PERAZINE (BioDeep_00001868285)
Main id: BioDeep_00000002827
代谢物信息卡片
PERAZINE
化学式: C20H25N3S (339.176909)
中文名称: 培拉嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=CC=CC=C42
InChI: InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3
描述信息
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AB - Phenothiazines with piperazine structure
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:59118
- KEGG: C16903
- PubChem: 4744
- DrugBank: DB12710
- ChEMBL: CHEMBL1697766
- MeSH: Perazine
- CAS: 84-97-9
- PubChem: 96023399
- NIKKAJI: J9.873F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pierre Baumann, Chin B Eap, Markus Gastpar. The effect of perazine on the CYP2D6 and CYP2C19 phenotypes as measured by the dextromethorphan and mephenytoin tests in psychiatric patients.
Basic & clinical pharmacology & toxicology.
2020 May; 126(5):444-447. doi:
10.1111/bcpt.13373. [PMID: 31814297] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Benedikt Stegmann, Sarah E Lammertz, Gerhard Gründer, Georgios Schoretsanitis. Cytochrome P450-mediated interaction between perazine and risperidone: implications for antipsychotic polypharmacy.
British journal of clinical pharmacology.
2017 08; 83(8):1668-1675. doi:
10.1111/bcp.13255. [PMID: 28160505] - Piotr Tybura, Beata Trześniowska-Drukała, Przemyslaw Bienkowski, Aleksander Beszlej, Dorota Frydecka, Pawel Mierzejewski, Agnieszka Samochowiec, Anna Grzywacz, Jerzy Samochowiec. Pharmacogenetics of adverse events in schizophrenia treatment: comparison study of ziprasidone, olanzapine and perazine.
Psychiatry research.
2014 Oct; 219(2):261-7. doi:
10.1016/j.psychres.2014.05.039. [PMID: 24930580] - Kwang H Choi, Brandon W Higgs, Serge Weis, Jonathan Song, Ida C Llenos, Jeannette R Dulay, Robert H Yolken, Maree J Webster. Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects.
BMC psychiatry.
2009 Sep; 9(?):57. doi:
10.1186/1471-244x-9-57. [PMID: 19758435] - Gerd Schaller, Andrea Jacobi, Andrea Rotter, Johannes Kornhuber, Thomas Hillemacher. Perazine elevates clozapine serum levels by inhibiting hepatic metabolism.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Aug; 33(5):908-9. doi:
10.1016/j.pnpbp.2009.04.006. [PMID: 19376183] - Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).
BMC psychiatry.
2008 Dec; 8(?):95. doi:
10.1186/1471-244x-8-95. [PMID: 19102734] - Einosuke Tanaka, Takako Nakamura, Masaru Terada, Tatsuo Shinozuka, Chikako Hashimoto, Katsuyoshi Kurihara, Katsuya Honda. Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):116-20. doi:
10.1016/j.jchromb.2007.04.004. [PMID: 17459789] - H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Oct; 843(1):100-13. doi:
10.1016/j.jchromb.2006.05.031. [PMID: 16798119] - Ewa Obuchowicz, Agnieszka Marcinowska, Lukasz Drzyzga, Jacek Wójcikowski, Władysława A Daniel, Zbigniew S Herman. Effect of chronic treatment with perazine on lipopolysaccharide-induced interleukin-1 beta levels in the rat brain.
Naunyn-Schmiedeberg's archives of pharmacology.
2006 Apr; 373(1):79-84. doi:
10.1007/s00210-006-0058-1. [PMID: 16583240] - Julia Sachse, Johannes Köller, Sebastian Härtter, Christoph Hiemke. Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jan; 830(2):342-8. doi:
10.1016/j.jchromb.2005.11.032. [PMID: 16337441] - Akemi Marumo, Takeshi Kumazawa, Xiao-Pen Lee, Koichiro Fujimaki, Ayako Kuriki, Chika Hasegawa, Keizo Sato, Hiroshi Seno, Osamu Suzuki. Analysis of phenothiazines in human body fluids using disk solid-phase extraction and liquid chromatography.
Journal of AOAC International.
2005 Nov; 88(6):1655-60. doi:
. [PMID: 16526447] - Andrea Schmitt, Thomas Bertsch, Heike Tost, Andrea Bergmann, Uwe Henning, Ansgar Klimke, Peter Falkai. Increased serum interleukin-1beta and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medication.
Neuropsychiatric disease and treatment.
2005 Jun; 1(2):171-7. doi:
10.2147/nedt.1.2.171.61048. [PMID: 18568063] - Amal Abou El Ela, Sebastian Härtter, Ulrich Schmitt, Christoph Hiemke, Hildegard Spahn-Langguth, Peter Langguth. Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates.
The Journal of pharmacy and pharmacology.
2004 Aug; 56(8):967-75. doi:
10.1211/0022357043969. [PMID: 15285840] - Grégori Gerebtzoff, Xiaochun Li-Blatter, Holger Fischer, Adrian Frentzel, Anna Seelig. Halogenation of drugs enhances membrane binding and permeation.
Chembiochem : a European journal of chemical biology.
2004 May; 5(5):676-84. doi:
10.1002/cbic.200400017. [PMID: 15122640] - Carsten Kratzsch, Frank T Peters, Thomas Kraemer, Armin A Weber, Hans H Maurer. Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.
Journal of mass spectrometry : JMS.
2003 Mar; 38(3):283-95. doi:
10.1002/jms.440. [PMID: 12644990] - Władysława A Daniel. Mechanisms of cellular distribution of psychotropic drugs. Significance for drug action and interactions.
Progress in neuro-psychopharmacology & biological psychiatry.
2003 Feb; 27(1):65-73. doi:
10.1016/s0278-5846(02)00317-2. [PMID: 12551728] - W A Daniel, M Syrek, A Haduch, J Wójcikowski. The effect of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics and metabolism of perazine in the rat.
The Journal of pharmacy and pharmacology.
2001 Apr; 53(4):449-61. doi:
10.1211/0022357011775749. [PMID: 11341361] - W A Daniel, M Syrek, A Haduch, J Wójcikowski. Different effects of amitriptyline and imipramine on the pharmacokinetics and metabolism of perazine in rats.
The Journal of pharmacy and pharmacology.
2000 Dec; 52(12):1473-81. doi:
10.1211/0022357001777685. [PMID: 11197075] - J Wójcikowski, W A Daniel. Distribution interactions between perazine and antidepressant drugs. In vivo studies.
Polish journal of pharmacology.
2000 Nov; 52(6):449-57. doi:
. [PMID: 11334238] - W A Daniel, M Syrek, A Haduch, J Wójcikowski. Pharmacokinetics of phenothiazine neuroleptics after chronic coadministration of carbamazepine.
Polish journal of pharmacology.
1998 Nov; 50(6):431-42. doi:
NULL. [PMID: 10385926] - M Schmolke, J Hallbach, W G Guder. False-positive results for urine amphetamine and opiate immunoassays in a patient intoxicated with perazine.
Clinical chemistry.
1996 Oct; 42(10):1725-6. doi:
10.1093/clinchem/42.10.1725. [PMID: 8855170] - U Roelcke, C Hornstein, E Hund, H P Schmitt, R Siess, M Kaltenmaier, J Fassler, H M Meinck. 'Sunbath polyneuritis': subacute axonal neuropathy in perazine-treated patients after intense sun exposure.
Muscle & nerve.
1996 Apr; 19(4):438-41. doi:
10.1002/(sici)1097-4598(199604)19:4<438::aid-mus2>3.0.co;2-d. [PMID: 8622721] - F Heigl, B Heigl, H P Kampfhammer, E Hiller, G Steinbeck. [Chronic recurrent thrombotic thrombocytopenic purpura (Moschcowitz disease). An unusual long-term course in a 43-year-old patient].
Der Internist.
1993 Oct; 34(10):974-80. doi:
NULL. [PMID: 8225848] - W Gaebel, B Müller-Oerlinghausen, J Schley. Early serum levels of neuroleptics do not predict therapeutic response in schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry.
1992; 16(6):891-900. doi:
10.1016/0278-5846(92)90107-p. [PMID: 1355303] - W Daniel. Pharmacokinetic interaction between imipramine and antidepressant neuroleptics in rats.
Polish journal of pharmacology and pharmacy.
1991 May; 43(3):197-206. doi:
. [PMID: 1683700] - M Masiak, J Perzyński, J Nagay, H Marmurowska-Michałowska, M Olajossy, A Wysocka. [Comparative studies of various clinical and psychopharmacological parameters of schizoaffective psychosis and paranoid schizophrenia].
Psychiatria polska.
1990 Sep; 24(5):1-9. doi:
. [PMID: 2131470] - M L Rao. Monitoring of serum bioactivity levels of perazine and its metabolites by radioreceptor assay.
Pharmacopsychiatry.
1989 May; 22(3):104-7. doi:
10.1055/s-2007-1014589. [PMID: 2568642] - U Breyer-Pfaff, M Brinkschulte. Binding of tricyclic psychoactive drugs in plasma: contribution of individual proteins and drug interactions.
Progress in clinical and biological research.
1989; 300(?):351-61. doi:
NULL. [PMID: 2674970] - C Dilger, Z Salama, H Jaeger. High-performance liquid chromatographic determination of trans-doxepin and desmethyldoxepin.
Arzneimittel-Forschung.
1988 Oct; 38(10):1525-8. doi:
NULL. [PMID: 3196396] - C Dilger, Z Salama, H Jaeger. Improved high-performance liquid chromatographic method for the determination of tiotixene in human serum.
Arzneimittel-Forschung.
1988 Oct; 38(10):1522-5. doi:
NULL. [PMID: 3196395] - U Breyer-Pfaff, K Nill, H W Schied, H J Gaertner, H Giedke. Single-dose kinetics of the neuroleptic drug perazine in psychotic patients.
Psychopharmacology.
1988; 95(3):374-7. doi:
10.1007/bf00181950. [PMID: 2901127] - J Schley. Inhibitory effect of phenothiazines on the binding of [3H]perazine to alpha 1-acid glycoprotein.
The Journal of pharmacy and pharmacology.
1987 Feb; 39(2):132-4. doi:
10.1111/j.2042-7158.1987.tb06960.x. [PMID: 2881999] - A Pietzcker, B Müller-Oerlinghausen. The outpatient clinic for patients under chronic lithium or neuroleptic treatment as a phase-IV research tool.
Pharmacopsychiatry.
1984 Sep; 17(5):162-7. doi:
10.1055/s-2007-1017430. [PMID: 6149570] - D Naber, N Nedopil, E Eben. No correlation between neuroleptic-induced increase of beta-endorphin serum level and therapeutic efficacy in schizophrenia.
The British journal of psychiatry : the journal of mental science.
1984 Jun; 144(?):651-3. doi:
10.1192/bjp.144.6.651. [PMID: 6146374] - U Breyer-Pfaff, M Brinkschulte, W Rein, H W Schied, E Straube. Prediction and evaluation criteria in perazine therapy of acute schizophrenics. Pharmacokinetic data.
Pharmacopsychiatria.
1983 Sep; 16(5):160-5. doi:
10.1055/s-2007-1019491. [PMID: 6140695] - W Rein, H W Schied, U Breyer-Pfaff, E Straube. Prediction and evaluation criteria in perazine therapy of acute schizophrenics. Methodological considerations, sample population, and research variables.
Pharmacopsychiatria.
1983 Sep; 16(5):147-51. doi:
10.1055/s-2007-1019489. [PMID: 6140693] - J Schley, B Müller-Oerlinghausen. The binding of chemically different psychotropic drugs to alpha 1-acid glycoprotein.
Pharmacopsychiatria.
1983 May; 16(3):82-5. doi:
10.1055/s-2007-1017454. [PMID: 6611652] - M Brinkschulte, H J Gaertner, H W Schied, U Breyer-Pfaff. Plasma protein binding of perazine and amitriptyline in psychiatric patients.
European journal of clinical pharmacology.
1982; 22(4):367-73. doi:
10.1007/bf00548407. [PMID: 6125396] - A Pietzcker, A Poppenberg, J Schley, B Müller-Oerlinghausen. Outcome and risks of ultra-long-term treatment with an oral neuroleptic drug. Relationship between perazine serum levels and clinical variables in schizophrenic outpatients.
Archiv fur Psychiatrie und Nervenkrankheiten.
1981; 229(4):315-29. doi:
10.1007/bf01833160. [PMID: 6111989] - J Schley, E Riedel, B Müller-Oerlinghausen. [Metabolism and excretion of the neuroleptic drug perazine in healthy volunteers].
International pharmacopsychiatry.
1981; 16(4):201-11. doi:
NULL. [PMID: 6121765] - J Schley, M Siegert, B Müller-Oerlinghausen. Binding of perazine to alpha 1-acid glycoprotein.
European journal of clinical pharmacology.
1980 Nov; 18(6):501-4. doi:
10.1007/bf00874663. [PMID: 6109633] - M Kresse, J Schley, B Müller-Oerlinghausen. Reliable routine method for determination of perazine in serum by thin-layer chromatography with an internal standard.
Journal of chromatography.
1980 Oct; 183(4):475-82. doi:
10.1016/s0378-4347(00)81590-x. [PMID: 6107303] - M Brinkschulte, U Breyer-Pfaff. The contribution of alpha 1-acid glycoprotein, lipoproteins, and albumin to the plasma binding of perazine, amitriptyline, and nortriptyline in healthy man.
Naunyn-Schmiedeberg's archives of pharmacology.
1980 Oct; 314(1):61-6. doi:
10.1007/bf00498432. [PMID: 6108517] - A Kinawi, B Lüth, H Mohamed-Ali. [Determination of the binding of perazine and perazine sulfoxide to human serum albumin].
Archiv der Pharmazie.
1980 May; 313(5):443-8. doi:
10.1002/ardp.19803130508. [PMID: 6105858] - M Brinkschulte, U Breyer-Pfaff. Binding of tricyclic antidepressants and perazine to human plasma. Methodology and findings in normals.
Naunyn-Schmiedeberg's archives of pharmacology.
1979 Jul; 308(1):1-7. doi:
10.1007/bf00499712. [PMID: 40137] - A Kinawi, K Min. [Comparative investigations of the binding of perazine dimalonate (PDM) to human and bovine serum albumin (author's transl)].
Archiv der Pharmazie.
1979 Mar; 312(3):205-13. doi:
10.1002/ardp.19793120306. [PMID: 35132] - J Schley, M Nündel, E Riedel, B Müller-Oerlinghausen. [Specific binding of perazine, a piperazine side-chain phenothiazine drug, to a serum protein (author's transl)].
Arzneimittel-Forschung.
1979; 29(1):106-8. doi:
NULL. [PMID: 36101] - J Schley, E Riedel, B Müller-Oerlinghausen. Determination of perazine serum levels by gas liquid chromatography under clinical routine conditions.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1978 May; 16(5):307-11. doi:
10.1515/cclm.1978.16.5.307. [PMID: 27569] - J Tomaszewski, M Tomaszewska. [Enzymatic pattern of serum and cerebrospinal fluid in children treated with pernazine].
Wiadomosci lekarskie (Warsaw, Poland : 1960).
1978 Apr; 31(8):511-6. doi:
NULL. [PMID: 27013] - U Breyer-Pfaff, H Kreft, H Rassner, A Prox. Formation of sulfone metabolites from chlorpromazine and perazine in man.
Drug metabolism and disposition: the biological fate of chemicals.
1978 Mar; 6(2):114-9. doi:
. [PMID: 26524] - A Pietzcker, B Müller-Oerlinghausen, J Schley, H Chaskel, A Poppenberg, R Urban. [Relationship between perazine serum concentration and clinical results in long-term treated schizophrenic outpatients (author's transl)].
Arzneimittel-Forschung.
1978; 28(8):1302-3. doi:
. [PMID: 37850] - A Hulshoff, J H Perrin. Quantitative correlations between albumin binding constants and chromatographic Rm values of phenothiazine derivatives.
Journal of medicinal chemistry.
1977 Mar; 20(3):430-9. doi:
10.1021/jm00213a022. [PMID: 576620] - U Breyer, W Junginger, D Villumsen. Phenobarbital-induced prolongation of half-life and alteration of distribution of a phenothiazine drug metabolite in the rat.
Biochemical pharmacology.
1976 Dec; 25(23):2623-9. doi:
10.1016/0006-2952(76)90518-9. [PMID: 10928] - F A Vanderheeren, D J Theunis. Gas-liquid chromotographic determination of perazine, thioridazine and thioridazine metabolites in human plasma.
Journal of chromatography.
1976 May; 120(1):123-8. doi:
10.1016/s0021-9673(01)99003-x. [PMID: 5459] - U Breyer, K Villumsen. Measurement of plasma levels of tricylic psychoactive drugs and their metabolites by UV reflectance photometry of thin layer chromatograms.
European journal of clinical pharmacology.
1976 Mar; 09(5-6):457-65. doi:
10.1007/bf00606565. [PMID: 971709] - J Modestin, A Petrin. [Correlation between plasma concentration and clinical effect of neuroleptics and antidepressants].
International journal of clinical pharmacology and biopharmacy.
1976 Jan; 13(1):11-21. doi:
NULL. [PMID: 2561] - F Petruch, R Schüppel, U Breyer. [Changes in drug elimination under the influence of perazine therapy (author's transl)].
Arzneimittel-Forschung.
1976; 26(6):1154-5. doi:
. [PMID: 9113] - U Breyer, F Petruch, H J Gaertner, B Pflug. [Thin-layer chromatographic determination of plasma levels of tricyclic psychopharmacological drugs: first results on their relationship to the clinical activity of neuroleptics (author's transl)].
Arzneimittel-Forschung.
1976; 26(6):1153. doi:
NULL. [PMID: 989405]