Framycetin (BioDeep_00001867660)

Main id: BioDeep_00000003472

 

Chemicals and Drugs


代谢物信息卡片


Framycetin

化学式: C23H46N6O13 (614.3122705999999)
中文名称: 新霉素B
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
InChI: InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

描述信息

A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05C - Irrigating solutions > B05CA - Antiinfectives
D - Dermatologicals > D09 - Medicated dressings > D09A - Medicated dressings > D09AA - Medicated dressings with antiinfectives
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06A - Antibiotics for topical use
S - Sensory organs > S03 - Ophthalmological and otological preparations > S03A - Antiinfectives > S03AA - Antiinfectives
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations > R02AB - Antibiotics
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
S - Sensory organs > S02 - Otologicals > S02A - Antiinfectives > S02AA - Antiinfectives
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

1 个代谢物同义名

Framycetin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lingbing Zhang, Yandan Zhang, Xuejun Jiang, Lejiao Mao, Yinyin Xia, Yinzhen Fan, Na Li, Ziqi Jiang, Xia Qin, Yu Jiang, Gang Liu, Feng Qiu, Jun Zhang, Zhen Zou, Chengzhi Chen. Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles. Toxicology. 2023 02; 485(?):153390. doi: 10.1016/j.tox.2022.153390. [PMID: 36535435]
  • Paula V Huertas-Abril, María-José Prieto-Álamo, Juan Jurado, Tamara García-Barrera, Nieves Abril. A selenium-enriched diet helps to recover liver function after antibiotic administration in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113519. doi: 10.1016/j.fct.2022.113519. [PMID: 36464106]
  • Varsha Saini, Devashish Mehta, Siddhi Gupta, Sandeep Kumar, Parul Rani, Kajal Rana, Kajal Rajput, Dolly Jain, Garima Pal, Bharti Aggarwal, Sanjay Pal, Sonu K Gupta, Yashwant Kumar, Vemanna S Ramu, Avinash Bajaj. Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid-Peptide Conjugates. Journal of medicinal chemistry. 2022 11; 65(22):15312-15326. doi: 10.1021/acs.jmedchem.2c01293. [PMID: 36331380]
  • Rikeshwer Prasad Dewangan, Devesh Pratap Verma, Neeraj Kumar Verma, Ankit Gupta, Garima Pant, Kalyan Mitra, Saman Habib, Jimut Kanti Ghosh. Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents. Journal of medicinal chemistry. 2022 04; 65(7):5433-5448. doi: 10.1021/acs.jmedchem.1c01809. [PMID: 35297625]
  • Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang. Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice. Toxicology. 2022 02; 467(?):153088. doi: 10.1016/j.tox.2021.153088. [PMID: 34979169]
  • Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Journal of natural products. 2021 03; 84(3):750-761. doi: 10.1021/acs.jnatprod.0c00946. [PMID: 33226219]
  • Zhi Xu. 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). European journal of medicinal chemistry. 2020 Nov; 206(?):112686. doi: 10.1016/j.ejmech.2020.112686. [PMID: 32795773]
  • Moriah Jospe-Kaufman, Liza Siomin, Micha Fridman. The relationship between the structure and toxicity of aminoglycoside antibiotics. Bioorganic & medicinal chemistry letters. 2020 07; 30(13):127218. doi: 10.1016/j.bmcl.2020.127218. [PMID: 32360102]
  • Xiaoxiao Liu, Yanzhuo Liu, Xuewei Chen, Chenlong Wang, Xuehan Chen, Wen Liu, Keqing Huang, Honglei Chen, Jing Yang. Multi-walled carbon nanotubes exacerbate doxorubicin-induced cardiotoxicity by altering gut microbiota and pulmonary and colonic macrophage phenotype in mice. Toxicology. 2020 04; 435(?):152410. doi: 10.1016/j.tox.2020.152410. [PMID: 32068018]
  • Ayush Jain, Bhupinder Singh Kalra, Siddharth Srivastava, Shalini Chawla. Effect of sofosbuvir and daclatasvir on lipid profile, glycemic control and quality of life index in chronic hepatitis C, genotype 3 patients. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 2019 Feb; 38(1):39-43. doi: 10.1007/s12664-019-00935-w. [PMID: 30710219]
  • Youn Hee Nam, Isabel Rodriguez, Seo Yeon Jeong, Thu Nguyen Minh Pham, Wanlapa Nuankaew, Yun Hee Kim, Rodrigo Castañeda, Seo Yule Jeong, Min Seon Park, Kye Wan Lee, Jung Suk Lee, Do Hoon Kim, Yu Hwa Park, Seung Hyun Kim, In Seok Moon, Se-Young Choung, Bin Na Hong, Kwang Won Jeong, Tong Ho Kang. Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes. Nutrients. 2019 Jan; 11(1):. doi: 10.3390/nu11010113. [PMID: 30626089]
  • Yanli Wu, Yongdong Feng, Yanling Li, Yiping Xu, Nian Shi, Guo-Fu Hu, Yunxia Wu. Sub-chronic 90-day toxicity of neamine in SD rats and its anti-liver cancer activity in vitro and in vivo. Toxicology and applied pharmacology. 2017 Jan; 315(?):50-59. doi: 10.1016/j.taap.2016.12.006. [PMID: 27940282]
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  • Guillaume Sautrey, Micheline El Khoury, Andreia Giro Dos Santos, Louis Zimmermann, Magali Deleu, Laurence Lins, Jean-Luc Décout, Marie-Paule Mingeot-Leclercq. Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY. The Journal of biological chemistry. 2016 Jun; 291(26):13864-74. doi: 10.1074/jbc.m115.665364. [PMID: 27189936]
  • Yaping Liu, Xiaoyan Zhang, Songlin An, Yanli Wu, Guofu Hu, Yunxia Wu. Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. Cancer chemotherapy and pharmacology. 2015 Mar; 75(3):465-74. doi: 10.1007/s00280-014-2658-7. [PMID: 25552400]
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  • Vinay Lomash, Satish C Pant. A novel decontaminant and wound healant formulation of N,N'-dichloro-bis[2,4,6-trichlorophenyl]urea against sulfur mustard-induced skin injury. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2014 Jan; 22(1):85-95. doi: 10.1111/wrr.12126. [PMID: 24393156]
  • Benedikt Huttner, Thomas Haustein, Ilker Uçkay, Gesuele Renzi, Andrew Stewardson, Danièle Schaerrer, Americo Agostinho, Antoine Andremont, Jacques Schrenzel, Didier Pittet, Stephan Harbarth. Decolonization of intestinal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae with oral colistin and neomycin: a randomized, double-blind, placebo-controlled trial. The Journal of antimicrobial chemotherapy. 2013 Oct; 68(10):2375-82. doi: 10.1093/jac/dkt174. [PMID: 23719234]
  • Bernhard Westermann, Simon Dörner, Sebastian Brauch, Angela Schaks, Ramona Heinke, Sebastian Stark, Floris L van Delft, Sander S van Berkel. CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides. Carbohydrate research. 2013 Apr; 371(?):61-7. doi: 10.1016/j.carres.2013.02.003. [PMID: 23507494]
  • Smritilekha Bera, Ramesh Dhondikubeer, Brandon Findlay, George G Zhanel, Frank Schweizer. Synthesis and antibacterial activities of amphiphilic neomycin B-based bilipid conjugates and fluorinated neomycin B-based lipids. Molecules (Basel, Switzerland). 2012 Aug; 17(8):9129-41. doi: 10.3390/molecules17089129. [PMID: 22858839]
  • V Lomash, S E Jadhav, F Ahmed, R Vijayaraghavan, S C Pant. Evaluation of wound-healing formulation against sulphur mustard-induced skin injury in mice. Human & experimental toxicology. 2012 Jun; 31(6):588-605. doi: 10.1177/0960327111429139. [PMID: 22144726]
  • Kathryn M Onesios, Edward J Bouwer. Biological removal of pharmaceuticals and personal care products during laboratory soil aquifer treatment simulation with different primary substrate concentrations. Water research. 2012 May; 46(7):2365-75. doi: 10.1016/j.watres.2012.02.001. [PMID: 22374299]
  • Mathieu Mével, Matthieu Sainlos, Benoît Chatin, Noufissa Oudrhiri, Michèle Hauchecorne, Olivier Lambert, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard, Jean-Marie Lehn. Paromomycin and neomycin B derived cationic lipids: synthesis and transfection studies. Journal of controlled release : official journal of the Controlled Release Society. 2012 Mar; 158(3):461-9. doi: 10.1016/j.jconrel.2011.12.019. [PMID: 22226775]
  • G M Lingaraju, V Krishna, H Joy Hoskeri, K Pradeepa, Venkatesh, P Suresh Babu. Wound healing promoting activity of stem bark extract of Semecarpus anacardium using rats. Natural product research. 2012; 26(24):2344-7. doi: 10.1080/14786419.2012.656108. [PMID: 22324385]
  • Myriam Ouberai, Farid El Garch, Antoine Bussiere, Mickael Riou, David Alsteens, Laurence Lins, Isabelle Baussanne, Yves F Dufrêne, Robert Brasseur, Jean-Luc Decout, Marie-Paule Mingeot-Leclercq. The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative?. Biochimica et biophysica acta. 2011 Jun; 1808(6):1716-27. doi: 10.1016/j.bbamem.2011.01.014. [PMID: 21291859]
  • Dhananjoy Mondal, George G Zhanel, Frank Schweizer. Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants. Carbohydrate research. 2011 Apr; 346(5):588-94. doi: 10.1016/j.carres.2011.01.025. [PMID: 21316648]
  • Smritilekha Bera, George G Zhanel, Frank Schweizer. Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates. The Journal of antimicrobial chemotherapy. 2010 Jun; 65(6):1224-7. doi: 10.1093/jac/dkq083. [PMID: 20332193]
  • Rajeev B Ahuja, Amit Gupta, Renu Gur. A prospective double-blinded comparative analysis of framycetin and silver sulphadiazine as topical agents for burns: a pilot study. Burns : journal of the International Society for Burn Injuries. 2009 Aug; 35(5):672-6. doi: 10.1016/j.burns.2008.08.015. [PMID: 19443125]
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  • Smritilekha Bera, George G Zhanel, Frank Schweizer. Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: polycationic lipids with potent gram-positive activity. Journal of medicinal chemistry. 2008 Oct; 51(19):6160-4. doi: 10.1021/jm800345u. [PMID: 18778047]
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  • Euisoon Jeong, Mitsuyo Hirai, Makoto Shoda. Removal of o-xylene using biofilter inoculated with Rhodococcus sp. BTO62. Journal of hazardous materials. 2008 Mar; 152(1):140-7. doi: 10.1016/j.jhazmat.2007.06.078. [PMID: 17681689]
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