Saponin V (BioDeep_00001867486)

Main id: BioDeep_00000000288

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid

化学式: C48H76O19 (956.4981)
中文名称: 人参皂苷 Ro, 人参皂苷Ro
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)CC[C@]2(C(=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]6O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1
InChI: InChI=1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1

描述信息

Chikusetsusaponin-V is a triterpenoid saponin. It has a role as a metabolite.
Ginsenoside Ro is a natural product found in Panax vietnamensis, Bassia indica, and other organisms with data available.
See also: Asian Ginseng (part of).
A natural product found in Panax japonicus var. major.
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet effect with an IC50 of 155 ?μM. Ginsenoside Ro reduces the production of TXA2 more than it reduces the activities of COX-1 and TXAS.
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet effect with an IC50 of 155 ?μM. Ginsenoside Ro reduces the production of TXA2 more than it reduces the activities of COX-1 and TXAS.

同义名列表

19 个代谢物同义名

(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid; 6-[[4,4,6a,6b,11,11,14b-Heptamethyl-8a-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4-dihydroxy-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid; .BETA.-D-GLUCOPYRANOSIDURONIC ACID, (3.BETA.)-28-(.BETA.-D-GLUCOPYRANOSYLOXY)-28-OXOOLEAN-12-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; beta-D-Glucopyranosiduronic acid, (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-beta-D-glucopyranosyl-; 28-O-glucopyranosyl-3-O-glucopyranosyl-1-2-glucopyranosyloleanate; Chikusetsusaponin-V; Chikusetsusaponin 5; Chikusetsusaponin V; Hericiumsaponin S3; UNII-OF1PLT74Q8; Ginsenoside Ro; ginsenoside-Ro; Ginsenoside R0; GINSENOSIDERO; Ginsenoside; OF1PLT74Q8; Saponin V; Polysciasaponin P3; Chikusetsusaponin V



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AIMP2, BCL2, DNMT3A, MAPK8, PIK3CA, PKM, PTGS2, RB1, SIRT1, STAT3, TLR4
Peripheral membrane protein 3 GORASP1, HK2, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 10 AIMP2, BCL2, DNMT3A, MAPK8, PKM, PPARGC1A, RB1, RBL2, SIRT1, STAT3
cytosol 12 AIMP2, BCL2, GPT, HK2, MAPK8, PIK3CA, PKM, PPARGC1A, RB1, RBL2, SIRT1, STAT3
centrosome 1 HK2
nucleoplasm 7 DNMT3A, MAPK8, PPARGC1A, RB1, RBL2, SIRT1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 ITGAM, TLR4, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell surface 3 ITGAM, TLR4, TNF
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
neuronal cell body 1 TNF
Cytoplasm, cytosol 2 AIMP2, HK2
plasma membrane 6 F2, ITGAM, PIK3CA, STAT3, TLR4, TNF
Membrane 5 AIMP2, BCL2, HK2, ITGAM, TLR4
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 5 F2, GPT, ITGAM, PKM, RBL2
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 4 F2, IL6, ITGAM, TNF
perinuclear region of cytoplasm 2 PIK3CA, TLR4
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, HK2, PKM, SIRT1
protein-containing complex 2 BCL2, PTGS2
intracellular membrane-bounded organelle 1 HK2
Microsome membrane 1 PTGS2
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 2 ITGAM, TLR4
Secreted 3 F2, HK2, IL6
extracellular region 4 F2, IL6, PKM, TNF
Mitochondrion outer membrane 2 BCL2, HK2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HK2
transcription regulator complex 2 RBL2, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ITGAM, TLR4, TNF
Extracellular vesicle 1 PKM
nucleolus 2 RBL2, SIRT1
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 PKM
heterochromatin 2 DNMT3A, SIRT1
Membrane raft 2 ITGAM, TNF
pore complex 1 BCL2
spindle 1 RB1
cis-Golgi network 1 GORASP1
sarcoplasmic reticulum 1 HK2
Nucleus, PML body 2 PPARGC1A, SIRT1
PML body 3 PPARGC1A, RB1, SIRT1
collagen-containing extracellular matrix 2 F2, PKM
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
cilium 1 PKM
chromatin 5 PPARGC1A, RB1, RBL2, SIRT1, STAT3
phagocytic cup 2 TLR4, TNF
Chromosome 2 DNMT3A, RBL2
blood microparticle 1 F2
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
euchromatin 2 DNMT3A, SIRT1
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 1 PKM
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, IL6, PTGS2
nuclear matrix 1 DNMT3A
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
XY body 1 DNMT3A
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
SWI/SNF complex 1 RB1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
chromosome, centromeric region 1 DNMT3A
[Isoform 1]: Nucleus 1 PPARGC1A
basal dendrite 1 MAPK8
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Rough endoplasmic reticulum 1 PKM
integrin complex 1 ITGAM
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
integrin alphaM-beta2 complex 1 ITGAM
catalytic complex 1 DNMT3A
interleukin-6 receptor complex 1 IL6
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
BAD-BCL-2 complex 1 BCL2
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun. Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. European journal of medicinal chemistry. 2021 Jan; 209(?):112932. doi: 10.1016/j.ejmech.2020.112932. [PMID: 33131725]
  • Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zhao. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. 2020 Sep; 882(?):173272. doi: 10.1016/j.ejphar.2020.173272. [PMID: 32535096]
  • Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang. Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome. Frontiers of medicine. 2020 Jun; 14(3):335-356. doi: 10.1007/s11684-019-0705-9. [PMID: 31749036]
  • Si-Wen Zheng, Sheng-Yuan Xiao, Jia Wang, Wei Hou, Ying-Ping Wang. Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites. Molecules (Basel, Switzerland). 2019 Aug; 24(16):. doi: 10.3390/molecules24162985. [PMID: 31426477]
  • Peihe Zheng, Yinbin Chen, Yangyang Fu, Hecheng Wang, Jia Wang, Siwen Zheng, Shengyuan Xiao, Yingping Wang. Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration. Journal of medicinal food. 2017 Nov; 20(11):1127-1132. doi: 10.1089/jmf.2017.3922. [PMID: 28880748]
  • Zhou Jiang, Jun Qian, Haiyan Dong, Jingyi Yang, Xiaobo Yu, Jianzhong Chen, Hongning Chen, Qing Shi, Lee Jia. The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology. Scientific reports. 2017 06; 7(1):3888. doi: 10.1038/s41598-017-02054-y. [PMID: 28634392]
  • Keisuke Tomohara, Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi. Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions. Bioorganic & medicinal chemistry letters. 2017 04; 27(7):1620-1623. doi: 10.1016/j.bmcl.2017.01.083. [PMID: 28202328]
  • Yujie Chen, Zhongzhen Zhao, Hubiao Chen, Tao Yi, Minjian Qin, Zhitao Liang. Chemical differentiation and quality evaluation of commercial Asian and American ginsengs based on a UHPLC-QTOF/MS/MS metabolomics approach. Phytochemical analysis : PCA. 2015 Mar; 26(2):145-60. doi: 10.1002/pca.2546. [PMID: 25448530]
  • Jung-Yeon Han, Min-Jun Kim, Yong-Wook Ban, Hwan-Su Hwang, Yong-Eui Choi. The involvement of β-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginseng. Plant & cell physiology. 2013 Dec; 54(12):2034-46. doi: 10.1093/pcp/pct141. [PMID: 24092881]
  • Xingxing Dai, Xinyuan Shi, Yuguang Wang, Yanjiang Qiao. Solubilization of saikosaponin a by ginsenoside Ro biosurfactant in aqueous solution: mesoscopic simulation. Journal of colloid and interface science. 2012 Oct; 384(1):73-80. doi: 10.1016/j.jcis.2012.06.018. [PMID: 22818794]
  • Kazuya Murata, Fumiaki Takeshita, Keiichi Samukawa, Tadato Tani, Hideaki Matsuda. Effects of ginseng rhizome and ginsenoside Ro on testosterone 5α-reductase and hair re-growth in testosterone-treated mice. Phytotherapy research : PTR. 2012 Jan; 26(1):48-53. doi: 10.1002/ptr.3511. [PMID: 21538628]
  • Juan Li, Ping Li, Hui-Jun Li, Yue Song, Zhi-Ming Bi, Yan-Jing Li. Simultaneous qualification and quantification of eight triterpenoids in radix achyranthis bidentatae by high-performance liquid chromatography with evaporative light scattering detection and mass spectrometric detection. Journal of separation science. 2007 Apr; 30(6):843-50. doi: 10.1002/jssc.200600341. [PMID: 17536729]
  • Kun Zou, Zhao-xia Liu, Shu Zhu, Shao-qing Cai, Katsuko Komatsu. [Research of ginsenosides in kou zi qi using HPLC-MS-MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2004 May; 39(5):385-8. doi: ". [PMID: 15338885]
  • H Matsuda, K Samukawa, M Kubo. Anti-hepatitic activity of ginsenoside Ro. Planta medica. 1991 Dec; 57(6):523-6. doi: . [PMID: 1818342]
  • A Dini, L Rastrelli, P Saturnino, O Schettino. [Minor components in food plants--II. Triterpenoid saponins from Ullucus tuberosus]. Bollettino della Societa italiana di biologia sperimentale. 1991 Dec; 67(12):1059-65. doi: ". [PMID: 1840798]
  • S M Swanson, J X Jiang, Y S Chang, N J De Souza, J M Pezzuto. A rapid and sensitive bioassay involving cultured rat glioma cells to screen for substances capable of elevating intracellular cyclic AMP concentration. Journal of natural products. 1988 Sep; 51(5):929-36. doi: 10.1021/np50059a019. [PMID: 2849641]