Rutaecarpine (BioDeep_00000000184)

   

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3,13,21-triazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-1(21),2(10),4(9),5,7,15(20),16,18-octaen-14-one

化学式: C18H13N3O (287.1059)
中文名称: 吴茱萸次碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 15.89%

分子结构信息

SMILES: C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4
InChI: InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2

描述信息

Rutecarpine is a member of beta-carbolines.
Rutaecarpine is a natural product found in Bouchardatia neurococca, Zanthoxylum dimorphophyllum, and other organisms with data available.
Rutaecarpine belongs to the family of Pyridopyrimidines. These are compounds containing a pyridopyrimidine, which consists of a pyridine fused to a pyrimidine.
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.

同义名列表

33 个代谢物同义名

3,13,21-triazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-1(21),2(10),4(9),5,7,15(20),16,18-octaen-14-one; 3,13,21-triazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one; InChI=1/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H; 3,13,21-triazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one; 3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one; Indolo(2,3:3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13-dihydro-; Indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-; 8,13-Dihydro-indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one; 8,13-dihydro-Indolo(2,3:3,4)pyrido(2,1-b)quinazolin-5(7H)-one; 7,8-dihydroindolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(13H)-one; 8,13-Dihydro-7H-indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5-one; 8,13-dihydroindolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one; 8,13-dihydroindolo(2,3:3,4)pyrido(2,1-b)quinazolin-5(7H)-one; Indolo[2,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-; ACVGWSKVRYFWRP-UHFFFAOYSA-N; Rutaecarpine, >98\\% (HPLC); Rutaecarpine (Rutecarpine); Rutaecarpine,(S); RUTECARPINE [MI]; UNII-8XZV289PRY; Oprea1_313284; Lopac0_001091; Rutaecarpine; Tox21_501091; NCI60_002069; Rutacarpine; SMP2_000103; rutecarpine; Rutaecarpin; 8XZV289PRY; C18H13N3O; Rhetine; Rutaecarpine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

49 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, BCL2, CASP3, CYP1A1, MAPK14, MYC, NFE2L2, PIK3CA, PRKAA2, PTGS2, RELA, S100A12
Peripheral membrane protein 4 CYP1A1, CYP1B1, PTGS2, S100A12
Endoplasmic reticulum membrane 6 BCL2, CYP1A1, CYP1A2, CYP1B1, HMOX1, PTGS2
Nucleus 10 AKT1, BCL2, CASP3, HMOX1, MAPK14, MYC, NFE2L2, PRKAA2, RELA, S100A12
cytosol 10 AKT1, BCL2, CASP3, HMOX1, MAPK14, NFE2L2, PIK3CA, PRKAA2, RELA, S100A12
dendrite 1 PRKAA2
centrosome 1 NFE2L2
nucleoplasm 8 AKT1, CASP3, HMOX1, MAPK14, MYC, NFE2L2, PRKAA2, RELA
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 AKT1, S100A12, TNF, TRPV1
Cytoplasmic side 1 HMOX1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 TRPV1
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 4 AKT1, CASP3, MAPK14, RELA
Golgi apparatus 2 NFE2L2, PRKAA2
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 4 CASP3, PRKAA2, TNF, TRPV1
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NFE2L2
plasma membrane 6 AKT1, NFE2L2, PIK3CA, S100A12, TNF, TRPV1
Membrane 7 AKT1, BCL2, CYP1B1, HMOX1, MYC, PRKAA2, TRPV1
axon 1 PRKAA2
caveola 1 PTGS2
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 5 HMOX1, IL10, IL6, INS, TNF
perinuclear region of cytoplasm 2 HMOX1, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CYP1A1, CYP1B1, MAPK14
protein-containing complex 4 AKT1, BCL2, MYC, PTGS2
intracellular membrane-bounded organelle 3 CYP1A1, CYP1A2, CYP1B1
Microsome membrane 4 CYP1A1, CYP1A2, CYP1B1, PTGS2
postsynaptic density 1 CASP3
Secreted 4 IL10, IL6, INS, S100A12
extracellular region 6 IL10, IL6, INS, MAPK14, S100A12, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
transcription regulator complex 1 RELA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TNF, TRPV1
microtubule cytoskeleton 1 AKT1
nucleolus 1 MYC
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 TRPV1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 S100A12
spindle 1 AKT1
GABA-ergic synapse 1 TRPV1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 TRPV1
Cell projection, neuron projection 1 TRPV1
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 MYC, NFE2L2, RELA
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cytoskeleton 1 S100A12
Nucleus, nucleolus 1 MYC
spindle pole 1 MAPK14
nuclear envelope 1 MYC
endosome lumen 1 INS
Nucleus, nucleoplasm 1 MYC
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 3 INS, MAPK14, S100A12
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
RNA polymerase II transcription repressor complex 1 MYC
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 MYC
nucleotide-activated protein kinase complex 1 PRKAA2
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, Yang-Chang Wu, Fang-Rong Chang, István Szatmári, Ferenc Fülöp. Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions. Organic & biomolecular chemistry. 2024 03; 22(13):2620-2629. doi: 10.1039/d4ob00056k. [PMID: 38451121]
  • Yongjian Li, Zhengping Tan, Wencan Li, Zongxuan Li, Guiying Zhang. Rutaecarpine ameliorates imiquimod-induced psoriasis-like dermatitis in mice associated with alterations in the gut microbiota. Acta biochimica et biophysica Sinica. 2024 03; 56(3):345-355. doi: 10.3724/abbs.2024018. [PMID: 38419497]
  • Zhen-Xing Li, Jin-Hong Hu, Rong-Shuang Luo, Tai-Hong Zhang, Yue Ding, Xiang Zhou, Li-Wei Liu, Zhi-Bing Wu, Song Yang. Identification of natural Rutaecarpine as a potent tobacco mosaic virus (TMV) helicase candidate for managing intractable plant viral diseases. Pest management science. 2024 Feb; 80(2):805-819. doi: 10.1002/ps.7817. [PMID: 37794206]
  • Min Xu, Li-Hui Qian, Jun-Xiang Wang, Zi-Yang He, Xiao-Yang Ling, Wen-Hua Wang, Jin-Wen Wang, Yue Hu, Ming-Jie Gong. Rutaecarpine Alleviates Early Brain Injury-Induced Inflammatory Response Following Subarachnoid Hemorrhage via SIRT6/NF-[Formula: see text]B Pathway. The American journal of Chinese medicine. 2024; 52(3):799-819. doi: 10.1142/s0192415x24500320. [PMID: 38752843]
  • Dalia Ali, Meshail Okla, Sarah Abuelreich, Radhakrishnan Vishnubalaji, Nicholas Ditzel, Rimi Hamam, Justyna M Kowal, Ahmed Sayed, Abdullah Aldahmash, Nehad M Alajez, Moustapha Kassem. Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells. Frontiers in endocrinology. 2024; 15(?):1360054. doi: 10.3389/fendo.2024.1360054. [PMID: 38638133]
  • Yong He, Hong-Hong Liu, Xue-Lin Zhou, Ting-Ting He, Ao-Zhe Zhang, Xin Wang, Shi-Zhang Wei, Hao-Tian Li, Li-Sheng Chen, Lei Chang, Yan-Ling Zhao, Man-Yi Jing. Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176294. [PMID: 37687125]
  • Min Xu, Zhenhua Shi, Ziyang He, Xiaoyang Ling, Wenhua Wang, Hua Liu, Mingjie Gong. Rutaecarpine alleviates migraine in nitroglycerin-induced mice by regulating PTEN/PGK1 signaling pathway to activate NRF2 antioxidant system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115300. doi: 10.1016/j.biopha.2023.115300. [PMID: 37557014]
  • Shengying Lin, Xiaoyang Wang, Hongsheng Guo, Niyu Dai, Roy Wai-Lun Tang, Hung Chun Lee, Ka Wing Leung, Tina Ting-Xia Dong, Sarah E Webb, Andrew L Miller, Karl Wah-Keung Tsim. The Ethanol Extract of Evodiae Fructus and Its Ingredient, Rutaecarpine, Inhibit Infection of SARS-CoV-2 and Inflammatory Responses. International journal of molecular sciences. 2023 Jan; 24(1):. doi: 10.3390/ijms24010762. [PMID: 36614206]
  • Jingli Liu, Hui Guo, Jing Zhou, Yuwei Wang, Hao Yan, Ruyi Jin, Yuping Tang. Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911513. [PMID: 36232809]
  • Li-Yu Wang, Shu-Lan Yeh, Shih-Tien Hsu, Chao-Hsiang Chen, Chien-Chih Chen, Cheng-Hung Chuang. The Anti-Proliferative and Apoptotic Effects of Rutaecarpine on Human Esophageal Squamous Cell Carcinoma Cell Line CE81T/VGH In Vitro and In Vivo. International journal of molecular sciences. 2022 Mar; 23(5):. doi: 10.3390/ijms23052843. [PMID: 35269987]
  • Cheng-Jie Yang, Hai-Xin Li, Jing-Ru Wang, Zhi-Jun Zhang, Tian-Lin Wu, Ying-Qian Liu, Chen Tang, Qing-Ru Chu, Sha-Sha Du, Ying-Hui He. Design, synthesis and biological evaluation of novel evodiamine and rutaecarpine derivatives against phytopathogenic fungi. European journal of medicinal chemistry. 2022 Jan; 227(?):113937. doi: 10.1016/j.ejmech.2021.113937. [PMID: 34710744]
  • Chun-Jen Huang, Wei-Chieh Huang, Wei-Ting Lin, Lan-Hsin Shu, Joen-Rong Sheu, Oanh-Thi Tran, Chih-Wei Hsia, Thanasekaran Jayakumar, Periyakali Saravana Bhavan, Cheng-Ying Hsieh, Chao-Chien Chang. Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β  Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222011109. [PMID: 34681769]
  • Zhijun Zhao, Yurun Xue, Gaohua Zhang, Jie Jia, Ruilian Xiu, Yugai Jia, Yuanyuan Wang, Xiangchong Wang, Honglin Li, Pingping Chen, Xuan Zhang. Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum. European journal of pharmacology. 2021 Oct; 908(?):174340. doi: 10.1016/j.ejphar.2021.174340. [PMID: 34265294]
  • Jin-Yuarn Lin, Tzu-He Yeh. Rutaecarpine administration inhibits cancer cell growth in allogenic TRAMP-C1 prostate cancer mice correlating with immune balance in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111648. doi: 10.1016/j.biopha.2021.111648. [PMID: 33945915]
  • Xian-Mei Song, Bing-Jie Li, Yan-Yan Zhang, Wen-Jing Ge, She-Feng Zhang, Wei-Feng Cui, Geng-Sheng Li, Rui-Feng Liang. Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jul; 51(7):818-830. doi: 10.1080/00498254.2021.1926573. [PMID: 33952086]
  • Ge Zhan, Fang Wang, Yun-Qi Ding, Xiang-Hua Li, Yue-Xin Li, Zheng-Rong Zhao, Jia-Xin Li, Yan Liu, Xin Zhao, Cai-Chuan Yan, Bao-Xin Li. Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia. Journal of cellular and molecular medicine. 2021 06; 25(11):4938-4949. doi: 10.1111/jcmm.16292. [PMID: 33939251]
  • Sichen Ren, Ying Wei, Ming Niu, Ruisheng Li, Ruilin Wang, Shizhang Wei, Jianxia Wen, Dan Wang, Tao Yang, Xing Chen, Shihua Wu, Yuling Tong, Manyi Jing, Haotian Li, Min Wang, Yanling Zhao. Mechanism of rutaecarpine on ethanol-induced acute gastric ulcer using integrated metabolomics and network pharmacology. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111490. doi: 10.1016/j.biopha.2021.111490. [PMID: 33773465]
  • Xue-Qi Liu, Juan Jin, Zeng Li, Ling Jiang, Yu-Hang Dong, Yu-Ting Cai, Ming-Fei Wu, Jia-Nan Wang, Tao-Tao Ma, Jia-Gen Wen, Ming-Ming Liu, Jun Li, Yong-Gui Wu, Xiao-Ming Meng. Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy. Biochemical pharmacology. 2020 10; 180(?):114132. doi: 10.1016/j.bcp.2020.114132. [PMID: 32622666]
  • Laishram Surbala, Chingakham Brajakishor Singh, Rajkumari Vidyabati Devi, Oinam Joychandra Singh. Rutaecarpine exhibits anti-diabetic potential in high fat diet-multiple low dose streptozotocin induced type 2 diabetic mice and in vitro by modulating hepatic glucose homeostasis. Journal of pharmacological sciences. 2020 Aug; 143(4):307-314. doi: 10.1016/j.jphs.2020.04.008. [PMID: 32536591]
  • Xiaojiaoyang Li, Junde Ge, Qi Zheng, Jiaxiang Zhang, Rong Sun, Runping Liu. Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153180. doi: 10.1016/j.phymed.2020.153180. [PMID: 32092638]
  • Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Tianxia Wang, Xiaoyan Liu, Jing Wang, Qiong Wang, Yuhong Luo, Ping Wang, Tomoki Yagai, Kristopher W Krausz, Xiuwei Yang, Frank J Gonzalez. Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis. Free radical biology & medicine. 2020 02; 148(?):33-41. doi: 10.1016/j.freeradbiomed.2019.12.012. [PMID: 31874248]
  • Li-Fei Nie, Si-Si Wang, Jian-Guo Cao, Fei-Ze Liu, Hainimu Xiamuxi, Haji Akber Aisa, Guo-Zheng Huang. Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones. Journal of Asian natural products research. 2020 Jan; 22(1):69-82. doi: 10.1080/10286020.2018.1540599. [PMID: 30588834]
  • Jinque Luo, Xiao Wang, Xinhai Jiang, Chao Liu, Yongzhen Li, Xiaowan Han, Xuan Zuo, Yining Li, Ni Li, Yanni Xu, Shuyi Si. Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 01; 34(1):1398-1411. doi: 10.1096/fj.201900903rrr. [PMID: 31914630]
  • Baofang Zhang, Zilin Chen. Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor. Journal of pharmaceutical and biomedical analysis. 2019 Nov; 176(?):112811. doi: 10.1016/j.jpba.2019.112811. [PMID: 31437748]
  • Yikun Liu, Wei Zhou, Zhenkun Mao, Zilin Chen. Analysis of Evodiae Fructus by capillary electrochromatography-mass spectrometry with methyl-vinylimidazole functionalized organic polymer monolilth as stationary phases. Journal of chromatography. A. 2019 Sep; 1602(?):474-480. doi: 10.1016/j.chroma.2019.06.011. [PMID: 31202495]
  • Kun-Ming Tian, Jing-Jie Li, Suo-Wen Xu. Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu). Pharmacological research. 2019 03; 141(?):541-550. doi: 10.1016/j.phrs.2018.12.019. [PMID: 30616017]
  • Yongjian Li, Guiying Zhang, Mingliang Chen, Min Tong, Ming Zhao, Fang Tang, Rong Xiao, Haiquan Wen. Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):1876-1883. doi: 10.1016/j.biopha.2018.10.062. [PMID: 30551443]
  • Yun-Xing Gao, Li-Li Jiang, Qian Zhang, Dong-Ze Zuo, Xian-Wei Li. [Rutaecarpine protects against bleomycin-induced pulmonary fibrosis through inhibiting Notch1/eIF3a signaling pathway in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Sep; 43(17):3530-3538. doi: 10.19540/j.cnki.cjcmm.20180530.005. [PMID: 30347923]
  • Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W Krausz, William H Bisson, Xiuwei Yang, Frank J Gonzalez. Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis. Drug metabolism and disposition: the biological fate of chemicals. 2018 07; 46(7):1030-1040. doi: 10.1124/dmd.117.080176. [PMID: 29691238]
  • Yang Xu, Xiu-Ping Chen, Feng Zhang, Hua-Hua Hou, Jing-Yi Zhang, Shu-Xian Lin, An-Sheng Sun. Rutaecarpine Inhibits Intimal Hyperplasia in A Balloon-Injured Rat Artery Model. Chinese journal of integrative medicine. 2018 Jun; 24(6):429-435. doi: 10.1007/s11655-017-2900-3. [PMID: 28861806]
  • Yongmei Yang, Qingquan Chen, Sujie Jia, Limei He, Aiping Wang, Dai Li, Yuanjian Li, Xiaohui Li. Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine. Molecular medicine reports. 2018 04; 17(4):5168-5174. doi: 10.3892/mmr.2018.8494. [PMID: 29393417]
  • Wei Cai, Ying Guan, Yang Zhou, Yuwei Wang, Huaiping Ji, Zhihua Liu. Detection and characterization of the metabolites of rutaecarpine in rats based on ultra-high-performance liquid chromatography with linear ion trap-Orbitrap mass spectrometer. Pharmaceutical biology. 2017 Dec; 55(1):294-298. doi: 10.1080/13880209.2016.1236392. [PMID: 27927077]
  • Yong-Tai Zhang, Zhe Li, Kai Zhang, Hong-Yu Zhang, Ze-Hui He, Qing Xia, Ji-Hui Zhao, Nian-Ping Feng. Co-delivery of evodiamine and rutaecarpine in a microemulsion-based hyaluronic acid hydrogel for enhanced analgesic effects on mouse pain models. International journal of pharmaceutics. 2017 Aug; 528(1-2):100-106. doi: 10.1016/j.ijpharm.2017.05.064. [PMID: 28571904]
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