Rutaecarpine (BioDeep_00000000184)

   

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


3,13,21-triazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-1(21),2(10),4(9),5,7,15(20),16,18-octaen-14-one

化学式: C18H13N3O (287.1058568)
中文名称: 吴茱萸次碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.95%

分子结构信息

SMILES: C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4
InChI: InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2

描述信息

Rutecarpine is a member of beta-carbolines.
Rutaecarpine is a natural product found in Bouchardatia neurococca, Zanthoxylum dimorphophyllum, and other organisms with data available.
Rutaecarpine belongs to the family of Pyridopyrimidines. These are compounds containing a pyridopyrimidine, which consists of a pyridine fused to a pyrimidine.
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.

同义名列表

32 个代谢物同义名

3,13,21-triazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-1(21),2(10),4(9),5,7,15(20),16,18-octaen-14-one; 3,13,21-triazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one; InChI=1/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H; 3,13,21-triazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one; 3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one; Indolo(2,3:3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13-dihydro-; Indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-; 8,13-Dihydro-indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one; 8,13-dihydro-Indolo(2,3:3,4)pyrido(2,1-b)quinazolin-5(7H)-one; 7,8-dihydroindolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(13H)-one; 8,13-Dihydro-7H-indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5-one; 8,13-dihydroindolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one; 8,13-dihydroindolo(2,3:3,4)pyrido(2,1-b)quinazolin-5(7H)-one; Indolo[2,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-; ACVGWSKVRYFWRP-UHFFFAOYSA-N; Rutaecarpine, >98\\% (HPLC); Rutaecarpine (Rutecarpine); Rutaecarpine,(S); RUTECARPINE [MI]; UNII-8XZV289PRY; Oprea1_313284; Lopac0_001091; Rutaecarpine; Tox21_501091; NCI60_002069; Rutacarpine; SMP2_000103; rutecarpine; Rutaecarpin; 8XZV289PRY; C18H13N3O; Rhetine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, Yang-Chang Wu, Fang-Rong Chang, István Szatmári, Ferenc Fülöp. Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions. Organic & biomolecular chemistry. 2024 03; 22(13):2620-2629. doi: 10.1039/d4ob00056k. [PMID: 38451121]
  • Yongjian Li, Zhengping Tan, Wencan Li, Zongxuan Li, Guiying Zhang. Rutaecarpine ameliorates imiquimod-induced psoriasis-like dermatitis in mice associated with alterations in the gut microbiota. Acta biochimica et biophysica Sinica. 2024 03; 56(3):345-355. doi: 10.3724/abbs.2024018. [PMID: 38419497]
  • Zhen-Xing Li, Jin-Hong Hu, Rong-Shuang Luo, Tai-Hong Zhang, Yue Ding, Xiang Zhou, Li-Wei Liu, Zhi-Bing Wu, Song Yang. Identification of natural Rutaecarpine as a potent tobacco mosaic virus (TMV) helicase candidate for managing intractable plant viral diseases. Pest management science. 2024 Feb; 80(2):805-819. doi: 10.1002/ps.7817. [PMID: 37794206]
  • Min Xu, Li-Hui Qian, Jun-Xiang Wang, Zi-Yang He, Xiao-Yang Ling, Wen-Hua Wang, Jin-Wen Wang, Yue Hu, Ming-Jie Gong. Rutaecarpine Alleviates Early Brain Injury-Induced Inflammatory Response Following Subarachnoid Hemorrhage via SIRT6/NF-[Formula: see text]B Pathway. The American journal of Chinese medicine. 2024; 52(3):799-819. doi: 10.1142/s0192415x24500320. [PMID: 38752843]
  • Dalia Ali, Meshail Okla, Sarah Abuelreich, Radhakrishnan Vishnubalaji, Nicholas Ditzel, Rimi Hamam, Justyna M Kowal, Ahmed Sayed, Abdullah Aldahmash, Nehad M Alajez, Moustapha Kassem. Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells. Frontiers in endocrinology. 2024; 15(?):1360054. doi: 10.3389/fendo.2024.1360054. [PMID: 38638133]
  • Yong He, Hong-Hong Liu, Xue-Lin Zhou, Ting-Ting He, Ao-Zhe Zhang, Xin Wang, Shi-Zhang Wei, Hao-Tian Li, Li-Sheng Chen, Lei Chang, Yan-Ling Zhao, Man-Yi Jing. Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176294. [PMID: 37687125]
  • Min Xu, Zhenhua Shi, Ziyang He, Xiaoyang Ling, Wenhua Wang, Hua Liu, Mingjie Gong. Rutaecarpine alleviates migraine in nitroglycerin-induced mice by regulating PTEN/PGK1 signaling pathway to activate NRF2 antioxidant system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115300. doi: 10.1016/j.biopha.2023.115300. [PMID: 37557014]
  • Shengying Lin, Xiaoyang Wang, Hongsheng Guo, Niyu Dai, Roy Wai-Lun Tang, Hung Chun Lee, Ka Wing Leung, Tina Ting-Xia Dong, Sarah E Webb, Andrew L Miller, Karl Wah-Keung Tsim. The Ethanol Extract of Evodiae Fructus and Its Ingredient, Rutaecarpine, Inhibit Infection of SARS-CoV-2 and Inflammatory Responses. International journal of molecular sciences. 2023 Jan; 24(1):. doi: 10.3390/ijms24010762. [PMID: 36614206]
  • Jingli Liu, Hui Guo, Jing Zhou, Yuwei Wang, Hao Yan, Ruyi Jin, Yuping Tang. Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911513. [PMID: 36232809]
  • Li-Yu Wang, Shu-Lan Yeh, Shih-Tien Hsu, Chao-Hsiang Chen, Chien-Chih Chen, Cheng-Hung Chuang. The Anti-Proliferative and Apoptotic Effects of Rutaecarpine on Human Esophageal Squamous Cell Carcinoma Cell Line CE81T/VGH In Vitro and In Vivo. International journal of molecular sciences. 2022 Mar; 23(5):. doi: 10.3390/ijms23052843. [PMID: 35269987]
  • Cheng-Jie Yang, Hai-Xin Li, Jing-Ru Wang, Zhi-Jun Zhang, Tian-Lin Wu, Ying-Qian Liu, Chen Tang, Qing-Ru Chu, Sha-Sha Du, Ying-Hui He. Design, synthesis and biological evaluation of novel evodiamine and rutaecarpine derivatives against phytopathogenic fungi. European journal of medicinal chemistry. 2022 Jan; 227(?):113937. doi: 10.1016/j.ejmech.2021.113937. [PMID: 34710744]
  • Chun-Jen Huang, Wei-Chieh Huang, Wei-Ting Lin, Lan-Hsin Shu, Joen-Rong Sheu, Oanh-Thi Tran, Chih-Wei Hsia, Thanasekaran Jayakumar, Periyakali Saravana Bhavan, Cheng-Ying Hsieh, Chao-Chien Chang. Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β  Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222011109. [PMID: 34681769]
  • Zhijun Zhao, Yurun Xue, Gaohua Zhang, Jie Jia, Ruilian Xiu, Yugai Jia, Yuanyuan Wang, Xiangchong Wang, Honglin Li, Pingping Chen, Xuan Zhang. Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum. European journal of pharmacology. 2021 Oct; 908(?):174340. doi: 10.1016/j.ejphar.2021.174340. [PMID: 34265294]
  • Jin-Yuarn Lin, Tzu-He Yeh. Rutaecarpine administration inhibits cancer cell growth in allogenic TRAMP-C1 prostate cancer mice correlating with immune balance in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111648. doi: 10.1016/j.biopha.2021.111648. [PMID: 33945915]
  • Xian-Mei Song, Bing-Jie Li, Yan-Yan Zhang, Wen-Jing Ge, She-Feng Zhang, Wei-Feng Cui, Geng-Sheng Li, Rui-Feng Liang. Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jul; 51(7):818-830. doi: 10.1080/00498254.2021.1926573. [PMID: 33952086]
  • Ge Zhan, Fang Wang, Yun-Qi Ding, Xiang-Hua Li, Yue-Xin Li, Zheng-Rong Zhao, Jia-Xin Li, Yan Liu, Xin Zhao, Cai-Chuan Yan, Bao-Xin Li. Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia. Journal of cellular and molecular medicine. 2021 06; 25(11):4938-4949. doi: 10.1111/jcmm.16292. [PMID: 33939251]
  • Sichen Ren, Ying Wei, Ming Niu, Ruisheng Li, Ruilin Wang, Shizhang Wei, Jianxia Wen, Dan Wang, Tao Yang, Xing Chen, Shihua Wu, Yuling Tong, Manyi Jing, Haotian Li, Min Wang, Yanling Zhao. Mechanism of rutaecarpine on ethanol-induced acute gastric ulcer using integrated metabolomics and network pharmacology. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111490. doi: 10.1016/j.biopha.2021.111490. [PMID: 33773465]
  • Xue-Qi Liu, Juan Jin, Zeng Li, Ling Jiang, Yu-Hang Dong, Yu-Ting Cai, Ming-Fei Wu, Jia-Nan Wang, Tao-Tao Ma, Jia-Gen Wen, Ming-Ming Liu, Jun Li, Yong-Gui Wu, Xiao-Ming Meng. Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy. Biochemical pharmacology. 2020 10; 180(?):114132. doi: 10.1016/j.bcp.2020.114132. [PMID: 32622666]
  • Laishram Surbala, Chingakham Brajakishor Singh, Rajkumari Vidyabati Devi, Oinam Joychandra Singh. Rutaecarpine exhibits anti-diabetic potential in high fat diet-multiple low dose streptozotocin induced type 2 diabetic mice and in vitro by modulating hepatic glucose homeostasis. Journal of pharmacological sciences. 2020 Aug; 143(4):307-314. doi: 10.1016/j.jphs.2020.04.008. [PMID: 32536591]
  • Xiaojiaoyang Li, Junde Ge, Qi Zheng, Jiaxiang Zhang, Rong Sun, Runping Liu. Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153180. doi: 10.1016/j.phymed.2020.153180. [PMID: 32092638]
  • Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Tianxia Wang, Xiaoyan Liu, Jing Wang, Qiong Wang, Yuhong Luo, Ping Wang, Tomoki Yagai, Kristopher W Krausz, Xiuwei Yang, Frank J Gonzalez. Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis. Free radical biology & medicine. 2020 02; 148(?):33-41. doi: 10.1016/j.freeradbiomed.2019.12.012. [PMID: 31874248]
  • Li-Fei Nie, Si-Si Wang, Jian-Guo Cao, Fei-Ze Liu, Hainimu Xiamuxi, Haji Akber Aisa, Guo-Zheng Huang. Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones. Journal of Asian natural products research. 2020 Jan; 22(1):69-82. doi: 10.1080/10286020.2018.1540599. [PMID: 30588834]
  • Jinque Luo, Xiao Wang, Xinhai Jiang, Chao Liu, Yongzhen Li, Xiaowan Han, Xuan Zuo, Yining Li, Ni Li, Yanni Xu, Shuyi Si. Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 01; 34(1):1398-1411. doi: 10.1096/fj.201900903rrr. [PMID: 31914630]
  • Baofang Zhang, Zilin Chen. Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor. Journal of pharmaceutical and biomedical analysis. 2019 Nov; 176(?):112811. doi: 10.1016/j.jpba.2019.112811. [PMID: 31437748]
  • Yikun Liu, Wei Zhou, Zhenkun Mao, Zilin Chen. Analysis of Evodiae Fructus by capillary electrochromatography-mass spectrometry with methyl-vinylimidazole functionalized organic polymer monolilth as stationary phases. Journal of chromatography. A. 2019 Sep; 1602(?):474-480. doi: 10.1016/j.chroma.2019.06.011. [PMID: 31202495]
  • Kun-Ming Tian, Jing-Jie Li, Suo-Wen Xu. Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu). Pharmacological research. 2019 03; 141(?):541-550. doi: 10.1016/j.phrs.2018.12.019. [PMID: 30616017]
  • Yongjian Li, Guiying Zhang, Mingliang Chen, Min Tong, Ming Zhao, Fang Tang, Rong Xiao, Haiquan Wen. Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):1876-1883. doi: 10.1016/j.biopha.2018.10.062. [PMID: 30551443]
  • Yun-Xing Gao, Li-Li Jiang, Qian Zhang, Dong-Ze Zuo, Xian-Wei Li. [Rutaecarpine protects against bleomycin-induced pulmonary fibrosis through inhibiting Notch1/eIF3a signaling pathway in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Sep; 43(17):3530-3538. doi: 10.19540/j.cnki.cjcmm.20180530.005. [PMID: 30347923]
  • Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W Krausz, William H Bisson, Xiuwei Yang, Frank J Gonzalez. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis. Drug metabolism and disposition: the biological fate of chemicals. 2018 07; 46(7):1030-1040. doi: 10.1124/dmd.117.080176. [PMID: 29691238]
  • Yang Xu, Xiu-Ping Chen, Feng Zhang, Hua-Hua Hou, Jing-Yi Zhang, Shu-Xian Lin, An-Sheng Sun. Rutaecarpine Inhibits Intimal Hyperplasia in A Balloon-Injured Rat Artery Model. Chinese journal of integrative medicine. 2018 Jun; 24(6):429-435. doi: 10.1007/s11655-017-2900-3. [PMID: 28861806]
  • Yongmei Yang, Qingquan Chen, Sujie Jia, Limei He, Aiping Wang, Dai Li, Yuanjian Li, Xiaohui Li. Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine. Molecular medicine reports. 2018 04; 17(4):5168-5174. doi: 10.3892/mmr.2018.8494. [PMID: 29393417]
  • Wei Cai, Ying Guan, Yang Zhou, Yuwei Wang, Huaiping Ji, Zhihua Liu. Detection and characterization of the metabolites of rutaecarpine in rats based on ultra-high-performance liquid chromatography with linear ion trap-Orbitrap mass spectrometer. Pharmaceutical biology. 2017 Dec; 55(1):294-298. doi: 10.1080/13880209.2016.1236392. [PMID: 27927077]
  • Yong-Tai Zhang, Zhe Li, Kai Zhang, Hong-Yu Zhang, Ze-Hui He, Qing Xia, Ji-Hui Zhao, Nian-Ping Feng. Co-delivery of evodiamine and rutaecarpine in a microemulsion-based hyaluronic acid hydrogel for enhanced analgesic effects on mouse pain models. International journal of pharmaceutics. 2017 Aug; 528(1-2):100-106. doi: 10.1016/j.ijpharm.2017.05.064. [PMID: 28571904]
  • Chunhua Wang, Zongyao Hao, Jun Zhou, Li Zhang, Yexiang Sun, Chaozhao Liang. Rutaecarpine alleviates renal ischemia reperfusion injury in rats by suppressing the JNK/p38 MAPK signaling pathway and interfering with the oxidative stress response. Molecular medicine reports. 2017 Jul; 16(1):922-928. doi: 10.3892/mmr.2017.6631. [PMID: 28560443]
  • Chi-Ming Lee, Jiun-An Gu, Tin-Gan Rau, Chi Wang, Chiao-Han Yen, Shih-Hao Huang, Feng-Yen Lin, Chun-Mao Lin, Sheng-Tung Huang. Synthetic Fluororutaecarpine Inhibits Inflammatory Stimuli and Activates Endothelial Transient Receptor Potential Vanilloid-Type 1. Molecules (Basel, Switzerland). 2017 Apr; 22(4):. doi: 10.3390/molecules22040656. [PMID: 28422079]
  • Sun Woo Jin, Yong Pil Hwang, Chul Yung Choi, Hyung Gyun Kim, Se Jong Kim, Yongan Kim, Young Chul Chung, Kyung Jin Lee, Tae Cheon Jeong, Hye Gwang Jeong. Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Feb; 100(?):138-148. doi: 10.1016/j.fct.2016.12.031. [PMID: 28025122]
  • Hui Guo, Dongmei Liu, Bin Gao, Xiaohui Zhang, Minli You, Hui Ren, Hongbo Zhang, Hélder A Santos, Feng Xu. Antiproliferative Activity and Cellular Uptake of Evodiamine and Rutaecarpine Based on 3D Tumor Models. Molecules (Basel, Switzerland). 2016 Jul; 21(7):. doi: 10.3390/molecules21070954. [PMID: 27455219]
  • Wen-Qun Li, Xiao-Hui Li, Jie Du, Wang Zhang, Dai Li, Xiao-Ming Xiong, Yuan-Jian Li. Rutaecarpine attenuates hypoxia-induced right ventricular remodeling in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2016 Jul; 389(7):757-67. doi: 10.1007/s00210-016-1240-8. [PMID: 27052575]
  • Shenglan Wang, Satoshi Yamamoto, Yoko Kogure, Wensheng Zhang, Koichi Noguchi, Yi Dai. Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa. Journal of natural products. 2016 05; 79(5):1225-30. doi: 10.1021/acs.jnatprod.5b00599. [PMID: 27159637]
  • Yanchuan Wu, Xueqiang Pan, Yongsong Xu, Xuran Lu, Shida He, Rui He, Muxin Gong. Optimization of combinations of ginsenoside-Rg1, ginsenoside-Rb1, evodiamine and rutaecarpine for effective therapy of mouse migraine. Journal of natural medicines. 2016 Apr; 70(2):207-16. doi: 10.1007/s11418-015-0960-2. [PMID: 26711833]
  • Xu-qiang Nie, Huai-hong Chen, Jian-yong Zhang, Yu-jing Zhang, Jian-wen Yang, Hui-jun Pan, Wen-xia Song, Ferid Murad, Yu-qi He, Ka Bian. Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways. Acta pharmacologica Sinica. 2016 Apr; 37(4):483-96. doi: 10.1038/aps.2015.167. [PMID: 26972495]
  • Yong Rao, Hong Liu, Lin Gao, Hong Yu, Tian-Miao Ou, Jia-Heng Tan, Shi-Liang Huang, Hong-Gen Wang, Ding Li, Lian-Quan Gu, Ji-Ming Ye, Zhi-Shu Huang. Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment. Journal of medicinal chemistry. 2015 Dec; 58(23):9395-413. doi: 10.1021/acs.jmedchem.5b01566. [PMID: 26572282]
  • Xueqiang Pan, Manyuan Wang, Yanchuan Wu, Xuran Lu, Yawen Shang, Yongsong Xu, Yongsong Zhai, Jing Li, Zhaoxia Li, Muxin Gong. Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association. Molecular medicine reports. 2015 Jul; 12(1):1524-34. doi: 10.3892/mmr.2015.3506. [PMID: 25815775]
  • Jong-Keun Son, Hyeun Wook Chang, Yurngdong Jahng. Progress in Studies on Rutaecarpine. II.--Synthesis and Structure-Biological Activity Relationships. Molecules (Basel, Switzerland). 2015 Jun; 20(6):10800-21. doi: 10.3390/molecules200610800. [PMID: 26111170]
  • John F Rebhun, Samantha J Roloff, Rodney A Velliquette, Stephen R Missler. Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ). Fitoterapia. 2015 Mar; 101(?):57-63. doi: 10.1016/j.fitote.2014.12.009. [PMID: 25542684]
  • Fang-Liang Zhang, Xin He, Yi-Ran Zhai, Li-Na He, Si-Chao Zhang, Li-Li Wang, Ai-Hong Yang, Li-Jun An. Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine. Xenobiotica; the fate of foreign compounds in biological systems. 2015; 45(11):978-89. doi: 10.3109/00498254.2015.1038742. [PMID: 26053557]
  • Qingyan Cai, Jingjing Wei, Wei Zhao, Si Shi, Yu Zhang, Renrong Wei, Yue Zhang, Weirong Li, Qi Wang. Toxicity of Evodiae fructus on rat liver mitochondria: the role of oxidative stress and mitochondrial permeability transition. Molecules (Basel, Switzerland). 2014 Dec; 19(12):21168-82. doi: 10.3390/molecules191221168. [PMID: 25521117]
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