Notoginsenoside (BioDeep_00001867457)

Main id: BioDeep_00000000014

 

PANOMIX_OTCML-2023


代谢物信息卡片


.BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,12-DIHYDROXYDAMMAR-24-EN-6-YL 2-O-.BETA.-D-XYLOPYRANOSYL-

化学式: C47H80O18 (932.5344380000001)
中文名称: 三七皂甙 R1, 三七皂苷 R1, 三七皂苷R1, 三七皂甙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(CO6)O)O)O)C)O)C)OC7C(C(C(C(O7)CO)O)O)O)C
InChI: InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1

描述信息

Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
Notoginsenoside R1 is a natural product found in Panax ginseng, Panax notoginseng, and other organisms with data available.
See also: Panax notoginseng root (part of).
A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].

同义名列表

20 个代谢物同义名

.BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,12-DIHYDROXYDAMMAR-24-EN-6-YL 2-O-.BETA.-D-XYLOPYRANOSYL-; beta-D-Glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-; (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside; b-D-Glucopyranoside,(3b,6a,12b)-20-(b-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-b-D-xylopyranosyl-; NOTOGINSENOSIDE R1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; NOTOGINSENOSIDE R1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); Notoginsenoside R1, analytical standard; Sanchinoside R1;Sanqi glucoside R1; Notoginsenoside R1, >=98\\% (HPLC); O-Acetylseudolaric acid C; (-)-Pseudolaric acid B; (20S)-ginsenoside R1; notoginsenoside R 1; netoginsenoside R1; notoginsenoside-R1; Notoginsenoside R1; Sanqi glucoside R1; NotoginsenosideR1; Notoginsenoside; sanchinoside R1



数据库引用编号

15 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shuxia Zhang, Qiuyan Chen, Meiqi Jin, Jiahui Ren, Xiao Sun, Zhixiu Zhang, Yun Luo, Xiaobo Sun. Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155530. doi: 10.1016/j.phymed.2024.155530. [PMID: 38493723]
  • Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu. Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation. Journal of natural medicines. 2024 Jun; 78(3):644-654. doi: 10.1007/s11418-023-01776-w. [PMID: 38409483]
  • Cheng Guo, Linying Lai, Boyu Ma, Qian Huang, Zhirong Wang. Notoginsenoside R1 targets PPAR-γ to inhibit hepatic stellate cell activation and ameliorates liver fibrosis. Experimental cell research. 2024 Apr; 437(1):113992. doi: 10.1016/j.yexcr.2024.113992. [PMID: 38492634]
  • Chunhou Li, Xican Li, Jingyuan Zeng, Rongxin Cai, Shaoman Chen, Ban Chen, Xiaojun Zhao. Detection of Adulterated Naodesheng Tablet (Naodesheng Pian) via In-Depth Chemical Analysis and Subsequent Reconstruction of Its Pharmacopoeia Q-Markers. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061392. [PMID: 38543029]
  • Caixia Pei, Nan Jia, Yilan Wang, Sijing Zhao, Zherui Shen, Shihua Shi, Demei Huang, Yongcan Wu, Xiaomin Wang, Shuiqin Li, Yacong He, Zhenxing Wang. Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1/2-P90rsk-BAD ignaling pathway. European journal of pharmacology. 2023 Sep; 959(?):176065. doi: 10.1016/j.ejphar.2023.176065. [PMID: 37775017]
  • Anna Lichota, Monika Sienkiewicz. Evaluation of antioxidant activity of NG-R1 saponin against bacterial cells in induced oxidative stress - a preliminary study. Annals of agricultural and environmental medicine : AAEM. 2023 Mar; 30(1):83-89. doi: 10.26444/aaem/161339. [PMID: 36999860]
  • Junchen Liu, Yuehang Wu, Wenrui Ma, Hongyan Zhang, Xianyao Meng, Huirong Zhang, Miaomiao Guo, Xiao Ling, Li Li. Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052416. [PMID: 36903661]
  • Ting Zhu, Qi Wan. Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury. Chinese journal of traumatology = Zhonghua chuang shang za zhi. 2023 Jan; 26(1):20-26. doi: 10.1016/j.cjtee.2022.06.008. [PMID: 35922249]
  • Ye Li, Yan-Yan Zhang, Di Wu, Ke-Ming Qi, Wei Lu, Yi-Cong Wei. [Antidepressant effect and molecular mechanism of notoginsenoside R_1 based on network pharmacology and animal experiments]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Oct; 47(20):5599-5609. doi: 10.19540/j.cnki.cjcmm.20220509.704. [PMID: 36471978]
  • Kangrui Hu, Changjian Li, Tengjie Yu, Huimin Guo, Hong Sun, Shuying Mao, Zhihao Zhou, Wei Jin, Keanqi Liu, Lin Xie, Guangji Wang, Yan Liang. Global analysis of qualitative and quantitative metabolism of Notoginsenoside R1 in rat liver-brain-gut axis based on LC-IT-TOF/MS combing mMDF strategy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154261. doi: 10.1016/j.phymed.2022.154261. [PMID: 35793598]
  • Han Li, Jing Zhu, Yan-Wu Xu, Fang-Fang Mou, Xiao-Li Shan, Qiang-Li Wang, Bao-Nian Liu, Ke Ning, Jia-Jia Liu, Ya-Chao Wang, Jin-Xia Mi, Xiaohui Wei, Shui-Jin Shao, Guo-Hong Cui, Rong Lu, Hai-Dong Guo. Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction. Redox biology. 2022 08; 54(?):102384. doi: 10.1016/j.redox.2022.102384. [PMID: 35777198]
  • Bowen Liu, Tingting Zhao, Yiyang Li, Yan Han, Youhua Xu, Hua Yang, Shengpeng Wang, Yonghua Zhao, Ping Li, Yitao Wang. Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia. Phytotherapy research : PTR. 2022 May; 36(5):2223-2235. doi: 10.1002/ptr.7450. [PMID: 35419891]
  • Xu Gong, Linlin Shan, Sisi Cao, Kaitao Li, Yanli Wu, Qing Zhang. Notoginsenoside R1, An Active Compound from Panax notoginseng, Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis via MAPK Signaling Pathway. The American journal of Chinese medicine. 2022; 50(2):511-523. doi: 10.1142/s0192415x22500197. [PMID: 35114912]
  • Ruiqi Han, Wenjuan Zhang, Lina Zhang, Jinghua Zou, Yanran Yang, Hongkun Li, Jun Zhang. Notoginsenoside R1 Promotes Proliferation and Osteogenic Differentiation of hPDLSCs via Wnt/β-Catenin Signaling Pathway. Drug design, development and therapy. 2022; 16(?):4399-4409. doi: 10.2147/dddt.s387004. [PMID: 36583114]
  • Xiao-Qing Li, Tian-Yi Huang. Notoginsenoside R1 alleviates high glucose-induced inflammation and oxidative stress in HUVECs via upregulating miR-147a. The Kaohsiung journal of medical sciences. 2021 Dec; 37(12):1101-1112. doi: 10.1002/kjm2.12433. [PMID: 34369659]
  • Z Jin, C Gan, G Luo, G Hu, X Yang, Z Qian, S Yao. Notoginsenoside R1 protects hypoxia-reoxygenation deprivation-induced injury by upregulation of miR-132 in H9c2 cells. Human & experimental toxicology. 2021 Dec; 40(12_suppl):S29-S38. doi: 10.1177/09603271211025589. [PMID: 34212764]
  • Xumin Li, Haiyan Lin, Xiaorong Zhang, Richard T Jaspers, Qihao Yu, Yinghui Ji, Tim Forouzanfar, Dongyun Wang, Shengbin Huang, Gang Wu. Notoginsenoside R1 attenuates oxidative stress-induced osteoblast dysfunction through JNK signalling pathway. Journal of cellular and molecular medicine. 2021 12; 25(24):11278-11289. doi: 10.1111/jcmm.17054. [PMID: 34786818]
  • Xuanming Zhang, Liwen Han, Peihai Li, Shanshan Zhang, Mengqi Zhang, Xiaobin Li, Jie Chu, Lizhen Wang, Pengfei Tu, Yun Zhang, Kechun Liu. Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of Panax quinquefolius from Wendeng, China. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226829. [PMID: 34833921]
  • Bowen Liu, Yiyang Li, Yan Han, Shengpeng Wang, Hua Yang, Yonghua Zhao, Ping Li, Yitao Wang. Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after acute ischemic stroke. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Sep; 90(?):153660. doi: 10.1016/j.phymed.2021.153660. [PMID: 34344565]
  • Ting Zhu, Wei-Jie Xie, Lei Wang, Xin-Biao Jin, Xiang-Bao Meng, Gui-Bo Sun, Xiao-Bo Sun. Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Aug; 140(?):111693. doi: 10.1016/j.biopha.2021.111693. [PMID: 34029951]
  • Minan Lu, Kegong Xie, Xianzhe Lu, Lu Lu, Yu Shi, Yujin Tang. Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced JAK2/STAT3 signaling. Investigational new drugs. 2021 04; 39(2):416-425. doi: 10.1007/s10637-020-01027-9. [PMID: 33128383]
  • Ting Cai, Wenquan Wu, Longhua Guo, Yongwu Xia, Xiaoxin Jiang, Limei Zhang, Feiding Peng, Pinghong Ming. Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation. Molecular medicine reports. 2021 04; 23(4):. doi: 10.3892/mmr.2021.11881. [PMID: 33537816]
  • Lei Wang, Hui Fu, Wenwen Wang, Yi Liu, Xumin Li, Jijing Yang, Lingli Li, Gang Wu, Yihuai Pan. Notoginsenoside R1 functionalized gelatin hydrogels to promote reparative dentinogenesis. Acta biomaterialia. 2021 03; 122(?):160-171. doi: 10.1016/j.actbio.2020.12.031. [PMID: 33348063]
  • Hai-Long Qin, Xue-Jun Wang, Bi-Xian Yang, Bin Du, Xue-Lin Yun. Notoginsenoside R1 attenuates breast cancer progression by targeting CCND2 and YBX3. Chinese medical journal. 2021 Jan; 134(5):546-554. doi: 10.1097/cm9.0000000000001328. [PMID: 33480613]
  • Qing Yuan, Jin-Xin Wang, Rui-Lin Li, Zhuang-Zhuang Jia, Shao-Xia Wang, Hong Guo, Li-Juan Chai, Li-Min Hu. Effects of salvianolate lyophilized injection combined with Xueshuantong injection in regulation of BBB function in a co-culture model of endothelial cells and pericytes. Brain research. 2021 01; 1751(?):147185. doi: 10.1016/j.brainres.2020.147185. [PMID: 33129805]
  • Jincheng Zhong, Weijin Lu, Jiayan Zhang, Maohua Huang, Wenyu Lyu, Geni Ye, Lijuan Deng, Minfeng Chen, Nan Yao, Yong Li, Guanping Liu, Yunfei Liang, Jingwen Fu, Dongmei Zhang, Wencai Ye. Notoginsenoside R1 activates the Ang2/Tie2 pathway to promote angiogenesis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153302. doi: 10.1016/j.phymed.2020.153302. [PMID: 32823242]
  • Ting Zhu, Lei Wang, Fang Tian, Xin Zhao, Xiao-Ping Pu, Gui-Bo Sun, Xiao-Bo Sun. Anti-ischemia/reperfusion injury effects of notoginsenoside R1 on small molecule metabolism in rat brain after ischemic stroke as visualized by MALDI-MS imaging. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110470. doi: 10.1016/j.biopha.2020.110470. [PMID: 32768957]
  • Fa Ren, Tianyu Feng, Tongjuan Niu, Yitian Yuan, Qi Liu, Jinhong Xiao, Gaoxiao Xu, Jianhong Hu. Notoginsenoside R1 protects boar sperm during liquid storage at 17°C. Reproduction in domestic animals = Zuchthygiene. 2020 Sep; 55(9):1072-1079. doi: 10.1111/rda.13745. [PMID: 32531853]
  • W Wang, L Huang, Y Hu, E R Thomas, X Li. Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12. Human & experimental toxicology. 2020 Jun; 39(6):797-807. doi: 10.1177/0960327120901586. [PMID: 31971015]
  • Lei Feng, Qiu-Ling Ma, Lin Shi, Yi Wu. [Effects of Sanchinoside R1 on Growth Invasion and Migration of HL-60 Cells and Survival of AML Model Mice]. Zhongguo shi yan xue ye xue za zhi. 2020 Apr; 28(2):394-399. doi: 10.19746/j.cnki.issn.1009-2137.2020.02.006. [PMID: 32319368]
  • Chuming Fan, Qingning Chen, Jingyu Ren, Xiaohua Yang, Jin Ru, Hongbo Zhang, Xinyue Yang. Notoginsenoside R1 Suppresses Inflammatory Signaling and Rescues Renal Ischemia-Reperfusion Injury in Experimental Rats. Medical science monitor : international medical journal of experimental and clinical research. 2020 Mar; 26(?):e920442. doi: 10.12659/msm.920442. [PMID: 32198879]
  • Hai Liu, Jianqiong Yang, Wanqing Yang, Shaonan Hu, Yali Wu, Bo Zhao, Haiyan Hu, Shouying Du. Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases. Drug design, development and therapy. 2020; 14(?):551-565. doi: 10.2147/dddt.s240511. [PMID: 32103897]
  • Xiabo Chen, Renxiong Wei, Tinglong Jin, Hanguang Du. Notoginsenoside R1 alleviates TNF-α-induced pancreatic β-cell Min6 apoptosis and dysfunction through up-regulation of miR-29a. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):2379-2388. doi: 10.1080/21691401.2019.1624368. [PMID: 31184222]
  • Shasha Guo, Xiaozhi Xi, Jia Li. Notoginsenoside R1: A systematic review of its pharmacological properties. Die Pharmazie. 2019 11; 74(11):641-647. doi: 10.1691/ph.2019.9534. [PMID: 31739829]
  • Sainan Zhang, Zhengcai Ju, Huida Guan, Lu Yu, Zhengtao Wang, Yuqing Zhao. Dose-dependent exposure profile and metabolic characterization of notoginsenoside R1 in rat plasma by ultra-fast liquid chromatography-electrospray ionization-tandem mass spectrometry. Biomedical chromatography : BMC. 2019 Nov; 33(11):e4670. doi: 10.1002/bmc.4670. [PMID: 31368122]
  • Lan Luo, Jiazhen Kang, Weijun Zhao, Yue Qi, Shengwang Liang. Validated LC-MS/MS method for simultaneous quantification of seven components of Naodesheng in rat serum after oral administration and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):1-7. doi: 10.1016/j.jpba.2019.05.036. [PMID: 31153133]
  • Jinrong Liu, Cun Hou, Xiaoyuan Chen, Lin Wu, Xinyue Wang. RETRACTED: Notoginsenoside R1 protects human renal proximal tubular epithelial cells from lipopolysaccharide-stimulated inflammatory damage by up-regulation of miR-26a. Chemico-biological interactions. 2019 08; 308(?):364-371. doi: 10.1016/j.cbi.2019.05.053. [PMID: 31158334]
  • Wei Li, Yi Wu, Mali Wan, Yang Chu, Xiangyang Wang, Shuming Li, Zuhui Liu, Xue Chen, Navaneethakrishnan Polachi, Shuiping Zhou, He Sun. Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 May; 169(?):254-259. doi: 10.1016/j.jpba.2019.03.008. [PMID: 30878903]
  • Lan Luo, Jiazhen Kang, Qiong He, Yue Qi, Xingyu Chen, Shumei Wang, Shengwang Liang. A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091831. [PMID: 31086027]
  • Ping Zhou, Weijie Xie, Xiangbao Meng, Yadong Zhai, Xi Dong, Xuelian Zhang, Guibo Sun, Xiaobo Sun. Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy. Cells. 2019 03; 8(3):. doi: 10.3390/cells8030213. [PMID: 30832367]
  • Chao Luo, Zhiguang Sun, Zhen Li, Liang Zheng, Xiaolin Zhu. Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats. Medical science monitor : international medical journal of experimental and clinical research. 2019 Feb; 25(?):1177-1186. doi: 10.12659/msm.911512. [PMID: 30757999]
  • Bin Zhang, Xuelian Zhang, Chenyang Zhang, Qiang Shen, Guibo Sun, Xiaobo Sun. Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression. Molecules (Basel, Switzerland). 2019 Jan; 24(2):. doi: 10.3390/molecules24020247. [PMID: 30634720]
  • Renjie Yan, Rui Chen, Jiahui Wang, Jian Shi, Wagner Ferreira Dos Santos, Zhiru Xu, Li Liu. Jingshu Keli and its Components Notoginsenoside R1 and Ginsenoside Rb1 Alleviate the Symptoms of Cervical Myelopathy through Kir3.1 Mediated Mechanisms. CNS & neurological disorders drug targets. 2019; 18(8):631-642. doi: 10.2174/0929866526666190911150514. [PMID: 31530268]
  • Hongxu Du, Shuaibing Zhang, Miao He, Ke Ming, Jinli Wang, Wenjuan Yuan, Mingyu Qiao, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu. Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo. BioMed research international. 2019; 2019(?):5201790. doi: 10.1155/2019/5201790. [PMID: 31080820]
  • Qiangyuan Fan, Yongtai Zhang, Xuefeng Hou, Zhe Li, Kai Zhang, Qun Shao, Nianping Feng. Improved oral bioavailability of notoginsenoside R1 with sodium glycocholate-mediated liposomes: Preparation by supercritical fluid technology and evaluation in vitro and in vivo. International journal of pharmaceutics. 2018 Dec; 552(1-2):360-370. doi: 10.1016/j.ijpharm.2018.10.005. [PMID: 30292894]
  • Ying Li, Dandan Yang, Chunyan Zhu. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules (Basel, Switzerland). 2018 Nov; 23(11):. doi: 10.3390/molecules23112990. [PMID: 30453465]
  • Jing Xiao, Ting Zhu, Yue-Zhang Yin, Bing Sun. Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-/- mice. European journal of pharmacology. 2018 Aug; 833(?):441-450. doi: 10.1016/j.ejphar.2018.07.004. [PMID: 29981750]
  • Liu Tu, Yan Wang, Di Chen, Ping Xiang, Jingjing Shen, Yingbo Li, Shali Wang. Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic-Ischemic Brain Injury. Neurochemical research. 2018 Jun; 43(6):1210-1226. doi: 10.1007/s11064-018-2538-3. [PMID: 29696512]
  • Haihong Fang, Shilin Yang, Yingying Luo, Cheng Zhang, Yi Rao, Renjing Liu, Yulin Feng, Jun Yu. Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling. Scientific reports. 2018 05; 8(1):7595. doi: 10.1038/s41598-018-25874-y. [PMID: 29765072]
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