Isopentenyl pyrophosphate (BioDeep_00000001656)

 

Secondary id: BioDeep_00000415832

human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


({hydroxy[(3-methylbut-3-en-1-yl)oxy]phosphoryl}oxy)phosphonic acid

化学式: C5H12O7P2 (246.0058262)
中文名称: 异戊烯焦磷酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.13%

分子结构信息

SMILES: C(O[P@](=O)(OP(=O)(O)O)O)CC(=C)C
InChI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)

描述信息

Isopentenyl pyrophosphate, also known as delta3-isopentenyl diphosphate or ipp, is a member of the class of compounds known as isoprenoid phosphates. Isoprenoid phosphates are prenol lipids containing a phosphate group linked to an isoprene (2-methylbuta-1,3-diene) unit. Thus, isopentenyl pyrophosphate is considered to be an isoprenoid lipid molecule. Isopentenyl pyrophosphate is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Isopentenyl pyrophosphate can be found in a number of food items such as american butterfish, conch, tea leaf willow, and butternut, which makes isopentenyl pyrophosphate a potential biomarker for the consumption of these food products. Isopentenyl pyrophosphate can be found primarily in human spleen tissue. Isopentenyl pyrophosphate exists in all living species, ranging from bacteria to humans. In humans, isopentenyl pyrophosphate is involved in several metabolic pathways, some of which include ibandronate action pathway, lovastatin action pathway, fluvastatin action pathway, and pravastatin action pathway. Isopentenyl pyrophosphate is also involved in several metabolic disorders, some of which include hypercholesterolemia, hyper-igd syndrome, lysosomal acid lipase deficiency (wolman disease), and wolman disease. Isopentenyl pyrophosphate (IPP, isopentenyl diphosphate, or IDP) is an isoprenoid precursor. IPP is an intermediate in the classical, HMG-CoA reductase pathway (commonly called the mevalonate pathway) and in the non-mevalonate MEP pathway of isoprenoid precursor biosynthesis. Isoprenoid precursors such as IPP, and its isomer DMAPP, are used by organisms in the biosynthesis of terpenes and terpenoids .
Isopentenyl pyrophosphate, IPP or isopentenyl diphosphate, is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes and terpenoids. IPP is formed from Mevalonate-5-pyrophosphate, in a reaction catalyzed by the enzyme mevalonate-5-pyrophosphate decarboxylase. (wikipedia).

同义名列表

40 个代谢物同义名

({hydroxy[(3-methylbut-3-en-1-yl)oxy]phosphoryl}oxy)phosphonic acid; 3-Methylbut-3-enyl phosphono hydrogen phosphoric acid; 3-Methylbut-3-en-1-yl trihydrogen diphosphoric acid; Diphosphoric acid mono(3-methyl-3-butenyl) ester; 3-Methylbut-3-enyl phosphono hydrogen phosphate; 3-Methylbut-3-en-1-yl trihydrogen diphosphate; Diphosphate mono(3-methyl-3-butenyl) ester; mono(3-Methyl-3-butenyl) diphosphoric acid; Isopentenyl pyrophosphate, 4-(14)C-labeled; delta3-Methyl-3-butenyl diphosphoric acid; delta-3-Isopentenyl pyrophosphoric acid; 3-Methyl-3-butenyl pyrophosphoric acid; Δ3-methyl-3-butenyl diphosphoric acid; δ3-methyl-3-butenyl diphosphate; mono(3-Methyl-3-butenyl) diphosphate; delta3-Isopentenyl diphosphoric acid; delta3-Methyl-3-butenyl diphosphate; Δ-3-isopentenyl pyrophosphoric acid; δ-3-Isopentenyl pyrophosphat; delta-3-Isopentenyl pyrophosphate; delta-3-Isopentenyl pyrophosphat; δ3-isopentenyl diphosphate; 3-Methyl-3-butenyl pyrophosphate; Δ3-isopentenyl diphosphoric acid; Δ3-methyl-3-butenyl diphosphate; Isopentenyl pyrophosphoric acid; delta3-Isopentenyl diphosphate; Isopentenyl pyrophosphic acid; Δ-3-isopentenyl pyrophosphate; Δ3-isopentenyl diphosphate; isopentenyl pyrophosphate; Isopentenyl-diphosphate; delta(3)-Isopentenyl-PP; Isopentenyl diphosphate; Isopentenyl-PP; IPPP; IPP; IPR; Isopentenyl pyrophosphate; Isopentenyl diphosphate



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(18)

BioCyc(3)

PlantCyc(0)

代谢反应

881 个相关的代谢反应过程信息。

Reactome(219)

BioCyc(15)

WikiPathways(4)

Plant Reactome(572)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(69)

PharmGKB(0)

44 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hanwen Yu, Bowen Chen, Jing Li, Nan Dong, Xiangwei Chang, Jutao Wang, Huasheng Peng, Liangping Zha, Shuangying Gui. Identification and functional characterization of two trans-isopentenyl diphosphate synthases and one squalene synthase involved in triterpenoid biosynthesis in Platycodon grandiflorus. Planta. 2023 Nov; 258(6):115. doi: 10.1007/s00425-023-04273-2. [PMID: 37943378]
  • Zarley Rebholz, Leena Shewade, Kylie Kaler, Hailey Larose, Florian Schubot, Dorothea Tholl, Alexandre V Morozov, Paul E O'Maille. Emergence of terpene chemical communication in insects: Evolutionary recruitment of isoprenoid metabolism. Protein science : a publication of the Protein Society. 2023 Mar; ?(?):e4634. doi: 10.1002/pro.4634. [PMID: 36974623]
  • Meng Xia, Yifeng Zhang, Haiyun Gao, Yuan Liu, Xiaoyi Wu, Wei Gao. [Effect of isopentenyl pyrophosphate translocation on the biosynthesis of triptolide]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2021 Jun; 37(6):2039-2049. doi: 10.13345/j.cjb.200752. [PMID: 34227293]
  • Toni Krause, Michael Reichelt, Jonathan Gershenzon, Axel Schmidt. Analysis of the isoprenoid pathway intermediates, dimethylallyl diphosphate and isopentenyl diphosphate, from crude plant extracts by liquid chromatography tandem mass spectrometry. Phytochemical analysis : PCA. 2020 Nov; 31(6):770-777. doi: 10.1002/pca.2941. [PMID: 32337807]
  • Hachemi Kadri, Taher E Taher, Qin Xu, Maria Sharif, Elizabeth Ashby, Richard T Bryan, Benjamin E Willcox, Youcef Mehellou. Aryloxy Diester Phosphonamidate Prodrugs of Phosphoantigens (ProPAgens) as Potent Activators of Vγ9/Vδ2 T-Cell Immune Responses. Journal of medicinal chemistry. 2020 10; 63(19):11258-11270. doi: 10.1021/acs.jmedchem.0c01232. [PMID: 32930595]
  • Satoshi Yamashita, Seiji Takahashi. Molecular Mechanisms of Natural Rubber Biosynthesis. Annual review of biochemistry. 2020 06; 89(?):821-851. doi: 10.1146/annurev-biochem-013118-111107. [PMID: 32228045]
  • Cuihua Liu, Min He, Zhuang Wang, Juan Xu. Integrative Analysis of Terpenoid Profiles and Hormones from Fruits of Red-Flesh Citrus Mutants and Their Wild Types. Molecules (Basel, Switzerland). 2019 Sep; 24(19):. doi: 10.3390/molecules24193456. [PMID: 31547628]
  • Geraldy L S Liman, Tyler Hulko, Hallie P Febvre, Aaron C Brachfeld, Thomas J Santangelo. A linear pathway for mevalonate production supports growth of Thermococcus kodakarensis. Extremophiles : life under extreme conditions. 2019 Mar; 23(2):229-238. doi: 10.1007/s00792-019-01076-w. [PMID: 30673855]
  • Sarada D Tetali. Terpenes and isoprenoids: a wealth of compounds for global use. Planta. 2019 Jan; 249(1):1-8. doi: 10.1007/s00425-018-3056-x. [PMID: 30467631]
  • Laura K Henry, Suzanne T Thomas, Joshua R Widhalm, Joseph H Lynch, Thomas C Davis, Sharon A Kessler, Jörg Bohlmann, Joseph P Noel, Natalia Dudareva. Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nature plants. 2018 09; 4(9):721-729. doi: 10.1038/s41477-018-0220-z. [PMID: 30127411]
  • Kevin W George, Mitchell G Thompson, Joonhoon Kim, Edward E K Baidoo, George Wang, Veronica Teixeira Benites, Christopher J Petzold, Leanne Jade G Chan, Suzan Yilmaz, Petri Turhanen, Paul D Adams, Jay D Keasling, Taek Soon Lee. Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli. Metabolic engineering. 2018 05; 47(?):60-72. doi: 10.1016/j.ymben.2018.03.004. [PMID: 29530749]
  • Marta Walczak, Suresh M Ganesan, Jacquin C Niles, Ellen Yeh. ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites. mBio. 2018 01; 9(1):. doi: 10.1128/mbio.02021-17. [PMID: 29295911]
  • Rui Huang, Yang Wang, Pingrong Wang, Chunmei Li, Fuliang Xiao, Nenggang Chen, Na Li, Caixia Li, Changhui Sun, Lihua Li, Rongjun Chen, Zhengjun Xu, Jianqing Zhu, Xiaojian Deng. A single nucleotide mutation of IspF gene involved in the MEP pathway for isoprenoid biosynthesis causes yellow-green leaf phenotype in rice. Plant molecular biology. 2018 Jan; 96(1-2):5-16. doi: 10.1007/s11103-017-0668-7. [PMID: 29143298]
  • Paola Andrade, Daniel Caudepón, Teresa Altabella, Montserrat Arró, Albert Ferrer, David Manzano. Complex interplays between phytosterols and plastid development. Plant signaling & behavior. 2017 Nov; 12(11):e1387708. doi: 10.1080/15592324.2017.1387708. [PMID: 28990832]
  • Lixia Yang, Liangzhen Jiang, Wei Li, Yun Yang, Guolin Zhang, Yinggang Luo. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli. Journal of industrial microbiology & biotechnology. 2017 Oct; 44(10):1431-1441. doi: 10.1007/s10295-017-1967-3. [PMID: 28695386]
  • Hiroyuki Kajiura, Nobuaki Suzuki, Yuji Tokumoto, Takuya Yoshizawa, Shinya Takeno, Kazuhito Fujiyama, Yoshinobu Kaneko, Hiroyoshi Matsumura, Yoshihisa Nakazawa. Two Eucommia farnesyl diphosphate synthases exhibit distinct enzymatic properties leading to end product preferences. Biochimie. 2017 Aug; 139(?):95-106. doi: 10.1016/j.biochi.2017.05.001. [PMID: 28478108]
  • Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore, Giorgia Mandili, Myriam Foglietta, Nico Mitro, Donatella Caruso, Francesco Novelli, Chiara Riganti, Massimo Massaia. The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. Nature communications. 2017 06; 8(?):15663. doi: 10.1038/ncomms15663. [PMID: 28580927]
  • Chen Xu, Yingjia Yu, Li Ling, Xueni Sun, Yan Li, Gengli Duan. Novel strategy for the facile enrichment of isopentenyl pyrophosphate in rat plasma via Ti4+ -immobilized polydopamine@Fe3 O4 core-shell microspheres. Journal of separation science. 2017 May; 40(10):2278-2285. doi: 10.1002/jssc.201600860. [PMID: 28371337]
  • Bok-Kyu Shin, Mihyang Kim, Jaehong Han. Exceptionally high percentage of IPP synthesis by Ginkgo biloba IspH is mainly due to Phe residue in the active site. Phytochemistry. 2017 Apr; 136(?):9-14. doi: 10.1016/j.phytochem.2017.01.012. [PMID: 28139297]
  • Julie E Chaves, Paloma Rueda Romero, Henning Kirst, Anastasios Melis. Role of isopentenyl-diphosphate isomerase in heterologous cyanobacterial (Synechocystis) isoprene production. Photosynthesis research. 2016 Dec; 130(1-3):517-527. doi: 10.1007/s11120-016-0293-3. [PMID: 27412351]
  • Ilya Pankratov, Ryan McQuinn, Jochanan Schwartz, Einat Bar, Zhangjun Fei, Efraim Lewinsohn, Dani Zamir, James J Giovannoni, Joseph Hirschberg. Fruit carotenoid-deficient mutants in tomato reveal a function of the plastidial isopentenyl diphosphate isomerase (IDI1) in carotenoid biosynthesis. The Plant journal : for cell and molecular biology. 2016 10; 88(1):82-94. doi: 10.1111/tpj.13232. [PMID: 27288653]
  • Mei Xia, Danny C Hesser, Prithwiraj De, Isaac G Sakala, Charles T Spencer, Jay S Kirkwood, Getahun Abate, Delphi Chatterjee, Karen M Dobos, Daniel F Hoft. A Subset of Protective γ9δ2 T Cells Is Activated by Novel Mycobacterial Glycolipid Components. Infection and immunity. 2016 09; 84(9):2449-62. doi: 10.1128/iai.01322-15. [PMID: 27297390]
  • Kariona A Grabińska, Eon Joo Park, William C Sessa. cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases. The Journal of biological chemistry. 2016 08; 291(35):18582-90. doi: 10.1074/jbc.r116.739490. [PMID: 27402831]
  • Lemeng Dong, Esmer Jongedijk, Harro Bouwmeester, Alexander Van Der Krol. Monoterpene biosynthesis potential of plant subcellular compartments. The New phytologist. 2016 Jan; 209(2):679-90. doi: 10.1111/nph.13629. [PMID: 26356766]
  • Aparajita Banerjee, Alyssa L Preiser, Thomas D Sharkey. Engineering of Recombinant Poplar Deoxy-D-Xylulose-5-Phosphate Synthase (PtDXS) by Site-Directed Mutagenesis Improves Its Activity. PloS one. 2016; 11(8):e0161534. doi: 10.1371/journal.pone.0161534. [PMID: 27548482]
  • Xianan Zhang, Hongyu Guan, Zhubo Dai, Juan Guo, Ye Shen, Guanghong Cui, Wei Gao, Luqi Huang. Functional Analysis of the Isopentenyl Diphosphate Isomerase of Salvia miltiorrhiza via Color Complementation and RNA Interference. Molecules (Basel, Switzerland). 2015 Nov; 20(11):20206-18. doi: 10.3390/molecules201119689. [PMID: 26569204]
  • Laura K Henry, Michael Gutensohn, Suzanne T Thomas, Joseph P Noel, Natalia Dudareva. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. Proceedings of the National Academy of Sciences of the United States of America. 2015 Aug; 112(32):10050-5. doi: 10.1073/pnas.1504798112. [PMID: 26216978]
  • Shakeel J Abbassi, Rishi K Vishwakarma, Parth Patel, Uma Kumari, Bashir M Khan. Bacopa monniera recombinant mevalonate diphosphate decarboxylase: Biochemical characterization. International journal of biological macromolecules. 2015 Aug; 79(?):661-8. doi: 10.1016/j.ijbiomac.2015.05.041. [PMID: 26027607]
  • Xiao-Mi Wang, Bo Yang, Cheng-Gang Ren, Hong-Wei Wang, Jin-Yan Wang, Chuan-Chao Dai. Involvement of abscisic acid and salicylic acid in signal cascade regulating bacterial endophyte-induced volatile oil biosynthesis in plantlets of Atractylodes lancea. Physiologia plantarum. 2015 Jan; 153(1):30-42. doi: 10.1111/ppl.12236. [PMID: 24862990]
  • Nazia Nisar, Li Li, Shan Lu, Nay Chi Khin, Barry J Pogson. Carotenoid metabolism in plants. Molecular plant. 2015 Jan; 8(1):68-82. doi: 10.1016/j.molp.2014.12.007. [PMID: 25578273]
  • Cinzia Formighieri, Anastasios Melis. Carbon partitioning to the terpenoid biosynthetic pathway enables heterologous β-phellandrene production in Escherichia coli cultures. Archives of microbiology. 2014 Dec; 196(12):853-61. doi: 10.1007/s00203-014-1024-9. [PMID: 25116411]
  • Sergiy G Krasutsky, Marek Urbansky, Chad E Davis, Christian Lherbet, Robert M Coates, C Dale Poulter. Synthesis of methylerythritol phosphate analogues and their evaluation as alternate substrates for IspDF and IspE from Agrobacterium tumefaciens. The Journal of organic chemistry. 2014 Oct; 79(19):9170-8. doi: 10.1021/jo501529k. [PMID: 25184438]
  • A Banerjee, T D Sharkey. Methylerythritol 4-phosphate (MEP) pathway metabolic regulation. Natural product reports. 2014 Aug; 31(8):1043-55. doi: 10.1039/c3np70124g. [PMID: 24921065]
  • Hao Zhang, Zheng-Xi Li. A type-III insect geranylgeranyl diphosphate synthase with a novel catalytic property. Protein and peptide letters. 2014 Jul; 21(7):615-23. doi: 10.2174/0929866521666140214123942. [PMID: 24527738]
  • Bhawna Saxena, Mayavan Subramaniyan, Karan Malhotra, Neel Sarovar Bhavesh, Shobha Devi Potlakayala, Shashi Kumar. Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth. Journal of biosciences. 2014 Mar; 39(1):33-41. doi: 10.1007/s12038-013-9402-z. [PMID: 24499788]
  • Changfang Zhou, Ziru Li, Amy E Wiberley-Bradford, Sean E Weise, Thomas D Sharkey. Isopentenyl diphosphate and dimethylallyl diphosphate/isopentenyl diphosphate ratio measured with recombinant isopentenyl diphosphate isomerase and isoprene synthase. Analytical biochemistry. 2013 Sep; 440(2):130-6. doi: 10.1016/j.ab.2013.05.028. [PMID: 23747531]
  • Aparajita Banerjee, Yan Wu, Rahul Banerjee, Yue Li, Honggao Yan, Thomas D Sharkey. Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway. The Journal of biological chemistry. 2013 Jun; 288(23):16926-16936. doi: 10.1074/jbc.m113.464636. [PMID: 23612965]
  • Nobuaki Suzuki, Hirotaka Uefuji, Takashi Nishikawa, Yukio Mukai, Atsushi Yamashita, Masahira Hattori, Naotake Ogasawara, Takeshi Bamba, Ei-ichiro Fukusaki, Akio Kobayashi, Yoshiyuki Ogata, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Yoshihisa Nakazawa. Construction and analysis of EST libraries of the trans-polyisoprene producing plant, Eucommia ulmoides Oliver. Planta. 2012 Nov; 236(5):1405-17. doi: 10.1007/s00425-012-1679-x. [PMID: 22729820]
  • Grégory Guirimand, Anthony Guihur, Michael A Phillips, Audrey Oudin, Gaëlle Glévarec, Samira Mahroug, Céline Melin, Nicolas Papon, Marc Clastre, Nathalie Giglioli-Guivarc'h, Benoit St-Pierre, Manuel Rodríguez-Concepción, Vincent Burlat, Vincent Courdavault. Triple subcellular targeting of isopentenyl diphosphate isomerases encoded by a single gene. Plant signaling & behavior. 2012 Nov; 7(11):1495-7. doi: 10.4161/psb.21892. [PMID: 22951398]
  • Kuo-Hsun Teng, Po-Huang Liang. Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. Molecular membrane biology. 2012 Nov; 29(7):267-73. doi: 10.3109/09687688.2012.674162. [PMID: 22471620]
  • Maryam Darabi, Ali Izadi-Darbandi, Ali Masoudi-Nejad, Mohammad Reza Naghavi, Ghorbanali Nemat-Zadeh. Bioinformatics study of the 3-hydroxy-3-methylglotaryl-coenzyme A reductase (HMGR) gene in Gramineae. Molecular biology reports. 2012 Sep; 39(9):8925-35. doi: 10.1007/s11033-012-1761-2. [PMID: 22722993]
  • Grégory Guirimand, Anthony Guihur, Michael A Phillips, Audrey Oudin, Gaëlle Glévarec, Céline Melin, Nicolas Papon, Marc Clastre, Benoit St-Pierre, Manuel Rodríguez-Concepción, Vincent Burlat, Vincent Courdavault. A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus. Plant molecular biology. 2012 Jul; 79(4-5):443-59. doi: 10.1007/s11103-012-9923-0. [PMID: 22638903]
  • Yimian Ma, Lichai Yuan, Bin Wu, Xian'en Li, Shilin Chen, Shanfa Lu. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. Journal of experimental botany. 2012 Apr; 63(7):2809-23. doi: 10.1093/jxb/err466. [PMID: 22291132]
  • Nicole van Deenen, Anne-Lena Bachmann, Thomas Schmidt, Hubert Schaller, Jennifer Sand, Dirk Prüfer, Christian Schulze Gronover. Molecular cloning of mevalonate pathway genes from Taraxacum brevicorniculatum and functional characterisation of the key enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Molecular biology reports. 2012 Apr; 39(4):4337-49. doi: 10.1007/s11033-011-1221-4. [PMID: 21833516]
  • Danilo Aros, Veronica Gonzalez, Rudolf K Allemann, Carsten T Müller, Carlo Rosati, Hilary J Rogers. Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers. Journal of experimental botany. 2012 Apr; 63(7):2739-52. doi: 10.1093/jxb/err456. [PMID: 22268153]
  • Insaf Thabet, Grégory Guirimand, Anthony Guihur, Arnaud Lanoue, Vincent Courdavault, Nicolas Papon, Sadok Bouzid, Nathalie Giglioli-Guivarc'h, Andrew J Simkin, Marc Clastre. Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus. Molecular biology reports. 2012 Mar; 39(3):3235-43. doi: 10.1007/s11033-011-1091-9. [PMID: 21706164]
  • Sol A Green, Xiuyin Chen, Niels J Nieuwenhuizen, Adam J Matich, Mindy Y Wang, Barry J Bunn, Yar-Khing Yauk, Ross G Atkinson. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). Journal of experimental botany. 2012 Mar; 63(5):1951-67. doi: 10.1093/jxb/err393. [PMID: 22162874]
  • Raimund Nagel, Jonathan Gershenzon, Axel Schmidt. Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. Analytical biochemistry. 2012 Mar; 422(1):33-8. doi: 10.1016/j.ab.2011.12.037. [PMID: 22266300]
  • Janina Post, Nicole van Deenen, Julia Fricke, Natalie Kowalski, David Wurbs, Hubert Schaller, Wolfgang Eisenreich, Claudia Huber, Richard M Twyman, Dirk Prüfer, Christian Schulze Gronover. Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum. Plant physiology. 2012 Mar; 158(3):1406-17. doi: 10.1104/pp.111.187880. [PMID: 22238421]
  • Keng-See Chow, Mohd-Noor Mat-Isa, Azlina Bahari, Ahmad-Kamal Ghazali, Halimah Alias, Zainorlina Mohd-Zainuddin, Chee-Choong Hoh, Kiew-Lian Wan. Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. Journal of experimental botany. 2012 Mar; 63(5):1863-71. doi: 10.1093/jxb/err363. [PMID: 22162870]
  • Randor Radakovits, Robert E Jinkerson, Susan I Fuerstenberg, Hongseok Tae, Robert E Settlage, Jeffrey L Boore, Matthew C Posewitz. Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. Nature communications. 2012 Feb; 3(?):686. doi: 10.1038/ncomms1688. [PMID: 22353717]
  • Djédoux Maxime Angaman, Rocco Petrizzo, Francesc Hernández-Gras, Carmen Romero-Segura, Irene Pateraki, Montserrat Busquets, Albert Boronat. Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. Plant methods. 2012 Jan; 8(1):1. doi: 10.1186/1746-4811-8-1. [PMID: 22243738]
  • Tahira Fatima, Crystal L Snyder, William R Schroeder, Dustin Cram, Raju Datla, David Wishart, Randall J Weselake, Priti Krishna. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. PloS one. 2012; 7(4):e34099. doi: 10.1371/journal.pone.0034099. [PMID: 22558083]
  • Tapan Kumar Mohanta, Andrea Occhipinti, Simon Atsbaha Zebelo, Maria Foti, Judith Fliegmann, Simone Bossi, Massimo E Maffei, Cinzia M Bertea. Ginkgo biloba responds to herbivory by activating early signaling and direct defenses. PloS one. 2012; 7(3):e32822. doi: 10.1371/journal.pone.0032822. [PMID: 22448229]
  • Xiumin Fu, Wenbin Kong, Gang Peng, Jingyi Zhou, Muhammad Azam, Changjie Xu, Don Grierson, Kunsong Chen. Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. Journal of experimental botany. 2012 Jan; 63(1):341-54. doi: 10.1093/jxb/err284. [PMID: 21994170]
  • Katrina Cornish, Wenshuang Xie. Natural rubber biosynthesis in plants: rubber transferase. Methods in enzymology. 2012; 515(?):63-82. doi: 10.1016/b978-0-12-394290-6.00004-5. [PMID: 22999170]
  • Eleanore T Wurtzel, Abby Cuttriss, Ratnakar Vallabhaneni. Maize provitamin a carotenoids, current resources, and future metabolic engineering challenges. Frontiers in plant science. 2012; 3(?):29. doi: 10.3389/fpls.2012.00029. [PMID: 22645578]
  • Md Sarfaraj Hussain, Sheeba Fareed, Saba Ansari, Md Akhlaquer Rahman, Iffat Zareen Ahmad, Mohd Saeed. Current approaches toward production of secondary plant metabolites. Journal of pharmacy & bioallied sciences. 2012 Jan; 4(1):10-20. doi: 10.4103/0975-7406.92725. [PMID: 22368394]
  • Takeru Yokoi, Keisuke Isobe, Tohru Yoshimura, Hisashi Hemmi. Archaeal phospholipid biosynthetic pathway reconstructed in Escherichia coli. Archaea (Vancouver, B.C.). 2012; 2012(?):438931. doi: 10.1155/2012/438931. [PMID: 22645416]
  • Adelene Ai Lian Song, Janna O Abdullah, Mohd Puad Abdullah, Norazizah Shafee, Raha A Rahim. Functional expression of an orchid fragrance gene in Lactococcus lactis. International journal of molecular sciences. 2012; 13(2):1582-1597. doi: 10.3390/ijms13021582. [PMID: 22408409]
  • Catarina M Quinzii, Saba Tadesse, Ali Naini, Michio Hirano. Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. PloS one. 2012; 7(2):e30606. doi: 10.1371/journal.pone.0030606. [PMID: 22359546]
  • Manoj Kumar, Ravinder Nagpal, Rajesh Kumar, R Hemalatha, Vinod Verma, Ashok Kumar, Chaitali Chakraborty, Birbal Singh, Francesco Marotta, Shalini Jain, Hariom Yadav. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Experimental diabetes research. 2012; 2012(?):902917. doi: 10.1155/2012/902917. [PMID: 22611376]
  • Yu-Guang Ma, Wen-Chao Liu, Shuo Dong, Cheng Du, Xiao-Jun Wang, Jin-Sheng Li, Xiao-Ping Xie, Li Wu, Da-Chang Ma, Zhi-Bin Yu, Man-Jiang Xie. Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells. PloS one. 2012; 7(5):e37451. doi: 10.1371/journal.pone.0037451. [PMID: 22655048]
  • LingLin Wan, Juan Han, Min Sang, AiFen Li, Hong Wu, ShunJi Yin, ChengWu Zhang. De novo transcriptomic analysis of an oleaginous microalga: pathway description and gene discovery for production of next-generation biofuels. PloS one. 2012; 7(4):e35142. doi: 10.1371/journal.pone.0035142. [PMID: 22536352]
  • Maha M Al-Bazi, Mohamed F Elshal, Samir M Khoja. Reduced coenzyme Q(10) in female smokers and its association with lipid profile in a young healthy adult population. Archives of medical science : AMS. 2011 Dec; 7(6):948-54. doi: 10.5114/aoms.2011.26605. [PMID: 22328876]
  • Hongmei Luo, Chao Sun, Yongzhen Sun, Qiong Wu, Ying Li, Jingyuan Song, Yunyun Niu, Xianglin Cheng, Hongxi Xu, Chuyuan Li, Juyan Liu, André Steinmetz, Shilin Chen. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. BMC genomics. 2011 Dec; 12 Suppl 5(?):S5. doi: 10.1186/1471-2164-12-s5-s5. [PMID: 22369100]
  • Roberto A Barrero, Brett Chapman, Yanfang Yang, Paula Moolhuijzen, Gabriel Keeble-Gagnère, Nan Zhang, Qi Tang, Matthew I Bellgard, Deyou Qiu. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. BMC genomics. 2011 Dec; 12(?):600. doi: 10.1186/1471-2164-12-600. [PMID: 22151917]
  • Axel Schmidt, Raimund Nagel, Trygve Krekling, Erik Christiansen, Jonathan Gershenzon, Paal Krokene. Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). Plant molecular biology. 2011 Dec; 77(6):577-90. doi: 10.1007/s11103-011-9832-7. [PMID: 22002747]
  • Craig A Atkins, R J Neil Emery, Penelope M C Smith. Consequences of transforming narrow leafed lupin (Lupinus angustifolius [L.]) with an ipt gene under control of a flower-specific promoter. Transgenic research. 2011 Dec; 20(6):1321-32. doi: 10.1007/s11248-011-9497-7. [PMID: 21344295]
  • Marc Clastre, Nicolas Papon, Vincent Courdavault, Nathalie Giglioli-Guivarc'h, Benoit St-Pierre, Andrew J Simkin. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. Plant signaling & behavior. 2011 Dec; 6(12):2044-6. doi: 10.4161/psb.6.12.18173. [PMID: 22080790]
  • Insaf Thabet, Grégory Guirimand, Vincent Courdavault, Nicolas Papon, Stéphanie Godet, Christelle Dutilleul, Sadok Bouzid, Nathalie Giglioli-Guivarc'h, Marc Clastre, Andrew J Simkin. The subcellular localization of periwinkle farnesyl diphosphate synthase provides insight into the role of peroxisome in isoprenoid biosynthesis. Journal of plant physiology. 2011 Nov; 168(17):2110-6. doi: 10.1016/j.jplph.2011.06.017. [PMID: 21872968]
  • Chun Sui, Jie Zhang, Jianhe Wei, Shilin Chen, Ying Li, Jiesen Xu, Yue Jin, Caixiang Xie, Zhihui Gao, Hongjiang Chen, Chengmin Yang, Zheng Zhang, Yanhong Xu. Transcriptome analysis of Bupleurum chinense focusing on genes involved in the biosynthesis of saikosaponins. BMC genomics. 2011 Nov; 12(?):539. doi: 10.1186/1471-2164-12-539. [PMID: 22047182]
  • Petra M Bleeker, Eleni A Spyropoulou, Paul J Diergaarde, Hanne Volpin, Michiel T J De Both, Philipp Zerbe, Joerg Bohlmann, Vasiliki Falara, Yuki Matsuba, Eran Pichersky, Michel A Haring, Robert C Schuurink. RNA-seq discovery, functional characterization, and comparison of sesquiterpene synthases from Solanum lycopersicum and Solanum habrochaites trichomes. Plant molecular biology. 2011 Nov; 77(4-5):323-36. doi: 10.1007/s11103-011-9813-x. [PMID: 21818683]
  • Juri Battilana, Francesco Emanuelli, Giorgio Gambino, Ivana Gribaudo, Flavia Gasperi, Paul K Boss, Maria Stella Grando. Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation. Journal of experimental botany. 2011 Nov; 62(15):5497-508. doi: 10.1093/jxb/err231. [PMID: 21868399]
  • Yunliu Zeng, Zhiyong Pan, Yuduan Ding, Andan Zhu, Hongbo Cao, Qiang Xu, Xiuxin Deng. A proteomic analysis of the chromoplasts isolated from sweet orange fruits [Citrus sinensis (L.) Osbeck]. Journal of experimental botany. 2011 Nov; 62(15):5297-309. doi: 10.1093/jxb/err140. [PMID: 21841170]
  • Nora C Lawo, Georg J F Weingart, Rainer Schuhmacher, Astrid Forneck. The volatile metabolome of grapevine roots: first insights into the metabolic response upon phylloxera attack. Plant physiology and biochemistry : PPB. 2011 Sep; 49(9):1059-63. doi: 10.1016/j.plaphy.2011.06.008. [PMID: 21764593]
  • Tsuyoshi Furumoto, Teppei Yamaguchi, Yumiko Ohshima-Ichie, Masayoshi Nakamura, Yoshiko Tsuchida-Iwata, Masaki Shimamura, Junichi Ohnishi, Shingo Hata, Udo Gowik, Peter Westhoff, Andrea Bräutigam, Andreas P M Weber, Katsura Izui. A plastidial sodium-dependent pyruvate transporter. Nature. 2011 Aug; 476(7361):472-5. doi: 10.1038/nature10250. [PMID: 21866161]
  • Qi Tang, Xiaojun Ma, Changming Mo, Iain W Wilson, Cai Song, Huan Zhao, Yanfang Yang, Wei Fu, Deyou Qiu. An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis. BMC genomics. 2011 Jul; 12(?):343. doi: 10.1186/1471-2164-12-343. [PMID: 21729270]
  • Wei Wen, Rongmin Yu. Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective. Pharmacognosy reviews. 2011 Jul; 5(10):189-94. doi: 10.4103/0973-7847.91118. [PMID: 22279377]
  • Juliana Almeida, Leandro Quadrana, Ramón Asís, Nathalia Setta, Fabiana de Godoy, Luisa Bermúdez, Santiago N Otaiza, Junia V Corrêa da Silva, Alisdair R Fernie, Fernando Carrari, Magdalena Rossi. Genetic dissection of vitamin E biosynthesis in tomato. Journal of experimental botany. 2011 Jul; 62(11):3781-98. doi: 10.1093/jxb/err055. [PMID: 21527625]
  • Ashkan Amirshahi, Charles Wan, Kenneth Beagley, Joanna Latter, Ian Symonds, Peter Timms. Modulation of the Chlamydia trachomatis in vitro transcriptome response by the sex hormones estradiol and progesterone. BMC microbiology. 2011 Jun; 11(?):150. doi: 10.1186/1471-2180-11-150. [PMID: 21702997]
  • Pilar Martinez-Moya, Steven Alexander Watt, Karsten Niehaus, Jennifer Alcaíno, Marcelo Baeza, Víctor Cifuentes. Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. BMC microbiology. 2011 Jun; 11(?):131. doi: 10.1186/1471-2180-11-131. [PMID: 21669001]
  • Yu-Juan Zhong, Jun-Chao Huang, Jin Liu, Yin Li, Yue Jiang, Zeng-Fu Xu, Gerhard Sandmann, Feng Chen. Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis. Journal of experimental botany. 2011 Jun; 62(10):3659-69. doi: 10.1093/jxb/err070. [PMID: 21398427]
  • Stuart Meier, Oren Tzfadia, Ratnakar Vallabhaneni, Chris Gehring, Eleanore T Wurtzel. A transcriptional analysis of carotenoid, chlorophyll and plastidial isoprenoid biosynthesis genes during development and osmotic stress responses in Arabidopsis thaliana. BMC systems biology. 2011 May; 5(?):77. doi: 10.1186/1752-0509-5-77. [PMID: 21595952]
  • Kenneth D Harrison, Eon Joo Park, Ningguo Gao, Andrew Kuo, Jeffrey S Rush, Charles J Waechter, Mark A Lehrman, William C Sessa. Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation. The EMBO journal. 2011 May; 30(12):2490-500. doi: 10.1038/emboj.2011.147. [PMID: 21572394]
  • Sangsu Bang, Sungjae Yoo, Tae-Jin Yang, Hawon Cho, Sun Wook Hwang. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain. 2011 May; 152(5):1156-1164. doi: 10.1016/j.pain.2011.01.044. [PMID: 21353389]
  • Qiuju Yu, Sandro Ghisla, Joseph Hirschberg, Varda Mann, Peter Beyer. Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions. The Journal of biological chemistry. 2011 Mar; 286(10):8666-8676. doi: 10.1074/jbc.m110.208017. [PMID: 21209101]
  • Linda Olofsson, Alexander Engström, Anneli Lundgren, Peter E Brodelius. Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. BMC plant biology. 2011 Mar; 11(?):45. doi: 10.1186/1471-2229-11-45. [PMID: 21388533]
  • Simon Atsbaha Zebelo, Cinzia M Bertea, Simone Bossi, Andrea Occhipinti, Giorgio Gnavi, Massimo E Maffei. Chrysolina herbacea modulates terpenoid biosynthesis of Mentha aquatica L. PloS one. 2011 Mar; 6(3):e17195. doi: 10.1371/journal.pone.0017195. [PMID: 21408066]
  • Elizabeth Cordoba, Helena Porta, Analilia Arroyo, Carolina San Román, Luis Medina, Manuel Rodríguez-Concepción, Patricia León. Functional characterization of the three genes encoding 1-deoxy-D-xylulose 5-phosphate synthase in maize. Journal of experimental botany. 2011 Mar; 62(6):2023-38. doi: 10.1093/jxb/erq393. [PMID: 21199890]
  • Jeff Holderness, Igor A Schepetkin, Brett Freedman, Liliya N Kirpotina, Mark T Quinn, Jodi F Hedges, Mark A Jutila. Polysaccharides isolated from Açaí fruit induce innate immune responses. PloS one. 2011 Feb; 6(2):e17301. doi: 10.1371/journal.pone.0017301. [PMID: 21386979]
  • Caren Rodriguez-Medina, Craig A Atkins, Anthea J Mann, Megan E Jordan, Penelope Mc Smith. Macromolecular composition of phloem exudate from white lupin (Lupinus albus L.). BMC plant biology. 2011 Feb; 11(?):36. doi: 10.1186/1471-2229-11-36. [PMID: 21342527]
  • Ziru Li, Ellen A Ratliff, Thomas D Sharkey. Effect of temperature on postillumination isoprene emission in oak and poplar. Plant physiology. 2011 Feb; 155(2):1037-46. doi: 10.1104/pp.110.167551. [PMID: 21177471]
  • Codruta Ignea, Ivana Cvetkovic, Sofia Loupassaki, Panagiotis Kefalas, Christopher B Johnson, Sotirios C Kampranis, Antonios M Makris. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microbial cell factories. 2011 Jan; 10(?):4. doi: 10.1186/1475-2859-10-4. [PMID: 21276210]
  • Peter Bergman, Charlotte Linde, Katrin Pütsep, Anton Pohanka, Staffan Normark, Birgitta Henriques-Normark, Jan Andersson, Linda Björkhem-Bergman. Studies on the antibacterial effects of statins--in vitro and in vivo. PloS one. 2011; 6(8):e24394. doi: 10.1371/journal.pone.0024394. [PMID: 21912631]
  • Linkun Wu, Haibin Wang, Zhixing Zhang, Rui Lin, Zhongyi Zhang, Wenxiong Lin. Comparative metaproteomic analysis on consecutively Rehmannia glutinosa-monocultured rhizosphere soil. PloS one. 2011; 6(5):e20611. doi: 10.1371/journal.pone.0020611. [PMID: 21655235]
  • William N Hunter. Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites. Current topics in medicinal chemistry. 2011; 11(16):2048-59. doi: 10.2174/156802611796575867. [PMID: 21619509]
  • Ching-Wei Chang, Frederick A Beland, Wade M Hines, James C Fuscoe, Tao Han, James J Chen. Identification and categorization of liver toxicity markers induced by a related pair of drugs. International journal of molecular sciences. 2011; 12(7):4609-24. doi: 10.3390/ijms12074609. [PMID: 21845099]
  • Lei Wang, Wei Chen, Yun Feng, Yan Ren, Zhennan Gu, Haiqin Chen, Hongchao Wang, Michael J Thomas, Baixi Zhang, Isabelle M Berquin, Yang Li, Jiansheng Wu, Huanxin Zhang, Yuanda Song, Xiang Liu, James S Norris, Suriguga Wang, Peng Du, Junguo Shen, Na Wang, Yanlin Yang, Wei Wang, Lu Feng, Colin Ratledge, Hao Zhang, Yong Q Chen. Genome characterization of the oleaginous fungus Mortierella alpina. PloS one. 2011; 6(12):e28319. doi: 10.1371/journal.pone.0028319. [PMID: 22174787]