1,5-Anhydrosorbitol (BioDeep_00000016646)

Main id: BioDeep_00000001221

Secondary id: BioDeep_00000821532

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


1,5-anhydro-D-Glucitol

化学式: C6H12O5 (164.06847019999998)
中文名称: 1,5-酐-D-山梨糖醇, 1,5-脱水-D-葡萄糖醇
谱图信息: 最多检出来源 Viridiplantae(plant) 1.17%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@@H]([C@H](CO1)O)O)O)O
InChI: InChI=1S/C6H12O5/c7-1-4-6(10)5(9)3(8)2-11-4/h3-10H,1-2H2/t3-,4+,5+,6+/m0/s1

描述信息

An anhydro sugar of D-glucitol.
1,5-Anhydrosorbitol is a short-term marker for glycemic control.
1,5-Anhydrosorbitol is a short-term marker for glycemic control.

同义名列表

5 个代谢物同义名

1,5-anhydro-D-Glucitol; 1,5-Anhydrosorbitol; 1,5-Anhydro-D-mannitol; 1,5-Anhydro-D-glucitol; 1,5-Anhydro-D-glucitol



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Thi Thanh Le, Manh Tuan Ha, Thao Quyen Cao, Jeong Ah Kim, Jae Sue Choi, Byung Sun Min. 1,5-Anhydro-d-glucitol derivative and galloylated flavonoids isolated from the leaves of Acer ginnala Maxim. as dual inhibitors of PTP1B and α-glucosidase enzymes: In vitro and in silico studies. Phytochemistry. 2023 Jun; 213(?):113769. doi: 10.1016/j.phytochem.2023.113769. [PMID: 37343738]
  • Marta Migała, Justyna Chałubińska-Fendler, Marzenna Zielińska. 1,5-Anhydroglucitol as a Marker of Acute Hyperglycemia in Cardiovascular Events. The review of diabetic studies : RDS. 2022 06; 18(2):68-75. doi: 10.1900/rds.2022.18.68. [PMID: 35831937]
  • Mengna Li, Dewen Yan, Mingyu Hao, Xiaohong Huang, Yun Xu, Weifeng Li, Wenlan Liu. Quantification of Glucose, fructose and 1,5-Anhydroglucitol in plasma of diabetic patients by ultra performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jun; 1200(?):123277. doi: 10.1016/j.jchromb.2022.123277. [PMID: 35533424]
  • Junyi Qian, Cheng Chen, Xiaohang Wang, Yuanyuan Tan, Jiao Yang, Yuexing Yuan, Juan Chen, Haijian Guo, Bei Wang, Zilin Sun, Yao Wang. HbA1c combined with glycated albumin or 1,5-anhydroglucitol improves the efficiency of diabetes screening in a Chinese population. Diabetic medicine : a journal of the British Diabetic Association. 2022 03; 39(3):e14685. doi: 10.1111/dme.14685. [PMID: 34473869]
  • Yuexing Yuan, Jinfeng Cheng, Cheng Chen, Yao Wang. Combining serum 1,5-anhydroglucitol with fasting plasma glucose to detect diabetes mellitus in a community-based population with hypertension. Annals of palliative medicine. 2021 Aug; 10(8):8746-8752. doi: 10.21037/apm-21-1305. [PMID: 34488364]
  • Moataz M Hanafy, Jeremie Z Lindeque, Shohda A El-Maraghy, Abdel-Hamid Z Abdel-Hamid, Nancy N Shahin. Time-based investigation of urinary metabolic markers for Type 2 diabetes: Metabolomics approach for diabetes management. BioFactors (Oxford, England). 2021 Jul; 47(4):645-657. doi: 10.1002/biof.1731. [PMID: 33836111]
  • Mana Ohigashi, Keiko Osugi, Yoshiki Kusunoki, Kahori Washio, Satoshi Matsutani, Taku Tsunoda, Toshihiro Matsuo, Kosuke Konishi, Tomoyuki Katsuno, Mitsuyoshi Namba, Hidenori Koyama. Association of time in range with hemoglobin A1c, glycated albumin and 1,5-anhydro-d-glucitol. Journal of diabetes investigation. 2021 Jun; 12(6):940-949. doi: 10.1111/jdi.13437. [PMID: 33058513]
  • C H Jian, A H Zhao, X J Ma, W Lu, W Zhu, Y F Wang, J Zhou, Y Q Bao. [Research on consistency of different measurement methods for saliva 1,5-anhydroglucitol]. Zhonghua yi xue za zhi. 2020 Nov; 100(42):3291-3295. doi: 10.3760/cma.j.cn112137-20200312-00726. [PMID: 33202489]
  • Bethany Warren, Alexandra K Lee, Christie M Ballantyne, Ron C Hoogeveen, James S Pankow, Morgan E Grams, Anna Köttgen, Elizabeth Selvin. Associations of 1,5-Anhydroglucitol and 2-Hour Glucose with Major Clinical Outcomes in the Atherosclerosis Risk in Communities (ARIC) Study. The journal of applied laboratory medicine. 2020 11; 5(6):1296-1306. doi: 10.1093/jalm/jfaa066. [PMID: 32529222]
  • Hyungjun Jang, Jusung Oh, Hangil Ki, Min-Gon Kim. Paper-based 1,5-anhydroglucitol quantification using enzyme-based glucose elimination. The Analyst. 2020 Aug; 145(17):5740-5743. doi: 10.1039/d0an00905a. [PMID: 32686804]
  • Sakurako Kira, Chikako Ito, Rumi Fujikawa, Munechika Misumi. Association between a biomarker of glucose spikes, 1,5-anhydroglucitol, and cancer mortality. BMJ open diabetes research & care. 2020 08; 8(1):. doi: 10.1136/bmjdrc-2020-001607. [PMID: 32792354]
  • Ryoko Asada, Kenji Tazawa, Shinkichi Sato, Nobuhiko Miwa. Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. Medical gas research. 2020 Jul; 10(3):114-121. doi: 10.4103/2045-9912.296041. [PMID: 33004708]
  • Chaohui Jian, Aihua Zhao, Xiaojing Ma, Kun Ge, Wei Lu, Wei Zhu, Yufei Wang, Jian Zhou, Wei Jia, Yuqian Bao. Diabetes Screening: Detection and Application of Saliva 1,5-Anhydroglucitol by Liquid Chromatography-Mass Spectrometry. The Journal of clinical endocrinology and metabolism. 2020 06; 105(6):. doi: 10.1210/clinem/dgaa114. [PMID: 32170297]
  • Cheng Chen, Xiaohang Wang, Yuanyuan Tan, Jiao Yang, Yuexing Yuan, Juan Chen, Haijian Guo, Bei Wang, Ziling Sun, Yao Wang. Reference intervals for serum 1,5-anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province. Journal of diabetes. 2020 Jun; 12(6):447-454. doi: 10.1111/1753-0407.13016. [PMID: 31846192]
  • Gong Su, Ming-Xi Gao, Gen-Ling Shi, Xi-Xi Dai, Wei-Feng Yao, Tao Zhang, Shao-Wei Zhuang. Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome. Cardiovascular diabetology. 2020 05; 19(1):71. doi: 10.1186/s12933-020-01045-0. [PMID: 32473648]
  • Asuka Morita, Motoshi Ouchi, Keitaro Satoh, Misao Terada, Hiroe Kon, Hidefumi Wakashin, Keitaro Hayashi, Naohiko Anzai, Kenzo Oba, Akira Shimizu, Tomoe Fujita. Development of an organ bath technique for isolated rat pancreas preparations to assess the effect of 1,5-AG on insulin secretion. Experimental animals. 2020 Apr; 69(2):127-134. doi: 10.1538/expanim.19-0059. [PMID: 31735767]
  • Qingqing Lou, Xiaodan Yuan, Shujie Hao, Joshua D Miller, Juan Yan, Panpan Zuo, Jianing Li, Lihong Yang, Hong Li. Effects of Glucose Fluctuation Targeted Intervention on the Prognosis of Patients with Type 2 Diabetes following the First Episode of Cerebral Infarction. Journal of diabetes research. 2020; 2020(?):2532171. doi: 10.1155/2020/2532171. [PMID: 32090117]
  • Lingwen Ying, Xiaojing Ma, Yun Shen, Jingyi Lu, Wei Lu, Wei Zhu, Yufei Wang, Yuqian Bao, Jian Zhou. Serum 1,5-Anhydroglucitol to Glycated Albumin Ratio Can Help Early Distinguish Fulminant Type 1 Diabetes Mellitus from Newly Onset Type 1A Diabetes Mellitus. Journal of diabetes research. 2020; 2020(?):1243630. doi: 10.1155/2020/1243630. [PMID: 32280712]
  • Shota Machida, Saki Mukai, Rina Kono, Megumi Funato, Hiroaki Saito, Taketo Uchiyama. Synthesis and Comparative Structure-Activity Study of Carbohydrate-Based Phenolic Compounds as α-Glucosidase Inhibitors and Antioxidants. Molecules (Basel, Switzerland). 2019 Nov; 24(23):. doi: 10.3390/molecules24234340. [PMID: 31783621]
  • Bruna R Martins, Letícia C Gomes, Kátia C Boritza, Mauren I Anghebem-Oliveira, Emanuel M Souza, Suzana N França, Geraldo Picheth, Fabiane G M Rego. Serum 1,5-Anhydroglucitol Concentration as a Biomarker for Type 1 Diabetes in Adults and Children. Clinical laboratory. 2019 Sep; 65(9):. doi: 10.7754/clin.lab.2019.190141. [PMID: 31532108]
  • Namrata Sanjeevi, Leah M Lipsky, Tonja R Nansel. Hyperglycemia and Carotenoid Intake Are Associated with Serum Carotenoids in Youth with Type 1 Diabetes. Journal of the Academy of Nutrition and Dietetics. 2019 08; 119(8):1340-1348. doi: 10.1016/j.jand.2019.03.009. [PMID: 31101482]
  • Qiaorui Liu, Xulei Zheng, Zhiwen Liu, Ling Qiu. Vitamin D status is associated with 1,5-anhydro-d-glucitol status in patients with type 2 diabetes mellitus. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2019 Aug; 44(8):857-860. doi: 10.1139/apnm-2018-0719. [PMID: 30633541]
  • Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Norihito Takahashi, Hirohisa Endo, Yoshiteru Kato, Manabu Ogita, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Kikuo Isoda, Kazunori Shimada, Satoru Suwa, Hiroyuki Daida. Impact of serum 1,5-anhydro-D-glucitol level on the prediction of severe coronary artery calcification: an intravascular ultrasound study. Cardiovascular diabetology. 2019 06; 18(1):69. doi: 10.1186/s12933-019-0878-1. [PMID: 31159826]
  • Stephanie J Loomis, Anna Köttgen, Man Li, Adrienne Tin, Josef Coresh, Eric Boerwinkle, Richard Gibbs, Donna Muzny, James Pankow, Elizabeth Selvin, Priya Duggal. Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study. Scientific reports. 2019 04; 9(1):5941. doi: 10.1038/s41598-019-42202-0. [PMID: 30976018]
  • Magdalena Szopa, Tomasz Klupa, Maria Kapusta, Bartlomiej Matejko, Damian Ucieklak, Wojciech Glodzik, Barbara Zapala, Cyrus Maurice Sani, Jerzy Hohendorff, Maciej T Malecki, Jan Skupien. A decision algorithm to identify patients with high probability of monogenic diabetes due to HNF1A mutations. Endocrine. 2019 04; 64(1):75-81. doi: 10.1007/s12020-019-01863-7. [PMID: 30778899]
  • Yuanyuan Bai, Ruihua Yang, Yanan Song, Yuhuan Wang. Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2019 Apr; 127(4):220-225. doi: 10.1055/s-0043-122142. [PMID: 29270924]
  • Thyparambil Aravindakshan Pramodkumar, Ramamoorthy Jayashri, Kuppan Gokulakrishnan, Kaliyaperumal Velmurugan, Rajendra Pradeepa, Ulagamathesan Venkatesan, Ponnusamy Saravanan, Ram Uma, Ranjit Mohan Anjana, Viswanathan Mohan. 1,5 Anhydroglucitol in gestational diabetes mellitus. Journal of diabetes and its complications. 2019 03; 33(3):231-235. doi: 10.1016/j.jdiacomp.2018.11.010. [PMID: 30594413]
  • Marciane Welter, Kátia C Boritza, Mauren I Anghebem-Oliveira, Railson Henneberg, Aline B Hauser, Fabiane G M Rego, Geraldo Picheth. Reference intervals for serum 1,5-anhydroglucitol in children, adolescents, adults, and pregnant women. Clinica chimica acta; international journal of clinical chemistry. 2018 Nov; 486(?):54-58. doi: 10.1016/j.cca.2018.07.018. [PMID: 30017617]
  • Neuza Mendes, Rogério Tavares Ribeiro, Fátima Serrano. Beyond self-monitored plasma glucose and HbA1c: the role of non-traditional glycaemic markers in gestational diabetes mellitus. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2018 Aug; 38(6):762-769. doi: 10.1080/01443615.2017.1412409. [PMID: 29620435]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Konrad Sydow, Christopher Wiedfeld, Frank Musshoff, Burkhard Madea, Diethelm Tschoepe, Bernd Stratmann, Cornelius Hess. Evaluation of 1,5-anhydro-d-glucitol in clinical and forensic urine samples. Forensic science international. 2018 Jun; 287(?):88-97. doi: 10.1016/j.forsciint.2018.03.002. [PMID: 29655100]
  • Zhide Zhou, Le Zhao, Zhihong Wang, Wen Xue, Yunxiao Wang, Yong Huang, Jintao Liang, Jiejing Chen, Guiyin Li. Colorimetric detection of 1,5-anhydroglucitol based on graphene quantum dots and enzyme-catalyzed reaction. International journal of biological macromolecules. 2018 Jun; 112(?):1217-1224. doi: 10.1016/j.ijbiomac.2018.02.093. [PMID: 29466711]
  • Siobhan M Corcoran, Natalie Achamallah, John O' Loughlin, Philip Stafford, Pat Dicker, Fergal D Malone, Fionnuala Breathnach. First trimester serum biomarkers to predict gestational diabetes in a high-risk cohort: Striving for clinically useful thresholds. European journal of obstetrics, gynecology, and reproductive biology. 2018 Mar; 222(?):7-12. doi: 10.1016/j.ejogrb.2017.12.051. [PMID: 29328940]
  • Gesiane Tavares, Gabriela Venturini, Kallyandra Padilha, Roberto Zatz, Alexandre C Pereira, Ravi I Thadhani, Eugene P Rhee, Silvia M O Titan. 1,5-Anhydroglucitol predicts CKD progression in macroalbuminuric diabetic kidney disease: results from non-targeted metabolomics. Metabolomics : Official journal of the Metabolomic Society. 2018 02; 14(4):39. doi: 10.1007/s11306-018-1337-9. [PMID: 30830377]
  • X Hu, X He, X Ma, H Su, L Ying, J Peng, Y Wang, Y Bao, J Zhou, W Jia. A decrease in serum 1,5-anhydroglucitol levels is associated with the presence of a first-degree family history of diabetes in a Chinese population with normal glucose tolerance. Diabetic medicine : a journal of the British Diabetic Association. 2018 01; 35(1):131-136. doi: 10.1111/dme.13534. [PMID: 29057494]
  • Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida. Low 1,5-anhydroglucitol levels are associated with long-term cardiac mortality in acute coronary syndrome patients with hemoglobin A1c levels less than 7.0. Cardiovascular diabetology. 2017 11; 16(1):151. doi: 10.1186/s12933-017-0636-1. [PMID: 29157245]
  • Morgan E Grams, Adrienne Tin, Casey M Rebholz, Tariq Shafi, Anna Köttgen, Ronald D Perrone, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Josef Coresh. Metabolomic Alterations Associated with Cause of CKD. Clinical journal of the American Society of Nephrology : CJASN. 2017 Nov; 12(11):1787-1794. doi: 10.2215/cjn.02560317. [PMID: 28971980]
  • Shinya Inada, Masafumi Koga. Alcohol consumption reduces HbA1c and glycated albumin concentrations but not 1,5-anhydroglucitol. Annals of clinical biochemistry. 2017 Nov; 54(6):631-635. doi: 10.1177/0004563216675646. [PMID: 27705886]
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  • Casey M Rebholz, Morgan E Grams, Yuan Chen, Alden L Gross, Yingying Sang, Josef Coresh, Elizabeth Selvin. Serum Levels of 1,5-Anhydroglucitol and Risk of Incident End-Stage Renal Disease. American journal of epidemiology. 2017 Oct; 186(8):952-960. doi: 10.1093/aje/kwx167. [PMID: 28535187]
  • S P Juraschek, E R Miller, L J Appel, R H Christenson, F M Sacks, E Selvin. Effects of dietary carbohydrate on 1,5-anhydroglucitol in a population without diabetes: results from the OmniCarb trial. Diabetic medicine : a journal of the British Diabetic Association. 2017 10; 34(10):1407-1413. doi: 10.1111/dme.13391. [PMID: 28574153]
  • Lingwen Ying, Xingxing He, Xiaojing Ma, Yun Shen, Hang Su, Jiahui Peng, Yufei Wang, Yuqian Bao, Jian Zhou, Weiping Jia. Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the efficiency of diabetes screening in a Chinese population. Scientific reports. 2017 09; 7(1):11968. doi: 10.1038/s41598-017-12210-z. [PMID: 28931928]
  • J Hohendorff, M Szopa, J Skupien, M Kapusta, B Zapala, T Platek, S Mrozinska, T Parpan, W Glodzik, A Ludwig-Galezowska, B Kiec-Wilk, T Klupa, M T Malecki. A single dose of dapagliflozin, an SGLT-2 inhibitor, induces higher glycosuria in GCK- and HNF1A-MODY than in type 2 diabetes mellitus. Endocrine. 2017 Aug; 57(2):272-279. doi: 10.1007/s12020-017-1341-2. [PMID: 28593615]
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  • Sadako Nakamura, Kenichi Tanabe, Kazuhiro Yoshinaga, Fumio Shimura, Tsuneyuki Oku. Effects of 1,5-anhydroglucitol on postprandial blood glucose and insulin levels and hydrogen excretion in rats and healthy humans. The British journal of nutrition. 2017 Jul; 118(2):81-91. doi: 10.1017/s0007114517001866. [PMID: 28820081]
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  • Hang Su, Xiaojing Ma, Jun Yin, Yufei Wang, Xingxing He, Yuqian Bao, Jian Zhou, Weiping Jia. Serum 1,5-anhydroglucitol levels slightly increase rather than decrease after a glucose load in subjects with different glucose tolerance status. Acta diabetologica. 2017 May; 54(5):463-470. doi: 10.1007/s00592-017-0968-z. [PMID: 28210869]
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