hydroxypyruvic acid (BioDeep_00001868161)
Main id: BioDeep_00000004388
PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
3-Hydroxypyruvic acid
化学式: C3H4O4 (104.011)
中文名称: β-羟基丙酮酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)C(=O)O)O
InChI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)
描述信息
A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism.
Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
同义名列表
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:30841
- KEGG: C00168
- PubChem: 964
- DrugBank: DB02951
- ChEMBL: CHEMBL1230192
- CAS: 131000-16-3
- CAS: 1113-60-6
- MetaboLights: MTBLC30841
- ChEBI: CHEBI:17180
- PubChem: 3468
- KNApSAcK: C00007563
- PDB-CCD: 3PY
- 3DMET: B00049
- NIKKAJI: J515.825G
- RefMet: Hydroxypyruvic acid
- medchemexpress: HY-113013
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-274
- KNApSAcK: 17180
- LOTUS: LTS0022279
- wikidata: Q2823271
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 29303 - Streptomyces cattleya: 10.1016/J.CHEMBIOL.2006.02.014
- 5691 - Trypanosoma brucei:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anne Jahn, Maike Petersen. Hydroxy(phenyl)pyruvic acid reductase in Actaea racemosa L.: a putative enzyme in cimicifugic and fukinolic acid biosynthesis.
Planta.
2024 Mar; 259(5):102. doi:
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Diabetes.
2015 Apr; 64(4):1383-94. doi:
10.2337/db14-1188. [PMID: 25368100] - Adam D Lietzan, Martin St Maurice. Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs.
Biochemical and biophysical research communications.
2013 Nov; 441(2):377-82. doi:
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Journal of experimental botany.
2012 Apr; 63(7):2705-16. doi:
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2012 Mar; 63(5):2089-103. doi:
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Plant physiology.
2010 Nov; 154(3):1143-57. doi:
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Physiologia plantarum.
2010 Jun; 139(2):192-204. doi:
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Plant physiology.
2010 Jun; 153(2):611-21. doi:
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The Plant cell.
2010 May; 22(5):1549-63. doi:
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Acta crystallographica. Section D, Biological crystallography.
2010 May; 66(Pt 5):593-603. doi:
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BMC genomics.
2010 Mar; 11(?):190. doi:
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PPAR research.
2010; 2010(?):. doi:
10.1155/2010/542359. [PMID: 20847941] - Itsara Pracharoenwattana, Wenxu Zhou, Steven M Smith. Fatty acid beta-oxidation in germinating Arabidopsis seeds is supported by peroxisomal hydroxypyruvate reductase when malate dehydrogenase is absent.
Plant molecular biology.
2010 Jan; 72(1-2):101-9. doi:
10.1007/s11103-009-9554-2. [PMID: 19812894] - Jianqiang Zhang, Ying Zhang, Ning Li, Zhihong Liu, Changming Xiong, Xinhai Ni, Yaoli Pu, Rutai Hui, Jianguo He, Jielin Pu. Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension.
Respiratory medicine.
2009 Dec; 103(12):1801-6. doi:
10.1016/j.rmed.2009.07.017. [PMID: 19703762] - Wendy L Allan, Shawn M Clark, Gordon J Hoover, Barry J Shelp. Role of plant glyoxylate reductases during stress: a hypothesis.
The Biochemical journal.
2009 Sep; 423(1):15-22. doi:
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BMC genomics.
2009 Aug; 10(?):378. doi:
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Planta.
2009 Feb; 229(3):659-66. doi:
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Molecular plant.
2009 Jan; 2(1):191-200. doi:
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Plant physiology.
2008 Oct; 148(2):786-95. doi:
10.1104/pp.108.122622. [PMID: 18685043] - Stefan Timm, Adriano Nunes-Nesi, Tiit Pärnik, Katja Morgenthal, Stefanie Wienkoop, Olav Keerberg, Wolfram Weckwerth, Leszek A Kleczkowski, Alisdair R Fernie, Hermann Bauwe. A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis.
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PLoS genetics.
2008 Aug; 4(8):e1000164. doi:
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2008 Jun; 2(?):51. doi:
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2008; 59(9):2555-64. doi:
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Genome biology.
2008; 9(11):R165. doi:
10.1186/gb-2008-9-11-r165. [PMID: 19025653] - Pei-Hong Shen, Bo Wu. Over-expression of a hydroxypyruvate reductase in Methylobacterium sp. MB200 enhances glyoxylate accumulation.
Journal of industrial microbiology & biotechnology.
2007 Oct; 34(10):657-63. doi:
10.1007/s10295-007-0238-0. [PMID: 17653579] - Maarten Fauvart, Kristien Braeken, Ruth Daniels, Karen Vos, Maxime Ndayizeye, Jean-Paul Noben, Johan Robben, Jos Vanderleyden, Jan Michiels. Identification of a novel glyoxylate reductase supports phylogeny-based enzymatic substrate specificity prediction.
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2007 Sep; 1774(9):1092-8. doi:
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Analytical biochemistry.
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