria Papini, Maria E Street. Di-(2-ethylhexyl) phthalate metabolites in urine show age-related changes and associations with adiposity and parameters of insulin sensitivity in childhood. PloS one. 2015; 10(2):e0117831. doi: 10.1371/journal.pone.0117831. [PMID: 25706863]
  • Nikki Gillum Posnack. The adverse cardiac effects of Di(2-ethylhexyl)phthalate and Bisphenol A. Cardiovascular toxicology. 2014 Dec; 14(4):339-57. doi: 10.1007/s12012-014-9258-y. [PMID: 24811950]
  • Xiaoya Hu, Yan Zhao, Beitao Chen, Yuan Liang, Luxi Li, Changming Xie, Yunhui Zhang, Zhenlang Lin, Ailan Xie, Shangqin Chen. [11beta-hydroxysteroid dehydrogenase type 2 enzyme activity effect after exposures phthalate esters in maternal]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2014 Sep; 48(9):800-4. doi: . [PMID: 25492292]
  • Li-Ping Huang, Ching-Chang Lee, Jer-Pei Fan, Po-Hsiu Kuo, Tung-Sheng Shih, Ping-Chi Hsu. Urinary metabolites of di(2-ethylhexyl) phthalate relation to sperm motility, reactive oxygen species generation, and apoptosis in polyvinyl chloride workers. International archives of occupational and environmental health. 2014 Aug; 87(6):635-46. doi: 10.1007/s00420-013-0905-6. [PMID: 23995610]
  • Kelly K Ferguson, Karen E Peterson, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Martha M Téllez-Rojo, John D Meeker. Prenatal and peripubertal phthalates and bisphenol A in relation to sex hormones and puberty in boys. Reproductive toxicology (Elmsford, N.Y.). 2014 Aug; 47(?):70-6. doi: 10.1016/j.reprotox.2014.06.002. [PMID: 24945889]
  • Ulla Nordström Joensen, Niels Jørgensen, Michael Meldgaard, Hanne Frederiksen, Anna-Maria Andersson, Torkil Menné, Jeanne Duus Johansen, Berit Christina Carlsen, Steen Stender, Pal Bela Szecsi, Niels Erik Skakkebæk, Ewa Rajpert-De Meyts, Jacob P Thyssen. Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men. Environmental health perspectives. 2014 Apr; 122(4):345-50. doi: 10.1289/ehp.1306720. [PMID: 24380925]
  • Xi Chen, Jing Ma, Hao Yu, Ling Leng, Qinghong Zhou, Zengrong Sun, Naijun Tang. [Study on the association between maternal urinary phthalate metabolites and testicular steroid hormones in the cord blood in a Chinese population]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2014 Mar; 48(3):167-71. doi: NULL. [PMID: 24844827]
  • Ting Ye, Mei Kang, Qiansheng Huang, Chao Fang, Yajie Chen, Heqing Shen, Sijun Dong. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma). Aquatic toxicology (Amsterdam, Netherlands). 2014 Jan; 146(?):115-26. doi: 10.1016/j.aquatox.2013.10.025. [PMID: 24292025]
  • Adrianne K Holmes, Kathryn R Koller, Stephanie M Kieszak, Andreas Sjodin, Antonia M Calafat, Frank D Sacco, D Wayne Varner, Anne P Lanier, Carol H Rubin. Case-control study of breast cancer and exposure to synthetic environmental chemicals among Alaska Native women. International journal of circumpolar health. 2014; 73(1):25760. doi: 10.3402/ijch.v73.25760. [PMID: 25442219]
  • Jin-Bao Ban, Xiao-Wu Fan, Qi Huang, Bin-Feng Li, Chen Chen, Hua-Chuan Zhang, Shun-Qing Xu. Mono-(2-ethylhexyl) phthalate induces injury in human umbilical vein endothelial cells. PloS one. 2014; 9(5):e97607. doi: 10.1371/journal.pone.0097607. [PMID: 24836450]
  • Joanna Jurewicz, Michał Radwan, Wojciech Sobala, Danuta Ligocka, Paweł Radwan, Michał Bochenek, Wanda Hawuła, Lucjusz Jakubowski, Wojciech Hanke. Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones. Reproductive toxicology (Elmsford, N.Y.). 2013 Dec; 42(?):232-41. doi: 10.1016/j.reprotox.2013.10.001. [PMID: 24140385]
  • Manori J Silva, Ella Samandar, Xiaoyun Ye, Antonia M Calafat. In vitro metabolites of di-2-ethylhexyl adipate (DEHA) as biomarkers of exposure in human biomonitoring applications. Chemical research in toxicology. 2013 Oct; 26(10):1498-502. doi: 10.1021/tx400215z. [PMID: 24016063]
  • Xiao-Li Feng, Shi-Ying Lu, Dong Liu, Le Li, Xin-Zi Wu, Jie Song, Pan Hu, Yan-Song Li, Feng Tang, Zhao-Hui Li, Guang-Ming Wang, Yu Zhou, Zeng-Shan Liu, Hong-Lin Ren. Direct competitive immunosorbent assay for detection of MEHP in human urine. Chemosphere. 2013 Jun; 92(1):150-5. doi: 10.1016/j.chemosphere.2013.02.062. [PMID: 23561568]
  • Hyunju Jung, Yonghee Hong, Donghwan Lee, Kijung Pang, Yunje Kim. The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism. Environmental toxicology and pharmacology. 2013 Mar; 35(2):278-83. doi: 10.1016/j.etap.2013.01.002. [PMID: 23376177]
  • Lauren M Tetz, Patricia W Kamau, Adrienne A Cheng, John D Meeker, Rita Loch-Caruso. Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species. Journal of pharmacological and toxicological methods. 2013 Mar; 67(2):56-60. doi: 10.1016/j.vascn.2013.01.195. [PMID: 23380227]
  • William J Breslin, April Paulman, Denise Sun-Lin, Keith M Goldstein, Angela Derr. The inhibin B (InhB) response to the testicular toxicants mono-2-ethylhexyl phthalate (MEHP), 1,3 dinitrobenzene (DNB), or carbendazim (CBZ) following short-term repeat dosing in the male rat. Birth defects research. Part B, Developmental and reproductive toxicology. 2013 Feb; 98(1):72-81. doi: 10.1002/bdrb.21043. [PMID: 23348955]
  • Taewoo Yum, Sanghouck Lee, Yunje Kim. Association between precocious puberty and some endocrine disruptors in human plasma. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2013; 48(8):912-7. doi: 10.1080/10934529.2013.762734. [PMID: 23485241]
  • Junjie Yang, Hong Ma, Jing Li, Hong Liu, Weitong Zhang, Yongzheng Zhou, Peng Zhao. [Effect of di-(2-ethylhexyl)phthalate and its metabolite mono(2-ethylhexyl)phthalate on spermatogenic cell apoptosis in young male Wistar rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2012 Dec; 32(12):1758-63. doi: NULL. [PMID: 23268404]
  • Chanjuan Hao, Xuejia Cheng, Hongfei Xia, Xu Ma. The endocrine disruptor mono-(2-ethylhexyl) phthalate promotes adipocyte differentiation and induces obesity in mice. Bioscience reports. 2012 Dec; 32(6):619-29. doi: 10.1042/bsr20120042. [PMID: 22953781]
  • Liangpo Liu, Tongwei Xia, Lihua Guo, Lanyu Cao, Benhua Zhao, Jie Zhang, Sijun Dong, Heqing Shen. Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example. Journal of exposure science & environmental epidemiology. 2012 Nov; 22(6):625-31. doi: 10.1038/jes.2012.51. [PMID: 22643239]
  • Pen-Hua Su, Yan-Zin Chang, Hua-Pin Chang, Shu-Li Wang, Hsin-I Haung, Po-Chin Huang, Jia-Yuh Chen. Exposure to di(2-ethylhexyl) phthalate in premature neonates in a neonatal intensive care unit in Taiwan. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2012 Nov; 13(6):671-7. doi: 10.1097/pcc.0b013e3182455558. [PMID: 22596068]