econazole (BioDeep_00001868001)
Main id: BioDeep_00000006656
代谢物信息卡片
econazole
化学式: C18H15Cl3N2O (380.024991)
中文名称: 益康唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
InChI: InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
描述信息
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:82873
- ChEBI: CHEBI:4754
- KEGG: C08068
- KEGGdrug: D03936
- PubChem: 3198
- DrugBank: DB01127
- ChEMBL: CHEMBL808
- MeSH: Econazole
- CAS: 27220-47-9
- PubChem: 10268
- NIKKAJI: J10.724G
- RefMet: Econazole
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhen Liang, Zhen Zhang, Ping Lu, Jingjing Yang, Lei Han, Susu Liu, Tianyang Zhou, Jingguo Li, Junjie Zhang. The effect of charges on the corneal penetration of solid lipid nanoparticles loaded Econazole after topical administration in rabbits.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2023 Aug; 187(?):106494. doi:
10.1016/j.ejps.2023.106494. [PMID: 37315870] - Qiong Li, Siyuan Qin, Hailong Tian, Ruolan Liu, Ling Qiao, Shanshan Liu, Bowen Li, Mei Yang, Jiayan Shi, Edouard C Nice, Jingquan Li, Tingyuan Lang, Canhua Huang. Nano-Econazole Enhanced PD-L1 Checkpoint Blockade for Synergistic Antitumor Immunotherapy against Pancreatic Ductal Adenocarcinoma.
Small (Weinheim an der Bergstrasse, Germany).
2023 Mar; ?(?):e2207201. doi:
10.1002/smll.202207201. [PMID: 36899444] - Arthur Neuberger, Kirill D Nadezhdin, Alexander I Sobolevsky. Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nature communications.
2021 11; 12(1):6284. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Junyuan Zhang, Beibei Liu, Zhen Jiang, Yan Cui, Xingjie Guo. Enantioselective determination of econazole in rat plasma and its application to a pharmacokinetic study.
Analytical biochemistry.
2020 08; 602(?):113791. doi:
10.1016/j.ab.2020.113791. [PMID: 32473119] - Young-Guk Na, Hyun Wook Huh, Min-Ki Kim, Jin-Ju Byeon, Min-Gu Han, Hong-Ki Lee, Cheong-Weon Cho. Development and evaluation of a film-forming system hybridized with econazole-loaded nanostructured lipid carriers for enhanced antifungal activity against dermatophytes.
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The Chinese journal of physiology.
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PloS one.
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Chemical & pharmaceutical bulletin.
2009 Jul; 57(7):680-4. doi:
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Antimicrobial agents and chemotherapy.
2009 Jul; 53(7):3034-41. doi:
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The Journal of pharmacy and pharmacology.
2009 May; 61(5):559-67. doi:
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