Fosphenytoin (BioDeep_00001868067)
Main id: BioDeep_00000006615
代谢物信息卡片
(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate
化学式: C16H15N2O6P (362.0668)
中文名称: 磷苯妥英
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)(O)O)C3=CC=CC=C3
InChI: InChI=1S/C16H15N2O6P/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23/h1-10H,11H2,(H,17,20)(H2,21,22,23)
描述信息
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AB - Hydantoin derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:5165
- KEGG: C07840
- KEGGdrug: D07993
- PubChem: 56339
- DrugBank: DB01320
- ChEMBL: CHEMBL1201336
- CAS: 93390-81-9
- PubChem: 10042
- NIKKAJI: J540.502E
- RefMet: Fosphenytoin
- KNApSAcK: 5165
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shusaku Noro, Yoshinobu Seo, Kaori Honjo, Masahiro Okuma, Bunsho Asayama, Yuki Amano, Masanori Kyono, Kazuya Sako, Hirohiko Nakamura. Intravenous fosphenytoin therapy for rescue of acute trigeminal neuralgia crisis in patients awaiting neurosurgical procedures: A cross-sectional study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 Dec; 94(?):59-64. doi:
10.1016/j.jocn.2021.09.040. [PMID: 34863463] - Abhishek G Sathe, Usha Mishra, Vijay Ivaturi, Richard C Brundage, James C Cloyd, Jordan J Elm, James M Chamberlain, Robert Silbergleit, Jaideep Kapur, Daniel H Lowenstein, Shlomo Shinnar, Hannah R Cock, Nathan B Fountain, Lynn Babcock, Lisa D Coles. Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High-Dose Intravenous Administration in Young Children With Benzodiazepine-Refractory Status Epilepticus.
Journal of clinical pharmacology.
2021 06; 61(6):763-768. doi:
10.1002/jcph.1801. [PMID: 33336359] - S Nishida, Y Hayashi, K Hirai, A Takekoshi, Y Yamada, R Kobayashi, S Shimizu, T Niwa, H Hayashi, T Shimohata, T Sugiyama, A Suzuki. Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy.
Die Pharmazie.
2020 10; 75(10):488-490. doi:
10.1691/ph.2020.0525. [PMID: 33305722] - Kavita Srivastava, Shirish Bhartiya, Vrushabh Gavli, Rahul Patil, Surekha Rajadhyaksha. Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus.
Indian pediatrics.
2020 03; 57(3):218-221. doi:
10.1007/s13312-020-1754-5. [PMID: 32198860] - Kanae Higuchi, Daiki Yamashita, Yushi Kashihara, Makoto Kakara, Takeshi Hirota, Masaaki Hirakawa, Ichiro Ieiri. Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients.
Therapeutic drug monitoring.
2019 10; 41(5):674-680. doi:
10.1097/ftd.0000000000000651. [PMID: 31095070] - Yuta Ohno, Takashi Niwa, Keita Hirai, Keiko Suzuki, Yuto Yamada, Yuichi Hayashi, Hideki Hayashi, Akio Suzuki, Yoshinori Itoh. Time-Dependent Decline in Serum Phenytoin Concentration With Heightened Convulsive Seizure Risk by Prolonged Administration of Fosphenytoin in Japanese: A Retrospective Study.
Therapeutic drug monitoring.
2018 08; 40(4):507-511. doi:
10.1097/ftd.0000000000000521. [PMID: 29683874] - Brady S Moffett, Mindl M Weingarten, Lindsay R Schmees, Marianne Galati, Jennifer Erklauer, James J Riviello. Fosphenytoin Population Pharmacokinetics in the Acutely Ill Pediatric Population.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2018 08; 19(8):748-754. doi:
10.1097/pcc.0000000000001627. [PMID: 29927880] - Ashley B Prusakov, Anup D Patel, Justin W Cole. Impact of Obesity on Fosphenytoin Volume of Distribution in Pediatric Patients.
Journal of child neurology.
2018 07; 33(8):534-536. doi:
10.1177/0883073818770801. [PMID: 29714095] - L Vrignaud, C Simon, M-S Agier, T Bejan-Angoulvant, E Bouquet, F Beau-Salinas, A-P Jonville-Béra. [Drugs news].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2017 Aug; 24(8):783-787. doi:
10.1016/j.arcped.2017.05.008. [PMID: 28668216] - Mindl M Messinger, Brady S Moffett, Angus Wilfong. Impact of Body Habitus on Phenytoin Levels Following Fosphenytoin Loading Dose in Pediatric Patients.
Therapeutic drug monitoring.
2015 Dec; 37(6):772-5. doi:
10.1097/ftd.0000000000000241. [PMID: 26402424] - Dong Wook Kim, Tae-Eun Kim, Misuk Ji, Young Il Chun. Safety, Tolerability, and Pharmacokinetics of Fosphenytoin Loading in Patients With Subarachnoid Hemorrhage.
Clinical neuropharmacology.
2015 Nov; 38(6):248-51. doi:
10.1097/wnf.0000000000000112. [PMID: 26536021] - Lisa D Coles, Ilo E Leppik, Edward E Patterson, Zachary Rivers, Usha Mishra, James C Cloyd. Use of IV fosphenytoin pharmacokinetics to determine the loading dose for a clinical trial of canine status epilepticus.
Epilepsia.
2015 Jun; 56(6):888-94. doi:
10.1111/epi.12961. [PMID: 25952988] - Edward E Patterson, Ilo E Leppik, Lisa D Coles, Michael Podell, Charles H Vite, William Bush, James C Cloyd. Canine status epilepticus treated with fosphenytoin: A proof of principle study.
Epilepsia.
2015 Jun; 56(6):882-7. doi:
10.1111/epi.12994. [PMID: 25953073] - Kevin A Kaucher, Nicole M Acquisto, Gauri G Rao, David C Kaufman, Jeff D Huntress, Alan Forrest, Curtis E Haas. Relative bioavailability of orally administered fosphenytoin sodium injection compared with phenytoin sodium injection in healthy volunteers.
Pharmacotherapy.
2015 May; 35(5):482-8. doi:
10.1002/phar.1589. [PMID: 26011141] - Monika Popławska, Kinga K Borowicz, Stanisław J Czuczwar. The safety and efficacy of fosphenytoin for the treatment of status epilepticus.
Expert review of neurotherapeutics.
2015; 15(9):983-92. doi:
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Neurological research.
2013 Nov; 35(9):984-7. doi:
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European journal of drug metabolism and pharmacokinetics.
2013 Jun; 38(2):139-48. doi:
10.1007/s13318-012-0105-x. [PMID: 22968854] - Jun Tanaka, Hidefumi Kasai, Kenji Shimizu, Shigeki Shimasaki, Yuji Kumagai. Population pharmacokinetics of phenytoin after intravenous administration of fosphenytoin sodium in pediatric patients, adult patients, and healthy volunteers.
European journal of clinical pharmacology.
2013 Mar; 69(3):489-97. doi:
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Journal of medical case reports.
2012 Mar; 6(?):89. doi:
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Expert opinion on drug metabolism & toxicology.
2012 Jan; 8(1):81-91. doi:
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Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.
2011 Jul; 15(3):190-3. doi:
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Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.
2011 Apr; 15(2):126-9. doi:
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Case reports in medicine.
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2010 Mar; 4(?):95. doi:
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2009 Jul; 11(4):231-41. doi:
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British journal of clinical pharmacology.
2008 Oct; 66(4):529-38. doi:
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2008 Oct; 24(10):705-18; quiz 719. doi:
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Neurology.
2008 Jul; 71(1):38-43. doi:
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Neuropsychiatric disease and treatment.
2008 Jun; 4(3):507-23. doi:
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2007 Dec; 22(12):1367-70. doi:
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2006 Dec; 67(12 Suppl 4):S34-8. doi:
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Clinical toxicology (Philadelphia, Pa.).
2006; 44(2):165-8. doi:
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Neurocritical care.
2006; 5(1):71-8. doi:
10.1385/ncc:5:1:71. [PMID: 16960300] - Kevin D McBryde, Jennifer Wilcox, Kanwal K Kher. Hyperphosphatemia due to fosphenytoin in a pediatric ESRD patient.
Pediatric nephrology (Berlin, Germany).
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Annals of emergency medicine.
2004 May; 43(5):605-25. doi:
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Seizure.
2003 Sep; 12(6):330-6. doi:
10.1016/s1059-1311(03)00099-2. [PMID: 12915078] - Bernhards R Ogutu, Charles R J C Newton, Simon N Muchohi, Godfrey O Otieno, Geoffrey Edwards, William M Watkins, Gilbert O Kokwaro. Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus.
British journal of clinical pharmacology.
2003 Jul; 56(1):112-9. doi:
10.1046/j.1365-2125.2003.01829.x. [PMID: 12848783] - Tycho Heimbach, Doo-Man Oh, Lilian Y Li, Markus Forsberg, Jouko Savolainen, Jukka Leppänen, Yasushi Matsunaga, Gordon Flynn, David Fleisher. Absorption rate limit considerations for oral phosphate prodrugs.
Pharmaceutical research.
2003 Jun; 20(6):848-56. doi:
10.1023/a:1023827017224. [PMID: 12817887] - James H Fischer, Tejal V Patel, Patricia A Fischer. Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures.
Clinical pharmacokinetics.
2003; 42(1):33-58. doi:
10.2165/00003088-200342010-00002. [PMID: 12489978] - Bernhards R Ogutu, Charles R J C Newton, Simon N Muchohi, Godfrey O Otieno, Gilbert O Kokwaro. Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration.
British journal of clinical pharmacology.
2002 Dec; 54(6):635-42. doi:
10.1046/j.1365-2125.2002.01689.x. [PMID: 12492612] - Mark T Keegan, Lois R Bondy, Joseph L Blackshear, William L Lanier. Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin.
Mayo Clinic proceedings.
2002 Jun; 77(6):584-6. doi:
10.4065/77.6.584. [PMID: 12059129] - S N Muchohi, G O Kokwaro, T E Maitho, R W Munenge, W M Watkins, G Edwards. Pharmacokinetics of phenytoin following intravenous and intramuscular administration of fosphenytoin and phenytoin sodium in the rabbit.
European journal of drug metabolism and pharmacokinetics.
2002 Apr; 27(2):83-9. doi:
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Clinical chemistry.
2001 May; 47(5):910-8. doi:
10.1093/clinchem/47.5.910. [PMID: 11325896] - F M Pryor, B Gidal, R E Ramsay, J DeToledo, R O Morgan. Fosphenytoin: pharmacokinetics and tolerance of intramuscular loading doses.
Epilepsia.
2001 Feb; 42(2):245-50. doi:
10.1046/j.1528-1157.2001.4220245.x. [PMID: 11240597] - A Dasgupta, E Schlette. Rapid in vitro conversion of fosphenytoin into phenytoin in sera of patients with liver disease: role of alkaline phosphatase.
Journal of clinical laboratory analysis.
2001; 15(5):244-50. doi:
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2000 Nov; 18(4):755-65. doi:
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American journal of clinical pathology.
2000 Jan; 113(1):87-92. doi:
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Clinical chemistry.
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Epilepsia.
1999 Jun; 40(6):777-82. doi:
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American journal of clinical pathology.
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Epilepsia.
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Journal of child neurology.
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Pharmacotherapy.
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