Lonol (BioDeep_00000176591)

   

human metabolite blood metabolite


代谢物信息卡片


N,N-Dimethyl-3-[[1-(phenylmethyl)-3-indazolyl]oxy]-1-propanamine

化学式: C19H23N3O (309.1841)
中文名称: 苄达明
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
InChI: InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3

描述信息

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CC - Antiinflammatory products for vaginal administration
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations
D000893 - Anti-Inflammatory Agents

同义名列表

42 个代谢物同义名

N,N-Dimethyl-3-[[1-(phenylmethyl)-3-indazolyl]oxy]-1-propanamine; {3-[(1-benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine; 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole; Pharmascience brand OF benzydamine hydrochloride; Farma lepori brand OF benzydamine hydrochloride; United drug brand OF benzydamine hydrochloride; Ratiopharm brand OF benzydamine hydrochloride; Novopharm brand OF benzydamine hydrochloride; Grossmann brand OF benzydamine hydrochloride; Innotech brand OF benzydamine hydrochloride; promeco Brand OF benzydamine hydrochloride; chefaro Brand OF benzydamine hydrochloride; eipico Brand OF benzydamine hydrochloride; Vantal brand OF benzydamine hydrochloride; CSC Brand OF benzydamine hydrochloride; Sun brand OF benzydamine hydrochloride; 3m Brand OF benzydamine hydrochloride; Monohydrochloride, benzydamine; Benzydamine monohydrochloride; Hydrochloride, benzydamine; Benzydamine hydrochloride; ratio Benzydamine; ratio-Benzydamine; novo Benzydamine; novo-Benzydamine; PMS Benzydamine; PMS-Benzydamine; Apo-benzydamine; Tantum topico; Benzydaminum; Benzindamine; BENZYDAMINE; Benzidamine; Bencidamina; Benzydamide; Rosalgin; Sun-benz; Opalgyne; Sun benz; Difflam; Tantum; Lonol



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 FPR1, PLA2G12A, XDH
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 7 CYP1A2, CYP1B1, FMO1, FMO3, FMO4, FMO5, HSP90B1
Nucleus 1 HSP90B1
cytosol 4 FMO5, HSP90B1, IL1B, XDH
Cell membrane 6 C5AR1, FPR1, KCNQ3, SCN10A, TNF, TRPA1
Multi-pass membrane protein 6 C5AR1, FPR1, KCNQ3, SCN10A, SLC45A2, TRPA1
Synapse 1 KCNQ3
cell surface 2 KCNQ3, TNF
glutamatergic synapse 1 SCN10A
neuronal cell body 1 TNF
presynaptic membrane 1 SCN10A
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
plasma membrane 7 C5AR1, CSF2, FPR1, KCNQ3, SCN10A, TNF, TRPA1
Membrane 6 CYP1B1, FPR1, HSP90B1, KCNQ3, SLC45A2, TRPA1
axon 1 SCN10A
basolateral plasma membrane 1 C5AR1
extracellular exosome 2 HSP90B1, SCN10A
endoplasmic reticulum 4 FMO1, FMO3, FMO5, HSP90B1
extracellular space 6 CSF2, CXCL8, IL1B, IL6, TNF, XDH
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 2 CYP1B1, KCNQ3
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 4 CSF2, CYP1A2, CYP1B1, FMO3
Microsome membrane 5 CYP1A2, CYP1B1, FMO3, FMO4, FMO5
Secreted 5 CSF2, CXCL8, IL1B, IL6, PLA2G12A
extracellular region 7 CSF2, CXCL8, HSP90B1, IL1B, IL6, PLA2G12A, TNF
Single-pass membrane protein 3 FMO1, FMO3, FMO4
external side of plasma membrane 1 TNF
cytoplasmic vesicle 1 C5AR1
Melanosome membrane 1 SLC45A2
midbody 1 HSP90B1
apical part of cell 1 C5AR1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
focal adhesion 1 HSP90B1
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 IL1B
stereocilium bundle 1 TRPA1
phagocytic cup 1 TNF
axon initial segment 1 KCNQ3
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
voltage-gated potassium channel complex 1 KCNQ3
secretory granule membrane 2 C5AR1, FPR1
endoplasmic reticulum lumen 3 FMO1, HSP90B1, IL6
azurophil granule membrane 1 FPR1
node of Ranvier 1 KCNQ3
Secreted, extracellular exosome 1 IL1B
Sarcoplasmic reticulum lumen 1 HSP90B1
ficolin-1-rich granule membrane 1 FPR1
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
voltage-gated sodium channel complex 1 SCN10A
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
clathrin complex 1 SCN10A
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Ali Alaiye, Ercan Kaya, Mehmet Özgür Pınarbaşlı, Nuşin Harmancı, Cafer Yıldırım, Dilek Burukoğlu Dönmez, Cemal Cingi. An Experimental Comparison of the Analgesic and Anti-Inflammatory Effects of Safflower Oil, Benzydamine HCl, and Naproxen Sodium. Journal of medicinal food. 2020 Aug; 23(8):862-869. doi: 10.1089/jmf.2019.0157. [PMID: 32216647]
  • A F D Di Stefano, M M Radicioni, A Vaccani, G Caccia, F Focanti, E Salvatori, F Pelacchi, R Picollo, M T Rosignoli, S Olivieri, G Bovi, A Comandini. Phase I Study in Healthy Women of a Novel Antimycotic Vaginal Ovule Combining Econazole and Benzydamine. Infectious diseases in obstetrics and gynecology. 2020; 2020(?):7201840. doi: 10.1155/2020/7201840. [PMID: 32410819]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Merve Harman, Nimet Ovayolu, Ozlem Ovayolu. The effect of three different solutions on preventing oral mucositis in cancer patients undergoing stem cell transplantation: a non-randomized controlled trial: A Turkish study - NON-RANDOMISED TRIAL. JPMA. The Journal of the Pakistan Medical Association. 2019 Jun; 69(6):811-816. doi: ". [PMID: 31189287]
  • Yasuhiro Uno, Makiko Shimizu, Hiromi Yoda, Hiroshi Yamazaki. Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney. Journal of medical primatology. 2019 02; 48(1):51-53. doi: 10.1111/jmp.12385. [PMID: 30252147]
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  • Mahnaz Sahebjamee, Arash Mansourian, Mohammad Hajimirzamohammad, Haji Mirza Mohammad Mohammad, Mohsen Taghi Zadeh, Reza Bekhradi, Ali Kazemian, Soheila Manifar, Sajjad Ashnagar, Kiavash Doroudgar. Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial. Oral health & preventive dentistry. 2015; 13(4):309-15. doi: 10.3290/j.ohpd.a33091. [PMID: 25431805]
  • Marek Smoluch, Przemyslaw Mielczarek, Edward Reszke, Gary M Hieftje, Jerzy Silberring. Determination of psychostimulants and their metabolites by electrochemistry linked on-line to flowing atmospheric pressure afterglow mass spectrometry. The Analyst. 2014 Sep; 139(17):4350-5. doi: 10.1039/c3an02067c. [PMID: 25010982]
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