Podophyllotoxin (BioDeep_00000271063)

Main id: BioDeep_00000407853

 

PANOMIX_OTCML-2023


代谢物信息卡片


5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

化学式: C22H22O8 (414.1315)
中文名称: 鬼臼毒素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
InChI: InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3

描述信息

Origin: Plant, Organic chemicals, Polycyclic compounds, Naphthalenes
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.992
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.994
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

同义名列表

9 个代谢物同义名

5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one; Podophyllotoxin; AXL1717; Picropodophyllotoxin; PPP; Picropodophyllin; Podofilox; Podophyllotoxin; Picropodophyllin



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Minoru Tomizawa, Fuminobu Shinozaki, Takao Sugiyama, Shigenori Yamamoto, Makoto Sueishi, Takanobu Yoshida. Insulin-like growth factor I receptor involvement in proliferation of NOR-P1 cells in serum-free media. Journal of cellular biochemistry. 2012 Aug; 113(8):2714-20. doi: 10.1002/jcb.24149. [PMID: 22441995]
  • Luqman Sulaiman, Inga-Lena Nilsson, C Christofer Juhlin, Felix Haglund, Anders Höög, Catharina Larsson, Jamileh Hashemi. Genetic characterization of large parathyroid adenomas. Endocrine-related cancer. 2012 Jun; 19(3):389-407. doi: 10.1530/erc-11-0140. [PMID: 22454399]
  • Helena Jernberg-Wiklund, Kenneth Nilsson. Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma. Upsala journal of medical sciences. 2012 May; 117(2):166-77. doi: 10.3109/03009734.2012.659293. [PMID: 22348393]
  • Emine Elif Ozkan. Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: a review. Molecular and cellular endocrinology. 2011 Sep; 344(1-2):1-24. doi: 10.1016/j.mce.2011.07.002. [PMID: 21782884]
  • Deeksha Vishwamitra, Ping Shi, Desiree Wilson, Roxsan Manshouri, Francisco Vega, Ellen J Schlette, Hesham M Amin. Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma. Haematologica. 2011 Jun; 96(6):871-80. doi: 10.3324/haematol.2010.031567. [PMID: 21330319]
  • Mayumi Miura, Mika Sasaki, Keiko Mizukoshi, Masayuki Shibasaki, Yuta Izumi, Goshun Shimosato, Fumimasa Amaya. Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury. Pain. 2011 Apr; 152(4):888-895. doi: 10.1016/j.pain.2011.01.004. [PMID: 21296499]
  • Yuko Rönquist-Nii, Staffan Eksborg, Magnus Axelson, Johan Harmenberg, Simon Ekman, Michael Bergqvist, Olof Beck. Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Feb; 879(5-6):326-34. doi: 10.1016/j.jchromb.2010.12.017. [PMID: 21251888]
  • Chiara Ristori, Luca Filippi, Massimo Dal Monte, Davide Martini, Maurizio Cammalleri, Pina Fortunato, Giancarlo la Marca, Patrizio Fiorini, Paola Bagnoli. Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade. Investigative ophthalmology & visual science. 2011 Jan; 52(1):155-70. doi: 10.1167/iovs.10-5536. [PMID: 20739470]
  • Ripu M Kunwar, Keshab P Shrestha, Rainer W Bussmann. Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. Journal of ethnobiology and ethnomedicine. 2010 Dec; 6(?):35. doi: 10.1186/1746-4269-6-35. [PMID: 21144003]
  • Thorsten Eierhoff, Eike R Hrincius, Ursula Rescher, Stephan Ludwig, Christina Ehrhardt. The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS pathogens. 2010 Sep; 6(9):e1001099. doi: 10.1371/journal.ppat.1001099. [PMID: 20844577]
  • Mario-Alexander Economou. Uveal melanoma and macular degeneration: molecular biology and potential therapeutic applications. Acta ophthalmologica. 2008 Dec; 86(8):930-1. doi: 10.1111/j.1755-3768.2008.01188.x. [PMID: 19086934]
  • Minoru Tomizawa, Osamu Yokosuka. Picropodophyllin suppresses the proliferation and invasion of hepatocellular carcinoma under serum starvation. Molecular medicine reports. 2008 Sep; 1(5):685-8. doi: 10.3892/mmr_00000013. [PMID: 21479470]
  • Helena Jernberg-Wiklund, Kenneth Nilsson. Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I). Advances in cancer research. 2007; 97(?):139-65. doi: 10.1016/s0065-230x(06)97006-7. [PMID: 17419944]
  • Eline Menu, Helena Jernberg-Wiklund, Thomas Stromberg, Hendrik De Raeve, Leonard Girnita, Olle Larsson, Magnus Axelson, Kewal Asosingh, Kenneth Nilsson, Ben Van Camp, Karin Vanderkerken. Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood. 2006 Jan; 107(2):655-60. doi: 10.1182/blood-2005-01-0293. [PMID: 16046527]