Ginsenoside (BioDeep_00001867470)
Main id: BioDeep_00000377020
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C36H62O9 (638.4394)
中文名称: 人参皂苷 F1, 人参皂甙F1, 人参皂苷F1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)O)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C
InChI: InChI=1S/C36H62O9/c1-19(2)10-9-13-36(8,45-31-29(43)28(42)27(41)23(18-37)44-31)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(40)32(3,4)30(33)22(39)17-35(24,34)7/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31-,33+,34+,35+,36-/m0/s1
描述信息
Ginsenoside F1 is a ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite and an apoptosis inhibitor. It is a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a beta-D-glucoside, a ginsenoside, a tetracyclic triterpenoid, a 6alpha-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
Ginsenoside F1 is a natural product found in Panax ginseng, Panax notoginseng, and Gynostemma yixingense with data available.
A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.
Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.
同义名列表
9 个代谢物同义名
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2S)-6-methyl-2-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,6,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-en-2-yl]oxyoxane-3,4,5-triol; (beta,6alpha,12beta)-3,6,12-trihydroxydammar-24-en-20-yl beta-D-glucopyranoside; Ginsenoside F1, >=98\\% (HPLC); 20(S)-ginsenoside F1; (20S)-ginsenoside F1; ginsenoside G-F1; Ginsenoside F1; GINSENOSIDEF1; Ginsenoside
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:77150
- KEGG: C20780
- PubChem: 9809542
- ChEMBL: CHEMBL584011
- MeSH: ginsenoside F1
- chemspider: 7985298
- CAS: 53963-43-2
- medchemexpress: HY-N0598
- MetaboLights: MTBLC77150
- PubChem: 254741247
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
- 555433 - Gynostemma yixingense: 10.1016/J.FITOTE.2009.09.009
- 4054 - Panax ginseng:
- 4054 - Panax ginseng C. A. Mey.: -
- 44586 - Panax notoginseng:
- 44586 - Panax Notoginseng (Burk.) F. H. Chen Ex C. Chow: -
- 33090 - Plants: -
- 4054 - 人参叶: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Danni Feng, Zhongxiang Fang, Pangzhen Zhang. The melanin inhibitory effect of plants and phytochemicals: A systematic review.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Dec; 107(?):154449. doi:
10.1016/j.phymed.2022.154449. [PMID: 36126406] - Chang-Hao Cui, Byeong-Min Jeon, Yaoyao Fu, Wan-Taek Im, Sun-Chang Kim. High-density immobilization of a ginsenoside-transforming β-glucosidase for enhanced food-grade production of minor ginsenosides.
Applied microbiology and biotechnology.
2019 Sep; 103(17):7003-7015. doi:
10.1007/s00253-019-09951-4. [PMID: 31289903] - Jiayan Zhang, Mingqun Liu, Maohua Huang, Minfeng Chen, Dong Zhang, Liangping Luo, Geni Ye, Lijuan Deng, Yinghui Peng, Xin Wu, Guanping Liu, Wencai Ye, Dongmei Zhang. Ginsenoside F1 promotes angiogenesis by activating the IGF-1/IGF1R pathway.
Pharmacological research.
2019 06; 144(?):292-305. doi:
10.1016/j.phrs.2019.04.021. [PMID: 31048033] - Ji In Kang, Yoonjung Choi, Chang-Hau Cui, Daeyoup Lee, Sun Chang Kim, Ho Min Kim. Pro-angiogenic Ginsenosides F1 and Rh1 Inhibit Vascular Leakage by Modulating NR4A1.
Scientific reports.
2019 03; 9(1):4502. doi:
10.1038/s41598-019-41115-2. [PMID: 30872732] - Yin-Ping Guo, Man-Yun Chen, Li Shao, Wei Zhang, Tai Rao, Hong-Hao Zhou, Wei-Hua Huang. Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS.
Chinese journal of natural medicines.
2019 Mar; 17(3):231-240. doi:
10.1016/s1875-5364(19)30026-3. [PMID: 30910060] - Xiu-Wei Yang, Li-Yuan Ma, Qi-Le Zhou, Wei Xu, You-Bo Zhang. SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng.
Bioorganic & medicinal chemistry letters.
2018 02; 28(3):240-243. doi:
10.1016/j.bmcl.2017.12.067. [PMID: 29317167] - Wei Wei, Pingping Wang, Yongjun Wei, Qunfang Liu, Chengshuai Yang, Guoping Zhao, Jianmin Yue, Xing Yan, Zhihua Zhou. Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.
Molecular plant.
2015 Sep; 8(9):1412-24. doi:
10.1016/j.molp.2015.05.010. [PMID: 26032089] - Xuewei Ye, Siran Yu, Ying Liang, Haocai Huang, Xiao-Yuan Lian, Zhizhen Zhang. Bioactive triterpenoid saponins and phenolic compounds against glioma cells.
Bioorganic & medicinal chemistry letters.
2014 Nov; 24(22):5157-63. doi:
10.1016/j.bmcl.2014.09.087. [PMID: 25442304] - Xue Li, Jinping Hu, Baolian Wang, Li Sheng, Zhihao Liu, Shuang Yang, Yan Li. Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp.
Toxicology and applied pharmacology.
2014 Mar; 275(2):163-75. doi:
10.1016/j.taap.2013.12.015. [PMID: 24380838] - Xin Liu, Lirui Qiao, Dan Xie, Yi Zhang, Jianhua Zou, Xiaoguang Chen, Jungui Dai. Microbial transformation of ginsenoside-Rg₁ by Absidia coerulea and the reversal activity of the metabolites towards multi-drug resistant tumor cells.
Fitoterapia.
2011 Dec; 82(8):1313-7. doi:
10.1016/j.fitote.2011.09.001. [PMID: 21946057] - Liang Feng, Chang-Jiang Hu, Ling-Ying Yu. [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 May; 45(5):636-40. doi:
NULL. [PMID: 20931768] - Huu Tung Nguyen, Gyu Yong Song, Jeong-Ah Kim, Jae-Hee Hyun, Hee-Kyoung Kang, Young Ho Kim. Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells.
Bioorganic & medicinal chemistry letters.
2010 Jan; 20(1):309-14. doi:
10.1016/j.bmcl.2009.10.110. [PMID: 19926279] - Mona Abdel Tawab, Ute Bahr, Michael Karas, Mario Wurglics, Manfred Schubert-Zsilavecz. Degradation of ginsenosides in humans after oral administration.
Drug metabolism and disposition: the biological fate of chemicals.
2003 Aug; 31(8):1065-71. doi:
10.1124/dmd.31.8.1065. [PMID: 12867496] - Sung-Ryong Ko, Kang-Ju Choi, Kei Suzuki, Yukio Suzuki. Enzymatic preparation of ginsenosides Rg2, Rh1, and F1.
Chemical & pharmaceutical bulletin.
2003 Apr; 51(4):404-8. doi:
10.1248/cpb.51.404. [PMID: 12672992] - Sung-Ryong Ko, Kang-Ju Choi, Kei Uchida, Yukio Suzuki. Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture.
Planta medica.
2003 Mar; 69(3):285-6. doi:
10.1055/s-2003-38476. [PMID: 12677539] - Yegao Chen, Eryi Zhan, Hongfen Chen, Xiuqiong Duan, Liqun Guo. [Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2002 Mar; 25(3):176-8. doi:
. [PMID: 12583159]
