1,2-dichloroethylene (BioDeep_00001867961)

Main id: BioDeep_00000006347

 


代谢物信息卡片


trans-1,2-Dichloroethylene

化学式: C2H2Cl2 (95.9534)
中文名称: 反-1,2-二氯乙烯, 二氯乙烯, 反式-1,2-二氯乙烯, 1,2-二氯乙烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(=CCl)Cl
InChI: InChI=1S/C2H2Cl2/c3-1-2-4/h1-2H/b2-1+



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, CAT, CYP1A1, CYP2B6, CYP2E1, CYP3A4, GZMB, HPGDS, PMP2, PSMA1
Peripheral membrane protein 3 CYP1A1, CYP2B6, CYP2E1
Endoplasmic reticulum membrane 5 CYP1A1, CYP1A2, CYP2B6, CYP2E1, CYP3A4
Nucleus 8 ALB, CENPB, FEN1, GZMB, H2AX, PMP2, PSMA1, TCEA1
cytosol 7 ALB, CAT, GCLM, GZMB, HPGDS, PMP2, PSMA1
nuclear body 1 CENPB
centrosome 3 ALB, H2AX, PSMA1
nucleoplasm 6 CENPB, FEN1, H2AX, HPGDS, PSMA1, TCEA1
Cell membrane 1 SLC3A1
Golgi apparatus 2 ALB, ATRN
mitochondrial inner membrane 2 CYP1A1, CYP2E1
plasma membrane 2 ATRN, SLC3A1
Membrane 5 CAT, CYP3A4, FEN1, GZMB, SLC3A1
apical plasma membrane 1 SLC3A1
extracellular exosome 7 ALB, ATRN, CAT, H2AX, PMP2, PSMA1, SLC3A1
endoplasmic reticulum 1 ALB
extracellular space 3 ALB, ATRN, TAC4
perinuclear region of cytoplasm 1 INF2
mitochondrion 3 CAT, CYP1A1, FEN1
protein-containing complex 3 ALB, CAT, FEN1
intracellular membrane-bounded organelle 8 CAT, CYP1A1, CYP1A2, CYP2B6, CYP2E1, CYP3A4, GZMB, HPGDS
Microsome membrane 5 CYP1A1, CYP1A2, CYP2B6, CYP2E1, CYP3A4
pericentric heterochromatin 1 CENPB
Single-pass type I membrane protein 1 ATRN
Secreted 3 ALB, GZMB, TAC4
extracellular region 3 ALB, CAT, GZMB
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
nucleolus 2 FEN1, TCEA1
Single-pass type II membrane protein 1 SLC3A1
Apical cell membrane 1 SLC3A1
Cytoplasm, perinuclear region 1 INF2
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
nuclear speck 1 H2AX
ciliary basal body 1 ALB
Chromosome 2 CENPB, H2AX
centriole 1 ALB
brush border membrane 1 SLC3A1
Nucleus, nucleolus 1 FEN1
spindle pole 1 ALB
chromosome, telomeric region 1 FEN1
condensed chromosome, centromeric region 1 CENPB
actin filament 1 INF2
blood microparticle 1 ALB
site of double-strand break 1 H2AX
[Isoform 3]: Secreted 1 ATRN
Chromosome, centromere 1 CENPB
Nucleus, nucleoplasm 1 FEN1
replication fork 1 H2AX
myelin sheath 1 PMP2
ficolin-1-rich granule lumen 1 CAT
proteasome complex 1 PSMA1
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 ALB
male germ cell nucleus 1 H2AX
transcription factor TFIID complex 1 TCEA1
platelet alpha granule lumen 1 ALB
XY body 1 H2AX
immunological synapse 1 GZMB
condensed nuclear chromosome 1 H2AX
chromosome, centromeric region 1 CENPB
proteasome core complex 1 PSMA1
proteasome core complex, alpha-subunit complex 1 PSMA1
[Isoform 1]: Cell membrane 1 ATRN
nucleosome 1 H2AX
site of DNA damage 1 H2AX
catalase complex 1 CAT
vacuolar membrane 1 SLC3A1
Cytolytic granule 1 GZMB
cytolytic granule lumen 1 GZMB
[Isoform FENMIT]: Mitochondrion 1 FEN1
glutamate-cysteine ligase complex 1 GCLM
ciliary transition fiber 1 ALB


文献列表

  • Othman Al-Hanbali, Nneka M Onwuzo, Kenneth J Rutt, Christopher M Dadswell, S Moein Moghimi, A Christy Hunter. Modification of the Stewart biphasic colorimetric assay for stable and accurate quantitative determination of Pluronic and Tetronic block copolymers for application in biological systems. Analytical biochemistry. 2007 Feb; 361(2):287-93. doi: 10.1016/j.ab.2006.11.028. [PMID: 17196543]
  • Samuel M Poloyac, Michael A Tortorici, Danielle I Przychodzin, Robert B Reynolds, Wen Xie, Reginald F Frye, Michael A Zemaitis. The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. Drug metabolism and disposition: the biological fate of chemicals. 2004 Jul; 32(7):727-33. doi: 10.1124/dmd.32.7.727. [PMID: 15205388]
  • Nancy B Ress. NTP Technical Report on the toxicity studies of trans-1,2-dichloroethylene (CAS no. 156-60-5) administered in microcapsules in feed to F344/N rats and B6C3F(1) mice. Toxicity report series. 2002 Apr; ?(55):1-F12. doi: . [PMID: 12118262]
  • P T McCauley, M Robinson, F B Daniel, G R Olson. The effects of subacute and subchronic oral exposure to cis-1,2-dichloroethylene in Sprague-Dawley rats. Drug and chemical toxicology. 1995 May; 18(2-3):171-84. doi: 10.3109/01480549509014319. [PMID: 7497910]
  • M Paolini, R Mesirca, L Pozzetti, A Sapone, G Cantelli-Forti. Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers. Chemico-biological interactions. 1995 Mar; 95(1-2):127-39. doi: 10.1016/0009-2797(94)03352-8. [PMID: 7697745]
  • S N Lin, F W Fu, J V Bruckner. Quantitation of 1,1- and 1,2-dichloroethylene in body tissues by purge-and-trap gas chromatography. Journal of chromatography. 1982 Jul; 244(2):311-20. doi: 10.1016/s0021-9673(00)85695-2. [PMID: 7119076]
  • A Galli, C Bauer, G Bronzetti, C Corsi, R Del Carratore, R Nieri, M Paolini. [Genetic activity of 1,2-dichloroethylene. B). In vivo studies: effect on microsomal enzymes]. Bollettino della Societa italiana di biologia sperimentale. 1982 Jul; 58(13):864-9. doi: . [PMID: 7126360]