guanabenz (BioDeep_00001868273)
Main id: BioDeep_00000001996
代谢物信息卡片
guanabenz
化学式: C8H8Cl2N4 (230.0126)
中文名称: 胍那苄
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
InChI: InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:92998
- ChEBI: CHEBI:5553
- KEGG: C07034
- KEGGdrug: D04375
- PubChem: 5702063
- ChEMBL: CHEMBL420
- MeSH: Guanabenz
- CAS: 60329-03-5
- CAS: 5051-62-7
- PubChem: 9246
- NIKKAJI: J9.632F
- RefMet: Guanabenz
- KNApSAcK: 5553
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Magdalena Kotańska, Joanna Knutelska, Noemi Nicosia, Kamil Mika, Małgorzata Szafarz. Guanabenz-an old drug with a potential to decrease obesity.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 08; 395(8):963-974. doi:
10.1007/s00210-022-02251-1. [PMID: 35511242] - Michihiro Iwaki, Takaomi Kessoku, Kosuke Tanaka, Anna Ozaki, Yuki Kasai, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Masato Yoneda, Noritoshi Kobayashi, Satoru Saito, Atsushi Nakajima. Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study.
BMJ open.
2022 07; 12(7):e060335. doi:
10.1136/bmjopen-2021-060335. [PMID: 35820743] - Jiashu Xie, Rongrong Jiang, Wei Xie, Bin Cao, Swati S More. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies.
Journal of pharmaceutical and biomedical analysis.
2021 Oct; 205(?):114331. doi:
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Brain : a journal of neurology.
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Veterinary therapeutics : research in applied veterinary medicine.
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2002 Jan; 25(1):41-8. doi:
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2002 Jan; 24(1-2):51-63. doi:
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American journal of physiology. Heart and circulatory physiology.
2001 Nov; 281(5):H1881-9. doi:
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2001 Sep; 134(2):295-304. doi:
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Journal of cardiovascular pharmacology.
2001 Jan; 37(1):89-93. doi:
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Cardiovascular drugs and therapy.
2000 Feb; 14(1):61-6. doi:
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1999 Mar; 33(3):409-13. doi:
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1998 Oct; 72(2-3):147-54. doi:
10.1016/s0165-1838(98)00099-x. [PMID: 9851563] - O Grisk, G F Dibona. Influence of arterial baroreceptors and intracerebroventricular guanabenz on synchronized renal nerve activity.
Acta physiologica Scandinavica.
1998 Jul; 163(3):209-18. doi:
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Anesthesia and analgesia.
1993 Mar; 76(3):585-91. doi:
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