Econazole (BioDeep_00000006656)

 

Secondary id: BioDeep_00001868001

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

化学式: C18H15Cl3N2O (380.025)
中文名称: 益康唑
谱图信息: 最多检出来源 Viridiplantae(plant) 53.4%

分子结构信息

SMILES: C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
InChI: InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2

描述信息

Econazole is only found in individuals that have used or taken this drug. It is a broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. [PubChem]Econazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
CONFIDENCE standard compound; INTERNAL_ID 646; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8761; ORIGINAL_PRECURSOR_SCAN_NO 8759
CONFIDENCE standard compound; INTERNAL_ID 646; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8812; ORIGINAL_PRECURSOR_SCAN_NO 8810
CONFIDENCE standard compound; INTERNAL_ID 646; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8821; ORIGINAL_PRECURSOR_SCAN_NO 8819
CONFIDENCE standard compound; INTERNAL_ID 646; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8721; ORIGINAL_PRECURSOR_SCAN_NO 8717
CONFIDENCE standard compound; INTERNAL_ID 646; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8770; ORIGINAL_PRECURSOR_SCAN_NO 8769
CONFIDENCE standard compound; INTERNAL_ID 646; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8808; ORIGINAL_PRECURSOR_SCAN_NO 8805
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

15 个代谢物同义名

1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; Nitrate, econazole; Econazole nitrate; gyno-Pervaryl 150; gyno Pervaryl 150; gyno-Pevaryl; gyno Pevaril; gyno Pevaryl; gyno-Pevaril; GynoPevaril; Spectazole; econazole; Ekonazole; Pevaryl; Econazole



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AHR, ALB, ANXA5, AR, BCL2, CAT, CYP1A1, CYP3A4, ITPR3
Peripheral membrane protein 3 ANXA5, CYP1A1, CYP1B1
Endoplasmic reticulum membrane 8 BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, CYP51A1, HSP90B1, ITPR3
Nucleus 6 AHR, ALB, AR, BCL2, HSP90B1, PLCZ1
cytosol 9 AHR, ALB, ANXA5, AR, BCL2, CAT, HSP90B1, PLCZ1, PRKCQ
centrosome 1 ALB
nucleoplasm 4 AHR, AR, ITPR3, PLCZ1
Cell membrane 3 TRPM2, TRPM3, TRPV5
Multi-pass membrane protein 6 CATSPER3, CYP19A1, ITPR3, TRPM2, TRPM3, TRPV5
Golgi apparatus 1 ALB
lysosomal membrane 1 TRPM2
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 ITPR3
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 1 TRPM2
acrosomal vesicle 1 CATSPER3
plasma membrane 8 AR, CATSPER3, ITPR3, KNG1, PRKCQ, TRPM2, TRPM3, TRPV5
Membrane 13 ANXA5, AR, BCL2, CAT, CYP19A1, CYP1B1, CYP3A4, CYP51A1, HSP90B1, ITPR3, TRPM2, TRPM3, TRPV5
apical plasma membrane 1 TRPV5
brush border 1 ITPR3
extracellular exosome 5 ALB, ANXA5, CAT, HSP90B1, KNG1
endoplasmic reticulum 6 ALB, BCL2, CATSPER3, CYP19A1, HSP90B1, ITPR3
extracellular space 2 ALB, KNG1
perinuclear region of cytoplasm 2 HSP90B1, PLCZ1
mitochondrion 4 BCL2, CAT, CYP1A1, CYP1B1
protein-containing complex 6 AHR, ALB, AR, BCL2, CAT, HSP90B1
intracellular membrane-bounded organelle 5 CAT, CYP1A1, CYP1B1, CYP3A4, CYP51A1
Microsome membrane 5 CYP19A1, CYP1A1, CYP1B1, CYP3A4, CYP51A1
pronucleus 1 PLCZ1
Secreted 1 ALB
extracellular region 5 ALB, ANXA5, CAT, HSP90B1, KNG1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYP51A1
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 AHR
centriolar satellite 1 PRKCQ
motile cilium 1 CATSPER3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
perikaryon 1 TRPM2
cytoplasmic vesicle 1 TRPM2
nucleolus 2 ITPR3, PLCZ1
midbody 1 HSP90B1
apical part of cell 1 ITPR3
Apical cell membrane 1 TRPV5
Cytoplasm, perinuclear region 1 PLCZ1
Mitochondrion inner membrane 1 CYP1A1
pore complex 1 BCL2
focal adhesion 3 ANXA5, CAT, HSP90B1
Peroxisome 1 CAT
sarcoplasmic reticulum 1 ITPR3
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 ANXA5, HSP90B1, KNG1
nuclear speck 1 AR
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 ALB
chromatin 2 AHR, AR
cell projection 1 TRPM2
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
[Isoform 2]: Cell membrane 1 TRPM2
Cell projection, cilium, flagellum membrane 1 CATSPER3
aryl hydrocarbon receptor complex 1 AHR
Cytoplasmic vesicle membrane 1 TRPM2
specific granule membrane 1 TRPM2
tertiary granule membrane 1 TRPM2
Melanosome 1 HSP90B1
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
secretory granule membrane 1 ITPR3
endoplasmic reticulum lumen 3 ALB, HSP90B1, KNG1
platelet alpha granule lumen 2 ALB, KNG1
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
vesicle membrane 1 ANXA5
Sarcoplasmic reticulum lumen 1 HSP90B1
platelet dense tubular network membrane 1 ITPR3
ficolin-1-rich granule membrane 1 TRPM2
[Isoform 1]: Cell membrane 1 TRPM2
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
[Isoform 3]: Cell membrane 1 TRPM2
endocytic vesicle lumen 1 HSP90B1
transport vesicle membrane 1 ITPR3
catalase complex 1 CAT
sperm head 1 PLCZ1
endoplasmic reticulum chaperone complex 1 HSP90B1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
ciliary transition fiber 1 ALB
CatSper complex 1 CATSPER3


文献列表

  • Zhen Liang, Zhen Zhang, Ping Lu, Jingjing Yang, Lei Han, Susu Liu, Tianyang Zhou, Jingguo Li, Junjie Zhang. The effect of charges on the corneal penetration of solid lipid nanoparticles loaded Econazole after topical administration in rabbits. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2023 Aug; 187(?):106494. doi: 10.1016/j.ejps.2023.106494. [PMID: 37315870]
  • Qiong Li, Siyuan Qin, Hailong Tian, Ruolan Liu, Ling Qiao, Shanshan Liu, Bowen Li, Mei Yang, Jiayan Shi, Edouard C Nice, Jingquan Li, Tingyuan Lang, Canhua Huang. Nano-Econazole Enhanced PD-L1 Checkpoint Blockade for Synergistic Antitumor Immunotherapy against Pancreatic Ductal Adenocarcinoma. Small (Weinheim an der Bergstrasse, Germany). 2023 Mar; ?(?):e2207201. doi: 10.1002/smll.202207201. [PMID: 36899444]
  • Arthur Neuberger, Kirill D Nadezhdin, Alexander I Sobolevsky. Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nature communications. 2021 11; 12(1):6284. doi: 10.1038/s41467-021-26608-x. [PMID: 34725357]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Junyuan Zhang, Beibei Liu, Zhen Jiang, Yan Cui, Xingjie Guo. Enantioselective determination of econazole in rat plasma and its application to a pharmacokinetic study. Analytical biochemistry. 2020 08; 602(?):113791. doi: 10.1016/j.ab.2020.113791. [PMID: 32473119]
  • Young-Guk Na, Hyun Wook Huh, Min-Ki Kim, Jin-Ju Byeon, Min-Gu Han, Hong-Ki Lee, Cheong-Weon Cho. Development and evaluation of a film-forming system hybridized with econazole-loaded nanostructured lipid carriers for enhanced antifungal activity against dermatophytes. Acta biomaterialia. 2020 01; 101(?):507-518. doi: 10.1016/j.actbio.2019.10.024. [PMID: 31629894]
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  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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