Classification Term: 680

Indazoles (ontology term: CHEMONTID:0000080)

Compounds containing an indazole, which is structurally characterized by a pyrazole fused to a benzene." []

found 15 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Benzopyrazoles

Child Taxonomies: Pyridazinoindazoles , Furoindazoles , Indazole-3-carboxamides

1H-Indazol-3-amine

2,3-dihydro-1H-indazol-3-imine

C7H7N3 (133.064)

COVID info from PDB, Protein Data Bank Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

Indazole

1H-Benzopyrazole

C7H6N2 (118.0531)

COVID info from PDB, Protein Data Bank Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

2-(1H-Indazol-3-yl)acetic acid

2-(2H-indazol-3-yl)acetic acid

C9H8N2O2 (176.0586)

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents D002491 - Central Nervous System Agents > D000927 - Anticonvulsants D002491 - Central Nervous System Agents > D000700 - Analgesics D020011 - Protective Agents D004791 - Enzyme Inhibitors

(R)-1-(5-Tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea

C21H24N4O (348.195)

bendazac

2-[(1-benzyl-1H-indazol-3-yl)oxy]acetic acid

C16H14N2O3 (282.1004)

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents

Lonol

N,N-Dimethyl-3-[[1-(phenylmethyl)-3-indazolyl]oxy]-1-propanamine

C19H23N3O (309.1841)

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CC - Antiinflammatory products for vaginal administration M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations D000893 - Anti-Inflammatory Agents

Benzydamine N-oxide

3-[(1-benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropanamine oxide

C19H23N3O2 (325.179)

Bindarit

2-[(1-benzyl-1h-indazol-3-yl)methoxy]-2-methylpropanoic acid

C19H20N2O3 (324.1474)

D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors C29629 - Combination Medication > C29634 - Antirheumatic Preparation D000893 - Anti-Inflammatory Agents Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity[1].

Indanidine

N-(4,5-dihydro-1H-imidazol-2-yl)-2-methyl-2H-indazol-4-amine

C11H13N5 (215.1171)

Lonidamine

1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid

C15H10Cl2N2O2 (320.0119)

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent D009676 - Noxae > D000988 - Antispermatogenic Agents D011838 - Radiation-Sensitizing Agents C1744 - Multidrug Resistance Modulator D000970 - Antineoplastic Agents Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis[1][2][3].