Lignans (BioDeep_00000001858)
Main id: BioDeep_00000014667
Secondary id: BioDeep_00000271063
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
(10R,11S,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
化学式: C22H22O8 (414.1315)
中文名称: 苦鬼臼毒素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
InChI: InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13?,18-,19-,20+/m1/s1
描述信息
Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas. Lignans is found in arrowroot and flaxseed.
Lignans is found in arrowroot. Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- KEGG: C10871
- PubChem: 443013
- HMDB: HMDB0031452
- Wikipedia: Lignan
- MeSH: Lignans
- KNApSAcK: C00002619 C00033300
- foodb: FDB005955
- chemspider: 391314
- CAS: 477-47-4
- ChEBI: CHEBI:75251
- PubChem: 13054
- KNApSAcK: C00002619
- 3DMET: B05516
- NIKKAJI: J112.698I
- medchemexpress: HY-15494
- KNApSAcK: 75251
- LOTUS: LTS0147106
- wikidata: Q27088385
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(1)
- podophyllotoxin glucosides metabolism:
UDP-α-D-glucose + podophyllotoxin ⟶ H+ + UDP + podophyllotoxin 7-glucoside
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haihui Jiang, Shibo Feng, Panpan Zhang, Jiaojiao Wang, Yi Jiang, Huawei Zhang, Xiaomei Song, Wenli Huang, Yundong Xie, Chong Deng. Petroleum ether extract of Schisandra sphenanthera prevents hyperglycemia and insulin resistance in association with modulation of sweet taste receptors and gut microbiota in T2DM rats.
Journal of ethnopharmacology.
2024 Sep; 331(?):118300. doi:
10.1016/j.jep.2024.118300. [PMID: 38718889] - Mengjia Lv, Shiyi Chen, Mengwen Shan, Yuan Si, Chenggang Huang, Jing Chen, Likun Gong. Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice.
European journal of pharmacology.
2024 Jul; 974(?):176629. doi:
10.1016/j.ejphar.2024.176629. [PMID: 38679116] - Xunliang Huang, Yue Xing, Hao Jiang, Ya Pu, Song Yang, Zhensheng Kang, Lin Cai. Nonphytotoxic and pH-responsive ZnO-ZIF‑8 loaded with honokiol as a 'nanoweapon' effectively controls the soil-borne bacterial pathogen Ralstonia solanacearum.
Journal of hazardous materials.
2024 Jul; 472(?):134502. doi:
10.1016/j.jhazmat.2024.134502. [PMID: 38743980] - Longchan Liu, Wenxiang Fan, Haoyue Zhang, Linhong Fan, Yuqi Mei, Ziying Wang, Linnan Li, Li Yang, Zhengtao Wang. A versatile economic strategy by HPLC-CAD for quantification of structurally diverse markers in quality control of Shengmai Formula from raw materials to preparations.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155625. doi:
10.1016/j.phymed.2024.155625. [PMID: 38692077] - Xiuxia Li, Zhuo Yuan, Yuxia Wang, Wenjing Wang, Jianyou Shi. Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship.
European journal of medicinal chemistry.
2024 Jun; 272(?):116471. doi:
10.1016/j.ejmech.2024.116471. [PMID: 38704945] - Di He, Xinyi Pei, Bo Liu, Jiajing Li, Juane Dong, Thomas Efferth, Pengda Ma. Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins-A new model for evaluating the content of prominent components of Chinese herbs.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155361. doi:
10.1016/j.phymed.2024.155361. [PMID: 38552434] - Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen Huy Hoang, Ngo Anh Bang, Pham Hai Yen, Do Thi Trang, Duong Thi Dung, Nguyen Thi Cuc, Phan Thi Thanh Huong, Bui Huu Tai. Undescribed (2-7')-neolignans and polyoxygenated cyclohexene glycosides from the aerial parts of Piper mutabile C. DC. and their inhibitory effects on nitric oxide production.
Fitoterapia.
2024 Jun; 175(?):105903. doi:
10.1016/j.fitote.2024.105903. [PMID: 38479620] - Ya-Ping Bai, Teng Zhang, Zheng-Yan Hu, Yan Zhang, De-Guo Wang, Meng-Yun Zhou, Ying Zhang, Fang Zhang, Xiang Kong. Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo.
Biochemical pharmacology.
2024 Jun; 224(?):116240. doi:
10.1016/j.bcp.2024.116240. [PMID: 38679210] - Weijuan Zou, Feng Gao, Zheying Meng, Xiaojun Cai, Wu Chen, Yuanyi Zheng, Tao Ying, Longchen Wang, Jianrong Wu. Lactic acid responsive sequential production of hydrogen peroxide and consumption of glutathione for enhanced ferroptosis tumor therapy.
Journal of colloid and interface science.
2024 Jun; 663(?):787-800. doi:
10.1016/j.jcis.2024.03.001. [PMID: 38442520] - Ping Shao, Sheng Dong, Lin-Tong Mu, Ling Han, Chong-Ning Lv, Jiu-Zhi Yuan, Jin-Cai Lu. Two new anti-inflammatory compounds from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi.
Natural product research.
2024 Jun; 38(11):1874-1881. doi:
10.1080/14786419.2023.2227912. [PMID: 37395431] - Xianggang Hu, Tong Chen, Pengju Guo, Qing Wang, Aoxue Ding, Guoqing Qin, Wenqiong Wang, Lijiang Xuan. Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression.
Fitoterapia.
2024 Jun; 175(?):105951. doi:
10.1016/j.fitote.2024.105951. [PMID: 38583637] - Xue-Yi Li, Jun Jiang, Beiyi Shu, Rui-Li Huang, Hai-Xia Yang, Ya-Li Chen, Wei Tang, Wen-Cai Ye, Ying Wang, Xiao-Jun Huang, Jian-Guo Song. Anti-inflammatory naphthoquinone-monoterpene adducts and neolignans from Eugenia caryophyllata.
Fitoterapia.
2024 Jun; 175(?):105982. doi:
10.1016/j.fitote.2024.105982. [PMID: 38685512] - Yin-Yin Wang, Jun-Jiang Li, Quan-Hao Wei, Xin-Xin Wang, Jun-Sheng Zhang, Jun-Jie Yan, Hua Zhang. Bioactive neolignan, iridoid and flavonoid glycosides from the leaves of Vaccinium bracteatum.
Journal of Asian natural products research.
2024 Jun; 26(6):690-698. doi:
10.1080/10286020.2023.2299781. [PMID: 38192122] - Zhuoqun Li, Lixing Cao, Kai Han, Lihong Fan, Chong Zhao, Shutao Yin, Hongbo Hu. Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis.
Biochemical and biophysical research communications.
2024 May; 710(?):149895. doi:
10.1016/j.bbrc.2024.149895. [PMID: 38593620] - Li Sun, Yumeng Wang, Jia Li, Shiqing Xu, Shuang Xu, Jun Li. Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells.
Chemico-biological interactions.
2024 May; 395(?):110999. doi:
10.1016/j.cbi.2024.110999. [PMID: 38608999] - Miao Zhao, Jun Wu, Yuchen Jin, Min Li, KeXin Yu, Haibo Yu. Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels.
Journal of ethnopharmacology.
2024 May; 326(?):117996. doi:
10.1016/j.jep.2024.117996. [PMID: 38431110] - Mengyun Dong, Tianliang Zhang, Xueli Liang, Xinyi Cheng, Fuyan Shi, Hang Yuan, Fengxiang Zhang, Qiqi Jiang, Xia Wang. Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells.
Biochemical and biophysical research communications.
2024 May; 708(?):149815. doi:
10.1016/j.bbrc.2024.149815. [PMID: 38531220] - Yuhang Gong, Yanan Wang, Yanfeng Li, Fanglin Weng, Tong Chen, Ling He. Curculigoside, a traditional Chinese medicine monomer, ameliorates oxidative stress in Alzheimer's disease mouse model via suppressing ferroptosis.
Phytotherapy research : PTR.
2024 May; 38(5):2462-2481. doi:
10.1002/ptr.8152. [PMID: 38444049] - Huiyun Zhang, Yu Zhang, Yunfei Hu, Shunru Wei, Michael Adu-Frimpong, Congyong Sun, Gang Qi. Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion.
Drug development and industrial pharmacy.
2024 May; 50(5):401-409. doi:
10.1080/03639045.2024.2329730. [PMID: 38466185] - Jingxian Feng, Yuan Yao, Yuqi Qiao, Xueqi Ma, Zongtai Wu, Yonghao Duan, Peng Di, Wansheng Chen, Ying Xiao. Effect of pinoresinol-lariciresinol reductases on biosynthesis of lignans with substrate selectivity in Schisandra chinensis.
Phytochemistry.
2024 May; 221(?):114053. doi:
10.1016/j.phytochem.2024.114053. [PMID: 38479587] - Marina de M Gonçalves, Carlos H Totini, Erica V De Castro, Vanessa Albuquerque, Guilherme M Antar, Andre G Tempone, João Henrique G Lago. Lignans Isolated from Piper truncatum Act as New Potent Antitrypanosomal Compounds.
Chemistry & biodiversity.
2024 May; 21(5):e202400547. doi:
10.1002/cbdv.202400547. [PMID: 38507773] - Yanwen Sun, Liyi Chen, Yan Zhou, Fei Han, Yifang Rong, Liqin Ding, Feng Qiu. Guided isolation of enantiomeric lignans from Cimicifuga heracleifolia Kom. by antioxidant activity and molecular networking.
Phytochemistry.
2024 May; 221(?):114050. doi:
10.1016/j.phytochem.2024.114050. [PMID: 38479586] - Matthew E Poynter, Madeleine M Mank, Jennifer L Ather. Obesity-associated inflammatory macrophage polarization is inhibited by capsaicin and phytolignans.
American journal of physiology. Regulatory, integrative and comparative physiology.
2024 May; 326(5):R370-R382. doi:
10.1152/ajpregu.00161.2023. [PMID: 38436058] - Ziwei Zhu, Daihan Chen, Min Sun, Maotao Xiao, Peng Huang, Dongsheng Ren, Yixi Yang, Zhen Zhang, Qi Zhao, Rui Li. Integrative analysis of the metabolome and transcriptome provides insights into the mechanisms of lignan biosynthesis in Herpetospermum pedunculosum (Cucurbitaceae).
BMC genomics.
2024 Apr; 25(1):421. doi:
10.1186/s12864-024-10306-1. [PMID: 38684979] - Yifan Ding, Na Guo, Yuhan Jiang, Sihan Liu, Tongpei Zhou, Haoyun Bai, Yanni Lv, Shengli Han, Langchong He. Establishment of cluster of differentiation 20 immobilized cell membrane chromatography for the screening of active antitumor components in traditional Chinese medicine.
Journal of chromatography. A.
2024 Apr; 1721(?):464845. doi:
10.1016/j.chroma.2024.464845. [PMID: 38552371] - Bowei Sun, Yiping Yan, Mingjie Ma, Jinli Wen, Yanli He, Yining Sun, Pengqiang Yuan, Peilei Xu, Yiming Yang, Zihao Zhao, Li Cao, Wenpeng Lu. Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed.
Molecules (Basel, Switzerland).
2024 Apr; 29(8):. doi:
10.3390/molecules29081893. [PMID: 38675712] - Zhaohui Ran, Zhi Li, Xu Xiao, Chao Yan, Mingtai An, Juyan Chen, Ming Tang. Extensive targeted metabolomics analysis reveals the identification of major metabolites, antioxidants, and disease-resistant active pharmaceutical components in Camellia tuberculata (Camellia L.) seeds.
Scientific reports.
2024 04; 14(1):8709. doi:
10.1038/s41598-024-58725-0. [PMID: 38622262] - Zak Towle, Faye Cruickshank, C Logan Mackay, David J Clarke, Louise E Horsfall. Utilising Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to track the oxidation of lignin by an alkaliphilic laccase.
The Analyst.
2024 Apr; 149(8):2399-2411. doi:
10.1039/d4an00124a. [PMID: 38477231] - Maoyuan Zhao, Yueqiang Wen, Yi Yang, Huafeng Pan, Shunkai Xie, Caifei Shen, Wenhao Liao, Nianzhi Chen, Qiao Zheng, Gang Zhang, Yuchen Li, Daoyin Gong, Jianyuan Tang, Ziyi Zhao, Jinhao Zeng. (-)-Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Apr; 126(?):155348. doi:
10.1016/j.phymed.2024.155348. [PMID: 38335913] - Jiahui Zhang, Tao Jiang, Yuxin Zhang, Kai Yang, Yichen Zhao, Qi Zhou, Zhuo Yang, Renhao Yang, Ruonan Ning, Tao Liu, Lianfu Deng, Xiaobing Xi, Xing Xu, Min Jiang. Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoA.
Phytotherapy research : PTR.
2024 Apr; 38(4):1863-1881. doi:
10.1002/ptr.8074. [PMID: 38358766] - Lisa S Mydy, Jordan Hungerford, Desnor N Chigumba, Jamie R Konwerski, Sarah C Jantzi, Di Wang, Janet L Smith, Roland D Kersten. An intramolecular macrocyclase in plant ribosomal peptide biosynthesis.
Nature chemical biology.
2024 Apr; 20(4):530-540. doi:
10.1038/s41589-024-01552-1. [PMID: 38355722] - Truong Thi Thu Hien, Hoang Dac Thang, Hoang Anh Tuan, Nguyen Thanh Chung, Do Thanh Tuan, Nguyen Ba Hung, Nguyen Thi Kim Thuy, Nguyen Thi Thu Hien, Nguyen Huy Hoang, Dan Thi Thuy Hang, Bui Huu Tai, Nguyen Xuan Nhiem, Phan Van Kiem. Kadsindutalignans A-C: three new dibenzocyclooctadiene lignans from Kasura induta A.C.Sm. and their nitric oxide production inhibitory activities.
Natural product research.
2024 Apr; 38(7):1127-1134. doi:
10.1080/14786419.2022.2134361. [PMID: 36255129] - Chenming Gu, Jiayuan Liu, Fei Qian, Wenchao Yu, Doudou Huang, Jingshan Shen, Chenguo Feng, Kaixian Chen, Yiming Li, Xiangrui Jiang, Yechun Xu, Liuqiang Zhang. Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model.
Journal of medicinal chemistry.
2024 Mar; 67(6):4855-4869. doi:
10.1021/acs.jmedchem.3c02424. [PMID: 38489246] - Wei Li, Jie Lin, Jie Zhou, Siqi He, Anqi Wang, Yingfan Hu, Hanmei Li, Liang Zou, Ya Liu. Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis.
International journal of pharmaceutics.
2024 Mar; 653(?):123878. doi:
10.1016/j.ijpharm.2024.123878. [PMID: 38325622] - Michal Rybnikář, Milan Malaník, Karel Šmejkal, Emil Švajdlenka, Polina Shpet, Pavel Babica, Stefano Dall'Acqua, Ondřej Smištík, Ondřej Jurček, Jakub Treml. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects.
International journal of molecular sciences.
2024 Mar; 25(6):. doi:
10.3390/ijms25063465. [PMID: 38542438] - Jing Chen, Hui Chen, Chengcheng Feng, Qiong Chen, Xiang Fang, Yong Wang, Ning Zhang. Anti-inflammatory effect of lignans from flaxseed after fermentation by lactiplantibacillus plantarum SCB0151 in vitro.
World journal of microbiology & biotechnology.
2024 Mar; 40(4):134. doi:
10.1007/s11274-024-03945-9. [PMID: 38480613] - Xiaoyang Bi, Meihong Lin, Yifeng Zhou, Dandan Li, Zuowei Xu, Lijuan Zhou, Jiguang Huang. Insecticidal Activity and Molecular Target by Morphological Analysis, RNAseq, and Molecular Docking of the Aryltetralin Lignan Lactone Helioxanthin, Isolated from Taiwania flousiana Gaussen.
Journal of agricultural and food chemistry.
2024 Mar; 72(10):5133-5144. doi:
10.1021/acs.jafc.3c06384. [PMID: 38427577] - Fangfang Duan, Chunlun Qin, Zihuan Sang, Xiaoyi Wei, Hanli Ruan. Lignans and [11]-chaetoglobosins from Pseudeurotium bakeri and their immunosuppressive activity.
Organic & biomolecular chemistry.
2024 03; 22(11):2271-2278. doi:
10.1039/d3ob02109b. [PMID: 38391281] - Shungang Jiao, Changxin Liu, Panlong Chen, Junjun Li, Jingjing Sun, Xiaoli Gao, Xingyun Chai. 9,9'-epoxylignans from Syringa pinnatifolia: A typical case of stereochemical assignment by a quantum chemical calculation with MAEΔΔδ parameter.
Phytochemistry.
2024 Mar; 219(?):113978. doi:
10.1016/j.phytochem.2024.113978. [PMID: 38237843] - Ninh Khac Thanh Tung, Duong Thi Dung, Phan Van Kiem, Dan Thi Thuy Hang, Nguyen Xuan Nhiem, Nguyen Van The, Yohan Seo, Jong Seong Kang, Bui Huu Tai. Alkaloids and Lignans from the Aerial Parts of Rauvolfia tetraphylla Inhibit NO Production in LPS-activated RAW 264.7 Cells.
Chemistry & biodiversity.
2024 Mar; 21(3):e202302123. doi:
10.1002/cbdv.202302123. [PMID: 38253808] - Shujun Chen, Fang Qin, Ying Yang, Yu Zhao, Shuyun Xiao, Wei Li, Toshihiro Akihisa, Pensak Jantrawut, Jingyu Ji, Jie Zhang. Extraction, purification, structural characterization, and bioactivities of the genus Schisandra polysaccharides: A review.
International journal of biological macromolecules.
2024 Mar; 262(Pt 1):130257. doi:
10.1016/j.ijbiomac.2024.130257. [PMID: 38423904] - Jin-Zhen Jian, Tian-Qiong Lang, Wei Zhang, Yun-Qian Feng, Guo-Yong Luo. [A new nor-neolignan compound identified from Itea yunnanensis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Mar; 49(6):1564-1569. doi:
10.19540/j.cnki.cjcmm.20231208.201. [PMID: 38621940] - Qing-Ren Lu, Yan Wang, Zhuo-Ya Tang, Ye Chen, Han-Zhuang Weng, Sheng Yin, Gui-Hua Tang. Chemical constituents of Wikstroemia alternifolia and their neuroprotective activities.
Natural product research.
2024 Mar; 38(6):986-993. doi:
10.1080/14786419.2023.2209821. [PMID: 37157835] - Katarzyna Szałabska-Rąpała, Maria Zych, Weronika Borymska, Piotr Londzin, Sławomir Dudek, Ilona Kaczmarczyk-Żebrowska. Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Mar; 172(?):116265. doi:
10.1016/j.biopha.2024.116265. [PMID: 38364735] - Chia-Liang Lin, Tsung-Ho Ying, Shun-Fa Yang, Chu-Liang Lin, Hui-Ling Chiou, Yi-Hsien Hsieh. Magnolin targeting of the JNK/Sp1/MMP15 signaling axis suppresses cervical cancer microenvironment and metastasis via microbiota modulation.
Cancer letters.
2024 Feb; 583(?):216584. doi:
10.1016/j.canlet.2023.216584. [PMID: 38123014] - Sukanya Sonowal, Urvashee Gogoi, Kabyashree Buragohain, Ratul Nath. Endophytic fungi as a potential source of anti-cancer drug.
Archives of microbiology.
2024 Feb; 206(3):122. doi:
10.1007/s00203-024-03829-4. [PMID: 38407579] - Irene Jeongin Kim, Lisa I Pilkington, David Barker. Total Synthesis of (-)-Amovillosumin A and Structure Correction of (-)-Amovillosumin C Using Chemical Synthesis.
Journal of natural products.
2024 02; 87(2):340-348. doi:
10.1021/acs.jnatprod.3c01069. [PMID: 38354299] - Hanyu Fu, Chuan Guo, Jiqing Peng, Fengxia Shao, Song Sheng, Sen Wang. Transcriptomic Insights and Cytochrome P450 Gene Analysis in Kadsura coccinea for Lignan Biosynthesis.
Genes.
2024 Feb; 15(3):. doi:
10.3390/genes15030270. [PMID: 38540329] - Takuto Kumano. Specialized metabolites degradation by microorganisms.
Bioscience, biotechnology, and biochemistry.
2024 Feb; 88(3):270-275. doi:
10.1093/bbb/zbad184. [PMID: 38169014] - Shulin Wan, Xiaoxia Xie, Gongjun Yang, Fang Feng. Discovery of the toxicity-related quality markers and mechanisms of Zhi-Zi-Hou-Po decoction based on Chinmedomics combined with differentially absorbed components and network pharmacology.
Journal of ethnopharmacology.
2024 Feb; 320(?):117408. doi:
10.1016/j.jep.2023.117408. [PMID: 37972910] - Jing Yu, Xiaoyan Gao, Lijun Zhang, Hang Shi, Yingxuan Yan, Yongli Han, Chengyuan Wu, Ying Liu, Minglv Fang, Cheng Huang, Shengjie Fan. Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance.
Scientific reports.
2024 02; 14(1):3158. doi:
10.1038/s41598-024-53374-9. [PMID: 38326350] - Chunbo Dong, Qiuyu Shao, Qingsong Ran, Xu Li, Yanfeng Han. Interactions of rhizosphere microbiota-environmental factors-pharmacological active ingredients of Eucommia ulmoides.
Planta.
2024 Feb; 259(3):59. doi:
10.1007/s00425-024-04338-w. [PMID: 38311641] - Yue Liang, Jing Fang, Xiaoxi Zhou, Zheng Zhang, Wei Liu, Yonghong Hu, Xiaohan Yu, Yongping Mu, Hua Zhang, Ping Liu, Jiamei Chen. Schisantherin A protects hepatocyte via upregulating DDAH1 to ameliorate liver fibrosis in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Feb; 124(?):155330. doi:
10.1016/j.phymed.2023.155330. [PMID: 38185067] - Peng Zhao, Shi-Fang Li, Jiao-Yang Hou, Shu-Yan Qin, Jia-Yi Li, Xiao-Fang Zhou, Xuan Liu, Jin-Le Hao, Bin Lin, Xiao-Xiao Huang, Shao-Jiang Song. Four pairs of neolignan enantiomers with distinctive isochroman moiety from the fruits of Crataegus pinnatifida and their protective activities against H2O2-induced SH-SY5Y cells.
Phytochemistry.
2024 Feb; 218(?):113933. doi:
10.1016/j.phytochem.2023.113933. [PMID: 38029952] - Yunhe Liu, Junzhe Wu, Luying Tan, Zhuoqiao Li, Peng Gao, Shanmei He, Qianyun Wang, Daohao Tang, Cuizhu Wang, Fang Wang, Pingya Li, Jinping Liu. (-)-Syringaresinol attenuates ulcerative colitis by improving intestinal epithelial barrier function and inhibiting inflammatory responses.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Feb; 124(?):155292. doi:
10.1016/j.phymed.2023.155292. [PMID: 38190784] - Liqin Ding, Tianyi Qiu, Yanwen Sun, Jiantong Ma, Zhaojun Meng, Lin Zhao, Na Zhu, Kun Zhou, Feng Qiu. Characterization of the metabolites of Eucommiae Cortex in rats provides a further insight into its estrogen-like effective substances.
Bioorganic chemistry.
2024 Feb; 143(?):107052. doi:
10.1016/j.bioorg.2023.107052. [PMID: 38171154] - Jian Jiang, Xuefeng Hou, Kangjie Xu, Kangkang Ji, Zhongkai Ji, Juqun Xi, Xin Wang. Bacteria-targeted magnolol-loaded multifunctional nanocomplexes for antibacterial and anti-inflammatory treatment.
Biomedical materials (Bristol, England).
2024 Jan; ?(?):. doi:
10.1088/1748-605x/ad2406. [PMID: 38290149] - Fei Hu, WenJie Hu, Hongming Xu. Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells.
The Journal of membrane biology.
2024 Jan; ?(?):. doi:
10.1007/s00232-023-00299-5. [PMID: 38285126] - Valentin Ambroise, Sylvain Legay, Marijke Jozefczak, Céline C Leclercq, Sebastien Planchon, Jean-Francois Hausman, Jenny Renaut, Ann Cuypers, Kjell Sergeant. Impact of Heavy Metals on Cold Acclimation of Salix viminalis Roots.
International journal of molecular sciences.
2024 Jan; 25(3):. doi:
10.3390/ijms25031545. [PMID: 38338824] - Baining Zhang, Zhiwei He, Jialin Guo, Feng Li, Zhi Huang, Wenkai Zheng, Wenhua Xing, Manglai Li, Yong Zhu, Xuejun Yang. Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Aging.
2024 Jan; 16(2):1145-1160. doi:
10.18632/aging.205386. [PMID: 38284902] - Yue Yang, Zihe Li, Hang Zong, Shimeng Liu, Qiuhui Du, Hao Wu, Zhenzhu Li, Xiao Wang, Lihui Huang, Changlong Lai, Meide Zhang, Wen Wang, Xianqing Chen. Identification and Validation of Magnolol Biosynthesis Genes in Magnolia officinalis.
Molecules (Basel, Switzerland).
2024 Jan; 29(3):. doi:
10.3390/molecules29030587. [PMID: 38338333] - Yongyan Ren, Zhenxia Xu, Zhixian Qiao, Xu Wang, Chen Yang. Flaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome.
Nutrients.
2024 Jan; 16(2):. doi:
10.3390/nu16020295. [PMID: 38257189] - Markéta Jarošová, František Lorenc, Jan Bedrníček, Eva Petrášková, Marie Bjelková, Veronika Bártová, Eva Jarošová, Zbyněk Zdráhal, Jan Kyselka, Pavel Smetana, Jaromír Kadlec, Adéla Stupková, Jan Bárta. Comparison of Yield Characteristics, Chemical Composition, Lignans Content and Antioxidant Potential of Experimentally Grown Six Linseed (Linum usitatissimum L.) Cultivars.
Plant foods for human nutrition (Dordrecht, Netherlands).
2024 Jan; ?(?):. doi:
10.1007/s11130-023-01136-9. [PMID: 38236453] - Meng Hao, Hui Xu. Chemistry and Biology of Podophyllotoxins: An Update.
Chemistry (Weinheim an der Bergstrasse, Germany).
2024 Jan; 30(4):e202302595. doi:
10.1002/chem.202302595. [PMID: 37814110] - Feng-Rui Li, Yang Yu, Yu-Meng Du, Liang Kong, Yang Liu, Jia-Hua Wang, Mu-Han Chen, Mo Liu, Zi-Xu Zhang, Xue-Tao Li, Rui-Jun Ju. Borneol-Modified Schisandrin B Micelles Cross the Blood-Brain Barrier To Treat Alzheimer's Disease in Aged Mice.
ACS chemical neuroscience.
2024 Jan; ?(?):. doi:
10.1021/acschemneuro.3c00625. [PMID: 38214579] - Xueling Li, Jue Wang, Jiayi Yan, John Cijiang He, Yi Li, Yifei Zhong. Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 171(?):116107. doi:
10.1016/j.biopha.2023.116107. [PMID: 38215692] - Shunfang Liu, Yaozhen He, Minding Feng, Yongtong Huang, Wenhao Wu, Jiu Wang. Targeted Delivery of Arctigenin Using Sialic Acid Conjugate-Modified Liposomes for the Treatment of Breast Cancer.
Molecules (Basel, Switzerland).
2024 Jan; 29(1):. doi:
10.3390/molecules29010278. [PMID: 38202860] - Yi Xiao, Hanlin Zhou, Yingwen Cui, Xinting Zhu, Sanhua Li, Changyan Yu, Nian Jiang, Liu Liu, Fang Liu. Schisandrin A enhances pathogens resistance by targeting a conserved p38 MAPK pathway.
International immunopharmacology.
2024 Jan; 128(?):111472. doi:
10.1016/j.intimp.2023.111472. [PMID: 38176342] - Mona Soltani, Reza Fotovat, Mohsen Sharifi, Najmeh Ahmadian Chashmi, Mehrdad Behmanesh. In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells.
Iranian journal of medical sciences.
2024 Jan; 49(1):30-39. doi:
10.30476/ijms.2023.94805.2611. [PMID: 38322161] - Chuan-Yun Xiao, Jian-Ming He, Jiao Huang, Xiao-Min Guo, Ping Yang, Qing Mu. A novel off-line multi-dimensional high-speed countercurrent chromatography strategy for preparative separation of bioactive neolignan isomers from Piper betle. L.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2024 Jan; 1232(?):123965. doi:
10.1016/j.jchromb.2023.123965. [PMID: 38109812] - Jie Ren, Aiqing Fang, Shungang Jiao, Rong Li, Yuting Huang, Xiaoting Ni, Yunkun Zhang, Yuan Ma, Shunxiang Li, Juan Li. Lignans from the leaves of Styrax japonicus and their anti-inflammatory activity.
Fitoterapia.
2024 Jan; 172(?):105774. doi:
10.1016/j.fitote.2023.105774. [PMID: 38097021] - Zai-Qi Luo, Xiao-Qian Shi, Xian-Ying Wang, Qiu-Lan Yang, Xin Pan, Wen-Xia Pan, Chun-Li Luo, Shan-Shan Yu, Wen-Wen Zhou, Bin-Rui Ren, Yin Yi, Xi-Min Zhang. Waterlogging in soil restricts the growth of Gleditsia sinensis seedlings and inhibits the accumulation of lignans and phenolic acids in thorns.
PeerJ.
2024; 12(?):e17137. doi:
10.7717/peerj.17137. [PMID: 38529310] - Wei Su, Xin-Yue Wang, Gang Fu, Wu-Xian Chen, Xiang-Ru Shen, Bin Li, Wei Wang. [Research progress on chemical constituents from Kadsura genus and its pharmacological activities and clinical application].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Jan; 49(1):26-38. doi:
10.19540/j.cnki.cjcmm.20230718.201. [PMID: 38403335] - Jinwang Mei, Xiaobo Li, Zhiyong Xu, Haiyang Zhao, Jingyun Zhang, Qin Xu, Zhaohui Xu. Acute and chronic toxicity in Sprague-Dawley rats of orally-administered total lignans from Arctii Fructus, a potential therapeutic drug for diabetes.
Regulatory toxicology and pharmacology : RTP.
2024 Jan; 146(?):105542. doi:
10.1016/j.yrtph.2023.105542. [PMID: 38070762] - Mario F C Santos, Karen de J Nicácio, Albert Katchborian-Neto, Miller S Ferreira, Daniel de Oliveira Miranda, João V Andrade, Herinque de A Pereira, Ester Gonçalves de Jesus, Thamires B, Silva Souza, Raquel P Morais-Urano, Danielle Ferreira Dias, Daniela A Chagas-Paula, Marisi G Soares. Ex vivo inhibition of PGE2 formation in human blood by four bicyclico [3.2.1] octane neolignans isolated from Aniba firmula bark, two with unusual structural pattern.
Natural product research.
2024 Jan; 38(3):393-401. doi:
10.1080/14786419.2022.2124248. [PMID: 36106991] - Shahab Ghaderi, Masome Rashno, Alireza Sarkaki, Seyed Esmaeil Khoshnam. Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress.
Brain research bulletin.
2024 Jan; 206(?):110852. doi:
10.1016/j.brainresbull.2023.110852. [PMID: 38141790] - Ying Wu, Chao Ding, Chenwang Liu, Linwei Dan, Haonan Xu, Xinzhuo Li, Yuze Li, Xiaomei Song, Dongdong Zhang. Schisandrol A, the Major Active Constitute in Schisandra chinensis: A Review of Its Preparation, Biological Activities, and Pharmacokinetics Analysis.
The American journal of Chinese medicine.
2024; 52(3):717-752. doi:
10.1142/s0192415x24500290. [PMID: 38716620] - Inés Domínguez-López, Polina Galkina, Isabella Parilli-Moser, Camila Arancibia-Riveros, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Mireia Malcampo, J Alfredo Martínez, Lucas Tojal-Sierra, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Manuel Santos-Lozano, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A Tur, María Rubín-García, Xavier Pintó, Fernando Fernández-Aranda, Miguel Delgado-Rodríguez, Ana Barabash-Bustelo, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Estefania Toledo, Alessandro Atzeni, Eva M Asensio, Natàlia Vera, Antonio Garcia-Rios, Laura Torres-Collado, Napoleón Pérez-Farinós, Marian Zulet, Alice Chaplin, Rosa Casas, Sandra Martín-Peláez, Jessica Vaquero-Luna, Ana Maria Gómez-Pérez, Zenaida Vázquez-Ruiz, Sangeetha Shyam, Carolina Ortega-Azorín, Natàlia Talens, Patricia J Peña-Orihuela, Alejandro Oncina-Canovas, Javier Diez-Espino, Nancy Babio, Montserrat Fitó, Rosa M Lamuela-Raventós. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health.
Molecular nutrition & food research.
2024 Jan; 68(2):e2300183. doi:
10.1002/mnfr.202300183. [PMID: 38062915] - Linhai Zhu, Yanye Wang, Xuhua Huang, Xide Liu, Bo Ye, Yi He, Haojie Yu, Wang Lv, Luming Wang, Jian Hu. Schizandrin A induces non-small cell lung cancer apoptosis by suppressing the epidermal growth factor receptor activation.
Cancer medicine.
2024 Jan; 13(2):e6942. doi:
10.1002/cam4.6942. [PMID: 38376003] - Youn Young Shim, Ji Hye Kim, Jae Youl Cho, Martin J T Reaney. Health benefits of flaxseed and its peptides (linusorbs).
Critical reviews in food science and nutrition.
2024; 64(7):1845-1864. doi:
10.1080/10408398.2022.2119363. [PMID: 36193986] - Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, Peihong Zhang, Hong Chang. Phillygenin Alleviates Arthritis through the Inhibition of the NLRP3 Inflammasome and Ferroptosis by AMPK.
Critical reviews in immunology.
2024; 44(5):59-70. doi:
10.1615/critrevimmunol.2024051467. [PMID: 38618729] - Yingxue Hu, Timothy J Tse, Youn Young Shim, Sarah K Purdy, Young Jun Kim, Venkatesh Meda, Martin J T Reaney. A review of flaxseed lignan and the extraction and refinement of secoisolariciresinol diglucoside.
Critical reviews in food science and nutrition.
2024; 64(15):5057-5072. doi:
10.1080/10408398.2022.2148627. [PMID: 36448088] - Nelma Nyvonne Tiqu Gina, Jui-Ling Kuo, Mei-Li Wu, Show-Mei Chuang. Sesamin and sesamolin potentially inhibit adipogenesis through downregulating the peroxisome proliferator-activated receptor γ protein expression and activity in 3T3-L1 cells.
Nutrition research (New York, N.Y.).
2023 Dec; 123(?):4-17. doi:
10.1016/j.nutres.2023.12.011. [PMID: 38228077] - Victor H B de Andrade, Erick Y M Rodrigues, Nayara A F Dias, Gabriela F C Ferreira, Diego B de Carvalho, Amarith R das Neves, Paola M V Coronel, Murilo K A Yonekawa, Eduardo B Parisotto, Edson A Dos Santos, Albert S Souza, Edgar J Paredes-Gamero, Kamylla S de Sousa, Letícia L de Souza, Leonardo B M Resstel, Adriano C M Baroni, Davi C Lagatta. Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment.
ACS chemical neuroscience.
2023 Dec; 14(24):4298-4310. doi:
10.1021/acschemneuro.3c00443. [PMID: 38048522] - Mareia Ahmed-M Elgaleidh, Hafize Dilek Tepe, Fatma Doyuk, Talip Çeter, İdris Yazgan. Identification of Marker Molecules in Aqueous Plant Extracts Affecting the Gold Nanostructures' Morphology and Size.
Chemistry & biodiversity.
2023 Dec; ?(?):e202301349. doi:
10.1002/cbdv.202301349. [PMID: 38108659] - Danil I Falev, Ilya S Voronov, Alexandra A Onuchina, Anna V Faleva, Nikolay V Ul'yanovskii, Dmitry S Kosyakov. Analysis of Softwood Lignans by Comprehensive Two-Dimensional Liquid Chromatography.
Molecules (Basel, Switzerland).
2023 Dec; 28(24):. doi:
10.3390/molecules28248114. [PMID: 38138599] - Yi Chu, Yazhen Zheng, Yingying Li, Sisi Gui, Jingwu Zhao, Yaxiang Zhao, Xiaodong Chen. Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism.
Poultry science.
2023 Dec; 103(3):103378. doi:
10.1016/j.psj.2023.103378. [PMID: 38228060] - Haipeng Feng, Jingyan Zhang, Kang Zhang, Xuezhi Wang, Zhiting Guo, Lei Wang, Jianxi Li. Synergistic anti-infectious bronchitis virus activity of Phillygenin combined Baicalin by modulating respiratory microbiota and improving metabolic disorders.
Poultry science.
2023 Dec; 103(2):103371. doi:
10.1016/j.psj.2023.103371. [PMID: 38150830] - Zi-Qiao Xu, Shuai Li, Guo-Qing Long, Dong-Dong Wang, Zi-Feng Guo, Yong-Cheng Yang. Wunorlactones A-G, seven undescribed 7/8/5 and 7/8/3 carbon skeleton schinortriterpenoids from the stems and leaves of Schisandra chinensis, and their neuroprotective activities.
Phytochemistry.
2023 Dec; 216(?):113882. doi:
10.1016/j.phytochem.2023.113882. [PMID: 37797664] - Heba A S El-Nashar, Ahmed M Sayed, Hany A M El-Sherief, Mostafa E Rateb, Lina Akil, Ibrahim Khadra, Taghreed A Majrashi, Sara T Al-Rashood, Faizah A Binjubair, Mahmoud A El Hassab, Wagdy M Eldehna, Usama Ramadan Abdelmohsen, Nada M Mostafa. Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia.
Journal of enzyme inhibition and medicinal chemistry.
2023 Dec; 38(1):2199950. doi:
10.1080/14756366.2023.2199950. [PMID: 37080775] - Ming Zhou, Fang Yuan, Han-Li Ruan, Jun Li, Jun-Feng Huang, Si Liu, Tian-Yue Huang, Yan-Jun Zhang, Qiong Liang. Neuroprotective neolignan glycosides from the pseudobulbs of Bletilla striata.
Fitoterapia.
2023 Dec; 171(?):105691. doi:
10.1016/j.fitote.2023.105691. [PMID: 37757922] - Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, Chao-Hsiung Lin. Galgravin Isolated from Piper kadsura Ameliorates Lipopolysaccharide (LPS)-Induced Endotoxemia in Mice.
International journal of molecular sciences.
2023 Nov; 24(23):. doi:
10.3390/ijms242316572. [PMID: 38068895] - Ze-Dong Nan, Yi-Dong Zhu, Chao-Fan Deng, Jing-Lin Yang, Xiao-Li Ma, Zhi-Bo Jiang, Yong Jiang, Pengfei Tu. Cistadesertosides B-E, Four New Diastereomeric Lignan Glycosides from the Stems of Cultural Cistanche deserticola in Tarim Desert.
Chemistry & biodiversity.
2023 Nov; ?(?):e202301600. doi:
10.1002/cbdv.202301600. [PMID: 37963833] - Pei-Qi Huang, Kai-Wen Kang, Dan-Yu Huang, Chun-Lin Zhao, Hao Zheng, Yong-Xin Luo, Yan Wen, Ming-Feng Zou, Dong-Li Li, Ri-Hui Wu, Yun-Cai Tian, Yong Tian, Wen-Huan Zhang, Jing-Wei Jin, Sheng Yin, Li-She Gan. Lignan glucosides from Gentiana macrophylla with potential anti-arthritis and hepatoprotective activities.
Phytochemistry.
2023 Nov; ?(?):113920. doi:
10.1016/j.phytochem.2023.113920. [PMID: 37951561] - Jie Li, Ya-Feng Chen, Lei Gao, Yi-Jie Li, Dian-Xu Feng. Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1.
Chinese journal of integrative medicine.
2023 Nov; ?(?):. doi:
10.1007/s11655-023-3562-y. [PMID: 37943488] - Jian Li, Xiaoyang Ma, Lianzhong Luo, Danqing Tang, Lingyu Zhang. The What and Who of Dietary Lignans in Human Health: Special Attention to Estrogen Effects and Safety Evaluation.
Journal of agricultural and food chemistry.
2023 Nov; 71(44):16419-16434. doi:
10.1021/acs.jafc.3c02680. [PMID: 37870451] - Neetu Agrawal, Deepika Goyal, Ahsas Goyal. A review on multi-therapeutic potential of (-)-cubebin: experimental evidences.
Natural product research.
2023 Nov; 37(24):4290-4301. doi:
10.1080/14786419.2023.2177849. [PMID: 36775642] - Keisuke Kobayashi, Masaomi Yamamura, Bunzo Mikami, Akira Shiraishi, Masato Kumatani, Honoo Satake, Eiichiro Ono, Toshiaki Umezawa. Anthriscus sylvestris Deoxypodophyllotoxin Synthase Involved in Podophyllotoxin Biosynthesis.
Plant & cell physiology.
2023 Oct; ?(?):. doi:
10.1093/pcp/pcad103. [PMID: 37948767] - Shu-Ming Huang, Cheng-Hung Chuang, Christine Joyce F Rejano, Lemmuel L Tayo, Cheng-Yang Hsieh, Steven Kuan-Hua Huang, Po-Wei Tsai. Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes.
Molecules (Basel, Switzerland).
2023 Oct; 28(21):. doi:
10.3390/molecules28217255. [PMID: 37959677]
