Anhydrotetracyclin (BioDeep_00000001661)

   


代谢物信息卡片


4-(dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide

  化学式: C22H22N2O7 (426.1427)
中文名称: 脱水四环素
  谱图信息: 最多检出来源 Homo sapiens(COVID-19)(blood) 7.96%

分子结构信息

SMILES: CC1=C2C=CC=C(C2=C(C3=C1CC4C(C(=O)C(=C(C4(C3=O)O)O)C(=O)N)N(C)C)O)O
InChI: InChI=1S/C22H22N2O7/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28/h4-6,11,16,25-27,31H,7H2,1-3H3,(H2,23,30)/t11-,16-,22-/m0/s1



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ASL, ERBB2, NT5C3A, RELB, RPS13
Peripheral membrane protein 2 PLOD2, PLOD3
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 2 PLOD2, PLOD3
Nucleus 6 CUL2, ERBB2, HELLS, RELB, RPS13, ZNF80
cytosol 8 ASL, CDC20, CLPX, CUL2, ERBB2, NT5C3A, RELB, RPS13
dendrite 1 C4A
nuclear body 1 NT5C3A
trans-Golgi network 1 PLOD3
centrosome 2 CDC20, RELB
nucleoplasm 9 ATP2B1, CDC20, CLPX, CUL2, ERBB2, NT5C3A, RELB, RPS13, SLC3A2
Cell membrane 4 ATP2B1, CD81, ERBB2, SLC3A2
ruffle membrane 1 ERBB2
Cell projection, axon 1 C4A
Multi-pass membrane protein 2 ATP2B1, CD81
Synapse 4 ATP2B1, C4A, RELB, SLC3A2
cell junction 1 SLC3A2
cell surface 2 ALPP, SLC3A2
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 PLOD3
lysosomal membrane 1 SLC3A2
mitochondrial inner membrane 1 CLPX
neuromuscular junction 1 ERBB2
neuronal cell body 1 C4A
presynaptic membrane 2 ATP2B1, ERBB2
plasma membrane 7 ALPP, ATP2B1, C4A, CD81, ERBB2, F2, SLC3A2
synaptic vesicle membrane 1 ATP2B1
Membrane 5 ATP2B1, CD81, ERBB2, RPS13, SLC3A2
apical plasma membrane 2 ERBB2, SLC3A2
axon 1 C4A
basolateral plasma membrane 4 ATP2B1, CD81, ERBB2, SLC3A2
extracellular exosome 9 ASL, ATP2B1, C4A, CD81, F2, PLOD2, PLOD3, RPS13, SLC3A2
Lysosome membrane 1 SLC3A2
Lumenal side 2 PLOD2, PLOD3
endoplasmic reticulum 3 NT5C3A, PLOD2, PLOD3
extracellular space 3 C4A, F2, PLOD3
perinuclear region of cytoplasm 1 ERBB2
mitochondrion 3 CLPP, CLPX, NT5C3A
protein-containing complex 1 RELB
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 1 RPS13
pericentric heterochromatin 1 HELLS
Single-pass type I membrane protein 1 ERBB2
Secreted 3 C4A, F2, PLOD3
extracellular region 3 C4A, ERBB2, F2
Mitochondrion matrix 1 CLPP
mitochondrial matrix 2 CLPP, CLPX
anchoring junction 1 SLC3A2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDC20, RELB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
cytoplasmic vesicle 1 ERBB2
nucleolus 2 CUL2, RPS13
Early endosome 1 ERBB2
Single-pass type II membrane protein 1 SLC3A2
vesicle 1 CD81
Apical cell membrane 1 SLC3A2
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
focal adhesion 2 CD81, RPS13
spindle 1 CDC20
mitochondrial nucleoid 1 CLPX
collagen-containing extracellular matrix 2 F2, PLOD3
lateral plasma membrane 2 ATP2B1, CD81
receptor complex 1 ERBB2
chromatin 1 RELB
cell projection 1 ATP2B1
Secreted, extracellular space 1 PLOD3
Nucleus, nucleolus 1 RPS13
spindle pole 1 CDC20
blood microparticle 2 C4A, F2
Basolateral cell membrane 3 ATP2B1, CD81, SLC3A2
Lipid-anchor, GPI-anchor 1 ALPP
Cytoplasm, cytoskeleton, spindle pole 1 CDC20
Cul2-RING ubiquitin ligase complex 1 CUL2
Chromosome, centromere, kinetochore 1 CDC20
Cell projection, dendrite 1 C4A
Melanosome 1 SLC3A2
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ALPP
myelin sheath 1 ERBB2
basal plasma membrane 3 CD81, ERBB2, SLC3A2
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 C4A, F2, PLOD3
transcription repressor complex 1 RELB
kinetochore 1 CDC20
rough endoplasmic reticulum membrane 1 PLOD2
small-subunit processome 1 RPS13
anaphase-promoting complex 1 CDC20
immunological synapse 2 ATP2B1, CD81
tetraspanin-enriched microdomain 1 CD81
chromosome, centromeric region 1 HELLS
semaphorin receptor complex 1 ERBB2
[Isoform 1]: Cell membrane 1 ERBB2
Rough endoplasmic reticulum 2 PLOD2, PLOD3
mitotic checkpoint complex 1 CDC20
cytosolic ribosome 1 RPS13
endopeptidase Clp complex 2 CLPP, CLPX
mitochondrial endopeptidase Clp complex 1 CLPX
ribosome 1 RPS13
ERBB3:ERBB2 complex 1 ERBB2
amino acid transport complex 1 SLC3A2
apical pole of neuron 1 SLC3A2
cytosolic small ribosomal subunit 1 RPS13
SCF ubiquitin ligase complex 1 CUL2
photoreceptor ribbon synapse 1 ATP2B1
NF-kappaB complex 1 RELB
cullin-RING ubiquitin ligase complex 1 CUL2
VCB complex 1 CUL2


文献列表

  • Dongmei Xu, Yingping Xiao, Hua Pan, Yu Mei. Toxic effects of tetracycline and its degradation products on freshwater green algae. Ecotoxicology and environmental safety. 2019 Jun; 174(?):43-47. doi: 10.1016/j.ecoenv.2019.02.063. [PMID: 30818259]
  • Min Wang, Qiong Wang, Xiang Gao, Zhong Su. Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite. Parasites & vectors. 2017 Jun; 10(1):315. doi: 10.1186/s13071-017-2253-y. [PMID: 28655332]
  • Murat Topal, Gülşad Uslu Şenel, Erdal Öbek, E Işıl Arslan Topal. Investigation of relationships between removals of tetracycline and degradation products and physicochemical parameters in municipal wastewater treatment plant. Journal of environmental management. 2016 May; 173(?):1-9. doi: 10.1016/j.jenvman.2016.02.046. [PMID: 26950498]
  • Murat Topal, E Işıl Arslan Topal. Occurrence and fate of tetracycline and degradation products in municipal biological wastewater treatment plant and transport of them in surface water. Environmental monitoring and assessment. 2015 Dec; 187(12):750. doi: 10.1007/s10661-015-4978-4. [PMID: 26566643]
  • Martha Ines Burgos, Ricardo Ariel Fernández, María Soledad Celej, Laura Isabel Rossi, Gerardo Daniel Fidelio, Sergio Alberto Dassie. Binding of the highly toxic tetracycline derivative, anhydrotetracycline, to bovine serum albumin. Biological & pharmaceutical bulletin. 2011; 34(8):1301-6. doi: 10.1248/bpb.34.1301. [PMID: 21804222]
  • John Love, George C Allen, Christiane Gatz, William F Thompson. Differential Top10 promoter regulation by six tetracycline analogues in plant cells. Journal of experimental botany. 2002 Sep; 53(376):1871-7. doi: 10.1093/jxb/erf050. [PMID: 12177125]
  • A M Jones, K H Im, M A Savka, M J Wu, N G DeWitt, R Shillito, A N Binns. Auxin-dependent cell expansion mediated by overexpressed auxin-binding protein 1. Science (New York, N.Y.). 1998 Nov; 282(5391):1114-7. doi: 10.1126/science.282.5391.1114. [PMID: 9804548]
  • W B Chang, Y B Zhao, Y X Ci, L Y Hu. Spectrofluorimetric determination of tetracycline and anhydrotetracycline in serum and urine. The Analyst. 1992 Aug; 117(8):1377-8. doi: 10.1039/an9921701377. [PMID: 1443636]
  • M Yanase, Y Orita, N Okada, T Nakanishi, M Horio, A Ando, H Abe. Decreased Na+-gradient-dependent D-glucose transport in brush-border membrane vesicles from rabbits with experimental Fanconi syndrome. Biochimica et biophysica acta. 1983 Aug; 733(1):95-101. doi: 10.1016/0005-2736(83)90094-9. [PMID: 6882758]


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